Hostname: page-component-848d4c4894-m9kch Total loading time: 0 Render date: 2024-05-07T18:21:01.368Z Has data issue: false hasContentIssue false
  • English
  • Français

Resistance to diamino-diphenylsulphone in Plasmodium gallinaceum

Published online by Cambridge University Press:  06 April 2009

Ann Bishop
Ann Bishop*
Affiliation:
The Molteno Institute, University of Cambridge
*
*This work was financed by the Medical Research Council.
Get access Rights & Permissions [Opens in a new window]

Extract

A fourfold enhancement of resistance to diamino-diphenylsulphone has been produced over a period of 15 months in strain A of P. gallinaceum by subjecting the strain, maintained in a state of patent infection, to increasing doses of the drug.

The DDS-resistant strain was cross-resistant to the minimum effective dose of sulphadiazine and slightly resistant to twice this dose, but it showed only a slight enhancement of resistance to pyrimethamine and proguanil.

The antimalarial action of DDS was antagonized by p–A.B. in the ratio of 100 to 1. DDS, in the minimum effective dose, was antagonized completely by folic acid if given in equal doses, but not by smaller doses of the antagonist; the antagonism was not competitive.

The relationship of cross-resistance between p–A.B.-inhibited sulphonamides and proguanil and pyrimethamine is discussed.

Type
Research Article
Information
Parasitology , Volume 55 , Issue 3 , August 1965 , pp. 407 - 414
Copyright
Copyright © Cambridge University Press 1965

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Archibald, H. M. & Ross, C. M. (1960). A preliminary report on the effect of diaminodiphenylsulphone on malaria in Northern Nigeria. J. trop. Med. Hyg. 63, 25–7.Google Scholar
Bishop, A. (1954). The action of 2:4-diamino-6:7-diisopropylpteridine upon Plasmodium gallinaceum and its relation to other compounds which are pteroylglutamic acid antagonists. Parasitology, 44, 450–64.CrossRefGoogle Scholar
Bishop, A. (1958). An analysis of the development of resistance to metachloridine in clones of plasmodium gallinaceum. Parasitology, 48, 210–34.CrossRefGoogle ScholarPubMed
Bishop, A. (1962). An analysis of the development of resistance to proguanil and pyrimethamine in Plasmodium gallinaceum. Parasitology, 52, 495–518.CrossRefGoogle Scholar
Bishop, A. & Birkett, B. (1948). Drug-resistance in Plasmodium gallinaceum and the persistence of paludrine-resistance after mosquito transmission. Parasitology, 39, 125–37.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 a). Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds. Parasitology, 40, 163–74.CrossRefGoogle ScholarPubMed
Bishop, A. & McConnachie, E. W. (1950 b). Cross-resistance between sulphanilamide and paludrine (proguanil) in a strain of Plasmodium gallinaceum resistant to sulphanilamide. Parasitology, 40, 175–8.CrossRefGoogle Scholar
Bishop, A. & McConnachie, E. W. (1951). The inhibition by p–aminobenzoic acid of the development of paludrine-resistance as produced by sulphonamides in Plasmodium gallinaceum. Parasitology, 41, 105–9.CrossRefGoogle ScholarPubMed
Coggeshall, L. T., Maier, J. & Best, C. A. (1941). The effectiveness of two new types of chemotherapeutic agents in malaria, sodium p.p’–diamino-diphenylsulfone N.N’–didextrose sulfonate (promin) and 2-sulfanilamido-pyrimidine (sulfadiazine). J. Amer. med. Ass. 117, 1077–81.CrossRefGoogle Scholar
Krishnaswami, A. K., Prakash, Sataya & Ramakrishnan, S. P. (1954). Studies on Plasmodium berghei Vincke & Lips, 1948. XV. Acquired resistance to sulphadiazine. Indian J. Malar. 8, 9–18.Google ScholarPubMed
Leiker, D. L. (1956). Note on sulphone activity in malaria infection. Lepr. Rev. 27, 66–7.Google Scholar
Levaditi, C. & Pérault, R. (1941). Mécanisme d'action des sulfamides, des sulfones et des sulfoxydes. Phénomène de Woods. C. r. Séanc. Soc. Biol. 135, 1043–6.Google Scholar
Maier, J. & Riley, E. (1942). Inhibition of antimalarial action of sulfonamides by p–aminobenzoic acid. Proc. Soc. exp. Biol. Med. 50, 152–4.CrossRefGoogle Scholar
Ramakrishnan, S. P., Basu, P. C., Singh, H. & Singh, N. (1962). Studies on the toxicity and action of diaminodiphenyl-sulfone (DDS) in avian and simian malaria. Bull. Wld. Hlth. Org. 27, 213–21.Google ScholarPubMed
Rollo, I. M. (1951). A 2:4-diamino pyrimidine in the treatment of proguanil-resistant laboratory malarial strains. Nature, Lond., 168, 332.CrossRefGoogle Scholar
Tarabini, G. (1958). The anti-protozoal action of the sulphones and the antimalarial action in particular. Lepr. Rev. 29, 111–13.Google ScholarPubMed
Thurston, J. P. (1953). The chemotherapy of Plasmodium berghei. I. Resistance to drugs. Parasitology, 43, 246–52.CrossRefGoogle ScholarPubMed
Woods, D. D. (1940). The relation of p–aminobenzoic acid to the mechanism of the action of sulphanilamide. Br. J. exp. Path. 21, 74–90.Google Scholar