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Phyto-oestrogens through the life cycle

Published online by Cambridge University Press:  28 February 2007

Aedin Cassidy  and
Marian Faughnan
Aedin Cassidy*
Affiliation:
Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
Marian Faughnan
Affiliation:
Centre for Nutrition and Food Safety, School of Biological Sciences, University of Surrey, Guildford GU2 5XH, UK
*
*Corresponding author: Dr Aedin Cassidy, present address Unilever Research, Colworth House, Sharnbrook, Beds. MK44 1QL, fax +44 (0)1234 222552, email aedin.cassidy@unilever.com
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Abstract

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The growing interest in the role of phyto-oestrogens in human health has prompted scientists to evaluate the risk : benefit which would result from consuming high levels of these compounds at different stages of the life cycle. These compounds have been shown to exert a wide range of hormonal and non-hormonal activities in animals and in vitro, and these activities suggest plausible mechanisms for potential health effects in human subjects consuming phyto-oestrogen-rich diets. In addition, experimental and epidemiological data are available supporting the concept that phyto-oestrogen-rich diets exert physiological effects in vivo; however, their relative importance to human health remains to be elucidated. Our understanding of factors involved in their absorption and metabolism, including the role of intestinal microflora, is limited, and these factors together with dose-related effects may well be important in determining clinical efficacy.

Keywords

Phyto-oestrogensIsoflavonesLignansSoyabean
Type
The Nutrition Society Medal Lecture
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 3 , August 2000 , pp. 489 - 496
Copyright
Copyright © The Nutrition Society 2000

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