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Turning Sickness, a Protozoan Encephalitis of Cattle in Uganda. Its Relationship with East Coast Fever

  • R. W. M. Mettam (a1) and J. Carmichael (a1)
Abstract

1. A specific disease of cattle is described which occurs sporadically in the East Coast fever areas of eastern equatorial Africa. Clinically, acute cases are characterised by peculiar nervous symptoms, absence of fever and blindness. Death occurs in most cases within 2 to 21 days of the onset of illness. Chronic cases are encountered from time to time and may survive up to 6 months.

2. The disease is widespread in Uganda. It affects cattle of both sexes and all breeds, and is commonest in young stock between 6 months and 2 years of age. It has, however, been observed in older animals.

3. Pathologically, in acute cases petechial haemorrhages or extravasations are found in various parts of the brain and meninges. Generally the haemorrhages are small and do not seriously injure the adjacent brain tissue. In some cases the extravasations are responsible for a considerable amount of damage.

4. Microscopic examination shows that the brain lesions are due to extensive embolism of cerebral vessels. The lymphocytes which form these emboli contain in their cytoplasm protozoan bodies indistinguishable in structure from the schizonts of the genus Theileria. These bodies occur in great numbers in the brain, but are extremely rare or absent in the lymphocytes of other parts of the body.

5. In chronic cases the haemorrhages have been absorbed but the brain is permanently damaged by replacement changes, and by the appearance of small cysts or cavities which contain a citron-coloured fluid. These cavities when numerous seriously disorganise certain parts of the brain.

6. The disease has not yet been transmitted experimentally, and its connection with the theileriases is still uncertain. However, much evidence has been collected to show that cases of turning sickness have been infected with East Coast fever some time previously, generally on an average of 6–8 months.

7. The possible relationship between turning sickness and East Coast fever is discussed at some length during the course of the paper.

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Ann. Rep. Dep. Agric. Kenya (1928), p. 97; (1933), p. 274.
Ann. Rep. vet. Dep. Uganda (1922), p. 19; (1932), p. 32; (1933), p. 42.
Andrews W. H. (1923). The so-called “staggers” or pushing disease of cattle in Natal. An intoxication due to the ingestion of Matricaria nigellaefolia D.C. Rep. Dir. Vet. Ed. and Res. Pretoria, Nos. 9 and 10, p. 121.
Bevan L. E. W. (1924). East Coast fever—the theory of latency. Trans. R. Soc. trap. Med. Hyg. 18, 328.
Bruce D. (1910). Amakebe. A disease of calves in Uganda. Proc. roy. Soc. B, 82, 35.
Carpano M. (1932). Localisation de T. theileri dans les organes internes des bovines. Son cycle évolutif. Ann. parasit. hum. comp. 10, 305.
Cowdry E. V. & Ham A. W. (1930). The life cycle of the parasite of East Coast fever in ticks transmitting the disease (preliminary note). Science, 72, 461.
Cowdry E. V. & Ham A. W. (1932). Studies on East Coast fever. I. The life cycle of the parasite in ticks. Parasitology, 24, 1.
Cowdry E. V. & Danks W. B. C. (1933). Studies on East Coast fever. II. Behaviour of the parasite and the development of distinctive lesions in susceptible animals. Parasitology 25, 1.
Galloway L. A. (1930). Heartwater, in A System of Bacteriology. London: Medical Research Council, 7, 390.
Gonder R. (1911). The development of Theileria parva, the cause of East Coast fever of cattle in South Africa. Rep. Gov. Vet. Bact. Pretoria, p. 69.
Gonder R. (1911 a). Die Entwicklung von Theileria parva, der Erreger des Küstenfiebers der Rinder in Afrika. Arch. Protistenk. 22, 170.
Knuth P. & du Toit P. J. (1921). Tropenkrankheiten der Haustiere. Mense's Handb. d. Trop.-Krankh. 2nd ed. 6, 361. Leipzig: J. A. Barth.
Mettam R. W. M. (1934). Turning sickness and East Coast fever. Preliminary communication. Parasitology, 26, 150.
Mettam R. W. M. (1935). Poisonous plants of Uganda. Vet. J. 91, 153.
Meyer K. F. (1909). Preliminary note on the transmission of East Coast fever to cattle by intraperitoneal inoculation of the spleen or portions of the spleen of a sick animal. J. comp. Path. 22, 213.
Meyer K. F. (1911). Note on the nature of Koch's granules and their role in the pathogenesis of East Coast fever. Rep. Gov. Vet. Bact. Pretoria, p. 56.
Meyer K. F. (1930). Theileriases. Rep. of XI Internat. Vet. Congress, London, p. 525.
Purvis G. B. (1927). Immunity in East Coast fever. Trans. R. Soc. trop. Med. Hyg. 20, 447.
Saceghem R. van (1924). Les theilérieses. Note preliminaire. Bull. Soc. Path. exot. 17, 637.
Saceghem R. van (1925). Propagation de Theileria parva par les tiques. Bull. méd. Katanga, 2, 213.
Schilling Cl. (1930). Immunität bei Protozoen-infektionen. In Kolle and Wassermann's Handb. d. path. Mikroorg. 8, 95.
Schilling Cl. & Meyer K. F. (1930). Piroplasmosen. Bull. méd. Katanga 8, 1.
Schwetz J. (1932). Sur une epizootie de theilériose mortelle (east coast fever) à Stanley-ville (Congo Belge). C.R. Soc. Biol., Paris, 111, 40 and 1100.
Schwetz J. (1934). Sur une epizootie de theilériose mortelle (east coast fever) à Stanleyville (Congo Belge). Ann. Parasit. hum. camp. 12, 228.
Steck W. (1928). Histological studies on East Coast fever. Rep. Dir. Vet. Ed. Res. Pretoria, Nos. 13 and 14, p. 248.
Theiler A. (1904). East Coast fever. J. R. Army med. Cps, 3, 599.
Todd C. (1930). Cattle plague, in A System of Bacteriology, 7, 284. London: Medical Research Council.
du Toit P. J. (1930). Rep. of XI Internat. Vet. Congress, London, p. 539.
du Toit P. J. (1931). Immunity in East Coast fever. 17th Rep. Dir. Vet. Serv. and Animal Industry, Pretoria, p. 3.
Velu H. (1921). La piroplasmose bovine au Maroc et ses rapports avec les piroplasmoses circumméditerranéennes. Bull. Soc. Path. exot. 15, 116.
Velu H. (1933). Existe-t-il des rechutes dans la theilériose Nord Africaine? Bull. Soc. Path. exot. 24, 779.
Walker J. (1930). Aids to Stockoumers. Depart. Agric. Nairobi. 158 pp.
Wenyon C. M. (1926). Protozoology, 8vo, 2 vols. London: Bailliére, Tindall and Cox.
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Parasitology
  • ISSN: 0031-1820
  • EISSN: 1469-8161
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