Acharya, P, Segall, ML, Zaiou, M, Morrow, J, Weisgraber, KH, Phillips, MC, Lund-Katz, S & Snow, J (2002) Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism. Biochimica et Biophysica Acta 1584, 9–19.
Aguilar, CA, Talavera, G, Ordovas, JM, Barriguete, JA, Guillen, LE, Leco, ME, Pedro-Botet, J, Gonzalez-Barranco, J, Gomez-Perez, FJ & Rull, JA (1999) The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle. Atherosclerosis 142, 409–414.
Almeida, S, Fiegenbaum, M, de Andrade, FM, Osorio-Wender, MC & Hutz, MH (2006) ESR1 and APOE gene polymorphisms, serum lipids, and hormonal replacement therapy. Maturitas 54, 119–126.
Aviram, M, Dornfeld, L, Rosenblat, M, Volkova, N, Kaplan, M, Coleman, R, Hayek, T, Presser, D & Fuhrman, B (2000) Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. American Journal of Clinical Nutrition 71, 1062–1076.
Basu, SK, Brown, MS, Ho, YK, Havel, RJ & Goldstein, JL (1981) Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E. Proceedings of the National Academy of Sciences USA 78, 7545–7549.
Basu, SK, Ho, YK, Brown, MS, Bilheimer, DW, Anderson, RG & Goldstein, JL (1982) Biochemical and genetic studies of the apoprotein E secreted by mouse macrophages and human monocytes. Journal of Biological Chemistry 257, 9788–9795.
Beilby, JP, Hunt, CC, Palmer, LJ, Chapman, CM, Burley, JP, McQuillan, BM, Thompson, PL & Hung, J (2003) Apolipoprotein E gene polymorphisms are associated with carotid plaque formation but not with intima-media wall thickening: results from the Perth Carotid Ultrasound Disease Assessment Study (CUDAS). Stroke 34, 869–874.
Bellosta, S, Mahley, RW, Sanan, DA, Murata, J, Newland, DL, Taylor, JM & Pitas, RE (1995) Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E-null mice. Journal of Clinical Investigation 96, 2170–2179.
Bercedo-Sanz, A, Gonzalez-Lamuno, D, Malaga, S & Garcia-Fuentes, M (1999) Impact of ApoE4 allele on total cholesterol levels of children in northern Spain. Clinical Genetics 55, 69–70.
Bhatnagar, D & Durrington, P (1993) Does measurement of apolipoproteins add to the clinical diagnosis and management of dyslipidaemias. Current Opinion of Lipidology 4, 299–304.
Blue, ML, Williams, DL, Zucker, S, Khan, SA & Blum, CB (1983) Apolipoprotein E synthesis in human kidney, adrenal gland, and liver. Proceedings of the National Academy of Sciences USA 80, 283–287.
Boerwinkle, E, Brown, S, Sharrett, AR, Heiss, G & Patsch, W (1994) Apolipoprotein E polymorphism influences postprandial retinyl palmitate but not triglyceride concentrations. American Journal of Human Genetics 54, 341–360.
Bradley, WA & Gianturco, SH (1986) ApoE is necessary and sufficient for the binding of large triglyceride-rich lipoproteins to the LDL receptor; apoB is unnecessary. Journal of Lipid Research 27, 40–48.
Brenninkmeijer, BJ, Stuyt, PM, Demacker, PN, Stalenhoef, AF & van't Laar, A (1987) Catabolism of chylomicron remnants in normolipidemic subjects in relation to the apoprotein E phenotype. Journal of Lipid Research 28, 361–370.
Brown, AJ & Roberts, DC (1991) The effect of fasting triacylglyceride concentration and apolipoprotein E polymorphism on postprandial lipemia. Arteriosclerosis, Thrombosis, and Vascular Biology 11, 1737–1744.
Chroni, A, Nieland, TJ, Kypreos, KE, Krieger, M & Zannis, VI (2005) SR-BI mediates cholesterol efflux via its interactions with lipid-bound ApoE. Structural mutations in SR-BI diminish cholesterol efflux. Biochemistry 44, 13132–13143.
Colton, CA, Brown, CM, Cook, D, Needham, LK, Xu, Q, Czapiga, M, Saunders, AM, Schmechel, DE, Rasheed, K & Vitek, MP (2002) APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. Neurobiology of Aging 23, 777–785.
Colton, CA, Czapiga, M, Snell-Callanan, J, Chernyshev, ON & Vitek, MP (2001) Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. Biochimica et Biophysica Acta 1535, 134–144.
Colton, CA, Needham, LK, Brown, C, Cook, D, Rasheed, K, Burke, JR, Strittmatter, WJ, Schmechel, DE & Vitek, MP (2004) APOE genotype-specific differences in human and mouse macrophage nitric oxide production. Journal of Neuroimmunology 147, 62–67.
Corbo, RM & Scacchi, R (1999) Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a ‘thrifty’ allele? Annals of Human Genetics 63, 301–310.
Corella, D, Guillen, M, Saiz, C, Portoles, O, Sabater, A, Cortina, S, Folch, J, Gonzalez, JI & Ordovas, JM (2001 a) Environmental factors modulate the effect of the APOE genetic polymorphism on plasma lipid concentrations: ecogenetic studies in a Mediterranean Spanish population. Metabolism 50, 936–944.
Corella, D, Tucker, K, Lahoz, C, Coltell, O, Cupples, LA, Wilson, PW, Schaefer, EJ & Ordovas, JM (2001 b) Alcohol drinking determines the effect of the APOE locus on LDL-cholesterol concentrations in men: the Framingham Offspring Study. American Journal of Clinical Nutrition 73, 736–745.
Cullen, P, Cignarella, A, Brennhausen, B, Mohr, S, Assmann, G & von Eckardstein, A (1998) Phenotype-dependent differences in apolipoprotein E metabolism and in cholesterol homeostasis in human monocyte-derived macrophages. Journal of Clinical Investigation 101, 1670–1677.
Dallongeville, J, Lussier-Cacan, S & Davignon, J (1992) Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. Journal of Lipid Research 33, 447–454.
Dallongeville, J, Tiret, L, Visvikis, S, O'Reilly, DS, Saava, M, Tsitouris, G, Rosseneu, M, DeBacker, G, Humphries, SE & Beisiegel, U (1999) Effect of apo E phenotype on plasma postprandial triglyceride levels in young male adults with and without a familial history of myocardial infarction: the EARS II study. European Atherosclerosis Research Study. Atherosclerosis 145, 381–388.
Davignon, J, Gregg, RE & Sing, CF (1988) Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 8, 1–21.
Dawson, PA, Lukaszewski, LM, Ells, PF, Malbon, CC & Williams, DL (1989) Quantification and regulation of apolipoprotein E expression in rat Kupffer cells. Journal of Lipid Research 30, 403–413.
Demant, T, Bedford, D, Packard, CJ & Shepherd, J (1991) Influence of apolipoprotein E polymorphism on apolipoprotein B-100 metabolism in normolipemic subjects. Journal of Clinical Investigation 88, 1490–1501.
Desai, K, Bruckdorfer, KR, Hutton, RA & Owen, JS (1989) Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation. Journal of Lipid Research 30, 831–840.
Dietrich, M, Hua, Y, Block, G, Olano, E, Packer, L, Morrow, JD, Hudes, M, Abdukeyum, G, Rimbach, G & Minihane, AM (2005) Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans. Lipids 40, 329–334.
Dong, LM & Weisgraber, KH (1996) Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. Journal of Biological Chemistry 271, 19053–19057.
Dove, DE, Linton, MF & Fazio, S (2005) ApoE-mediated cholesterol efflux from macrophages: separation of autocrine and paracrine effects. American Journal of Physiology 288, C586–C592.
Eichner, JE, Dunn, ST, Perveen, G, Thompson, DM, Stewart, KE & Stroehla, BC (2002) Apolipoprotein E polymorphism and cardiovascular disease: a HuGE review. American Journal of Epidemiology 155, 487–495.
Elosua, R, Ordovas, JM, Cupples, LA, Fox, CS, Polak, JF, Wolf, PA, SrD'Agostino, RA & O'Donnell, CJ (2004) Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study. Journal of Lipid Research 45, 1868–1875.
Fazio, S & Yao, Z (1995) The enhanced association of apolipoprotein E with apolipoprotein B-containing lipoproteins in serum-stimulated hepatocytes occurs intracellularly. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 593–600.
Gregg, RE & Brewer, HB Jr (1988) The role of apolipoprotein E and lipoprotein receptors in modulating the in vivo metabolism of apolipoprotein B-containing lipoproteins in humans. Clinical Chemistry 34, B28–B32.
Gregg, RE, Zech, LA, Schaefer, EJ, Stark, D, Wilson, D & Brewer, HB Jr (1986) Abnormal in vivo metabolism of apolipoprotein E4 in humans. Journal of Clinical Investigation 78, 815–821.
Gylling, H, Kontula, K & Miettinen, TA (1995) Cholesterol absorption and metabolism and LDL kinetics in healthy men with different apoprotein E phenotypes and apoprotein B Xba I and LDL receptor Pvu II genotypes. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 208–213.
Hallman, DM, Boerwinkle, E, Saha, N, Sandholzer, C, Menzel, HJ, Csazar, A & Utermann, G (1991) The apolipoprotein E polymorphism: a comparison of allele frequencies and effects in nine populations. American Journal of Human Genetics 49, 338–349.
Hara, M, Matsushima, T, Satoh, H, Iso-o, N, Noto, H, Togo, M, Kimura, S, Hashimoto, Y & Tsukamoto, K (2003) Isoform-dependent cholesterol efflux from macrophages by apolipoprotein E is modulated by cell surface proteoglycans. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 269–274.
Harris, WS (1997) n-3 fatty acids and serum lipoproteins: human studies. American Journal of Clinical Nutrition 65, 1645S–1654S.
Hatters, DM, Peters-Libeu, CA & Weisgraber, KH (2006) Apolipoprotein E structure: insights into function. Trends in Biochemical Sciences 31, 445–454.
Hayek, T, Oiknine, J, Brook, JG & Aviram, M (1994) Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice. Biochemical and Biophysical Research Communications 201, 1567–1574.
Howard, BV, Gidding, SS & Liu, K (1998) Association of apolipoprotein E phenotype with plasma lipoproteins in African-American and white young adults. The CARDIA Study. Coronary Artery Risk Development in Young Adults. American Journal of Epidemiology 148, 859–868.
Huang, Y, Ji, ZS, Brecht, WJ, Rall, SC Jr, Taylor, JM & Mahley, RW (1999) Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 2952–2959.
Hui, DY & Basford, JE (2005) Distinct signaling mechanisms for apoE inhibition of cell migration and proliferation. Neurobiology of Aging 26, 317–323.
Humphries, SE, Talmud, PJ, Hawe, E, Bolla, M, Day, IN & Miller, GJ (2001) Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 358, 115–119.
Ilveskoski, E, Perola, M, Lehtimaki, T, Laippala, P, Savolainen, V, Pajarinen, J et al. (1999) Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men: an autopsy study. Circulation 100, 608–613.
Inamdar, PA, Kelkar, SM, Devasagayam, TP & Bapat, MM (2000) Apolipoprotein E polymorphism in non-insulin-dependent diabetics of Mumbai, India and its effect on plasma lipids and lipoproteins. Diabetes Research and Clinical Practice 47, 217–223.
Innerarity, TL, Friedlander, EJ, Rall, SC Jr, Weisgraber, KH & Mahley, RW (1983) The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments. Journal of Biological Chemistry 258, 12341–12347.
Ishida, BY, Bailey, KR, Duncan, KG, Chalkley, RJ, Burlingame, AL, Kane, JP & Schwartz, DM (2004) Regulated expression of apolipoprotein E by human retinal pigment epithelial cells. Journal of Lipid Research 45, 263–271.
Jackson, KG, Maitin, V, Leake, DS, Yaqoob, P & Williams, CM (2006) Saturated fat-induced changes in Sf 60–400 particle composition reduces uptake of LDL by HepG2 cells. Journal of Lipid Research 47, 393–403.
Jarvik, GP, Austin, MA, Fabsitz, RR, Auwerx, J, Reed, T, Christian, JC & Deeb, S (1994) Genetic influences on age-related change in total cholesterol, low density lipoprotein-cholesterol, and triglyceride levels: longitudinal apolipoprotein E genotype effects. Genetic Epidemiology 11, 375–384.
Jofre-Monseny, L, de Pascual-Teresa, S, Plonka, E, Huebbe, P, Boesch-Saasatmandi, C, Minihane, AM & Rimbach, G (2007) Differential effects of apolipoprotein E3 and E4 on markers of oxidative status in macrophages. British Journal of Nutrition (In the Press).
Jolivalt, C, Leininger-Muller, B, Bertrand, P, Herber, R, Christen, Y & Siest, G (2000) Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids. Free Radical Biology and Medicine 28, 129–140.
Kayden, HJ, Maschio, F & Traber, MG (1985) The secretion of apolipoprotein E by human monocyte-derived macrophages. Archives of Biochemistry and Biophysics 239, 388–395.
Kesaniemi, YA, Ehnholm, C & Miettinen, TA (1987) Intestinal cholesterol absorption efficiency in man is related to apoprotein E phenotype. Journal of Clinical Investigation 80, 578–581.
Kim, DH, Iijima, H, Goto, K, Sakai, J, Ishii, H, Kim, HJ, Suzuki, H, Kondo, H, Saeki, S & Yamamoto, T (1996) Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. Journal of Biological Chemistry 271, 8373–8380.
Kitagawa, K, Matsumoto, M, Kuwabara, K, Takasawa, K, Tanaka, S, Sasaki, T, Matsushita, K, Ohtsuki, T, Yanagihara, T & Hori, M (2002) Protective effect of apolipoprotein E against ischemic neuronal injury is mediated through antioxidant action. Journal of Neuroscience Research 68, 226–232.
Kuusisto, J, Mykkanen, L, Kervinen, K, Kesaniemi, YA & Laakso, M (1995) Apolipoprotein E4 phenotype is not an important risk factor for coronary heart disease or stroke in elderly subjects. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 1280–1286.
Lahoz, C, Schaefer, EJ, Cupples, LA, Wilson, PW, Levy, D, Osgood, D, Parpos, S, Pedro-Botet, J, Daly, JA & Ordovas, JM (2001) Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis 154, 529–537.
Law, MR, Wald, NJ & Thompson, SG (1994) By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? British Medical Journal 308, 367–372.
Lehtimaki, T, Metso, S, Ylitalo, R, Rontu, R, Nikkila, M, Wuolijoki, E & Ylitalo, P (2005) Microcrystalline chitosan is ineffective to decrease plasma lipids in both apolipoprotein E epsilon 4 carriers and non-carriers: a long-term placebo-controlled trial in hypercholesterolaemic volunteers. Basic & Clinical Pharmacology & Toxicology 97, 98–103.
Lenzen, HJ, Assmann, G, Buchwalsky, R & Schulte, H (1986) Association of apolipoprotein E polymorphism, low-density lipoprotein cholesterol, and coronary artery disease. Clinical Chemistry 32, 778–781.
Li, X, Kypreos, K, Zanni, EE & Zannis, V (2003) Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain. Biochemistry 42, 10406–10417.
Libeu, CP, Lund-Katz, S, Phillips, MC, Wehrli, S, Hernaiz, MJ, Capila, I, Linhardt, RJ, Raffai, RL, Newhouse, YM, Zhou, F & Weisgraber, KH (2001) New insights into the heparan sulfate proteoglycan-binding activity of apolipoprotein E. Journal of Biological Chemistry 276, 39138–39144.
Lin, CY, Duan, H & Mazzone, T (1999) Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E. Journal of Lipid Research 40, 1618–1627.
Lynch, JR, Tang, W, Wang, H, Vitek, MP, Bennett, ER, Sullivan, PM, Warner, DS & Laskowitz, DT (2003) APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. Journal of Biological Chemistry 278, 48529–48533.
Mahley, RW (1988) Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240, 622–630.
Mahley, RW & Ji, ZS (1999) Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. Journal of Lipid Research 40, 1–16.
Marques-Vidal, P, Bongard, V, Ruidavets, JB, Fauvel, J, Hanaire-Broutin, H, Perret, B & Ferrieres, J (2003) Obesity and alcohol modulate the effect of apolipoprotein E polymorphism on lipids and insulin. Obesity Research 11, 1200–1206.
Masson, LF, McNeill, G & Avenell, A (2003) Genetic variation and the lipid response to dietary intervention: a systematic review. American Journal of Clinical Nutrition 77, 1098–1111.
Mazzone, T & Reardon, C (1994) Expression of heterologous human apolipoprotein E by J774 macrophages enhances cholesterol efflux to HDL3. Journal of Lipid Research 35, 1345–1353.
Miettinen, TA, Gylling, H, Vanhanen, H & Ollus, A (1992) Cholesterol absorption, elimination, and synthesis related to LDL kinetics during varying fat intake in men with different apoprotein E phenotypes. Arteriosclerosis, Thrombosis, and Vascular Biology 12, 1044–1052.
Miltiadous, G, Hatzivassiliou, M, Liberopoulos, E, Bairaktari, E, Tselepis, A, Cariolou, M & Elisaf, M (2005) Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population. Nutrition, Metabolism and Cardiovascular Diseases 15, 219–224.
Minihane, AM, Khan, S, Leigh-Firbank, EC, Talmud, P, Wright, JW, Murphy, MC, Griffin, BA & Williams, CM (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology 20, 1990–1997.
Mistry, MJ, Clay, MA, Kelly, ME, Steiner, MA & Harmony, JA (1995) Apolipoprotein E restricts interleukin-dependent T lymphocyte proliferation at the G1A/G1B boundary. Cellular Immunology 160, 14–23.
Miyata, M & Smith, JD (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides. Nature Genetics 14, 55–61.
Morrow, JA, Hatters, DM, Lu, B, Hochtl, P, Oberg, KA, Rupp, B & Weisgraber, KH (2002) Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. Journal of Biological Chemistry 277, 50380–50385.
National Center for Biotechnology Information (2006) Single nucleotide polymorphism. www.ncbi.nlm.nih.gov/SNP/ (accessed November 2006)
Newman, TC, Dawson, PA, Rudel, LL & Williams, DL (1985) Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates. Journal of Biological Chemistry 260, 2452–2457.
Nolte, RT & Atkinson, D (1992) Conformational analysis of apolipoprotein A-I and E-3 based on primary sequence and circular dichroism. Biophysical Journal 63, 1221–1239.
Ophir, G, Amariglio, N, Jacob-Hirsch, J, Elkon, R, Rechavi, G & Michaelson, DM (2005) Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascade. Neurobiology of Disease 20, 709–718.
Ophir, G, Meilin, S, Efrati, M, Chapman, J, Karussis, D, Roses, A & Michaelson, DM (2003) Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiology of Disease 12, 56–64.
Orth, M, Wahl, S, Hanisch, M, Friedrich, I, Wieland, H & Luley, C (1996) Clearance of postprandial lipoproteins in normolipemics: role of the apolipoprotein E phenotype. Biochimica et Biophysica Acta 1303, 22–30.
Pablos-Mendez, A, Mayeux, R, Ngai, C, Shea, S & Berglund, L (1997) Association of apo E polymorphism with plasma lipid levels in a multiethnic elderly population. Arteriosclerosis, Thrombosis, and Vascular Biology 17, 3534–3541.
Paik, YK, Chang, DJ, Reardon, CA, Davies, GE, Mahley, RW & Taylor, JM (1985) Nucleotide sequence and structure of the human apolipoprotein E gene. Proceedings of the National Academy of Sciences USA 82, 3445–3449.
Patsch, W, Esterbauer, H, Foger, B & Patsch, JR (2000) Postprandial lipemia and coronary risk. Current Atherosclerosis Reports 2, 232–242.
Pham, T, Kodvawala, A & Hui, DY (2005) The receptor binding domain of apolipoprotein e is responsible for its antioxidant activity. Biochemistry 44, 7577–7582.
Polacek, D, Beckmann, MW & Schreiber, JR (1992) Rat ovarian apolipoprotein E: localization and gonadotropic control of messenger RNA. Biology of Reproduction 46, 65–72.
Pratico, D, Lee, VM-Y, Trojanowski, JQ, Rokach, J & Fitzgerald, GA (1998) Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. FASEB Journal 12, 1777–1783.
Rall, SC Jr, Weisgraber, KH & Mahley, RW (1982) Human apolipoprotein E. The complete amino acid sequence. Journal of Biological Chemistry 257, 4171–4178.
Ranjith, N, Pegoraro, RJ, Rom, L, Rajput, MC & Naidoo, DP (2004) Lp(a) and apoE polymorphisms in young South African Indians with myocardial infarction. Cardiovascular Journal of South Africa 15, 111–117.
Rastas, S, Mattila, K, Verkkoniemi, A, Niinisto, L, Juva, K, Sulkava, R & Lansimies, E (2004) Association of apolipoprotein E genotypes, blood pressure, blood lipids and ECG abnormalities in a general population aged 85+. BMC Geriatrics 4, 1.
Remaley, AT, Stonik, JA, Demosky, SJ, Neufeld, EB, Bocharov, AV, Vishnyakova, TG, Eggerman, TL, Patterson, AP, Duverger, NJ, Santamarina-Fojo, S & Brewer, HB Jr (2001) Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Biochemical and Biophysical Research Communications 280, 818–823.
Riddell, DR, Graham, A & Owen, JS (1997) Apolipoprotein E inhibits platelet aggregation through the L-arginine:nitric oxide pathway. Implications for vascular disease. Journal of Biological Chemistry 272, 89–95.
Riddell, DR, Sun, XM, Stannard, AK, Soutar, AK & Owen, JS (2001) Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane. Journal of Lipid Research 42, 998–1002.
Riddell, DR, Vinogradov, DV, Stannard, AK, Chadwick, N & Owen, JS (1999) Identification and characterization of LRP8 (apoER2) in human blood platelets. Journal of Lipid Research 40, 1925–1930.
Ruiz, J, Kouiavskaia, D, Migliorini, M, Robinson, S, Saenko, EL, Gorlatova, N, Li, D, Lawrence, D, Hyman, BT, Weisgraber, KH & Strickland, DK (2005) The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. Journal of Lipid Research 46, 1721–1731.
Sacre, SM, Stannard, AK & Owen, JS (2003) Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells. FEBS Letters 540, 181–187.
Saito, H, Dhanasekaran, P, Baldwin, F, Weisgraber, KH, Phillips, MC & Lund-Katz, S (2003) Effects of polymorphism on the lipid interaction of human apolipoprotein E. Journal of Biological Chemistry 278, 40723–40729.
Saito, M, Eto, M, Nitta, H, Kanda, Y, Shigeto, M, Nakayama, K et al. (2004) Effect of apolipoprotein E4 allele on plasma LDL cholesterol response to diet therapy in type 2 diabetic patients. Diabetes Care 27, 1276–1280.
Sanada, M, Nakagawa, H, Kodama, I, Sakasita, T & Ohama, K (1998) Apolipoprotein E phenotype associations with plasma lipoproteins and bone mass in postmenopausal women. Climacteric 1, 188–195.
Sarkkinen, E, Korhonen, M, Erkkila, A, Ebeling, T & Uusitupa, M (1998) Effect of apolipoprotein E polymorphism on serum lipid response to the separate modification of dietary fat and dietary cholesterol. American Journal of Clinical Nutrition 68, 1215–1222.
Schaefer, EJ, Gregg, RE, Ghiselli, G, Forte, TM, Ordovas, JM, Zech, LA & Brewer, HB Jr (1986) Familial apolipoprotein E deficiency. Journal of Clinical Investigation 78, 1206–1219.
Schaefer, EJ, Lamon-Fava, S, Ausman, LM, Ordovas, JM, Clevidence, BA, Judd, JT, Goldin, BR, Woods, M, Gorbach, S & Lichtenstein, AH (1997) Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets. American Journal of Clinical Nutrition 65, 823–830.
Schaefer, EJ, Lamon-Fava, S, Johnson, S, Ordovas, JM, Schaefer, MM, Castelli, WP & Wilson, PW (1994) Effects of gender and menopausal status on the association of apolipoprotein E phenotype with plasma lipoprotein levels. Results from the Framingham Offspring Study. Arteriosclerosis, Thrombosis, and Vascular Biology 14, 1105–1113.
Scuteri, A, Najjar, SS, Muller, D, Andres, R, Morrell, CH, Zonderman, AB & Lakatta, EG (2005) apoE4 allele and the natural history of cardiovascular risk factors. American Journal of Physiology 289, E322–E327.
Sheehan, D, Bennett, T & Cashman, K (2000) Apolipoprotein E gene polymorphisms and serum cholesterol in healthy Irish adults: a proposed genetic marker for coronary artery disease risk. Irish Journal of Medical Sciences 169, 50–54.
Shimano, H, Ohsuga, J, Shimada, M, Namba, Y, Gotoda, T, Harada, K, Katsuki, M, Yazaki, Y & Yamada, N (1995) Inhibition of diet-induced atheroma formation in transgenic mice expressing apolipoprotein E in the arterial wall. Journal of Clinical Investigation 95, 469–476.
Shin, MH, Kim, HN, Cui, LH, Kweon, SS, Park, KS, Heo, H, Nam, HS, Jeong, SK, Chung, EK & Choi, JS (2005) The effect of apolipoprotein E polymorphism on lipid levels in Korean adults. Journal of Korean Medical Science 20, 361–366.
Shore, VG & Shore, B (1973) Heterogeneity of human plasma very low density lipoproteins. Separation of species differing in protein components. Biochemistry 12, 502–507.
Singh, P, Singh, M & Mastana, S (2006) APOE distribution in world populations with new data from India and the UK. Annals of Human Biology 33, 297–308.
Song, Y, Stampfer, MJ & Liu, S (2004) Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Annals of Internal Medicine 141, 137–147.
Srinivasan, SR, Ehnholm, C, Elkasabany, A & Berenson, G (1999) Influence of apolipoprotein E polymorphism on serum lipids and lipoprotein changes from childhood to adulthood: the Bogalusa Heart Study. Atherosclerosis 143, 435–443.
Stannard, AK, Riddell, DR, Sacre, SM, Tagalakis, AD, Langer, C, von Eckardstein, A, Cullen, P, Athanasopoulos, T, Dickson, G & Owen, JS (2001) Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. Journal of Biological Chemistry 276, 46011–46016.
Strickland, DK, Gonias, SL & Argraves, WS (2002) Diverse roles for the LDL receptor family. Trends in Endocrinology and Metabolism 13, 66–74.
Swertfeger, DK & Hui, DY (2001) Apolipoprotein E receptor binding versus heparan sulfate proteoglycan binding in its regulation of smooth muscle cell migration and proliferation. Journal of Biological Chemistry 276, 25043–25048.
Szalai, C, Csaszar, A, Czinner, A, Palicz, T, Halmos, B & Romics, L (1999) Genetic investigation of patients with hypercholesterolemia type IIa. Clinical Genetics 55, 67–68.
Szalai, C, Czinner, A & Csaszar, A (2000) Influence of apolipoprotein E genotypes on serum lipid parameters in a biracial sample of children. European Journal of Pediatrics 159, 257–260.
Talmud, PJ, Stephens, JW, Hawe, E, Demissie, S, Cupples, LA, Hurel, SJ, Humphries, SE & Ordovas, JM (2005) The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: potential relationship between reduced antioxidant status and ApoE4. Annals of Human Genetics 69, 613–622.
Tamaoka, A, Miyatake, F, Matsuno, S, Ishii, K, Nagase, S, Sahara, N et al. (2000) Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease. Neurology 54, 2319–2321.
Tan, CE, Tai, ES, Tan, CS, Chia, KS, Lee, J, Chew, SK & Ordovas, JM (2003) APOE polymorphism and lipid profile in three ethnic groups in the Singapore population. Atherosclerosis 170, 253–260.
Terry, JG, Howard, G, Mercuri, M, Bond, MG & Crouse, JR 3rd (1996) Apolipoprotein E polymorphism is associated with segment-specific extracranial carotid artery intima-media thickening. Stroke 27, 1755–1759.
Thorngate, FE, Rudel, LL, Walzem, RL & Williams, DL (2000) Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 20, 1939–1945.
Utermann, G, Hardewig, A & Zimmer, F (1984) Apolipoprotein E phenotypes in patients with myocardial infarction. Human Genetics 65, 237–241.
Von Bergmann, K, Lutjohann, D, Lindenthal, B & Steinmetz, A (2003) Efficiency of intestinal cholesterol absorption in humans is not related to apoE phenotype. Journal of Lipid Research 44, 193–197.
Wallis, SC, Rogne, S, Gill, L, Markham, A, Edge, M, Woods, D, Williamson, R & Humphries, S (1983) The isolation of cDNA clones for human apolipoprotein E and the detection of apoE RNA in hepatic and extra-hepatic tissues. The EMBO Journal 2, 2369–2373.
Wang-Iverson, P, Gibson, JC & Brown, WV (1985) Plasma apolipoprotein secretion by human monocyte-derived macrophages. Biochimica et Biophysica Acta 834, 256–262.
Weintraub, MS, Eisenberg, S & Breslow, JL (1987) Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. Journal of Clinical Investigation 80, 1571–1577.
Weisgraber, KH (1990) Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. Journal of Lipid Research 31, 1503–1511.
Weisgraber, KH (1994) Apolipoprotein E: structure-function relationships. Advances in Protein Chemistry 45, 249–302.
Weisgraber, KH, Innerarity, TL & Mahley, RW (1982) Abnormal lipoprotein receptor-binding activity of the human E apoprotein due to cysteine-arginine interchange at a single site. Journal of Biological Chemistry 257, 2518–2521.
Weisgraber, KH, Rall, SC Jr & Mahley, RW (1981) Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. Journal of Biological Chemistry 256, 9077–9083.
Welty, FK, Lichtenstein, AH, Barrett, PH, Jenner, JL, Dolnikowski, GG & Schaefer, EJ (2000) Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans. Arteriosclerosis, Thrombosis, and Vascular Biology 20, 1807–1810.
Wetterau, JR, Aggerbeck, LP, Rall, SC Jr & Weisgraber, KH (1988) Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains. Journal of Biological Chemistry 263, 6240–6248.
Wilson, C, Wardell, MR, Weisgraber, KH, Mahley, RW & Agard, DA (1991) Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 252, 1817–1822.
Wilson, PW, Myers, RH, Larson, MG, Ordovas, JM, Wolf, PA & Schaefer, EJ (1994) Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. Journal of the American Medical Association 272, 1666–1671.
Wilson, PW, Schaefer, EJ, Larson, MG & Ordovas, JM (1996) Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. Arteriosclerosis, Thrombosis, and Vascular Biology 16, 1250–1255.
Yue, P, Isley, WL, Harris, WS, Rosipal, S, Akin, CD & Schonfeld, G (2005) Genetic variants of ApoE account for variability of plasma low-density lipoprotein and apolipoprotein B levels in FHBL. Atherosclerosis 178, 107–113.
Zechner, R, Moser, R, Newman, TC, Fried, SK & Breslow, JL (1991) Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content. Journal of Biological Chemistry 266, 10583–10588.
Zeleny, M, Swertfeger, DK, Weisgraber, KH & Hui, DY (2002) Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry 41, 11820–11823.
Zhang, B, Liu, ZH, Zeng, CH, Zheng, JM, Chen, HP, Zhou, H & Li, LS (2005) Plasma level and genetic variation of apolipoprotein E in patients with lipoprotein glomerulopathy. Chinese Medical Journal 118, 555–560.
Zhang, WY, Gaynor, PM & Kruth, HS (1996) Apolipoprotein E produced by human monocyte-derived macrophages mediates cholesterol efflux that occurs in the absence of added cholesterol acceptors. Journal of Biological Chemistry 271, 28641–28646.
Zhao, Y, Thorngate, FE, Weisgraber, KH, Williams, DL & Parks, JS (2005) Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins. Biochemistry 44, 1013–1025.
Zilversmit, DB (1979) Atherogenesis: a postprandial phenomenon. Circulation 60, 473–485.