Adachi, M, Higuchi, H, Miura, S, Azuma, T, Inokuchi, S, Saito, H, Kato, S & Ishii, H (2004) Bax interacts with voltage-dependent anion channel and mediates ethanol-induced apoptosis in rat hepatocytes. American Journal of Physiology 287 G695–G705.
Adachi, M & Ishii, H (2002) Role of mitochondria in alcoholic liver injury. Free Radical Biology and Medicine 32 487–491.
Albano, E (2002) Free radicals and alcohol-induced liver injury. In Ethanol and the Liver, pp. 153–190 [Sherman, CDIN, Preedy, VR and Watson, RR, editors]. London: Taylor and Francis.
Albano, E, Clot, P, Morimoto, M, Tomasi, A, Ingelman-Sundberg, M & French, SW (1996) Role of cytochrome P4502E1-dependent formation of hydroxyethyl free radicals in the development of liver damage in rats intragastrically fed with ethanol. Hepatology 23 155–163.
Albano, E, Mottaran, E, Vidali, M, Vidali, M, Reale, E, Saksena, S, Occhino, D, Burt, AD & Day, CP (2005) Immune response toward lipid peroxidation products as a predictor of the progression of non-alcoholic fatty liver disease (NAFLD) to advanced fibrosis. Gut 54 987–993.
Albano, E, Parola, M, Comoglio, A & Dianzani, MU (1993) Evidence for the covalent binding of hydroxyethyl radicals to rat liver microsomal proteins. Alcohol and Alcoholism 28 453–459.
Albano, E, Tomasi, A & Ingelman-Sundberg, M (1994) Spin trapping of alcohol-derived radicals in microsomes and reconstituted systems by electron spin resonance. Methods in Enzymology 233 117–127.
Aleynik, SI, Leo, MA, Aleynik, MK & Lieber, CS (1998) Increased circulating products of lipid peroxidation in patients with alcoholic liver disease. Alcoholism, Clinical and Experimental Research 22 192–196.
Arteel, GE (2003) Oxidant and antioxidant in alcohol-induced liver disease. Gastroenterology 124 778–790.
Bailey, SM & Cunningham, CC (2002) Contribution of mitochondria to oxidative stress associated with alcohol liver disease. Free Radical Biology and Medicine 32 11–16.
Bardag-Gorce, F, Yuan, QX, Li, J, French, BA, Fang, C, Ingelman-Sundberg, M & French, SW (2000) The effect of ethanol-induced cytochrome P4502E1 on the inhibition of proteasome activity by alcohol. Biochemical and Biophysical Research Communications 279 23–29.
Batey, RG, Cao, Q & Gould, B (2002) Lymphocyte-mediated liver injury in alcohol-related hepatitis. Alcohol 27 37–41.
Battaler, R & Brenner, DA (2005) Liver fibrosis. Journal of Clinical Investigation 115 209–218.
Bautista, AP (2002) Neutrophilic infiltration in alcoholic hepatitis. Alcohol 27 17–21.
Bautista, AP & Spitzer, JJ (1994) Inhibition of nitric oxide formation in vivo enhances superoxide release by the perfused liver. American Journal of Physiology 266 G783–G788.
Bautista, AP & Spitzer, JJ (1996) Postbinge effects of acute alcohol intoxication on hepatic free radical formation. Alcoholism, Clinical and Experimental Research 20 502–509.
Beckman, JS & Koppenol, WH (1996) Nitric oxide, superoxide and peroxynitrite: the good, the bad and the ugly. American Journal of Physiology 271 C1424–C1437.
Bell, H, Bjørneboe, A, Eidsvoll, B, Norum, KR, Raknerud, N, Try, K, Thomansen, Y & Drevon, CA (1992) Reduced concentration of hepatic α-tocopherol in patients with alcoholic liver cirrhosis. Alcohol and Alcoholism 27 39–46.
Bernardi, P, Petronilli, V, Di Lisa, F & Forte, M (2001) A mitochondrial perspective on cell death. Trends in Biochemical Sciences 26 112–117.
Bradford, BU, Kona, H, Isayama, F, Kosyk, O, Wheeler, MD, Akiyama, TE, Bleye, L, Krausz, KW, Gonzalez, FJ, Koop, DR & Rusyn, I (2005) Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology 41 336–344.
Brind, AM, Hurlstone, A, Edrisinghe, D, Gilmore, I, Fisher, N, Pirmohamed, M & Fryer, AA (2004) The role of polymorphisms of glutathione S-transferases GSTM1, M3, P1, T1 and A1 in susceptibility to alcoholic liver disease. Alcohol and Alcoholism 39 478–483.
Canbay, A, Feldstein, AE, Higuchi, H, Werneburg, N, Grambihler, A, Bronk, SF & Gores, GJ (2003) Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression. Hepatology 38 1188–1198.
Caro, AA & Cederbaum, AI (2004) Oxidative stress, toxicology and pharmacology of CYP2E1. Annual Review of Pharmacology and Toxicology 44 27–42.
Chamulitrat, W & Spitzer, JJ (1996) Nitric oxide and liver injury in alcohol-fed rats after lipipolysaccaride administration. Alcoholism, Clinical and Experimental Research 20 1065–1070.
Chedid, A, Mendenhall, CL, Moritz, TE, French, SA, Chen, TS & Morgan, TR, et al. (1993) Cell-mediated hepatic injury in alcoholic liver disease. Veterans Affairs Cooperative Study Group 275. Gastroenterology 105 254–266.
Child, CG & Turcotte, JG (1964) Surgery and portal hypertension. In The Liver and Portal Hypertension, pp. 50–64 [Child, CG, editor]. Philadelphia, PA: Saunders.
Clot, P, Albano, E, Elliasson, E, Tabone, M, Aricò, S, Israel, Y, Moncada, Y & Ingelman-Sundberg, M (1996) Cytochrome P4502E1 hydroxyethyl radical adducts as the major antigenic determinant for autoantibody formation among alcoholics. Gastroenterology 111 206–216.
Clot, P, Bellomo, G, Tabone, M, Aricò, S & Albano, E (1995) Detection of antibodies against proteins modified by hydroxyethyl free radicals in patients with alcoholic cirrhosis. Gastroenterology 108 201–207.
Clot, P, Parola, M, Bellomo, G, Dianzani, U, Carini, R, Tabone, M, Aricò, S, Ingelman-Sundberg, M & Albano, E (1997) Plasma membrane hydroxyethyl radical adducts cause antibody-dependent cytotoxicity in rat hepatocytes exposed to alcohol. Gastroenterology 113 265–276.
Clot, P, Tabone, M, Aricò, S & Albano, E (1994) Monitoring oxidative damage in patients with liver cirrhosis and different daily alcohol intake. Gut 35 1637–1643.
Coll, O, Colell, A, Garcia-Ruiz, C, Kaplowitz, N & Fernandez-Checa, JC (2003) Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Hepatology 38 692–702.
Dandona, P, Aljada, A & Bandyopadhyay, A (2004) Inflammation: the link between insulin resistance, obesity and diabetes. Trends in Immunology 25 4–7.
Di Luzio, NR (1963) Prevention of acute ethanol-induced fatty liver by antioxidants. Physiologist 6 169–173.
Dupont, I, Lucas, D, Clot, P, Ménez, C & Albano, E (1998) Cytochrome P4502E1 inducibility and hydroxyethyl radical formation among alcoholics. Journal of Hepatology 28 564–571.
Egen, JG, Kuhns, MS & Allison, JP (2002) CTLA-4: new insights into its biological function and use in tumor immunotherapy. Nature Immunology 3 611–618.
Fang, C, Lindros, KO, Badger, TM, Ronis, JJ & Ingelman-Sundberg, M (1998) Zonated expression of cytokines in rat liver: effect of chronic ethanol and cytochrome P4502E1 inhibitor, chlormethiazole. Hepatology 27 1304–1310.
Felver, ME, Mezey, E, McGuire, M, Mitchell, MC, Herlong, HF, Veech, GA & Veech, RL (1990) Plasma tumor necrosis factor alpha predicts decreased long-term survival in severe alcoholic hepatitis. Alcohol, Clinical and Experimental Research 14 255–259.
Fernandez-Checa, JC, Garcia-Ruiz, C, Ookhtens, M & Kaplowitz, N (1991) Impaired uptake of glutathione by hepatic mitochondria from ethanol fed rats. Journal of Clinical Investigation 87 397–405.
Fernandez-Checa, JC & Kaplowitz, N (2005) Hepatic mitochondrial glutathione: transport and role in disease and toxicity. Toxicology and Applied Pharmacology 204 263–273.
French, SW, Benson, NC & Sun, PS (1984) Centrilobular liver necrosis induced by hypoxia in chronic ethanol-fed rats. Hepatology 4 912–917.
Friedman, SL (2003) Liver fibrosis: from bench to bedside. Journal of Hepatology 38, Suppl. 1 S38–S53
Fromenty, B, Grimbert, S, Mansouri, A, Beaugrand, M, Erlinger, S, Röting, A & Pessayre, D (1995) Hepatic mitochondrial DNA deletion in alcoholics: association with microvesicular steatosis. Gastroenterology 108 193–200.
Fromenty, B & Pessayre, D (1995) Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacology and Therapeutics 67 101–154.
Garcia-Ruiz, C, Colell, A, Paris, R & Fernandez-Checa, JC (2000) Direct interaction of GD3 ganglioside with mitochondria generates reactive oxygen species followed by mitochondrial permeability transition, cytochrome c release and caspase activation. FASEB Journal 14 847–850.
Garcia-Ruiz, C, Morales, A, Ballesta, A, Rhodes, J, Kaplowitz, N & Fernandez-Checa, JC (1994) Effect of chronic ethanol feeding on glutathione and functional integrity of mitochondria in periportal and perivenous rat hepatocytes. Journal of Clinical Investigation 94 193–201.
Girre, C, Lucas, D, Hispard, E, Ménez, C, Dally, S & Ménez, JF (1994) Assessment of cytochrome P4502E1 induction in alcoholic patients by chlozoxazone pharmacokinetics. Biochemical Pharmacology 47 1503–1508.
Gouillon, Z, Lucas, D, Li, J, Hagbjork, AL, French, BA, Fu, P, Fang, C, Ingelman-Sundberg, M, Donohue, TM & French, SW (2000) Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole. Proceedings of the Society for Experimental Biology and Medicine 224 302–308.
Green, DR & Kroemer, G (2004) The pathophysiology of mitochondrial cell death. Science 305 626–629.
Gregory, CD & Devitt, A (2004) The macrophage and the apoptotic cell: an innate immune interaction viewed simplistically. Immunology 113 1–14.
Herkel, J, Jagemann, B, Weigard, C, Garcia Lazaro, JF, Lueth, S, Kanzler, S, Blessing, M, Schmitt, E & Lohse, AW (2003) MCH class II-expressing hepatocytes function as antigen presenting cells and activate specific CD4 T lymphocytes. Hepatology 37 1079–1085.
Hines, IN & Wheeler, MD (2004) Recent advances in alcoholic liver disease III. Role of the innate immune response in alcoholic hepatitis. American Journal of Physiology 287 G310–G314.
Hirano, T, Kaplowitz, N, Kamimura, T, Tsukamoto, H & Fernandez-Checa, JC (1992) Hepatic mitochondrial GSH depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16 1423–1428.
Hoek, JB, Cahill, A & Pastorino, JG (2002) Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 122 2049–2063.
Hoek, JB & Pastorino, JG (2004) Cellular signalling mechanisms in alcoholic liver damage. Seminars in Liver Diseases 24 257–272.
Iimuro, Y, Bradford, BU, Yamashina, S, Rusyn, I, Nakagami, M, Enomoto, N, Kono, H, Frey, W, Forman, D, Brenner, D & Thurman, RG (2000) The glutathione precursor l -2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology 31 391–398.
Ioannou, GN, Dominitz, JA, Weiss, NS, Haegerty, PJ & Wowdley, KV (2004) The effect of alcohol consumption on the prevalence of iron overload, iron deficiency and ion deficiency anemia. Gastroenterology 126 1293–1301.
Irving, MG, Halliday, JW & Powell, LW (1988) Association between alcoholism and increased hepatic iron store. Alcoholism, Clinical and Experimental Research 12 7–12.
Ishak, KG, Zimmerman, HJ & Ray, MB (1991) Alcoholic liver disease: pathology, pathogenetic and clinical aspects. Alcoholism, Clinical and Experimental Research 15 45–66.
Izumi, N, Sato, C, Hamusura, Y & Takeuchi, J (1985) Serum antibodies against alcohol-treated hepatocytes in patients with alcoholic liver diseases. Clinical and Experimental Immunology 61 585–592.
Jaeschke, H (2002) Neutrophil-mediated tissue injury in alcoholic hepatitis. Alcohol 27 23–27.
Jarvelainen, HA, Fang, C, Ingelman-Sundberg, M & Lindros, KO (1999) Effect of chronic coadministration of endotoxin and ethanol on rat liver pathology and proinflammatory and anti-inflammatory cytokines. Hepatology 29 1503–1510.
Kagan, VE, Borisenko, GG, Serinkan, BF, Tyurina, YY, Tyurin, VA, Jiang, J, Liu, SX, Shvedova, AA, Fabisial, JP, Uthsaisang, W & Fadeel, B (2003) Appetizing rancidity of apoptotic cells for macrophages: oxidation, externalization and recognition of phosphatidylserine. American Journal of Physiology 285 L1–L17.
Kamimura, S, Gall, K, Britton, SR, Bacon, BR, Triadafilopulos, G & Tsukamoto, H (1992) Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis. Hepatology 16 448–453.
Kamimura, S & Tsukamoto, H (1995) Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 21 1304–1309.
Kawase, T, Kato, S & Lieber, CS (1989) Lipid peroxidation and antioxidant defense systems in rat liver after chronic ethanol feeding. Hepatology 10 815–821.
Kessova, IG, Ho, YS, Thung, S & Cederbaum, AI (2003) Alcohol-induced liver injury in mice lacking Cu, Zn-superoxide dismutase. Hepatology 38 1136–1145.
Kita, H, Mackay, IR, Van de Water, J & Gershwin, EM (2001) The lymphoid liver: considerations on pathways to autoimmune injury. Gastroenterology 120 1485–1501.
Knecht, KT, Adachi, Y, Bradfort, BU, Iimuro, Y, Kadiiska, M, Qun-Hui, X & Thurman, RG (1995) Free radical adducts in the bile of ras treated chronically with intragastric alcohol: inhibition by destruction of Kupffer cells. Molecular Pharmacology 47 1028–1034.
Kono, H, Arteel, GE, Rusyn, I, Sies, H & Thurman, RG (2001a) Ebselen prevents early alcohol-induced liver injury in rats. Free Radical Biology and Medicine 30 403–411.
Kono, H, Bradford, BU, Yin, M, Sulik, KK, Koop, DR & Peters, JM, et al. (1999) CYP2E1 is not involved in early alcohol-induced liver injury. American Journal of Physiology 277 G1259–G1267.
Kono, H, Rusyn, I, Yin, M, Gabele, E, Yamashina, S & Dikalova, A, et al. (2000) NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. Journal of Clinical Investigation 106 867–872.
Kono, H, Uesugi, T, Froh, M, Rusyn, I, Bradford, BU & Thurman, RG (2001b) ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. American Journal of Physiology 280 G1289–G1295.
Levine, JS, Koh, JS, Subang, R & Rauch, J (1999) Apoptotic cells as immunogen and antigen in the anti-phospholipid syndrome. Experimental and Molecular Pathology 66 82–98.
Li, J & Billiar, TR (1999) Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver. American Journal of Physiology 276 G1069–G1073.
Liangpunsakul, S, Kolwankar, D, Pinto, A, Gorski, CJ, Hall, SD & Chalasani, N (2005) Activity of CYP2E1 and CYP3A enzymes in adults with moderate alcohol consumption: a comparison with nonalcoholics. Hepatology 41 1144–1150.
McClain, CJ, Song, Z, Barve, SS, Hill, DB & Deaciuc, I (2004) Recent advances in alcoholic liver disease IV. Dysregulated cytokine metabolism in alcoholic liver disease. American Journal of Physiology 287 G497–G502.
McFarlane, IG (2000) Autoantibodies in alcoholic liver disease. Addiction Research 5 141–151.
McKim, SE, Gabele, E, Isayama, F, Lambert, JC, Tucker, LM, Wheeler, MD, Connor, HD, Mason, RP, Doll, MA, Hein, DW & Arteel, GE (2003) Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterology 125 1834–1844.
McVicker, BL, Tuma, DJ, Kubik, JA, Hindemith, AM, Baldwin, CR & Casey, CA (2002) The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes. Hepatology 36 1478–1487.
Mansouri, A, Fromenty, B, Berson, A, Robin, MA, Grimbert, S, Beaugrand, M, Erlinger, S & Pessayre, D (1997) Multiple hepatic mitochondrial DNA deletions suggest premature oxidative aging in alcoholics. Journal of Hepatology 27 96–102.
Matsuhashi, T, Karbowski, M, Liu, X, Usukura, J, Wozniak, M & Wakabayashi, T (1998) Complete suppression of ethanol-induced formation of megamitochondria by 4-hydroxy-2,2,6,6,-tetramethyl-piperidine-1-oxyl (4-OH-TEMPO). Free Radical Biology and Medicine 24 139–147.
Meager, EA, Barry, OP, Burke, A, Lucey, MR, Lawson, JA, Rokach, J & FitzGerald, GA (1999) Alcohol-induced generation of lipid peroxidation products in humans. Journal of Clinical Investigation 104 805–813.
Mezey, E, Potter, JJ, Rennie-Tankersley, l, Caballeire, J & Pares, A (2004) A randomized placebo controlled trial of vitamin E for alcoholic hepatitis. Journal of Hepatology 40 40–46.
Minagawa, M, Deng, Q, Liu, ZX, Tzukamoto, H & Dennert, G (2004) Activated natural killer T cells induce liver injury by Fas and tumor necrosis factor-α during alcohol consumption. Gastroenterology 126 1387–1399.
Moncada, C, Torres, V, Vargese, E, Albano, E & Israel, Y (1994) Ethanol-derived immunoreactive species formed by free radical mechanisms. Molecular Pharmacology 46 786–791.
Morgan, K, French, SW & Morgan, TR (2002) Production of a cytochrome P450 2E1 transgenic mouse and initial evaluation of alcoholic liver damage. Hepatology 36 122–134.
Mottaran, E, Stewart, SF, Rolla, R, Vay, D, Cipriani, V, Moretti, MG, Vidali, M, Sartori, M, Rigamonti, C, Day, CP & Albano, E (2002) Lipid peroxidation contributes to immune reactions associated with alcoholic liver disease. Free Radical Biology and Medicine 32 38–48.
Nakao, LS & Augusto, O (1998) Nucleic acid alkylation by free radical metabolites of ethanol. Formation of 8-(1-hydroxyethyl)guanine and 8-(2-hydroxyethyl)guanineadducts. Chemical Research in Toxicology 11 888–894.
Nanji, AA & French, SW (1989) Dietary linoleic acid is required for development of experimentally induced alcoholic liver disease. Life Sciences 44 223–227.
Nanji, AA, Greenberg, SS, Tahan, SR, Fogt, F, Loscalzo, J, Sadrzadeh, SMH, Xie, J & Stamler, JS (1995a) Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology 109 899–907.
Nanji, AA, Griniuviene, B, Sadrzadeh, SMH, Levitsky, S & McCully, JD (1995b) Effect of dietary fat and ethanol on antioxidant enzyme mRNA induction in rat liver. Journal of Lipid Research 36 736–744.
Nanji, AA, Khwaja, S, Tahan, SR & Sadrzadeh, HSM (1994a) Plasma levels of a novel noncyclooxygenase-derived prostanoid (8-isoprostane) correlate with severity of liver injury in experimental alcoholic liver disease. Journal of Pharmacology and Experimental Therapeutics 269 1280–1285.
Nanji, AA, Miao, L, Thomas, P, Rahemtulla, T, Khwaja, S, Zhao, S, Peters, D, Tahan, SR & Dannenberg, AJ (1997) Enhanced cycloxygenase-2 gene expression in alcoholic liver disease in rats. Gastroenterology 112 943–951.
Nanji, AA, Sadrzadeh, SMH, Yang, EK, Fogt, F, Maydani, M & Dannenberg, AJ (1995b) Dietary saturated fatty acids: A novel treatment for alcoholic liver disease. Gastroenterology 109 547–554.
Nanji, AA, Yang, EK, Fogt, F, Sadrzadeh, SMH & Dannenberg, AJ (1996) Medium chain triglycerides and vitamin E reduce the severity of established experimental alcoholic liver disease. Journal of Pharmacology and Experimental Therapeutics 277 1694–1700.
Nanji, AA, Zhao, S, Sadrzadeh, SMH, Dannenberg, AJ, Tahan, SR & Waxman, DJ (1994b) Markedly enhanced cytochrome P4502E1 induction and lipid peroxidation is associated with severe liver injury in fish oil-treated ethanol-fed rats. Alcoholism, Clinical and Experimental Research 18 1280–1285.
Natori, S, Rust, C, Stadheim, LM, Srinivasan, A, Burgart, LJ & Gores, GJ (2001) Hepatocyte apoptosis is a pathological feature of human alcoholic hepatitis. Journal of Hepatology 34 248–253.
Neuberger, J, Crossley, IR, Saunders, JB, Davis, M, Portmann, B, Eddleston, ALWF & Williams, R (1984) Antibodies to alcohol altered liver cell determinants in patients with alcoholic liver disease. Gut 25 300–304.
Neve, EP & Ingelman-Sundberg, M (2001) Identification and characterization of a mitochondrial targeting signal in rat cytochrome P450 2E1 (CYP2E1). Journal of Biological Chemistry 276 11317–11322.
Niemelä, O, Parkkila, S, Ylä-Herttuala, S, Halsted, C, Witztum, JL, Lanca, A & Israel, Y (1994) Covalent protein adducts in the liver as a result of ethanol metabolism and lipid peroxidation. Laboratory Investigation 70 537–546.
Niemelä, O, Parkkila, S, Ylä-Herttuala, S, Villanueva, J, Ruebner, B & Halsted, CH (1995) Sequential acetaldehyde production, lipid peroxidation and fibrogenesis in micropigs model of alcohol-induced liver disease. Hepatology 22 1208–1214.
Nordmann, R, Ribière, C & Rouach, H (1992) Implication of free radical mechanisms in ethanol induced cellular injury. Free Radical Biology and Medicine 12 219–240.
Parola, M & Robino, G (2001) Oxidative stress-related molecules and liver fibrosis. Journal of Hepatology 35 297–306.
Polavarapu, R, Spitz, DR, Sim, JE, Follansbee, MH, Oberley, LW, Rahemtulla, A & Nanji, AA (1998) Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil. Hepatology 27 1317–1323.
Rao, RK, Seth, A & Sheth, P (2004) Recent advances in alcoholic liver disease. I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. American Journal of Physiology 286 G881–G884.
Rolla, R, Vay, D, Mottaran, E, Parodi, M, Traverso, N & Arico, S, et al. (2000) Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease. Hepatology 31 878–884.
Ronis, MJJ, Butura, A, Sampey, BP, Prior, RL, Korourian, S, Albano, E, Ingelman-Sundberg, M, Petersen, DR & Badger, TM (2005) Effects of N-acetyl cysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition. Free Radical Biology and Medicine 36 616–630.
Ronis, MJJ, Hakkak, R, Korourian, S, Albano, E, Yoon, S, Ingelman-Sundberg, M, Lindros, KO & Badger, TM (2004) Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate diets. Experimental Biology and Medicine 229 351–360.
Ronis, MJJ, Lindros, KO & Ingelman-Sundberg, M (1996) The CYP2E family. In Cytochromes P450: Metabolic and Toxicological Aspects, pp. 211–239 [Ioannides, C, editor]. Boca Raton, FL: CRC Press.
Rouach, H, Fattaccioli, V, Gentil, M, French, SW, Morimoto, M & Nordmann, R (1997) Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 25 351–355.
Rouault, TA (2003) Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis. Alcohol 30 103–106.
Sadrzadeh, SMH, Hallaway, PE & Nanji, AA (1997) The long-acting parenteral iron chelator hydroxyethylstarch-desferoxamine fails to protect against alcohol-induced liver injury in rats. Journal of Pharmacology and Experimental Therapeutics 280 1038–1042.
Sadrzadeh, SMH, Meydani, M, Khettry, U & Nanji, AA (1995) High-dose vitamin E supplementation has no effect on ethanol-induced pathological liver injury. Journal of Pharmacology and Experimental Therapeutics 273 455–460.
Sadrzadeh, SMH & Nanji, AA (1998) The 21-aminosterolid 16-desmethyl-tirilazad mesylate prevents necroinflammatory changes in experimental alcoholic liver disease. Journal of Pharmacology and Experimental Therapeutics 284 406–412.
Sadrzadeh, SMH, Nanji, AA & Meydani, M (1994a) Effect of chronic ethanol feeding on plasma and liver α- and γ-tocopherol levels in normal and vitamin E-deficient rats. Biochemical Pharmacology 47 2005–2010.
Sadrzadeh, SMH, Nanji, AA & Prince, PL (1994b) The oral iron chelator 1,2-dimethyl-3-hydroxypyrid-4-one reduces hepatic free iron, lipid peroxidation and fat accumulation in chronically ethanol-fed rats. Journal of Pharmacology and Experimental Therapeutics 269 632–636.
Safadi, R, Ohta, M, Alvarez, CE, Fiel, MI, Bansal, M, Mehal, WZ & Friedman, SL (2004) Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes. Gastroenterology 127 870–882.
Savill, J, Dransfield, I, Gregory, C & Haslett, C (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nature Reviews Immunology 2 965–975.
Schneiderhan, W, Schmid-Kotsas, A, Zhao, J, Grunert, A, Nusslaer, A, Weidenbach, H, Menke, A, Schmid, RM, Adler, G & Bachem, MG (2001) Oxidized low-density lipoproteins bind to the scavenger receptor, CD36, of hepatic stellate cells and stimulate extracellular matrix synthesis. Hepatology 34 729–737.
Sergent, O, Griffon, B, Morel, I, Chevanne, M, Dubus, MP, Cillard, P & Cillard, J (1997) Effect of nitric oxide on iron-mediated oxidative stress in primary hepatocyte culture. Hepatology 23 122–127.
Shulga, N, Hoek, JB & Pastorino, JG (2005) Elevated PTEN levels account for the increased sensitivity of ethanol-exposed cells to tumor necrosis factor-induced cytotoxicity. Journal of Biological Chemistry 280 9416–9424.
Stewart, SF, Jones, DEJ, Vidali, M, Haugk, B, Brunt, AD, Albano, E & Day, CP (2004a) Correlation between antiCYP2E1 titre and lymphocyte infiltration in ALD–an autoimmune disease in some patients. Journal of Hepatology 40, Suppl. 1 176
Stewart, SF, Leathart, JB, Chen, Y, Daly, AK, Rolla, R, Mottaran, E, Vay, D, Vidali, M, Day, CP & Albano, E (2002) Valine-alanine manganese superoxide dismutase polymorphism is not associated with alcohol-induced oxidative stress or fibrosis. Hepatology 36 1355–1360.
Stewart, SF, Vidali, M, Day, CP, Albano, E & Jones, DEJ (2004b) Oxidative stress as a trigger for cellular immune response in patients with alcoholic liver disease. Hepatology 39 197–203.
Stoyanovsky, DA & Cederbaum, AI (1998) ESR and HPLC-EC analysis of ethanol oxidation to 1-hydroxyethyl radical: rapid reduction and quantification of POBN and PBN nitroxides. Free Radical Biology and Medicine 25 536–545.
Stoyanovsky, DA, Wu, D & Cederbaum, AI (1998) Interaction of 1-hydroxyethyl radical with glutathione, ascorbic acid and α-tocopherol. Free Radical Biology and Medicine 24 132–138.
Sutton, A, Khoury, H, Prop-Buus, C, Cepanec, C, Pessayre, D & Degoul, F (2003) The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics 13 145–157.
Suzuki, M, Fujimoto, Y, Suzuki, Y, Hosoki, Y, Saito, H, Nakayama, K, Ohtake, T & Kohgo, Y (2004) Induction of transferrin receptor by ethanol in rat primary hepatocyte culture. Alcoholism, Clinical and Experimental Research 28 98S–105S.
Takase, S, Tsutsumi, M, Kawahara, H, Takada, N & Takada, A (1993) The alcohol-altered liver membrane antibody and hepatitis C virus infection in the progression of alcoholic liver disease. Hepatology 17 9–13.
Thiele, GM, Freeman, TK & Klassen, LW (2004) Immunological mechanisms of alcoholic liver disease. Seminar of Liver Diseases 24 273–287.
Thurman, RG (1998) Alcoholic liver injury involves activation of Kupffer cells by endotoxins. American Journal of Physiology 275 G605–G611.
Tsukamoto, H, French, SW, Benson, N, Delgado, G, Rao, GA, Larkin, EC & Largman, C (1985) Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5 224–232.
Tsukamoto, H, Horne, W, Kamimura, S, Niemelä, O, Parkkila, S, Ylä-Herttuala, S & Brittenham, GM (1995) Experimental liver cirrhosis induced by alcohol and iron. Journal of Clinical Investigation 96 620–630.
Tsukamoto, H, Lin, M, Ohata, M, Giulivi, C, French, SW & Brittenham, G (1999) Iron primes hepatic macrophages for NF-κB activation in alcoholic liver injury. American Journal of Physiology 277 G1240–G1250.
Uesugi, T, Froh, M, Arteel, GE, Bradford, BU & Thurman, RG (2001) Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34 101–108.
Van Pelt, FNAM, Straub, P & Manns, MP (1995) Molecular basis of drug-induced immunological liver injury. Seminars in Liver Diseases 15 283–300.
Vay, D, Rigamonti, C, Vidali, M, Mottaran, E, Alchera, E, Occhino, G, Sartori, M & Albano, E (2006) Anti-phospholipid antibodies associated with alcoholic liver disease target oxidized phosphatidylserine on apoptotic cell plasma membranes. Journal of Hepatology 44 183–189.
Vidali, M, Hidestrand, M, Eliasson, E, Mottaran, E, Reale, E, Rolla, R, Occhino, G, Albano, E & Ingelman-Sundberg, M (2004) Use of molecular simulation for mapping conformational CYP2E1 epitopes. Journal of Biological Chemistry 279 50949–50955.
Vidali, M, Stewart, SF, Rolla, R, Daly, AK, Chen, Y, Mottaran, E, Jones, DEJ, Leathart, JB, Day, CP & Albano, E (2003) Genetic and epigenetic factors in autoimmune reactions toward cytochrome P4502E1 in alcoholic liver disease. Hepatology 37 277–285.
Wajant, H, Pfizenmaier, K & Scheurich, P (2003) Tumor necrosis factor signalling. Cell Death and Differentiation 10 45–65.
Wheeler, MD, Kono, H, Yin, M, Rusyn, I, Froh, M, Connor, HD, Mason, RP, Samulski, RJ & Thurman, RG (2001a) Delivery of Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology 120 1241–1250.
Wheeler, MD, Nakagami, M, Bradford, BU, Uesugi, T, Mason, RP, Connor, HD, Dikalova, A, Kadiiska, M & Thurman, RG (2001b) Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Journal of Biological Chemistry 276 36664–36672.
Yin, M, Bradford, BU, Wheeler, MD, Uesugi, T, Froh, M, Goyert, SM & Thurman, RG (2001) Reduced early alcohol-induced liver injury in CD14-deficient mice. Journal of Immunology 166 4737–4742.
You, M & Crabb, DW (2004) Recent advances in alcoholic liver disease. II. Molecular mechanisms of alcoholic fatty liver. American Journal of Physiology 287 G1–G6.
Zamara, E, Novo, E, Marra, F, Gentilini, A, Romanelli, RG & Caligiuri, A, et al. (2004) 4-Hydroxynonenenal as a selective pro-fibrogeneic stimulus for activated human hepatic stellate cells. Journal of Hepatology 40 60–68.
Ziegler-Heitbrock, HW (1995) Molecular mechanism in tolerance to lipopolysaccharide. Journal of Inflammation 45 13–26.
Ziol, M, Tepper, M, Lohez, M, Arcangeli, G, Ganne, N, Christidis, C, Trinchet, JC, Beaugrand, M, Guillet, JG & Guettier, C (2001) Clinical and biological relevance of hepatocyte apoptosis in alcoholic hepatitis. Journal of Hepatology 34 254–260.