Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-06-03T02:06:05.827Z Has data issue: false hasContentIssue false

Multiple-Models Juxtaposition and Trade-Offs among Modeling Desiderata

Published online by Cambridge University Press:  01 January 2022

Abstract

This article offers a characterization of what I call multiple-models juxtaposition (MMJ), a strategy for managing trade-offs among modeling desiderata. MMJ displays models of distinct phenomena together and fulfills different desiderata both in the individual models and by a comparison of those models. I discuss a concrete case from developmental biology, where MMJ coordinates generality and detail. I also clarify the distinction between MMJ and multiple-models idealization (MMI), which also uses multiple models to manage trade-offs among desiderata. MMJ and MMI differ in several points, such as the ways they manage trade-offs and the purposes of using multiple models.

Type
Research Article
Copyright
Copyright © The Philosophy of Science Association

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

I am grateful to Alan Love, Max Dresow, Katherine Liu, Michael Travisano, Samuel Fletcher, Michael Bennett McNulty, Christopher Nagel, Kelle Dhein, Aaron Vesey, and Nathan Lackey for their helpful comments on earlier drafts. Financial support for the research and writing of this article came from a Baruch Spinoza travel award, the International Society for the History, Philosophy, and Social Studies of Biology, and the Department of Philosophy at the University of Minnesota. Conversation with William Bausman helped me revise the article. I would also like to thank the two anonymous reviewers for their useful suggestions.

References

Abrahamsen, Adele, and Bechtel, William. 2014. “Diagrams as Tools for Scientific Reasoning.” Review of Philosophy and Psychology 6 (1): 117–31..Google Scholar
Abrahamsen, Adele, Sheredos, Benjamin, and Bechtel, William. 2018. “Explaining Visually Using Mechanism Diagrams.” In The Routledge Handbook of Mechanisms and Mechanical Philosophy, ed. Glennan, Stuart S. and Illari, Phyllis, 238–54. New York: Routledge.Google Scholar
Affolter, Markus, Bellusci, Savério, Itoh, Nobuyuki, Shilo, Benny, Thiery, Jean Paul, and Werb, Zena. 2003. “Tube or Not Tube: Remodeling Epithelial Tissues by Branching Morphogenesis.” Developmental Cell 4:1118.CrossRefGoogle ScholarPubMed
Affolter, Markus, Zeller, Rolf, and Caussinus, Emmanuel. 2009. “Tissue Remodelling through Branching Morphogenesis.” Nature Reviews Molecular Cell Biology 10:831–42.CrossRefGoogle ScholarPubMed
Bechtel, William. 2009. “Generalization and Discovery by Assuming Conserved Mechanisms: Cross-Species Research on Circadian Oscillators.” Philosophy of Science 76 (5): 762–73..CrossRefGoogle Scholar
Bechtel, William. 2017. “Explaining Features of Fine-Grained Phenomena Using Abstract Analyses of Phenomena and Mechanisms: Two Examples from Chronobiology.” Synthese. https://doi.org/10.1007/s11229-017-1469-x.CrossRefGoogle Scholar
Bellusci, Savério, Grindley, Justin, Emoto, Hisayo, Itoh, Nobuyuki, and Hogan, Brigid L. M.. 1997. “Fibroblast Growth Factor 10 (FGF10) and Branching Morphogenesis in the Embryonic Mouse Lung.” Development 124:4867–78.CrossRefGoogle ScholarPubMed
Burian, Richard M., and Thieffry, Denis. 2000. “Introduction to the Special Issue ‘From Embryology to Developmental Biology.’History and Philosophy of Life Sciences 22 (3): 313–23..Google Scholar
Davies, Jamie A. 2002. “Do Different Branching Epithelia Use a Conserved Developmental Mechanism?BioEssays 24 (10): 937–48..CrossRefGoogle ScholarPubMed
Fontana, Luigi, Partridge, Linda, and Longo, Valter D.. 2010. “Extending Healthy Life Span: From Yeast to Humans.” Science 328 (5976): 321–26..CrossRefGoogle ScholarPubMed
Gelfert, Axel. 2013. “Strategies of Model-Building in Condensed Matter Physics: Trade-Offs as a Demarcation Criterion between Physics and Biology?Synthese 190:253–72.CrossRefGoogle Scholar
Gerhardt, Holger, et al. 2003. “VEGF Guides Angiogenic Sprouting Utilizing Endothelial Tip Cell Filopodia.” Journal of Cell Biology 161 (6): 1163–77..Google ScholarPubMed
Ghabrial, Amin S., and Krasnow, Mark A.. 2006. “Social Interactions among Epithelial Cells during Tracheal Branching Morphogenesis.” Nature 441:746–49.CrossRefGoogle ScholarPubMed
Gilbert, Scott F. 2014. Developmental Biology. 10th ed. Sunderland, MA: Sinauer.Google Scholar
Glennan, Stuart S., and Illari, Phyllis. 2018. “Introduction: Mechanisms and Mechanical Philosophies.” In The Routledge Handbook of Mechanisms and Mechanical Philosophy, ed. Glennan, Stuart S. and Illari, Phyllis, 19. New York: Routledge.Google Scholar
Halina, Marta, and Bechtel, William. 2013. “Mechanism, Conserved.” In Encyclopedia of Systems Biology, ed. Dubitzky, Werner, Wolkenhauer, Olaf, Cho, Kwang-Hyun, and Yokota, Hiroki, 1201–4. New York: Springer.Google Scholar
Harmer, Stacey L., Panda, Satchidananda, and Kay, Steve A.. 2001. “Molecular Bases of Circadian Rhythms.” Annual Review of Cell and Developmental Biology 17:215–53.CrossRefGoogle ScholarPubMed
Hellström, Mats, et al. 2007. “Dll4 Signalling through Notch1 Regulates Formation of Tip Cells during Angiogenesis.” Nature 445 (7129): 776–80..CrossRefGoogle ScholarPubMed
Hopwood, Nick. 2009. “Embryology.” In The Cambridge History of Science: The Modern Biological and Earth Sciences, ed. Bowler, Peter J. and Pickstone, John V., 285315. Cambridge: Cambridge University Press.CrossRefGoogle Scholar
Levins, Richard. 1966. “The Strategy of Model Building in Population Biology.” American Scientist 54 (4): 421–31..Google Scholar
Levy, Arnon, and Bechtel, William. 2013. “Abstraction and the Organization of Mechanisms.” Philosophy of Science 80:241–61.CrossRefGoogle Scholar
Llimargas, Marta. 1999. “The Notch Pathway Helps to Pattern the Tips of the Drosophila Tracheal Branches by Selecting Cell Fates.” Development 126:2355–64.CrossRefGoogle ScholarPubMed
Love, Alan C. 2018. “Developmental Mechanisms.” In The Routledge Handbook of Mechanisms and Mechanical Philosophy, ed. Glennan, Stuart S. and Illari, Phyllis, 332–47. New York: Routledge.Google Scholar
Matthewson, John. 2011. “Trade-Offs in Model-Building: A More Target-Oriented Approach.” Studies in History and Philosophy of Science A 42:324–33.Google Scholar
Matthewson, John. 2020. “Detail and Generality in Mechanistic Explanation.” Studies in History and Philosophy of Science A 80:2836.CrossRefGoogle ScholarPubMed
Matthewson, John, and Weisberg, Michael. 2009. “The Structure of Tradeoffs in Model Building.” Synthese 170:169–90.CrossRefGoogle Scholar
Metzger, Ross J., and Krasnow, Mark A.. 1999. “Genetic Control of Branching Morphogenesis.” Science 284:1635–40.CrossRefGoogle ScholarPubMed
Min, Hosung, Danilenko, Dimitry M., Scully, Sheila A., Bolon, Brad, Ring, Brian D., Tarpley, John E., DeRose, Margaret, and Simonet, W. Scott. 1998. “Fgf-10 Is Required for Both Limb and Lung Development and Exhibits Striking Functional Similarity to Drosophila Branchless.Genes and Development 12:3156–61.CrossRefGoogle ScholarPubMed
Munóz-Chápuli, R. 2011. “Evolution of Angiogenesis.” International Journal of Developmental Biology 55:345–51.CrossRefGoogle ScholarPubMed
Murray, Michael J. 2015. “Drosophila Models of Cancer.” AIMS Genetics 2 (1): 97103..Google Scholar
Nogawa, Hiroyuki, Morita, Kuniharu, and Cardoso, Wellington V.. 1998. “Bud Formation Precedes the Appearance of Differential Cell Proliferation during Branching Morphogenesis of Mouse Lung Epithelium in Vitro.” Developmental Dynamics 213:228–35.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Ochoa-Espinosa, Amanda, and Affolter, Markus. 2012. “Branching Morphogenesis: From Cells to Organs and Back.” Cold Spring Harbor Perspectives in Biology 4:114.CrossRefGoogle Scholar
Odenbaugh, Jay. 2003. “Complex Systems, Trade-Offs, and Theoretical Population Biology: Richard Levin’s ‘Strategy of Model Building in Population Biology’ Revisited.” Philosophy of Science 70:1496–507.CrossRefGoogle Scholar
Orzack, Steven Hecht, and Sober, Elliott. 1993. “A Critical Assessment of Levins’s ‘The Strategy of Model Building in Population Biology’ (1966).Quarterly Review of Biology 68 (4): 533–46..CrossRefGoogle Scholar
Park, William Y., Miranda, Barbara, Lebeche, Djamel, Hashimoto, Gakuji, and Cardoso, Wellington V.. 1998. “FGF-10 Is a Chemotactic Factor for Distal Epithelial Buds during Lung Development.” Developmental Biology 201:125–34.CrossRefGoogle ScholarPubMed
Ryan, Tomás J., and Grant, Seth G. N.. 2009. “The Origin and Evolution of Synapses.” Nature Reviews Neuroscience 10:701–12.Google ScholarPubMed
Sekine, Keisuke, et al. 1999. “Fgf10 Is Essential for Limb and Lung Formation.” Nature Genetics 21:138–41.CrossRefGoogle ScholarPubMed
Sheredos, Benjamin, Burnston, Daniel, Abrahamsen, Adele, and Bechtel, William. 2013. “Why Do Biologists Use So Many Diagrams?Philosophy of Science 80 (5): 931–44..CrossRefGoogle Scholar
Siekmann, Arndt F., Covassin, Laurence, and Lawson, Nathan D.. 2008. “Modulation of VEGF Signalling Output by the Notch Pathway.” BioEssays 30 (4): 303–13..CrossRefGoogle ScholarPubMed
Siekmann, Arndt F., and Lawson, Nathan D.. 2007. “Notch Signalling Limits Angiogenic Cell Behaviour in Developing Zebrafish Arteries.” Nature 445:781–84.CrossRefGoogle ScholarPubMed
Spurlin, James W., and Nelson, Celeste M.. 2017. “Building Branched Tissue Structures: From Single Cell Guidance to Coordinated Construction.” Philosophical Transactions of the Royal Society B 372:115.Google ScholarPubMed
Sutherland, David, Samakovlis, Christos, and Krasnow, Mark A.. 1996. “Branchless Encodes a Drosophila FGF Homolog That Controls Tracheal Cell Migration and the Pattern of Branching.” Cell 87:1091–101.CrossRefGoogle Scholar
Trinkaus, John P. 1969. Cells into Organs: The Forces That Shape the Embryo. Englewood Cliffs, NJ: Prentice Hall.Google Scholar
Varner, Victor D., and Nelson, Celeste M.. 2014. “Cellular and Physical Mechanisms of Branching Morphogenesis.” Development 141:2750–59.CrossRefGoogle ScholarPubMed
Waddington, Conrad Hal. 1956. Principles of Embryology. New York: Macmillan.Google Scholar
Wang, Shaohe, Sekiguchi, Rei, Daley, William P., and Yamada, Kenneth M.. 2017. “Patterned Cell and Matrix Dynamics in Branching Morphogenesis.” Journal of Cell Biology 216 (3): 559–70..Google ScholarPubMed
Waters, C. Kenneth. 1998. “Causal Regularities in the Biological World of Contingent Distribution.” Biology and Philosophy 13:536.CrossRefGoogle Scholar
Weisberg, Michael. 2004. “Qualitative Theory and Chemical Explanation.” Philosophy of Science 71:1071–81.CrossRefGoogle Scholar
Weisberg, Michael. 2006. “Robustness Analysis.” Philosophy of Science 73:730–42.CrossRefGoogle Scholar
Weisberg, Michael. 2007. “Three Kinds of Idealization.” Journal of Philosophy 104 (12): 639–59..CrossRefGoogle Scholar
Weisberg, Michael. 2013. Simulation and Similarity: Using Models to Understand the World. Oxford: Oxford University Press.CrossRefGoogle Scholar
Wimsatt, William C. 2012. “Robustness, Reliability, and Overdetermination (1981).” In Characterizing the Robustness of Science, ed. Soler, Léna, Trizio, Emiliano, Nickles, Thomas, and Wimsatt, William C., 6187. Dordrecht: Springer.CrossRefGoogle Scholar
Woody, Andrea I. 2004. “More Telltale Signs: What Attention to Representation Reveals about Scientific Explanation.” Philosophy of Science 71:780–93.CrossRefGoogle Scholar
Woody, Andrea I.. 2014. “Chemistry’s Periodic Law: Rethinking Representation and Explanation after the Turn to Practice.” In Science after the Practice Turn in the Philosophy, History, and the Social Studies of Science, ed. Soler, Léna, Zwart, Sjoerd, Lynch, Michael, and Israel-Jost, Vincent, 123–50. New York: Routledge.Google Scholar
Woody, Andrea I.. 2015. “Re-orienting Discussions of Scientific Explanation: A Functional Perspective.” Studies in History and Philosophy of Science A 52:7987.CrossRefGoogle ScholarPubMed