Kong, Fanping Saldarriaga, Omar A. Spratt, Heidi Osorio, E. Yaneth Travi, Bruno L. Luxon, Bruce A. Melby, Peter C. and Engwerda, Christian R. 2017. Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype. PLOS Pathogens, Vol. 13, Issue. 1, p. e1006165.
Dos-Santos, A.L.A. Carvalho-Kelly, L.F. Dick, C.F. and Meyer-Fernandes, J.R. 2016. Innate immunomodulation to trypanosomatid parasite infections. Experimental Parasitology, Vol. 167, p. 67.
Higa, Leticia H. Arnal, Laura Vermeulen, Mónica Perez, Ana Paula Schilrreff, Priscila Mundiña-Weilenmann, Cecilia Yantorno, Osvaldo Vela, María Elena Morilla, María José Romero, Eder Lilia and Saha, Bhaskar 2016. Ultradeformable Archaeosomes for Needle Free Nanovaccination with Leishmania braziliensis Antigens. PLOS ONE, Vol. 11, Issue. 3, p. e0150185.
Yau, Wai-Lok Lambertz, Ulrike Colineau, Lucie Pescher, Pascale MacDonald, Andrea Zander, Dorothea Retzlaff, Silke Eick, Julia Reiner, Neil E. Clos, Joachim and Späth, Gerald F. 2016. Phenotypic Characterization of a Leishmania donovani Cyclophilin 40 Null Mutant. Journal of Eukaryotic Microbiology, Vol. 63, Issue. 6, p. 823.
Calegari-Silva, Teresa C. Vivarini, Áislan C. Miqueline, Marina Dos Santos, Guilherme R. R. M. Teixeira, Karina Luiza Saliba, Alessandra Mattos Nunes de Carvalho, Simone de Carvalho, Laís and Lopes, Ulisses G. 2015. The human parasiteLeishmania amazonensisdownregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway. Open Biology, Vol. 5, Issue. 9, p. 150118.
Geraci, N. S. Tan, J. C. and McDowell, M. A. 2015. Characterization of microRNA expression profiles inLeishmania-infected human phagocytes. Parasite Immunology, Vol. 37, Issue. 1, p. 43.
Gomes, Rodrigo Saar de Carvalho, Luana Cristina Faria de Souza Vasconcellos, Raphael Fietto, Juliana Lopes Rangel and Afonso, Luís Carlos Crocco 2015. E-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) of Leishmania amazonensis inhibits macrophage activation. Microbes and Infection, Vol. 17, Issue. 4, p. 295.
Olekhnovitch, Romain and Bousso, Philippe 2015. Induction, Propagation, and Activity of Host Nitric Oxide: Lessons from Leishmania Infection. Trends in Parasitology, Vol. 31, Issue. 12, p. 653.
Kima, Peter E. 2014. Leishmania molecules that mediate intracellular pathogenesis. Microbes and Infection, Vol. 16, Issue. 9, p. 721.
Marr, Alexandra K. MacIsaac, Julia L. Jiang, Ruiwei Airo, Adriana M. Kobor, Michael S. McMaster, W. Robert and Horn, David 2014. Leishmania donovani Infection Causes Distinct Epigenetic DNA Methylation Changes in Host Macrophages. PLoS Pathogens, Vol. 10, Issue. 10, p. e1004419.
Lima-Junior, Djalma S Costa, Diego L Carregaro, Vanessa Cunha, Larissa D Silva, Alexandre L N Mineo, Tiago W P Gutierrez, Fredy R S Bellio, Maria Bortoluci, Karina R Flavell, Richard A Bozza, Marcelo T Silva, João S and Zamboni, Dario S 2013. Inflammasome-derived IL-1β production induces nitric oxide–mediated resistance to Leishmania. Nature Medicine, Vol. 19, Issue. 7, p. 909.
Das, Sushmita Pandey, Krishna Kumar, Ashish Sardar, Abul H Purkait, Bidyut Kumar, Manish Kumar, Sudeep Ravidas, Vidya N Roy, Syamal Singh, Dharmendra and Das, Pradeep 2012. TGF-β1 re-programs TLR4 signaling in L. donovani infection: enhancement of SHP-1 and ubiquitin-editing enzyme A20. Immunology and Cell Biology, Vol. 90, Issue. 6, p. 640.
de Assis, Rafael Ramiro Ibraim, Izabela Coimbra Nogueira, Paula Monalisa Soares, Rodrigo Pedro and Turco, Salvatore J. 2012. Glycoconjugates in New World species of Leishmania: Polymorphisms in lipophosphoglycan and glycoinositolphospholipids and interaction with hosts. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1820, Issue. 9, p. 1354.
Oladiran, Ayoola and Belosevic, Miodrag 2012. Recombinant glycoprotein 63 (Gp63) of Trypanosoma carassii suppresses antimicrobial responses of goldfish (Carassius auratus L.) monocytes and macrophages. International Journal for Parasitology, Vol. 42, Issue. 7, p. 621.
Farrow, Anitra L. Rana, Tanu Mittal, Mukul K. Misra, Smita and Chaudhuri, Gautam 2011. Leishmania-induced repression of selected non-coding RNA genes containing B-box element at their promoters in alternatively polarized M2 macrophages. Molecular and Cellular Biochemistry, Vol. 350, Issue. 1-2, p. 47.
Jeronimo, Selma M.B. de Queiroz Sousa, Anastacio and Pearson, Richard D. 2011. Tropical Infectious Diseases: Principles, Pathogens and Practice.
Kaye, Paul and Scott, Phillip 2011. Leishmaniasis: complexity at the host–pathogen interface. Nature Reviews Microbiology, Vol. 9, Issue. 8, p. 604.
Escalona-Montaño, Alma R. Pardavé-Alejandre, Daniel Cervantes-Sarabia, Rocely García-López, Patricia Gutiérrez-Quiroz, Manuel Gutiérrez-Kobeh, Laila Becker-Fauser, Ingeborg and Aguirre-García, Maria M. 2010. Leishmania mexicana promastigotes secrete a protein tyrosine phosphatase. Parasitology Research, Vol. 107, Issue. 2, p. 309.
Ben-Othman, Rym Dellagi, Koussay and Guizani-Tabbane, Lamia 2009. Leishmania major parasites induced macrophage tolerance: Implication of MAPK and NF-κB pathways. Molecular Immunology, Vol. 46, Issue. 16, p. 3438.
Boggiatto, Paola Mercedes Jie, Fei Ghosh, Mousumi Gibson-Corley, Katherine Nicole Ramer-Tait, Amanda Ellen Jones, Douglas Elliot and Petersen, Christine Anne 2009. Altered Dendritic Cell Phenotype in Response to Leishmania amazonensis Amastigote Infection Is Mediated by MAP Kinase, ERK. The American Journal of Pathology, Vol. 174, Issue. 5, p. 1818.
The protozoa Leishmania spp. are obligate intracellular parasites that inhabit the macrophages of their host. Since macrophages are specialized for the identification and destruction of invading pathogens, both directly and by triggering an innate immune response, Leishmania have evolved a number of mechanisms for suppressing some critical macrophage activities. In this review, we discuss how various species of Leishmania distort the host macrophage's own signalling pathways to repress the expression of various cytokines and microbicidal molecules (nitric oxide and reactive oxygen species), and antigen presentation. In particular, we describe how MAP Kinase and JAK/STAT cascades are repressed, and intracellular Ca2+ and the activities of protein tyrosine phosphatases, in particular SHP-1, are elevated.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
Full text views reflects the number of PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.
Abstract views reflect the number of visits to the article landing page.
* Views captured on Cambridge Core between September 2016 - 30th March 2017. This data will be updated every 24 hours.