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Species-specific probes for the identification of the African tsetse-transmitted trypanosomes†

Published online by Cambridge University Press:  02 June 2009

W. GIBSON
W. GIBSON*
Affiliation:
School of Biological Sciences, University of Bristol, Bristol BS8 1UG, UK
*
*Corresponding author. Tel: 44 (0) 117 928 8249. Fax: 44 (0) 117 331 7985. E-mail: w.gibson@bris.ac.uk
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Summary

The first step in studying the epidemiology of a disease is the accurate identification of the pathogen. Traditional reliance on morphological identification has given way to the use of molecular methods for the detection and identification of pathogens, greatly improving our understanding of epidemiology. For the African tsetse-transmitted trypanosomes, the growth of PCR methods for identification of trypanosomes has led to increased appreciation of trypanosome genetic diversity and discovery of hitherto unknown trypanosome species, as well as greater knowledge about the number and type of trypanosome infections circulating in mammalian hosts and vectors. Sequence data and phylogenetic analysis have provided quantitative information on the relatedness of different trypanosome species and allowed the new trypanosome genotypes discovered through the use of species identification methods in the field to be accurately placed in the phylogenetic tree.

Keywords

African trypanosomiasisTrypanosoma bruceiTrypanosoma congolenseTrypanosoma simiaeTrypanosoma vivaxreservoir host
Type
Research Article
Information
Parasitology , Volume 136 , Special Issue 12: Special Centenary Issue – Parasitology 1908–2008 , October 2009 , pp. 1501 - 1507
Copyright
Copyright © Cambridge University Press 2009

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Footnotes

†

This paper is dedicated to my Ph.D. supervisor and mentor, David Godfrey, 1929–2007.

References

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