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Brain–adipose tissue cross talk

  • Timothy J. Bartness (a1), C. Kay Song (a1), Haifei Shi (a1), Robert R. Bowers (a1) and Michelle T. Foster (a1)
  • DOI: http://dx.doi.org/10.1079/PNS2004409
  • Published online: 01 March 2007
Abstract

While investigating the reversible seasonal obesity of Siberian hamsters, direct sympathetic nervous system (SNS) postganglionic innervation of white adipose tissue (WAT) has been demonstrated using anterograde and retrograde tract tracers. The primary function of this innervation is lipid mobilization. The brain SNS outflow to WAT has been defined using the pseudorabies virus (PRV), a retrograde transneuronal tract tracer. These PRV-labelled SNS outflow neurons are extensively co-localized with melanocortin-4 receptor mRNA, which, combined with functional data, suggests their involvement in lipolysis. The SNS innervation of WAT also regulates fat cell number, as noradrenaline inhibits and WAT denervation stimulates fat cell proliferation in vitro and in vivo respectively. The sensory innervation of WAT has been demonstrated by retrograde tract tracing, electrophysiological recording and labelling of the sensory-associated neuropeptide calcitonin gene-related peptide in WAT. Local injections of the sensory nerve neurotoxin capsaicin into WAT selectively destroy this innervation. Just as surgical removal of WAT pads triggers compensatory increases in lipid accretion by non-excised WAT depots, capsaicin-induced sensory denervation triggers increases in lipid accretion of non-capsaicin-injected WAT depots, suggesting that these nerves convey information about body fat levels to the brain. Finally, parasympathetic nervous system innervation of WAT has been suggested, but the recent finding of no WAT immunoreactivity for the possible parasympathetic marker vesicular acetylcholine transporter (VAChT) argues against this claim. Collectively, these data suggest several roles for efferent and afferent neural innervation of WAT in body fat regulation.

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*Corresponding author: Dr Timothy J. Bartness, fax +1 404 651 2509, email bartness@gsu.edu
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

J Aberdeen , L Corr , P Milner , J Lincoln & G Burnstock (1990) Marked increase in calcitonin gene-related peptide containing nerves in the developing rat following long-term sympathectomy with guanethidine. Neurosciences 35, 175184.

A Ainsworth , P Halim , PD Wall , G Allt , M Mackenzie , S Gibson & J Polak (1981) Effects of capsaicin applied locally to adult peripheral nerves. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cord. Pain 11, 379388.

K Ballard , T Malmfors & S Rosell (1974) Adrenergic innervation and vascular patterns in canine adipose tissue. Microvascular Research 8, 164171.

TJ Bartness (1995) Short day-induced depletion of lipid stores is fat pad- and gender-specific in Siberian hamsters. Physiology and Behavior 58, 539550.

TJ Bartness (1996) Photoperiod, sex, gonadal steroids and housing density affect body fat in hamsters. Physiology and Behavior 60, 517529.

TJ Bartness (2002) Dual innervation of white adipose tissue: some evidence for parasympathetic nervous system involvement. Journal of Clinical Investigation 110, 12351237.

TJ Bartness & BD Goldman (1989) Mammalian pineal melatonin: A clock for all seasons. Experientia 45, 939945.

TJ Bartness & GN Wade (1985) Photoperiodic control of seasonal body weight cycles in hamsters. Neuroscience and Behavioral Reviews 9, 599612.

GA Bray & Y Nishizawa (1978) Ventromedial hypothalamus modulates fat mobilisation during fasting. Nature 274, 900901.

AA Butler & RD Cone (2002) The melanocortin receptors: lessons from knockout models. Neuropeptides 36, 7784.

RV Considine , EL Considine , CJ Williams , TM Hyde & JF Caro (1996) The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45, 992994.

B Cousin , L Casteilla , M Lafontan , L Ambid , D Langin , M-F Berthault & L Penicaud (1993) Local sympathetic denervation of white adipose tissue in rats induces preadipocyte proliferation without noticeable changes in metabolism. Endocrinology 133, 22552262.

H Daniel & DM Derry (1969) Criteria for differentiation of brown and white fat in the rat. Canadian Journal of Physiology and Pharmacology 47, 941945.

GE Demas & TJ Bartness (2001a) Novel method for localized, functional sympathetic nervous system denervation of peripheral tissue using guanethidine. Journal of Neuroscience Methods 112, 2128.

I Diculescu & M Stoica (1970) Fluorescence histochemical investigations on the adrenergic innervation of the white adipose tissue in the rat. Journal of Neuro-visceral Relations 32, 2536.

C Dodt , P Lonnroth , JP Wellhoner , HL Fehm & M Elam (2003) Sympathetic control of white adipose tissue in lean and obese humans. Acta Physiologica Scandinavica 177, 351357.

AS Dogiel (1898) Die sensiblen Nervenendigungen im Herzen und in den Blutgefassen der Saugethiere (The afferent nerve endings in the heart and in the blood vessels of mammals). Archiv für Mikroskopischen Anatomie 52, 4470.

A Dua , MI Hennes , RG Hoffmann , DL Maas , GR Krakower , GE Sonnenberg & AH Kissebah (1996) Leptin: a significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women. Diabetes 45, 16351637.

AG Dulloo & DS Miller (1987) Obesity: a disorder of the sympathetic nervous system. World Review of Nutrition and Dietetics 50, 156.

SL Edwards , CR Anderson , BR Southwell & RM McAllen (1996) Distinct preganglioinic neurons innervate noradrenaline and adrenaline cells in the cat adrenal medulla. Neurosciences 70, 825832.

LW Enquist & JP Card (2003) Recent advances in the use of neurotropic viruses for circuit analysis. Current Opinion in Neurobiology 13, 603606.

G Ferry , E Tellier , A Try , S Gres , I Naime , MF Simon (2003) Autotaxin is released from adipocytes, catalyzes lysophosphatidic acid synthesis, and activates preadipocyte proliferation. Up-regulated expression with adipocyte differentiation and obesity. Journal of Biological Chemistry 278, 1816218169.

RC Frederich , B Lollmann , A Hamann , A Napolitano-Rosen , BB Kahn , BB Lowell & JS Flier (1995) Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity. Journal of Clinical Investigation 96, 16581663.

BB Fredholm (1985) Nervous control of circulation and metabolism in white adipose tissue.In New Perspectives in Adipose Tissue: Structure, Function and Development, 4564 [A Cryer RLR Van , editors]. Boston, MA: Butterworth.

MAR Garofalo , IC Kettelhut , JES Roselino & RH Migliorini (1996) Effect of acute cold exposure on norepinephrine turnover rates in rat white adipose tissue. Journal of the Autonomic Nervous System 60, 206208.

C Gasteyger & A Tremblay (2002) Metabolic impact of body fat distribution. Journal of Endocrinological Investigation 25, 876883.

A Giordano , M Morroni , G Santone , GF Marchesi & S Cinti (1996) Tyrosine hydroxylase, neuropeptide Y, substance P, calcitonin gene-related peptide and vasoactive intestinal peptide in nerves of rat periovarian adipose tissue: an immunohistochemical and ultrastructural investigation. Journal of Neurocytology 25, 125136.

RM Gold (1973) Hypothalamic obesity: the myth of the ventromedial nucleus. Science 182, 488490.

RM Gold , AP Jones & PE Sawchenko (1977) Paraventricular area: critical focus of a longitudinal neurocircuitry mediating food intake. Physiology and Behavior 18, 11111119.

DG Gwyn , TC Ritchie & JD Coulter (1985) The central distribution of vagal catecholaminergic neurons which project into the abdomen in the rat. Brain Research 328, 139144.

LJ Hardie , DV Rayner , S Holmes & P Trayhurn (1996) Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochemical and Biophysical Research Communications 223, 660665.

RBS Harris (2000) Leptin – much more than a satiety signal. Annual Review of Nutrition 20, 4575.

C Haskell-Luevano , H Miwa , C Dickinson , VJ Hruby , T Yamada & I Gantz (1994) Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochemical and Biophysical Research Communications 204, 11371142.

DB Hausman , M DiGirolamo , TJ Bartness , GJ Hausman & RJ Martin (2001) The biology of white adipocyte proliferation. Obesity Reviews 2, 239254.

B Hill , V Ralevic , R Crowe & G Burnstock (1996) Innervation and nitric oxide modulation of mesenteric arteries of the Golden hamster. European Journal of Pharmacology 317, 275283.

NA Hillarp & B Hokfelt (1953) Evidence of adrenaline and noradrenaline in separate adrenal medullary cells. Acta Physiologica Scandinavica 30, 5568.

GE Hoffman , MS Smith & JG Verbalis (1993) c-Fos and related immediate early gene products as markers of activity in neuroendocrine systems. Frontiers in Neuroendocrinology 14, 173213.

I Janssen , A Fortier , R Hudson & R Ross (2002) Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care 25, 431438.

M Kalia , K Fuxe , M Goldstein , A Harfstrand , LF Agnati & JT Coyle (1984) Evidence for the existence of putative dopamine-, adrenaline- and noradrenaline-containing vagal motor neurons in the brainstem of the rat. Neuroscience Letters 50, 5762.

KM Kras , DB Hausman , GJ Hausman & RJ Martin (1999) Adipocyte development is dependent upon stem cell recruitment and proliferation of preadipocytes. Obesity Research 7, 491497.

F Kreier , E Fliers , PJ Voshol , CG Van Eden , LM Havekes , A Kalsbeek , CL Van Heijningen , AA Sluiter , TC Mettenleiter , JA Romijn , HP Sauerwein & RM Buijs (2002) Selective parasympathetic innervation of subcutaneous and intra-abdominal fat – functional implications. Journal of Clinical Investigation 110, 12431250.

PGM Luiten , Horst ter , Karst GJ , Steffens AB H (1985) The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Research 329, 374378.

M Maffei , H Fei , GH Lee , C Dani , P Leroy , Y Zhang , R Proenca , R Negrel , G Ailhaud & JM Friedman (1995) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proceedings of the National Academy of Sciences USA 92, 69576960.

CS Mantzoros , DQ Qu , RC Frederich , VS Susulic , BB Lowell , E Maratos-Flier & JS Flier (1996) Activation of β 3 adrenergic receptors suppresses leptin expression and mediates a leptin-independent inhibition of food intake in mice. Diabetes 45, 909914.

M Mione , JFR Cavanagh , KA Kirkpatrick & G Burnstock (1992) Plasticity in expression of calcitonin gene-related peptide and substance P immunoreactivity in ganglia and fibres following guanethidine and/or capsaicin denervation. Cell Tissue Research 268, 491504.

TB Ng & CM Wong (1986) Effects of pineal indoles and arginine vasotocin on lipolysis and lipogenesis in isolated adipocytes. Journal of Pineal Research 3, 5566.

A Niijima (1998) Afferent signals from leptin sensors in the white adipose tissue of the epididymis, and their reflex effect in the rat. Journal of the Autonomic Nervous System 73, 1925.

Y Nishizawa & GA Bray (1978) Ventromedial hypothalamic lesions and the mobilization of fatty acids. Journal of Clinical Investigation 61, 714721.

MM Ollmann , BD Wilson , YK Yang , JA Kerns , Y Chen , I Gantz & GS Barsh (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135138.

Z Orban , AT Remaley , M Sampson , Z Trajanoski & GP Chrousos (1999) The differential effect of food intake and beta-adrenergic stimulation on adipose-derived hormones and cytokines in man. Journal of Clinical Endocrinology and Metabolism 84, 21262133.

RE Ostlund , Yang Jr , Klein JW , Gingerich R S (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. Journal of Clinical Endocrinology and Metabolism 81, 39093913.

N Ozaki , Y Sugiura , M Yamamoto & Y Nishiyama (1996) Induction of Fos protein expression in spinal cord neurons by herpes simplex virus infections in the mouse. Neuroscience Letters 216, 6164.

PD Raposinho , RB White & ML Aubert (2003) The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. Journal of Neuroendocrinology 15, 173181.

DV Rayner , E Simon , JS Duncan & P Trayhurn (1998) Hyperleptinaemia in mice induced by administration of the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine. FEBS Letters 429, 395398.

J Robidoux , P Pirouzi , J Lafond & R Savard (1995) Site-specific effects of sympathectomy on the adrenergic control of lipolysis in hamster fat cells. Canadian Journal of Physiology and Pharmacology 73, 450458.

MK Schafer , LE Eiden & E Weihe (1998) Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter. II. The peripheral nervous system. Neuroscience 84, 361376.

H Shi & TJ Bartness (2001) Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat. Brain Research Bulletin 54, 375385.

H Shi , A Giordano , S Cinti & TJ Bartness (2005) Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity American Journal of Physiology.

G Skofitsch & DM Jacobowitz (1985) Calcitonin gene-related peptide coexists with substance P in capsaicin sensitive neurons and sensory ganglia of the rat. Peptides 6, 747754.

BG Slavin & KW Ballard (1978) Morphological studies on the adrenergic innervation of white adipose tissue. Anatomical Record 191, 377389.

CK Song & TJ Bartness (1996) The effects of anterior hypothalamic lesions on short-day responses in Siberian hamsters given timed melatonin infusions. Journal of Biological Rhythms 11, 1426.

CK Song & TJ Bartness (1998) Dorsocaudal SCN microknife-cuts do not block short day responses in Siberian hamsters given melatonin infusions. Brain Research Bulletin 45, 239246.

AM Strack , WB Sawyer , KB Platt & AD Loewy (1989) CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Research 491, 274296.

AF Sved , G Cano & JP Card (2001) Neuroanatomical specificity of the circuits controlling sympathetic outflow to different targets. Clinical and Experimental Pharmacology and Physiology 28, 115119.

A Takahashi , Y Ikarashi , H Ishimaru & Y Maruyama (1993) Compensation between sympathetic nerves and adrenal medullary activity: effects of adrenomedullation and chemical sympathectomy on catecholamine turnover. Life Sciences 53, 15671572.

A Takahashi & T Shimazu (1981) Hypothalamic regulation of lipid metabolism in the rat: effect of hypothalamic stimulation on lipolysis. Journal of the Autonomic Nervous System 4, 195205.

P Trayhurn , JS Duncan & DV Rayner (1995) Acute cold-induced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic nervous system. Biochemical Journal 311, 729733.

P Trayhurn , JS Duncan , DV Rayner & LJ Hardie (1996) Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochemical and Biophysical Research Communications 228, 605610.

LC Turtzo , R Marx & MD Lane (2001) Cross-talk between sympathetic neurons and adipocytes in coculture. Proceedings of the National Academy of Sciences USA 98, 1238512390.

H Underwood & BD Goldman (1987) Vertebrate circadian and photoperiodic systems: role of the pineal gland and melatonin. Journal of Biological Rhythms 2, 279315.

J Vague , P Vague , M Tramoni , B Vialettes & P Mercier (1980) Obesity and diabetes. Acta Diabetologica Latina 17, 8799.

P Valet , C Pages , O Jeanneton , D Daviaud , P Barbe , M Record , JS Saulnier-Blache & M Lafontan (1998) Alpha 2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth. Journal of Clinical Investigation 101, 14311438.

ML Weiss & SI Chowdhury (1998) The renal afferent pathways in the rat: a pseudorabies virus study. Brain Research 812, 227241.

JE White & FL Engel (1958) A lipolytic action of epinephrine and norepinephrine on rat adipose tissue in vitro. Proceedings of the Society for Experimental Biology and Medicine 99, 375378.

C Wirsen (1964) Adrenergic innervation of adipose tissue examined by fluorescence microscopy. Nature 202, 913.

JB Young , E Saville , NJ Rothwell , MJ Stock & L Landsberg (1982) Effect of diet and cold exposure on norepinephrine turnover in brown adipose tissue of the rat. Journal of Clinical Investigation 69, 10611071.

Y Zhang , R Proenca , M Maffei , M Barone , L Leopold & JM Friedman (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425432.

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