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Toxoplasma gondii: the changing paradigm of congenital toxoplasmosis

  • D. S. LINDSAY (a1) and J. P. DUBEY (a2)

Summary

Researchers have learned much concerning the population biology of Toxoplasma gondii over the past 2 decades. It is now apparent that many atypical genotypes exist besides the typical 3 genotypes (type I, type II and type III) first described from samples from Europe and the United States. These genotypes can differ in pathogenicity and transmissibility from the typical genotypes that have been used in the majority of scientific research over the past 70 years. These differences impact much of what we used to believe as facts about congenital toxoplasmosis (CT) and will be important in developing new recommendations for prevention of CT and the monitoring of women at risk for developing CT. The present review highlights new information on T. gondii genotypes and how this information will change the way we convey information about CT to pregnant women, physicians and students.

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Corresponding author

*Corresponding author: Department of Biomedical Sciences and Pathobiology, Virginia Tech, 1410 Prices Fork Road, Blacksburg, VA 24061, USA. Tel: +1 540 321 6302. Fax: +1 540 231 3426. E-mail: lindsayd@vt.edu

References

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Ajzenberg, D., Cogné, N., Paris, L., Bessières, M. H., Thulliez, P., Filisetti, D., Pelloux, H., Marty, P. and Dardé, M. L. (2002). Genotype of 86 Toxoplasma gondii isolates associated with human congenital toxoplasmosis, and correlation with clinical findings. Journal of Infectious Diseases 186, 684689.
Azevedo, K. M., Setúbal, S., Lopes, V. G., Camacho, L. A. and Oliveira, S. A. (2010). Congenital toxoplasmosis transmitted by human immunodeficiency-virus infected women. Brazilian Journal of Infectious Disease 14, 186189.
Bachmeyer, C., Mouchnino, G., Thulliez, P. and Blum, L. (2006). Congenital toxoplasmosis from an HIV-infected woman as a result of reactivation. Journal of Infection 52, e5557.
Boumahni, B., Randrianivo, H., Flodrops, H., Kauffmann, E., Sauve, F., Chauvet, O., Renouil, M. and Fourmaintraux, A. (2004). Maternal toxoplasmosis before conception and chorioretinitis in twin sisters. Journal of Gynecology Obstetrics and Biology of Reproduction (Paris) 33, 248250.
Cneude, F., Deliege, R., Barbier, C., Durand-Joly, I., Bourlet, A., Sonna, M., El Kohen, R., Locquet, A, Vittu, G. and Decoster, A. (2003). Septic shock due to congenital disseminated toxoplasmosis? Archives of Pediatrics 10, 326328.
Delhaes, L., Ajzenberg, D., Sicot, B., Bourgeot, P., Dardé, M. L., Dei-Cas, E. and Houfflin-Debarge, V. (2010). Severe congenital toxoplasmosis due to a Toxoplasma gondii strain with an atypical genotype: case report and review. Prenatal Diagnosis 30, 902905.
Demar, M., Ajzenberg, D., Maubon, D., Djossou, F., Panchoe, D., Punwasi, W., Valery, N., Peneau, C., Daigre, J. L., Aznar, C., Cottrelle, B., Terzan, L., Dardé, M. L. and Carme, B. (2007). Fatal outbreak of human toxoplasmosis along the Maroni River: epidemiological, clinical, and parasitological aspects. Clinical Infectious Diseases 45, e88e95.
Desmonts, G., Couvreur, J. and Thulliez, P. (1990). Congenital toxoplasmosis: 5 cases of mother-to-child transmission of pre-pregnancy infection. La Presse Médicale 19, 14451449.
Dollfus, H., Dureau, P., Hennequin, C., Uteza, Y., Bron, A. and Dufier, J. L. (1998). Congenital Toxoplasma chorioretinitis transmitted by preconceptionally immune women. British Journal of Ophthalmology 82, 14441445.
Dubey, J. P. (2010). Toxoplasmosis of Animals and Humans, 2nd Edn. CRC Press, Boca Raton, FL, USA.
Dunn, D., Wallon, M., Peyron, F., Petersen, E., Peckham, C. and Gilbert, R. (1999). Mother-to-child transmission of toxoplasmosis: risk estimates for clinical counseling. Lancet 353, 18291833.
Elbez-Rubinstein, A., Ajzenberg, D., Darde, M. L., Cohen, R., Dumètre, A., Yera, H., Gondon, E., Janaud, J. C. and Thulliez, P. (2009). Congenital toxoplasmosis and reinfection during pregnancy: case report, strain characterization, experimental model of reinfection, and review. Journal of Infectious Diseases 199, 280285.
Fortier, B., Aissi, E., Ajana, F., Dieusart, P., Denis, P., Martin de Lassalle, E., Lecomte-Houcke, M. and Vinatier, D. (1991). Spontaneous abortion and reinfection by Toxoplasma gondii. Lancet 338, 444.
Gavinet, M. F., Robert, F., Firtion, G., Delouvrier, E., Hennequin, C., Maurin, J. R., Tourte-Schaefer, C. and Dupouy-Camet, J. (1997). Congenital toxoplasmosis due to maternal reinfection during pregnancy. Journal of Clinical Microbiology 35, 12761277.
Gilbert, R. E., Freeman, K., Lago, E. G., Bahia-Oliveira, L. M., Tan, H. K., Wallon, M., Buffolano, W., Stanford, M. R., Petersen, E. and European Multicentre Study on Congenital Toxoplasmosis (EMSCOT) (2008). Ocular sequelae of congenital toxoplasmosis in Brazil compared with Europe. PLoS Neglected Tropical Diseases 2, e277.
Hennequin, C., Dureau, P., N'Guyen, L., Thulliez, P., Gagelin, B. and Dufier, J. L. (1997). Congenital toxoplasmosis acquired from an immune woman. Pediatric Infectious Disease Journal 16, 7577.
Howe, D. K. and Sibley, L. D. (1995). Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease. Journal of Infections Diseases 172, 15611566.
Khan, A., Dubey, J. P., Su, C., Ajioka, J. W., Rosenthal, B. M. and Sibley, L. D. (2011). Genetic analyses of a typical Toxoplasma gondii strains reveal a fourth clonal lineage in North America. International Journal for Parasitology 41, 645655.
Kodjikian, L., Hoigne, I., Adam, O., Jacquier, P., Aebi-Ochsner, C., Aebi, C. and Garweg, J. (2004). Vertical transmission of toxoplasmosis from a chronically infected immunocompetent woman. Pediatric Infectious Disease Journal 23, 272274.
Lebas, F., Ducrocq., S, Mucignat, V., Paris, L., Mégier, P., Baudon, J. J. and Gold, F. (2004). Congenital toxoplasmosis: a new case of infection during pregnancy in a previously immunized and immunocompetent woman. Archives de Pédiatrie 11, 926928.
Marty, P., Bongain, A., Loiseau, S., Benoit, B., Chevallier, A., Gillet, J. Y. and Le Fichoux, Y. (2002). Lethal congenital toxoplasmosis resulting from reactivation of toxoplasmosis in a pregnant HIV-positive patient. La Presse Médicale 31, 1558.
Marty, P., Bongain, A., Rahal, A., Thulliez, P., Wasfi, D., Lambert, J. C., Le Fichoux, Y. and Gillet, J. Y. (1994). Prenatal diagnosis of severe fetal toxoplasmosis as a result of toxoplasmic reactivation in an HIV-1 seropositive woman. Prenatal Diagnosis 14, 414415.
Marty, P., Le Fichoux, Y., Deville, A. and Forest, H. (1991). Congenital toxoplasmosis and preconceptional maternal ganglionic toxoplasmosis [in French]. La Presse Médicale 20, 387.
Pons, J. C., Sigrand, C., Grangeot-Keros, L., Frydman, R., Frydman, R. and Thulliez, P. (1995). Congenital toxoplasmosis: transmission to the fetus of a pre-pregnancy maternal infection. La Presse Médicale 24, 179182.
Remington, J. S., McLeod, R., Thuilliez, P. and Desmonts, G. (2006). Toxoplasmosis. In Infectious Diseases of the Fetus and Newborn Infant 6th Edn (ed. Remington, J. S., Klein, J. O., Wilson, C. B. and Baker, C.), pp. 9471091. Elsevier Saunders, Philadelphia, PA, USA.
Sterkers, Y., Varlet-Marie, E., Marty, P., Bastien, P. and the ANOFEL Toxoplasma-PCR Quality Control Group. (2010). Diversity and evolution of methods and practices for the molecular diagnosis of congenital toxoplasmosis in France: a 4-year survey. Clinical Microbiology and Infection 16, 15941602.
Su, C., Shwab, E. K., Zhou, P., Zhu, X. Q. and Dubey, J. P. (2010). Moving towards an integrated approach to molecular detection and identification of Toxoplasma gondii. Parasitology 137, 111.
Villena, I., Ancelle, T., Delmas, C., Garcia, P., Brezin, A. P., Thulliez, P., Wallon, M., King, L., Goulet, V. and the Toxosurv network and National Reference Centre for Toxoplasmosis. (2010). Congenital toxoplasmosis in France in 2007: first results from a national surveillance system. European Surveillance 15, pii: 19600.
Villena, I., Chemla, C., Quereux, C., Dupouy, D., Leroux, B., Foudrinier, F. and Pinon, J. M. (1998). Prenatal diagnosis of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception. Reims Toxoplasmosis Group. Prenatal Diagnosis 18, 10791081.
Vogel, N., Kirisits, M., Michael, E., Bach, H., Hostetter, M., Boyer, K., Simpson, R., Holfels, E., Hopkins, J., Mack, D., Mets, M. B., Swisher, C. N., Patel, D., Roizen, N., Stein, L., Stein, M., Withers, S., Mui, E., Egwuagu, C., Remington, J., Dorfman, R. and McLeod, R. (1996). Congenital toxoplasmosis transmitted from an immunologically competent mother infected before conception. Clinical Infectious Diseases 23, 10551060.
Weiss, L. M. and Dubey, J. P. (2009). Toxoplasmosis: A history of clinical observations. International Journal for Parasitology 39, 895901.
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Parasitology
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