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Predisposition to ascariasis: patterns, mechanisms and implications

  • C. V. HOLLAND (a1)
  • DOI:
  • Published online: 19 May 2009

Ascaris lumbricoides, the human roundworm, is a remarkably infectious and persistent parasite. It is a member of the soil-transmitted helminths or geohelminths and infects in the order of 1472 million people worldwide. Despite, its high prevalence and wide distribution it remains along with its geohelminth counterparts, a neglected disease. Ascariasis is associated with both chronic and acute morbidity, particularly in growing children, and the level of morbidity assessed as disability-adjusted life years is about 10·5 million. Like other macroparasite infections, the frequency distribution of A. lumbricoides is aggregated or overdispersed with most hosts harbouring few or no worms and a small proportion harbouring very heavy infections. Furthermore, after chemotherapeutic treatment, individuals demonstrate consistency in the pattern of re-infection with ascariasis, described as predisposition. These epidemiological phenomena have been identified, in a consistent manner, from a range of geographical locations in both children and adults. However, what has proved to be much more refractory to investigation has been the mechanisms that contribute to the observed epidemiological patterns. Parallel observations utilizing human subjects and appropriate animal model systems are essential to our understanding of the mechanisms underlying susceptibility/resistance to ascariasis. Furthermore, these patterns of Ascaris intensity and re-infection have broader implications with respect to helminth control and interactions with other important bystander infections.

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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

M. Albonico , H. Allen , L. Chitsulo , D. Engels , A.-F. Gabrielli and L. Savioli (2008). Controlling soil-transmitted helminthiasis in pre-school age children through preventive chemotherapy. PLOS Neglected Tropical Diseases 2, e126.

M. Albonico , A. Montresor , D. W. T. Crompton and L. Savioli (2006). Intervention for the control of soil-transmitted helminthiasis in the community. Advances in Parasitology 61, 311348.

T. J. C. Anderson , M. S. Blouin and R. N. Beech (1998). Population biology of parasitic nematodes: applications of genetic markers. Advances in Parasitology 41, 219283.

C. I. Bliss and R. A. Fisher (1953). Fitting the negative binomial distribution to biological data. Biometrics 9, 176199.

D. A. P. Bundy , M. S. Wong , L. L. Lewis and J. Horton (1990). Control of geohelminths by delivery of targeted chemotherapy through schools. Transactions of the Royal Society of Tropical and Medicine and Hygiene 84, 115120.

L. Chan , D. A. P. Bundy and S. P. Kan (1994 a). Aggregation and predisposition at the familial level. Transactions of the Royal Society of Tropical and Medicine and Hygiene 88, 4648.

L. J. Cliffe and R. K. Grencis (2004). The Trichuris muris system: a paradigm of resistance and susceptibility to intestinal nematode infection. Advances in Parasitology 57, 255307.

P. J. Cooper , M. E. Chico , C. Sandoval , I. Espinel , A. Guevara , M. W. Kennedy , J. F. Urban Jr., G. E. Griffin and T. B. Nutman (2000). Human infection with Ascaris lumbricoides is associated with a polarized cytokine response. The Journal of Infectious Diseases 182, 12071213.

D. W. T. Crompton (2001). Ascaris and ascariasis. Advances in Parasitology 48, 285375.

D. Elkins , M. R. Haswell-Elkins and R. M. Anderson (1986). The epidemiology and control of intestinal helminths in the Pulicat region of Southern India. I Study design and pre- and post-treatment observations on Ascaris lumbricoides infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 80, 774792.

E. M. Fraser and M. W. Kennedy (1991). Heterogeneity in the expression of surface-exposed epitopes among larvae of Ascaris lumbricoides. Parasite Immunology 13, 219225.

J. E. Forrester , M. E. Scott , D. A. P. Bundy and M. H. N. Golden (1990). Predisposition of individuals and families in Mexico to heavy infection with Ascaris lumbricoides and Trichuris trichiura. Transactions of the Royal Society of Tropical Medicine and Hygiene 84, 272276.

E. Frontera , A. Roepstorff , A. Gazquez , D. Reina , F. J. Serrano and I. Navarrete (2003). Immunohistochemical distribution of antigens in liver of infected and immunized pigs with Ascaris suum. Veterinary Parasitology 111, 9–18.

A. Hall , K. S. Anwar and A. Tomkins (1992). Intensity of reinfection with Ascaris lumbricoides and its implications for parasite control. Lancet 339, 12531257.

F. J. Henry (1988). Reinfection with Ascaris lumbricoides after chemotherapy: a comparative study in three villages with varying sanitation. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 460464.

C. V. Holland , S. O. Asaolu , D. W. T. Crompton , W. B. Crichton , S. E. A. Torimiro and D. E. Walters (1992). A possible genetic factor influencing protection from infection with Ascaris lumbricoides. Journal of Parasitology 78, 915916.

C. Holland , E. O'Shea , S. O. Asaolu , O. Turley and D. W. T. Crompton (1996). A cost-effective analysis of anthelmintic intervention for community control of soil-transmitted helminth infection: Levamisole and Ascaris lumbricoides. Journal of Parasitology 82, 527530.

P. J. Hotez , D. H. Molyneux , A. Fenwick , J. Kumaresan , S. Ehrlich Sachs , J. Sachs and L. Savioli (2007). Control of neglected tropical diseases. New England Journal of Medicine 357, 10181027.

G. Javid , N. A. Wani , G. M. Gulzar , B. A. Khan , A. H. Shah , O. J. Shah and M. Khan (1999). Ascaris-induced liver abscess. World Journal of Surgery 23, 11911194.

A. M. Kuris , J. H. R. Goddard , M. E. Torchin , N. Murphy , R. Gurney and K. D. Lafferty (2007). An experimental evaluation of host specificity: the role of encounter and compatability filters for a rhizocephalan parasite of crabs. International Journal for Parasitology 37, 539545.

R. M. Maizels and A. Kurniawan-Atmadja (2002). Variation and polymorphism in helminth parasites. Parasitology 125, S25S37.

R. M. Maizels and M. Yazdanbakhsh (2003). Immune regulation by helminth parasites: cellular and molecular mechanisms. Nature Reviews Immunology 3, 733744.

K. D. Murrell , L. Eriksen , P. Nansen , H.-C. Slotved and T. Rasmussen (1997). Ascaris suum: a revision of its early migratory path and implications for human ascariasis. Journal of Parasitology 83, 255260.

P. Nejsum , A. Roepstorff , C. B. Jorgensen , M. Fredholm , H. H. H. Goring , T. J. C. Anderson & S. M. Thamsborg (2009 b). High heritability for Ascaris and Trichuris infection levels in pigs. Heredity 102, 357364.

W. Peng , X. Zhou , X. Cui , D. W. T. Crompton , R. R. Whitehead , J. Xiong , H. Wu , Y. Yang , W. Wu , K. Xu and Y. Yan (1998). Transmission and natural regulation of infection with Ascaris lumbricoides in a rural community in China. Journal of Parasitology 84, 252258.

J. Perez , P. M. Garcia , E. Mozos , M. J. Bautista and L. Carrasco (2001). Immunohistochemical characterization of hepatic lesions associated with migrating larvae of Ascaris suum in pigs. Journal of Comparative Pathology 124, 200206.

R. J. Quinnell (2003). Genetics of susceptibility to human helminth infection. International Journal for Parasitology 33, 12191231.

A. F. Read and M. E. Viney (1996). Helminth immunogenetics: why bother? Parasitology Today 12, 337343.

M. Richard , R. K. Grencis , N. E. Humphreys , J. C. Renauld and J. Van Snick (2000). Anti-IL-9 vaccination prevents worm expulsion and blood eosinophilia in Trichuris muris-infected mice. Proceedings of the National Academy of Sciences, USA 97, 767772.

G. A. Schad and R. M. Anderson (1985). Predisposition to hookworm infection in humans. Science 228, 15371540.

L. R. Schopf , K. F. Hoffman , A. W. Cheever , J. F. Urban Jr. and T. A. Wynn (2002). IL-10 is critical for host resistance and survival during gastrointestinal helminth infection. Journal of Immunology 168, 23832392.

H.-C. Slotved , L. Eriksen , K. D. Murrell and P. Nansen (1998). Early Ascaris suum migration in mice as a model for pigs. Journal of Parasitology 84, 1618.

L. A. Tchuente , J. M. Behnke , F. S. Gilbert , V. R. Southgate and J. Vercruysse (2003). Polyparasitism with Schistosoma haematobium and soil-transmitted helminth infections among school children in Loum, Cameroon. Tropical Medicine and International Health 8, 975986.

Thein-Hlaing, Than-Saw and Myint-Lwin (1987). Reinfection of people with Ascaris lumbricoides following single 6-month and 12-month interval mass chemotherapy in Opko village, rural Burma. Transactions of the Royal Society of Tropical Medicine and Hygiene 81, 140146.

J. D. Turner , H. Faulkner , J. Kamgno , F. Cormont , J. Van Snick , K. J. Else , R. K. Grencis , J. M. Behnke , M. Boussinesq and J. E. Bradley (2003). Th2 cytokines are associated with reduced worm burdens in a human intestinal helminth infection. The Journal of Infectious Diseases 188, 17681775.

J. F. Urban Jr., I. M. Katona , W. E. Paul and F. D. Finkelman (1991). Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proceedings of the National Academy of Sciences, USA 88, 55135517.

M. S. Wong , D. A. P. Bundy and M. H. N. Golden (1988). Quantitative assessment of geophageous behaviour as a potential source of exposure to geohelminth infection. Transactions of the Royal Society of Tropical Medicine and Hygiene 82, 621625.

S. Williams-Blangero , J. L. VandeBerg , J. Subedi , M. J. Aivaliotis , D. R. Rai , R. P. Upadhayay , B. Jha and J. Blangero (2002). Genes on chromosomes 1 and 13 have significant effects on Ascaris infection. Proceedings of the National Academy of Sciences, USA 99, 55335538.

S. Williams-Blangero , J. L. VandeBerg , J. Subedi , B. Jha , R. Correa-Oiveira and J. Blangero (2008). Localization of multiple quantitative trait loci influencing susceptibility to infection with Ascaris lumbricoides. The Journal of Infectious Diseases 197, 6671.

M. Yazdanbakhsh , P. G. Kremsner and R. van Ree (2002). Allergy, parasites and the Hygiene Hypothesis. Science 296, 490494.

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