Agostoni, C, Grandi, F, Gianni, ML, Silano, M, Torcoletti, M, Giovannini, M & Riva, E (1999) Growth patterns of breast fed and formula fed infants in the first 12 months of life: an Italian study. Archives of Disease in Childhood 81, 395–399.
Ahima, RS, Prabakaran, D & Flier, JS (1998) Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. Journal of Clinical Investigation 101, 1020–1027.
Ahima, RS, Prabakaran, D, Mantzoros, C, Qu, D, Lowell, B, Maratos-Flier, E & Flier, JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252.
Barker, DJ, Hales, CN, Fall, CH, Osmond, C, Phipps, K & Clark, PM (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36, 62–67.
Benediktsson, R, Calder, AA, Edwards, CR & Seckl, JR (1997) Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clinical Endocrinology 46, 161–166.
Bennis-Taleb, N, Remacle, C, Hoet, JJ & Reusens, B (1999) A low-protein isocaloric diet during gestation affects brain development and alters permanently cerebral cortex blood vessels in rat offspring. Journal of Nutrition 129, 1613–1619.
Bispham, J, Gopalakrishnan, GS, Dandrea, J, Wilson, V, Budge, H, Keisler, DH, Broughton, F, Stephenson, T & Symonds, ME (2003) Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development. Endocrinology 144, 3575–3585.
Bouret, SG, Draper, SJ & Simerly, RB (2004) Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108–110.
Brown, RW, Chapman, KE, Kotelevtsev, Y, Yau, JL, Lindsay, RS, Brett, L et al. (1996) Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2. Biochemical Journal 313, 1007–1017.
Cherif, H, Reusens, B, Ahn, MT, Hoet, JJ & Remacle, C (1998) Effects of taurine on the insulin secretion of rat fetal islets from dams fed a low-protein diet. Journal of Endocrinology 159, 341–348.
Condon, J, Gosden, C, Gardener, D, Nickson, P, Hewison, M, Howie, AJ & Stewart, PM (1998) Expression of type 2 11beta-hydroxysteroid dehydrogenase and corticosteroid hormone receptors in early human fetal life. Journal of Clinical Endocrinology and Metabolism 83, 4490–4497.
Crescenzo, R, Samec, S, Antic, V, Rohner-Jeanrenaud, F, Seydoux, J, Montani, JP & Dulloo, AG (2003) A role for suppressed thermogenesis favoring catch-up fat in the pathophysiology of catch-up growth. Diabetes 52, 1090–1097.
Dave-Sharma, S, Wilson, RC, Harbison, MD, Newfield, R, Azar, MR, Krozowski, ZS et al. (1998) Examination of genotype and phenotype relationships in 14 patients with apparent mineralocorticoid excess. Journal of Clinical Endocrinology and Metabolism 83, 2244–2254.
Desai, M, Byrne, CD, Zhang, J, Petry, CJ, Lucas, A & Hales, CN (1997) Programming of hepatic insulin-sensitive enzymes in offspring of rat dams fed a protein-restricted diet. American Journal of Physiology 272, G1083–G1090.
Desai, M, Crowther, NJ, Lucas, A & Hales, CN (1996) Organ-selective growth in the offspring of protein-restricted mothers. British Journal of Nutrition 76, 591–603.
Dessolin, S, Schalling, M, Champigny, O, Lonnqvist, F, Ailhaud, G, Dani, C & Ricquier, D (1997) Leptin gene is expressed in rat brown adipose tissue at birth. FASEB Journal 11, 382–387.
Dewey, KG, Heinig, MJ, Nommsen, LA, Peerson, JM & Lonnerdal, B (1993) Breast-fed infants are leaner than formula-fed infants at 1 y of age: the DARLING study. American Journal of Clinical Nutrition 57, 140–145.
Ehrhardt, RA, Greenwood, PL, Bell, AW & Boisclair, YR (2003) Plasma leptin is regulated predominantly by nutrition in preruminant lambs. Journal of Nutrition 133, 4196–4201.
Eriksson, JG, Forsen, T, Tuomilehto, J, Winter, PD, Osmond, C & Barker, DJ (1999) Catch-up growth in childhood and death from coronary heart disease: longitudinal study. British Medical Journal 318, 427–431.
Fall, CH (2001) Non-industrialised countries and affluence. British Medical Bulletin 60, 33–50.
Frayling, TM & Hattersley, AT (2001) The role of genetic susceptibility in the association of low birth weight with type 2 diabetes. British Medical Bulletin 60, 89–101.
Gale, CR, Martyn, CN, Kellingray, S, Eastell, R & Cooper, C (2001) Intrauterine programming of adult body composition. Journal of Clinical Endocrinology and Metabolism 86, 267–272.
Glazier, JD, Cetin, I, Perugino, G, Ronzoni, S, Grey, AM, Mahendran, D, Marconi, AM, Pardi, G & Sibley, CP (1997) Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatric Research 42, 514–519.
Goland, RS, Tropper, PJ, Warren, WB, Stark, RI, Jozak, SM & Conwell, IM (1995) Concentrations of corticotrophin-releasing hormone in the umbilical-cord blood of pregnancies complicated by pre-eclampsia. Reproduction, Fertility, and Development 7, 1227–1230.
Hales, CN & Barker, DJ (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35, 595–601.
Hales, CN, Barker, DJ, Clark, PM, Cox, LJ, Fall, C, Osmond, C & Winter, PD (1991) Fetal and infant growth and impaired glucose tolerance at age 64. British Medical Journal 303, 1019–1022.
Hales, CN, Desai, M, Ozanne, SE & Crowther, NJ (1996) Fishing in the stream of diabetes: from measuring insulin to the control of fetal organogenesis. Biochemical Society Transactions 24, 341–350.
Hales, CN & Ozanne, SE (2003) The dangerous road of catch-up growth. Journal of Physiology 547, 5–10.
Hattersley, AT, Beards, F, Ballantyne, E, Appleton, M, Harvey, R & Ellard, S (1998) Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nature Genetics 19, 268–270.
Hofmann, M, Pollow, K, Bahlmann, F, Casper, F, Steiner, E & Brockerhoff, P (2001) 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD-II) activity in human placenta: its relationship to placental weight and birth weight and its possible role in hypertension. Journal of Perinatal Medicine 29, 23–30.
Holmes, MC, Yau, JL, Kotelevtsev, Y, Mullins, JJ & Seckl, JR (2003) 11 Beta-hydroxysteroid dehydrogenases in the brain: two enzymes two roles. Annals of the New York Academy of Sciences 1007, 357–366.
Jansson, N, Greenwood, SL, Johansson, BR, Powell, TL & Jansson, T (2003) Leptin stimulates the activity of the system A amino acid transporter in human placental villous fragments. Journal of Clinical Endocrinology and Metabolism 88, 1205–1211.
Jaquet, D, Gaboriau, A, Czernichow, P, Levy-Marchal, C (2000) Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. Journal of Clinical Endocrinology and Metabolism 85, 1401–1406.
Langley, SC, Browne, RF & Jackson, AA (1994) Altered glucose tolerance in rats exposed to maternal low protein diets in utero. Comparative Biochemistry and Physiology 109, 223–229.
Langley-Evans, SC (1997) Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. Journal of Hypertension 15, 537–544.
Langley-Evans, SC, Phillips, GJ, Benediktsson, R, Gardner, DS, Edwards, CR, Jackson, AA & Seckl, JR (1996) Protein intake in pregnancy, placental glucocorticoid metabolism and the programming of hypertension in the rat. Placenta 17, 169–172.
Leon, DA, Koupilova, I, Lithell, HO, Berglund, L, Mohsen, R, Vagero, D, Lithell, UB & McKeigue, PM (1996) Failure to realise growth potential in utero and adult obesity in relation to blood pressure in 50 year old Swedish men. British Medical Journal 312, 401–406.
Léonhardt, M, Lesage, J, Croix, D, Dutriez-Casteloot, I, Beauvillain, JC & Dupouy, JP (2003) Effects of perinatal maternal food restriction on pituitary-gonadal axis and plasma leptin level in rat pup at birth and weaning and on timing of puberty. Biology of Reproduction 68, 390–400.
Lesage, J, Blondeau, B, Grino, M, Breant, B & Dupouy, JP (2001) Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 142, 1692–1702.
Lindsay, RS, Lindsay, RM, Waddell, BJ & Seckl, JR (1996) Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11 beta-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia 39, 1299–1305.
Locke, R (2002) Preventing obesity: the breast milk-leptin connection. Acta Paediatrica 91, 891–894.
Maloney, CA, Gosby, AK, Phuyal, JL, Denyer, GS, Bryson, JM & Caterson, ID (2003) Site-specific changes in the expression of fat-partitioning genes in weanling rats exposed to a low-protein diet in utero. Obesity Research 11, 461–468.
Matthews, SG (2002) Early programming of the hypothalamo-pituitary-adrenal axis. Trends in Endocrinology and Metabolism 13, 373–380.
Montgomery, SM & Ekbom, A (2002) Smoking during pregnancy and diabetes mellitus in a British longitudinal birth cohort. British Medical Journal 324, 26–27.
Newsome, CA, Shiell, AW, Fall, CH, Phillips, DI, Shier, R & Law, CM (2003) Is birth weight related to later glucose and insulin metabolism? – A systematic review. Diabetic Medicine 20, 339–348.
Nilsson, C, Swolin-Eide, D, Ohlsson, C, Eriksson, E, Ho, HP, Bjorntorp, P & Holmang, A (2003) Reductions in adipose tissue and skeletal growth in rat adult offspring after prenatal leptin exposure. Journal of Endocrinology 176, 13–21.
Njolstad, PR, Sagen, JV, Bjorkhaug, L, Odili, S, Shehadeh, N, Bakry, D et al. (2003) Permanent neonatal diabetes caused by glucokinase deficiency: inborn error of the glucose-insulin signaling pathway. Diabetes 52, 2854–2860.
Nyirenda, MJ, Lindsay, RS, Kenyon, CJ, Burchell, A & Seckl, JR (1998) Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. Journal of Clinical Investigation 101, 2174–2181.
Ong, KK, Ahmed, ML, Sherriff, A, Woods, KA, Watts, A, Golding, J & Dunger, DB (1999) Cord blood leptin is associated with size at birth and predicts infancy weight gain in humans. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Journal of Clinical Endocrinology and Metabolism 84, 1145–1148.
Ong, KK, Preece, MA, Emmett, PM, Ahmed, ML & Dunger, DB (2002) Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatric Research 52, 863–867.
Ounsted, M & Sleigh, G (1975) The infant's self-regulation of food intake and weight gain. Difference in metabolic balance after growth constraint or acceleration in utero. Lancet i, 1393–1397.
Ozanne, SE (2001) Metabolic programming in animals. British Medical Bulletin 60, 143–152.
Ozanne, SE & Hales, CN (1999) The long-term consequences of intra-uterine protein malnutrition for glucose metabolism. Proceedings of the Nutrition Society 58, 615–619.
Ozanne, SE & Hales, CN (2004) Lifespan: catch-up growth and obesity in male mice. Nature 427, 411–412.
Ozanne, SE, Lewis, R, Jennings, BJ & Hales, CN (2004) Early programming of weight gain in mice prevents the induction of obesity by a highly palatable diet. Clinical Science 106, 141–145.
Ozanne, SE, Nave, BT, Wang, CL, Shepherd, PR, Prins, J & Smith, GD (1997) Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes. American Journal of Physiology 273, E46–E51.
Ozanne, SE, Olsen, GS, Hansen, LL, Tingey, KJ, Nave, BT, Wang, CL, Hartil, K, Petry, CJ, Buckley, AJ, Mosthaf-Seedorf, L (2003) Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. Journal of Endocrinology 177, 235–241.
Ozanne, SE, Smith, GD, Tikerpae, J & Hales, CN (1996) Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. American Journal of Physiology 270, E559–E564.
Park, KS, Kim, SK, Kim, MS, Cho, EY, Lee, JH, Lee, KU, Pak, YK & Lee, HK (2003) Fetal and early postnatal protein malnutrition cause long-term changes in rat liver and muscle mitochondria. Journal of Nutrition 133, 3085–3090.
Perez-Escamilla, R, Cohen, RJ, Brown, KH, Rivera, LL, Canahuati, J & Dewey, KG (1995) Maternal anthropometric status and lactation performance in a low-income Honduran population: evidence for the role of infants. American Journal of Clinical Nutrition 61, 528–534.
Petry, CJ, Dorling, MW, Wang, CL, Pawlak, DB & Ozanne, SE (2000) Catecholamine levels and receptor expression in low protein rat offspring. Diabetic Medicine 17, 848–853.
Petry, CJ, Ozanne, SE, Wang, CL & Hales, CN (1997) Early protein restriction and obesity independently induce hypertension in 1-year-old rats. Clinical Science 93, 147–152.
Phillips, DI, Walker, BR, Reynolds, RM, Flanagan, DE, Wood, PJ, Osmond, C, Barker, DJ & Whorwood, CB (2000) Low birth weight predicts elevated plasma cortisol concentrations in adults from 3 populations. Hypertension 35, 1301–1306.
Poulsen, P, Vaag, AA, Kyvik, KO, Moller, D, Beck-Nielsen, H (1997) Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia 40, 439–446.
Proulx, K, Clavel, S, Nault, G, Richard, D & Walker, CD (2001) High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats. Endocrinology 142, 4607–4616.
Proulx, K, Richard, D & Walker, CD (2002) Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Endocrinology 143, 4683–4692.
Ravelli, AC, van der Meulen, JH, Michels, RP, Osmond, C, Barker, DJ, Hales, CN & Bleker, OP (1998) Glucose tolerance in adults after prenatal exposure to famine. Lancet 351, 173–177.
Sagawa, N, Yura, S, Itoh, H, Kakui, K, Takemura, M, Nuamah, MA, Ogawa, Y, Masuzaki, H, Nakao, K & Fujii, S (2002) Possible role of placental leptin in pregnancy: a review. Endocrine 19, 65–71.
Savino, F, Costamagna, M, Prino, A, Oggero, R & Silvestro, L (2002) Leptin levels in breast-fed and formula-fed infants. Acta Paediatrica 91, 897–902.
Seeber, RM, Smith, JT & Waddell, BJ (2002) Plasma leptin-binding activity and hypothalamic leptin receptor expression during pregnancy and lactation in the rat. Biology of Reproduction 66, 1762–1767.
Smith, JT & Waddell, BJ (2003) Leptin distribution and metabolism in the pregnant rat: transplacental leptin passage increases in late gestation but is reduced by excess glucocorticoids. Endocrinology 144, 3024–3030.
Snoeck, A, Remacle, C, Reusens, B & Hoet, JJ (1990) Effect of a low protein diet during pregnancy on the fetal rat endocrine pancreas. Biology of the Neonate 57, 107–118.
Soto, N, Bazaes, RA, Pena, V, Salazar, T, Avila, A, Iniguez, G, Ong, KK, Dunger, DB & Mericq, MV (2003) Insulin sensitivity and secretion are related to catch-up growth in small-for-gestational-age infants at age 1 year: results from a prospective cohort. Journal of Clinical Endocrinology and Metabolism 88, 3645–3650.
Sparre, T, Reusens, B, Cherif, H, Larsen, MR, Roepstorff, P, Fey, SJ, Mose, P, Remacle, C & Nerup, J (2003) Intrauterine programming of fetal islet gene expression in rats – effects of maternal protein restriction during gestation revealed by proteome analysis. Diabetologia 46, 1497–1511.
Stocker, C, O'Dowd, J, Morton, NM, Wargent, E, Sennitt, MV, Hislop, D, Glund, S, Seckl, JR, Arch, JR & Cawthorne, MA (2004) Modulation of susceptibility to weight gain and insulin resistance in low birthweight rats by treatment of their mothers with leptin during pregnancy and lactation. International Journal of Obesity and Related Metabolic Disorders 28, 129–136.
Stocker, C, Wargent, E, Sennitt, M, Nolan, A, O'Dowd, J, Subramaniam, K, Wang, S & Cawthorne, MA (2001) Maternal leptin administration induces resistance to diet-induced obesity of early growth restricted rats. Diabetologia 44 Suppl.1, 641 Abstr.
Symonds, ME, Mostyn, A, Pearce, S, Budge, H & Stephenson, T (2003) Endocrine and nutritional regulation of fetal adipose tissue development. Journal of Endocrinology 179, 293–299.
Toschke, AM, Koletzko, B, Slikker, W Jr, Hermann, M & von Kries, R (2002) Childhood obesity is associated with maternal smoking in pregnancy. European Journal of Pediatrics 161, 445–448.
Vickers, MH, Breier, BH, Cutfield, WS, Hofman, PL & Gluckman, PD (2000) Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. American Journal of Physiology 279, E83–E87.
Waterland, RA & Jirtle, RL (2003) Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology 23, 5293–5300.
Wilson, MR & Hughes, SJ (1997) The effect of maternal protein deficiency during pregnancy and lactation on glucose tolerance and pancreatic islet function in adult rat offspring. Journal of Endocrinology 154, 177–185.
Yuen, BS, Owens, PC, Muhlhausler, BS, Roberts, CT, Symonds, ME, Keisler, DH, McFarlane, JR, Kauter, KG, Evens, Y & McMillen, IC (2003) Leptin alters the structural and functional characteristics of adipose tissue before birth. FASEB Journal 17, 1102–1104.