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Circadian regulation of lipid metabolism

  • Joshua J Gooley (a1) (a2) (a3)

The circadian system temporally coordinates daily rhythms in feeding behaviour and energy metabolism. The objective of the present paper is to review the mechanisms that underlie circadian regulation of lipid metabolic pathways. Circadian rhythms in behaviour and physiology are generated by master clock neurons in the suprachiasmatic nucleus (SCN). The SCN and its efferent targets in the hypothalamus integrate light and feeding signals to entrain behavioural rhythms as well as clock cells located in peripheral tissues, including the liver, adipose tissue and muscle. Circadian rhythms in gene expression are regulated at the cellular level by a molecular clock comprising a core set of clock genes/proteins. In peripheral tissues, hundreds of genes involved in lipid biosynthesis and fatty acid oxidation are rhythmically activated and repressed by clock proteins, hence providing a direct mechanism for circadian regulation of lipids. Disruption of clock gene function results in abnormal metabolic phenotypes and impaired lipid absorption, demonstrating that the circadian system is essential for normal energy metabolism. The composition and timing of meals influence diurnal regulation of metabolic pathways, with food intake during the usual rest phase associated with dysregulation of lipid metabolism. Recent studies using metabolomics and lipidomics platforms have shown that hundreds of lipid species are circadian-regulated in human plasma, including but not limited to fatty acids, TAG, glycerophospholipids, sterol lipids and sphingolipids. In future work, these lipid profiling approaches can be used to understand better the interaction between diet, mealtimes and circadian rhythms on lipid metabolism and risk for obesity and metabolic diseases.

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Corresponding author: J. J. Gooley, fax +65 6221 8625, email
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1. Czeisler, CA & Gooley, JJ (2007) Sleep and circadian rhythms in humans. Cold Spring Harb Symp Quant Biol 72, 579597.
2. Albrecht, U (2012) Timing to perfection: the biology of central and peripheral circadian clocks. Neuron 74, 246260.
3. Zarrinpar, A, Chaix, A & Panda, S (2016) daily eating patterns and their impact on health and disease. Trends Endocrinol Metab 27, 6983.
4. Gooley, JJ & Chua, EC (2014) Diurnal regulation of lipid metabolism and applications of circadian lipidomics. J Genet Genomic 41, 231250.
5. Buhr, ED & Takahashi, JS (2013) Molecular components of the Mammalian circadian clock. Handb Exp Pharmacol 217, 327.
6. Yamazaki, S, Kerbeshian, MC, Hocker, CG et al. (1998) Rhythmic properties of the hamster suprachiasmatic nucleus in vivo . J Neurosci 18, 1070910723.
7. Berson, DM, Dunn, FA & Takao, M (2002) Phototransduction by retinal ganglion cells that set the circadian clock. Science 295, 10701073.
8. Gooley, JJ, Lu, J, Chou, TC et al. (2001) Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci 4, 1165.
9. Hattar, S, Liao, HW, Takao, M et al. (2002) Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 295, 10651070.
10. Dacey, DM, Liao, HW, Peterson, BB et al. (2005) Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. Nature 433, 749754.
11. Golombek, DA & Rosenstein, RE (2010) Physiology of circadian entrainment. Physiol Rev 90, 10631102.
12. Hannibal, J (2006) Roles of PACAP-containing retinal ganglion cells in circadian timing. Int Rev Cytol 251, 139.
13. Meijer, JH & Schwartz, WJ (2003) In search of the pathways for light-induced pacemaker resetting in the suprachiasmatic nucleus. J Biol Rhythms 18, 235249.
14. Ho Mien, I, Chua, EC, Lau, P et al. (2014) Effects of exposure to intermittent versus continuous red light on human circadian rhythms, melatonin suppression, and pupillary constriction. PLoS ONE 9, e96532.
15. Fukuhara, C & Tosini, G (2003) Peripheral circadian oscillators and their rhythmic regulation. Front Biosci 8, d642d651.
16. Yamazaki, S, Numano, R, Abe, M et al. (2000) Resetting central and peripheral circadian oscillators in transgenic rats. Science 288, 682685.
17. Chou, TC, Scammell, TE, Gooley, JJ et al. (2003) Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms. J Neurosci 23, 1069110702.
18. Gooley, JJ, Schomer, A & Saper, CB (2006) The dorsomedial hypothalamic nucleus is critical for the expression of food-entrainable circadian rhythms. Nat Neurosci 9, 398407.
19. Lu, J, Zhang, YH, Chou, TC et al. (2001) Contrasting effects of ibotenate lesions of the paraventricular nucleus and subparaventricular zone on sleep–wake cycle and temperature regulation. J Neurosci 21, 48644874.
20. Hardeland, R, Madrid, JA, Tan, DX et al. (2012) Melatonin, the circadian multioscillator system and health: the need for detailed analyses of peripheral melatonin signaling. J Pineal Res 52, 139166.
21. Kumar Jha, P, Challet, E & Kalsbeek, A (2015) Circadian rhythms in glucose and lipid metabolism in nocturnal and diurnal mammals. Mol Cell Endocrinol 418, 7488.
22. Balsalobre, A, Brown, SA, Marcacci, L et al. (2000) Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289, 23442347.
23. Le Minh, N, Damiola, F, Tronche, F et al. (2001) Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J 20, 71287136.
24. Damiola, F, Le Minh, N, Preitner, N et al. (2000) Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 14, 29502961.
25. Tahara, Y, Kuroda, H, Saito, K et al. (2012) In vivo monitoring of peripheral circadian clocks in the mouse. Curr Biol 22, 10291034.
26. Gnocchi, D, Pedrelli, M, Hurt-Camejo, E et al. (2015) Lipids around the clock: focus on circadian rhythms and lipid metabolism. Biology (Basel) 4, 104132.
27. Oosterman, JE, Kalsbeek, A, la Fleur, SE et al. (2015) Impact of nutrients on circadian rhythmicity. Am J Physiol Regul Integr Comp Physiol 308, R337R350.
28. Sahar, S & Sassone-Corsi, P (2012) Regulation of metabolism: the circadian clock dictates the time. Trends Endocrinol Metab 23, 18.
29. Bunger, MK, Wilsbacher, LD, Moran, SM et al. (2000) Mop3 is an essential component of the master circadian pacemaker in mammals. Cell 103, 10091017.
30. Gekakis, N, Staknis, D, Nguyen, HB et al. (1998) Role of the CLOCK protein in the mammalian circadian mechanism. Science 280, 15641569.
31. Reick, M, Garcia, JA, Dudley, C et al. (2001) NPAS2: an analog of clock operative in the mammalian forebrain. Science 293, 506509.
32. Griffin, EA Jr, Staknis, D & Weitz, CJ (1999) Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. Science 286, 768771.
33. Kume, K, Zylka, MJ, Sriram, S et al. (1999) mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. Cell 98, 193205.
34. Lee, C, Etchegaray, JP, Cagampang, FR et al. (2001) Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107, 855867.
35. Sato, TK, Yamada, RG, Ukai, H et al. (2006) Feedback repression is required for mammalian circadian clock function. Nat Genet 38, 312319.
36. Eide, EJ, Woolf, MF, Kang, H et al. (2005) Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. Mol Cell Biol 25, 27952807.
37. Godinho, SI, Maywood, ES, Shaw, L et al. (2007) The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period. Science 316, 897900.
38. Shirogane, T, Jin, J, Ang, XL et al. (2005) SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem 280, 2686326872.
39. Siepka, SM, Yoo, SH, Park, J et al. (2007) Circadian mutant overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression. Cell 129, 10111023.
40. Yoo, SH, Mohawk, JA, Siepka, SM et al. (2013) Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. Cell 152, 10911105.
41. Crumbley, C, Wang, Y, Kojetin, DJ et al. (2010) Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene. J Biol Chem 285, 3538635392.
42. Preitner, N, Damiola, F, Lopez-Molina, L et al. (2002) The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator. Cell 110, 251260.
43. Akashi, M & Takumi, T (2005) The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol 12, 441448.
44. Sato, TK, Panda, S, Miraglia, LJ et al. (2004) A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron 43, 527537.
45. Takeda, Y, Kang, HS, Angers, M et al. (2011) Retinoic acid-related orphan receptor gamma directly regulates neuronal PAS domain protein 2 transcription in vivo . Nucl Acids Res 39, 47694782.
46. Crumbley, C & Burris, TP (2011) Direct regulation of CLOCK expression by REV-ERB. PLoS ONE 6, e17290.
47. Lowrey, PL & Takahashi, JS (2011) Genetics of circadian rhythms in Mammalian model organisms. Adv Genet 74, 175230.
48. Sahar, S & Sassone-Corsi, P (2012) Circadian rhythms and memory formation: regulation by chromatin remodeling. Front Mol Neurosci 5, Article 37.
49. Hatanaka, F, Matsubara, C, Myung, J et al. (2010) Genome-wide profiling of the core clock protein BMAL1 targets reveals a strict relationship with metabolism. Mol Cell Biol 30, 56365648.
50. Rey, G, Cesbron, F, Rougemont, J et al. (2011) Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biol 9, e1000595.
51. Bugge, A, Feng, D, Everett, LJ et al. (2012) Rev-erbalpha and Rev-erbbeta coordinately protect the circadian clock and normal metabolic function. Genes Dev 26, 657667.
52. Cho, H, Zhao, X, Hatori, M et al. (2012) Regulation of circadian behaviour and metabolism by REV-ERB-alpha and REV-ERB-beta. Nature 485, 123127.
53. Feng, D, Liu, T, Sun, Z et al. (2011) A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism. Science 331, 13151319.
54. Koike, N, Yoo, SH, Huang, HC et al. (2012) Transcriptional architecture and chromatin landscape of the core circadian clock in mammals. Science 338, 349354.
55. Panda, S, Antoch, MP, Miller, BH et al. (2002) Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109, 307320.
56. Yang, X, Downes, M, Yu, RT et al. (2006) Nuclear receptor expression links the circadian clock to metabolism. Cell 126, 801810.
57. Adamovich, Y, Aviram, R & Asher, G (2015) The emerging roles of lipids in circadian control. Biochim Biophys Acta 1851, 10171025.
58. Li, MD, Li, CM & Wang, Z (2012) The role of circadian clocks in metabolic disease. Yale J Biol Med 85, 387401.
59. Liu, C, Li, S, Liu, T et al. (2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature 447, 477481.
60. Gilardi, F, Migliavacca, E, Naldi, A et al. (2014) Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet 10, e1004155.
61. Le Martelot, G, Claudel, T, Gatfield, D et al. (2009) REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol 7, e1000181.
62. Shostak, A, Meyer-Kovac, J & Oster, H (2013) Circadian regulation of lipid mobilization in white adipose tissues. Diabetes 62, 21952203.
63. Lehrke, M & Lazar, MA (2005) The many faces of PPARgamma. Cell 123, 993999.
64. McCarthy, JJ, Andrews, JL, McDearmon, EL et al. (2007) Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics 31, 8695.
65. Pan, X, Zhang, Y, Wang, L et al. (2010) Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP. Cell Metab 12, 174186.
66. Hussain, MM & Pan, X (2015) Circadian regulation of macronutrient absorption. J Biol Rhythms 30, 459469.
67. Stubblefield, JJ, Terrien, J & Green, CB (2012) Nocturnin: at the crossroads of clocks and metabolism. Trends Endocrinol Metab 23, 326333.
68. Douris, N, Kojima, S, Pan, X et al. (2011) Nocturnin regulates circadian trafficking of dietary lipid in intestinal enterocytes. Curr Biol 21, 13471355.
69. Turek, FW, Joshu, C, Kohsaka, A et al. (2005) Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308, 10431045.
70. Lamia, KA, Storch, KF & Weitz, CJ (2008) Physiological significance of a peripheral tissue circadian clock. Proc Natl Acad Sci USA 105, 1517215177.
71. Shimba, S, Ogawa, T, Hitosugi, S et al. (2011) Deficient of a clock gene, brain and muscle Arnt-like protein-1 (BMAL1), induces dyslipidemia and ectopic fat formation. PLoS ONE 6, e25231.
72. Marcheva, B, Ramsey, KM, Buhr, ED et al. (2010) Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature 466, 627631.
73. Sadacca, LA, Lamia, KA, deLemos, AS et al. (2011) An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice. Diabetologia 54, 120124.
74. Dyar, KA, Ciciliot, S, Wright, LE et al. (2014) Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. Mol Metab 3, 2941.
75. Paschos, GK, Ibrahim, S, Song, WL et al. (2012) Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nat Med 18, 17681777.
76. Wu, X, Wiater, MF & Ritter, S (2010) NPAS2 deletion impairs responses to restricted feeding but not to metabolic challenges. Physiol Behav 99, 466471.
77. Dudley, CA, Erbel-Sieler, C, Estill, SJ et al. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301, 379383.
78. Lamia, KA, Papp, SJ, Yu, RT et al. (2011) Cryptochromes mediate rhythmic repression of the glucocorticoid receptor. Nature 480, 552556.
79. Lau, P, Fitzsimmons, RL, Raichur, S et al. (2008) The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem 283, 1841118421.
80. Mamontova, A, Seguret-Mace, S, Esposito, B et al. (1998) Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation 98, 27382743.
81. Arble, DM, Bass, J, Laposky, AD et al. (2009) Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) 17, 21002102.
82. Hatori, M, Vollmers, C, Zarrinpar, A et al. (2012) Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab 15, 848860.
83. Gill, S & Panda, S (2015) A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell Metab 22, 789798.
84. Garaulet, M, Gomez-Abellan, P, Alburquerque-Bejar, JJ et al. (2013) Timing of food intake predicts weight loss effectiveness. Int J Obes (Lond) 37, 604611.
85. Jakubowicz, D, Barnea, M, Wainstein, J et al. (2013) High caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women. Obesity (Silver Spring) 21, 25042512.
86. Mukherji, A, Kobiita, A, Damara, M et al. (2015) Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome. Proc Natl Acad Sci USA 112, E6691E6698.
87. De Bacquer, D, Van Risseghem, M, Clays, E et al. (2009) Rotating shift work and the metabolic syndrome: a prospective study. Int J Epidemiol 38, 848854.
88. Brown, DL, Feskanich, D, Sanchez, BN et al. (2009) Rotating night shift work and the risk of ischemic stroke. Am J Epidemiol 169, 13701377.
89. Karlsson, B, Alfredsson, L, Knutsson, A et al. (2005) Total mortality and cause-specific mortality of Swedish shift- and dayworkers in the pulp and paper industry in 1952–2001. Scand J Work Environ Health 31, 3035.
90. Kawachi, I, Colditz, GA, Stampfer, MJ et al. (1995) Prospective study of shift work and risk of coronary heart disease in women. Circulation 92, 31783182.
91. Pan, A, Schernhammer, ES, Sun, Q et al. (2011) Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS Med 8, e1001141.
92. Hampton, SM, Morgan, LM, Lawrence, N et al. (1996) Postprandial hormone and metabolic responses in simulated shift work. J Endocrinol 151, 259267.
93. Ribeiro, DC, Hampton, SM, Morgan, L et al. (1998) Altered postprandial hormone and metabolic responses in a simulated shift work environment. J Endocrinol 158, 305310.
94. Scheer, FA, Hilton, MF, Mantzoros, CS et al. (2009) Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci USA 106, 44534458.
95. Esquirol, Y, Bongard, V, Mabile, L et al. (2009) Shift work and metabolic syndrome: respective impacts of job strain, physical activity, and dietary rhythms. Chronobiol Int 26, 544559.
96. Sookoian, S, Gemma, C, Fernandez, GT et al. (2007) Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation. J Intern Med 261, 285292.
97. Moller-Levet, CS, Archer, SN, Bucca, G et al. (2013) Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome. Proc Natl Acad Sci USA 110, E1132E1141.
98. Ando, H, Yanagihara, H, Hayashi, Y et al. (2005) Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 146, 56315636.
99. Caton, PW, Kieswich, J, Yaqoob, MM et al. (2011) Metformin opposes impaired AMPK and SIRT1 function and deleterious changes in core clock protein expression in white adipose tissue of genetically-obese db/db mice. Diab Obes Metab 13, 10971104.
100. van der Spek, R, Kreier, F, Fliers, E et al. (2012) Circadian rhythms in white adipose tissue. Prog Brain Res 199, 183201.
101. Kohsaka, A, Laposky, AD, Ramsey, KM et al. (2007) High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 6, 414421.
102. Wenk, MR (2010) Lipidomics: new tools and applications. Cell 143, 888895.
103. Gooley, JJ (2014) Applications of circadian metabolomics. Curr Metab 2, 214.
104. Dallmann, R, Viola, AU, Tarokh, L et al. (2012) The human circadian metabolome. Proc Natl Acad Sci USA 109, 26252629.
105. Kasukawa, T, Sugimoto, M, Hida, A et al. (2012) Human blood metabolite timetable indicates internal body time. Proc Natl Acad Sci USA 109, 1503615041.
106. Ang, JE, Revell, V, Mann, A et al. (2012) Identification of human plasma metabolites exhibiting time-of-day variation using an untargeted liquid chromatography-mass spectrometry metabolomic approach. Chronobiol Int 29, 868881.
107. Davies, SK, Ang, JE, Revell, VL et al. (2014) Effect of sleep deprivation on the human metabolome. Proc Natl Acad Sci USA 111, 1076110766.
108. Chua, EC, Shui, G, Lee, IT et al. (2013) Extensive diversity in circadian regulation of plasma lipids and evidence for different circadian metabolic phenotypes in humans. Proc Natl Acad Sci USA 110, 1446814473.
109. Chua, EC, Shui, G, Cazenave-Gassiot, A et al. (2015) Changes in plasma lipids during exposure to total sleep deprivation. Sleep 38, 16831691.
110. Eckel-Mahan, KL, Patel, VR, Mohney, RP et al. (2012) Coordination of the transcriptome and metabolome by the circadian clock. Proc Natl Acad Sci USA 109, 55415546.
111. Grimaldi, B, Bellet, MM, Katada, S et al. (2010) PER2 controls lipid metabolism by direct regulation of PPARgamma. Cell Metab 12, 509520.
112. Adamovich, Y, Rousso-Noori, L, Zwighaft, Z et al. (2014) Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides. Cell Metab 19, 319330.
113. Eckel-Mahan, KL, Patel, VR, de Mateo, S et al. (2013) Reprogramming of the circadian clock by nutritional challenge. Cell 155, 14641478.
114. Masri, S, Rigor, P, Cervantes, M et al. (2014) Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism. Cell 158, 659672.
115. Liu, S, Brown, JD, Stanya, KJ et al. (2013) A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature 502, 550554.
116. Garaulet, M, Lee, YC, Shen, J et al. (2009) CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids. Am J Clin Nutr 90, 14661475.
117. Scott, EM, Carter, AM & Grant, PJ (2008) Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond) 32, 658662.
118. Sookoian, S, Gemma, C, Gianotti, TF et al. (2008) Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity. Am J Clin Nutr 87, 16061615.
119. Uemura, H, Katsuura-Kamano, S, Yamaguchi, M et al. (2015) A variant of the CLOCK gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population. J Diab (Epublication ahead of print version).
120. Pivovarova, O, Jurchott, K, Rudovich, N et al. (2015) Changes of dietary fat and carbohydrate content alter central and peripheral clock in humans. J Clin Endocrinol Metab 100, 22912302.
121. Krauss, RM, Zhu, H & Kaddurah-Daouk, R (2013) Pharmacometabolomics of statin response. Clin Pharmacol Ther 94, 562565.
122. Bordag, N, Klie, S, Jurchott, K et al. (2015) Glucocorticoid (dexamethasone)-induced metabolome changes in healthy males suggest prediction of response and side effects. Sci Rep 5, 15954.
123. Solt, LA, Wang, Y, Banerjee, S et al. (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485, 6268.
124. Levi, F & Schibler, U (2007) Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol 47, 593628.
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