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Plasmodium knowlesi: a relevant, versatile experimental malaria model

Published online by Cambridge University Press:  12 December 2016

ERICA M. PASINI ,
ANNE-MARIE ZEEMAN ,
ANNEMARIE VOORBERG-VAN DER WEL  and
CLEMENS H. M. KOCKEN
ERICA M. PASINI
Affiliation:
Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
ANNE-MARIE ZEEMAN
Affiliation:
Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
ANNEMARIE VOORBERG-VAN DER WEL
Affiliation:
Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
CLEMENS H. M. KOCKEN*
Affiliation:
Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands
*
*Corresponding author: Department of Parasitology, Biomedical Primate Research Centre, PO Box 3306, 2280 GH Rijswijk, The Netherlands. E-mail: kocken@bprc.nl
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Summary

The primate malaria Plasmodium knowlesi has a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite–host interactions. The adaptation to long-term in vitro continuous blood stage culture in rhesus monkey, Macaca fascicularis and human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence that P. knowlesi is an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.

Keywords

Plasmodium knowlesimalariamodelzoonosisnon-human primatesin vitrovaccinetransfectionsevere malaria

Information

Type
Special Issue Review
Information
Parasitology , Volume 145 , Special Issue 1: Plasmodium knowlesi , January 2018 , pp. 56 - 70
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Copyright
Copyright © Cambridge University Press 2016 

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