Skip to main content
×
×
Home

Dietary and genetic modulation of DNA repair in healthy human adults

  • J. Tyson (a1) and J. C. Mathers (a1)
Abstract

The DNA in all cells of the human body is subject to damage continuously from exogenous agents, internal cellular processes and spontaneous decomposition. Failure to repair such damage is fundamental to the development of many diseases and to ageing. Fortunately, the vast majority of DNA damage is detected and repaired by one of five complementary DNA repair systems. However, recent studies have shown that even in healthy individuals there is a wide inter-individual variation in DNA repair capacity. Part of this variation can be accounted for by polymorphisms in the genes encoding DNA repair proteins. However, it is probable that environmental factors, including dietary exposure as well as diet–gene interactions, are also responsible for much of the difference in repair capacity between individuals. Whilst there is some evidence from human studies that generalised malnutrition or low intakes of specific nutrients may affect DNA repair, as yet there is limited understanding of the molecular mechanisms through which nutrients can modulate this key cellular process.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Dietary and genetic modulation of DNA repair in healthy human adults
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Dietary and genetic modulation of DNA repair in healthy human adults
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Dietary and genetic modulation of DNA repair in healthy human adults
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: John Tyson, fax +44 191 222 8684, john.tyson@ncl.ac.uk
References
Hide All
Ana S, Neumann EMS & Wei Q (2005) Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: A review of molecular epidemiological studies. Molecular Carcinogenesis 42, 6592.
Astley SB, Elliott RM, Archer DB & Southon S (2004) Evidence that dietary supplementation with carotenoids and carotenoid-rich foods modulates the DNA damage: repair balance in human lymphocytes. British Journal of Nutrition 91, 6372.
Basten GP, Duthie SJ, Pirie L, Vaughan N, Hill MH & Powers HJ (2006) Sensitivity of markers of DNA stability and DNA repair activity to folate supplementation in healthy volunteers. British Journal of Cancer 94, 19421947.
Benhamou S & Sarasin A (2000) Variability in nucleotide excision repair and cancer risk: a review. Mutation Research 462, 149158.
Benhamou S & Sarasin A (2005) ERCC2/XPD gene polymorphisms and lung cancer: A HuGE review. American Journal of Epidemiology 161, 114.
Berwick M & Vineis P (2000) Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. Journal of the National Cancer Institute 92, 874897.
Bingham SA, Day NE, Luben R, Ferrari P, Slimani N, Norat T et al. (2003) Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet 361, 14961501.
Blessing H, Kraus S, Heindl P, Bal W & Hartwig A (2004) Interaction of selenium compounds with zinc finger proteins involved in DNA repair. European Journal of Biochemistry 271, 31903199.
Cabelof DC, Yanamadala S, Raffoul JJ, Guo Z, Soofi A & Heydari AR (2003) Caloric restriction promotes genomic stability by induction of base excision repair and reversal of its age-related decline. DNA Repair (Amst) 2, 295307.
Chiricolo M, Musa AR, Monti D, Zannotti M & Franceschi C (1993) Enhanced DNA repair in lymphocytes of Down syndrome patients: the influence of zinc nutritional supplementation. Mutation Research 295, 105111.
Christmann M, Tomicic MT, Roos WP & Kaina B (2003) Mechanisms of human DNA repair: an update. Toxicology 193, 334.
Collins AR, Harrington V, Drew J & Melvin R (2003) Nutritional modulation of DNA repair in a human intervention study. Carcinogenesis 24, 511515.
de Boer J & Hoeijmakers JH (2000) Nucleotide excision repair and human syndromes. Carcinogenesis 21, 453460.
de Laat WL, Jaspers NG & Hoeijmakers JH (1999) Molecular mechanism of nucleotide excision repair. Genes and Development 13, 768785.
Department of Health (2002) Folic Acid and the Prevention of Disease. Report on Health and Social Subjects no. 50. London: The Stationery Office.
Dirx MJ, Zeegers MP, Dagnelie PC, van den Bogaard T & van den Brandt PA (2003) Energy restriction and the risk of spontaneous mammary tumors in mice: a meta-analysis. International Journal of Cancer 106, 766770.
Doll R & Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. Journal of the National Cancer Institute 66, 11911308.
Duell EJ, Wiencke JK, Cheng TJ, Varkonyi A, Zuo ZF, Ashok TD, Mark EJ, Wain JC, Christiani DC & Kelsey KT (2000) Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21, 965971.
Duthie SJ & Hawdon A (1998) DNA instability (strand breakage, uracil misincorporation, and defective repair) is increased by folic acid depletion in human lymphocytes in vitro. FASEB Journal 12, 14911497.
Feinberg AP & Tycko B (2004) The history of cancer epigenetics. Nature Reviews Cancer 4, 143153.
Fischer JL, Lancia JK, Mathur A & Smith ML (2006) Selenium protection from DNA damage involves a Ref1/p53/Brca1 protein complex. Anticancer Research 26, 899904.
Friedberg EC (2001) How nucleotide excision repair protects against cancer. Nature Reviews Cancer 1, 2233.
Friso S & Choi S-W (2002) Gene-nutrient interactions and DNA methylation. Anticancer Research 132, 2382S2387S.
Gedik CM, Grant G, Morrice PC, Wood SG & Collins AR (2005) Effects of age and dietary restriction on oxidative DNA damage, antioxidant protection and DNA repair in rats. European Journal of Nutrition 44, 263272.
Gonzalez C, Najera O, Cortes E, Toledo G, Lopez L, Betancourt M & Ortiz R (2002) Hydrogen peroxide-induced DNA damage and DNA repair in lymphocytes from malnourished children. Environmental and Molecular Mutagenesis 39, 3342.
Guo Z, Heydari A & Richardson A (1998) Nucleotide excision repair of actively transcribed versus nontranscribed DNA in rat hepatocytes: effect of age and dietary restriction. Experimental Cell Research 245, 228238.
Handel M, Watts C, DeFazio A, Day R & Sutherland R (1995) Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos. Proceedings of the National Academy of Sciences USA 92, 44974501.
Ho E (2004) Zinc deficiency DNA damage and cancer risk. Journal of Nutritional Biochemistry 15, 572578.
Hou SM, Falt S, Angelini S, Yang K, Nyberg F, Lambert B & Hemminki K (2002) The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis 23, 599603.
Hung RJ, Hall J, Brennan P & Boffetta P (2005) Genetic polymorphisms in the base excision repair pathway and cancer risk: A HuGE review. American Journal of Epidemiology 162, 925942.
Jackson AL & Loeb LA (2001) The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutation Research 477, 721.
Jiricny J & Nystrom-Lahti M (2000) Mismatch repair defects in cancer. Current Opinion in Genetics and Development 10, 157161.
Lee CK, Klopp RG, Weindruch R & Prolla TA (1999) Gene expression profile of aging and its retardation by caloric restriction. Science 285, 13901393.
Mathers JC (2006) Candidate mechanisms for interactions between nutrients and genes. In Nutrient–Gene Interactions in Cancer, pp. 19–36 [S-W Choi and S Friso, editors]. Boca Raton, USA: Taylor & Francis Group.
Mohankumar MN, Paul SF, Venkatachalam P & Jeevanram RK (1998) Influence of in vitro low-level gamma-radiation on the UV-induced DNA repair capacity of human lymphocytes – analysed by unscheduled DNA synthesis (UDS) and comet assay. Radiation and Environmental Biophysics 37, 267275.
Mohrenweiser HW, Xi T, Vazquez-Matias J & Jones IM (2002) Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans. Cancer Epidemiology, Biomarkers and Prevention 11, 10541064.
Moller P & Loft S (2004) Interventions with antioxidants and nutrients in relation to oxidative DNA damage and repair. Mutation Research 551, 7989.
Moller P, Vogel U, Pedersen A, Dragsted LO, Sandstrom B & Loft S (2003) No effect of 600 grams fruit and vegetables per day on oxidative DNA damage and repair in healthy nonsmokers. Cancer Epidemiology, Biomarkers and Prevention 12, 10161022.
Nakagawachi T, Soejima H, Urano T, Zhao W, Higashimoto K, Satoh Y et al. (2003) Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene 22, 88358844.
Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M et al. (2005) Meat, fish, and colorectal cancer risk: the European Prospective Investigation into Cancer and Nutrition. Journal of the National Cancer Institute 97, 906916.
Pachkowski BF, Winkel S, Kubota Y, Swenberg JA, Millikan RC & Nakamura J (2006) XRCC1 genotype and breast cancer: functional studies and epidemiologic data show interactions between XRCC1 codon 280 His and smoking. Cancer Research 66, 28602868.
Palli D, Russo A, Masala G, Saieva C, Guarrera S, Carturan S, Munnia A, Matullo G & Peluso M (2001) DNA adduct levels and DNA repair polymorphisms in traffic-exposed workers and a general population sample. International Journal of Cancer 94, 121127.
Paz-Elizur T, Krupsky M, Blumenstein S, Elinger D, Schechtman E & Livneh Z (2003) DNA repair activity for oxidative damage and risk of lung cancer. Journal of the National Cancer Institute 95, 13121319.
Pfeiffer P, Goedecke W & Obe G (2000) Mechanisms of DNA double-strand break repair and their potential to induce chromosomal aberrations. Mutagenesis 15, 289302.
Qiao Y, Spitz MR, Guo Z, Hadeyati M, Grossman L, Kraemer KH & Wei Q (2002 a) Rapid assessment of repair of ultraviolet DNA damage with a modified host-cell reactivation assay using a luciferase reporter gene and correlation with polymorphisms of DNA repair genes in normal human lymphocytes. Mutation Research 509, 165174.
Qiao Y, Spitz MR, Shen H, Guo Z, Shete S, Hedayati M, Grossman L, Mohrenweiser H & Wei Q (2002 b) Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. Carcinogenesis 23, 295299.
Ralhan R, Kaur J, Kreienberg R & Wiesmuller L (2006) Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases. Cancer Letters (In the Press).
Seeberg E, Eide L & Bjoras M (1995) The base excision repair pathway. Trends in Biochemical Sciences 20, 391397.
Seo YR, Kelley MR & Smith ML (2002 a) Selenomethionine regulation of p53 by a ref1-dependent redox mechanism. Proceedings of the National Academy of Sciences USA 99, 1454814553.
Seo YR, Sweeney C & Smith ML (2002 b) Selenomethionine induction of DNA repair response in human fibroblasts. Oncogene 21, 36633669.
Sheng Y, Pero RW, Olsson AR, Bryngelsson C & Hua J (1998) DNA repair enhancement by a combined supplement of carotenoids, nicotinamide, and zinc. Cancer Detection and Prevention 22, 284292.
Sokhansanj BA & Wilson DM 3rd (2006) Estimating the effect of human base excision repair protein variants on the repair of oxidative DNA base damage. Cancer Epidemiology, Biomarkers and Prevention 15, 10001008.
Spitz MR, Wu X, Wang Y, Wang LE, Shete S, Amos CI, Guo Z, Lei L, Mohrenweiser H & Wei Q (2001) Modulation of nucleotide excision repair capacity by XPD polymorphisms in lung cancer patients. Cancer Research 61, 13541357.
Stuart JA, Karahalil B, Hogue BA, Souza-Pinto NC & Bohr VA (2004) Mitochondrial and nuclear DNA base excision repair are affected differently by caloric restriction. FASEB Journal 18, 595597.
Tang D, Cho S, Rundle A, Chen S, Phillips D, Zhou J, Hsu Y, Schnabel F, Estabrook A & Perera FP (2002) Polymorphisms in the DNA repair enzyme XPD are associated with increased levels of PAH-DNA adducts in a case-control study of breast cancer. Breast Cancer Research and Treatment 75, 159166.
Tomasetti M, Alleva R, Borghi B & Collins AR (2001) In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB Journal 15, 14251427.
Tyson J, Spiers A, Caple F, Hesketh JE & Mathers JC (2005) Inter-individual variation in nucleotide excision repair capacity: potential scope for dietary modulation of DNA repair. Proceedings of the Nutrition Society 64, 68A.
Tyson J, Spiers A, Caple F, Hesketh JE & Mathers JC (2006) Effects of age, BMI and genotype on nucleotide excision repair in healthy adults. Proceedings of the Nutrition Society 65, 114A.
Wei Q, Shen H, Wang LE, Duphorne CM, Pillow PC, Guo Z, Qiao Y & Spitz MR (2003) Association between low dietary folate intake and suboptimal cellular DNA repair capacity. Cancer Epidemiology, Biomarkers and Prevention 12, 939–963.
Weindruch R, Kayo T, Lee C-K & Prolla TA (2001) Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice. Journal of Nutrition 131, 918S923S.
World Cancer Research Fund/American Institute for Cancer Research (1997) Food, Nutrition and the Prevention of Cancer: A Global Perspective. London: WCRF UK.
Youn BW, Fiala ES & Sohn OS (2001) Mechanisms of organoselenium compounds in chemoprevention: effects on transcription factor-DNA binding. Nutrition and Cancer 40, 2833.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 12
Total number of PDF views: 53 *
Loading metrics...

Abstract views

Total abstract views: 121 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 21st January 2018. This data will be updated every 24 hours.