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Food patterns and the prevention of depression

  • Miguel A. Martínez-González (a1) (a2) (a3) and Almudena Sánchez-Villegas (a2) (a3) (a4)


An emerging field of research in nutritional epidemiology is the assessment of several links between nutritional quality and mental health. Specifically, some studies have pointed out that several food patterns could be associated with a reduced risk of depression among adults. This association seems to be consistent across countries, cultures and populations according to several systematic reviews and meta-analyses of observational studies. Some previously described food patterns, specifically the Mediterranean Food Pattern, the Alternative Healthy Eating Index, the Prudent diet or the Provegetarian Food Pattern may be effective to reduce the future risk of depression. Among them, only the Mediterranean Food Pattern has been tested for primary prevention in a large randomised trial, but the inverse association found was not statistically significant. The scientific report of the 2015 Dietary Guidelines for Americans Advisory Committee concluded that current evidence is still limited. Notwithstanding, this field is promising and, according to large and well-conducted observational studies, food patterns potentially associated with reduced risk of depression are those emphasising seafood, vegetables, fruits and nuts. There is a need to assess whether differences in the intake of some micro or macronutrients between these dietary patterns can make a difference in their association with a lower risk of depression. Moreover, the shape of the dose–response curve and the potential existence of a nonlinear threshold effect have not yet been established.

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Corresponding author

* Corresponding author: Professor Miguel A. Martinez-Gonzalez, fax + 34 948 42 57 40, email


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Both the authors contributed equally to this work.



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1. Kessler, RC, Chiu, WT, Demler, O et al. (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62, 617627.
2. Hasin, D, Goodwin, RD, Stinson, F et al. (2005) Epidemiology of major depressive disorder: results from the national epidemiologic survey on alcoholism and related conditions. Arch Gen Psychiatry 62, 10971106.
3. Mathers, CD & Loncar, D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3, e442.
4. Chishti, P, Stone, DH, Corcoran, P et al. (2003) Suicide mortality in the European Union. Eur J Public Health 13, 108114.
5. Belmaker, RH & Agam, G (2008) Major depressive disorder. N Engl J Med 358, 5568.
6. Almeida, OP, McCaul, K, Hankey, GJ et al. (2008) Homocysteine and depression in later life. Arch Gen Psychiatry 65, 12861294.
7. Rothman, KJ, Greenland, S & Lash, TL (2008) Modern Epidemiology, 3rd ed. Philadelphia, USA: Lippincott Williams & Wilkins.
8. Sanchez-Villegas, A & Martínez-González, MA (2013) Diet, a new target to prevent depression? BMC Med 11, 3.
9. Lloyd-Jones, DM, Hong, Y, Labarthe, D et al. (2010) Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association's strategic Impact Goal through 2020 and beyond. Circulation 121, 586613.
10. España-Romero, V, Artero, EG, Lee, DC et al. (2013) A prospective study of ideal cardiovascular health and depressive symptoms. Psychosomatics 54, 525535.
11. Gilbody, S, Lightfoot, T & Sheldon, T (2007) Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Commun Health 61, 631637.
12. Astorg, P, Couthouis, A, de Courcy, GP et al. (2008) Association of folate intake with the occurrence of depressive episodes in middle-aged French men and women. Br J Nutr 100, 183187.
13. Beydoun, MA, Fanelli Kuczmarski, MT, Beydoun, HA et al. (2015) Associations of the ratios of n-3 to n-6 dietary fatty acids with longitudinal changes in depressive symptoms among US women. Am J Epidemiol 181, 691705.
14. Lucas, M, Mirzaei, F, O'Reilly, EJ et al. (2011) Dietary intake of n-3 and n-6 fatty acids and the risk of clinical depression in women: a 10-y prospective follow-up study. Am J Clin Nutr 93, 13371343.
15. Sanchez-Villegas, A, Henríquez, P, Figueiras, A et al. (2007) Long chain omega-3 fatty acids intake, fish consumption and mental disorders in the SUN cohort study. Eur J Nutr 46, 337346.
16. Kyrozis, A, Psaltopoulou, T, Stathopoulos, P et al. (2009) Dietary lipids and geriatric depression scale score among elders: the EPIC-Greece cohort. J Psychiatric Res 43, 763769.
17. Sánchez-Villegas, A, Verberne, L, De Irala, J et al. (2011) Dietary fat intake and the risk of depression: the SUN Project. PLoS ONE 6, e16268.
18. Gea, A, Martinez-Gonzalez, MA, Toledo, E et al. (2012) A longitudinal assessment of alcohol intake and incident depression: the SUN project. BMC Public Health 12, 954.
19. Gea, A, Beunza, JJ, Estruch, R et al. (2013) Alcohol intake, wine consumption and the development of depression: the PREDIMED study. BMC Med 11, 192.
20. Sánchez-Villegas, A, Toledo, E, de Irala, J et al. (2012) Fast-food and commercial baked goods consumption and the risk of depression. Public Health Nutr 15, 424432.
21. Hu, FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 13, 39.
22. Martínez-González, & Martín-Calvo, N (2013) The major European dietary patterns and metabolic syndrome. Rev Endocr Metab Disord 14, 265271.
23. Scientific Report of the 2015 Dietary Guidelines Advisory Committee (DGAC) (2015) Evidence Basis and Key Recommendations. (accessed July 2015).
24. Trichopoulou, A, Martínez-González, MA, Tong, TY et al. (2014) Definitions and potential health benefits of the Mediterranean diet: views from experts around the world. BMC Med 12, 112.
25. Hu, FB, Rimm, EB, Stampfer, MJ et al. (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. Am J Clin Nutr 72, 912921.
26. Quirk, SE, Williams, LJ, O'Neil, A et al. (2013) The association between diet quality, dietary patterns and depression in adults: a systematic review. BMC Psychiatry 13, 175.
27. Lai, J, Hiles, S, Bisquera, A et al. (2014) A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults. Am J Clin Nutr 99, 181197.
28. Rahe, C, Unrath, M & Berger, K (2014) Dietary patterns and the risk of depression in adults: a systematic review of observational studies. Eur J Nutr 53, 9971013.
29. Sánchez-Villegas, A, Martínez-González, MA, Estruch, R et al. (2013) Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC Med 11, 208.
30. Torres, SJ & Nowson, CA (2012) A moderate-sodium DASH-type diet improves mood in postmenopausal women. Nutrition 28, 896900.
31. Sánchez-Villegas, A, Delgado-Rodríguez, M, Alonso, A et al. (2009) Association of the Mediterranean dietary pattern with the incidence of depression: the Seguimiento Universidad de Navarra/University of Navarra follow-up (SUN) cohort. Arch Gen Psychiatry 66, 10901098.
32. Skarupski, KA, Tangney, CC, Li, H et al. (2013) Mediterranean diet and depressive symptoms among older adults over time. J Nutr Health Aging 17, 441445.
33. Trichopoulou, A, Costacou, T, Bamia, C et al. (2003) Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 348, 25992608.
34. Psaltopoulou, T, Kyrozis, A, Stathopoulos, P et al. (2008) Diet, physical activity and cognitive impairment among elders: the EPIC-Greece cohort (European Prospective Investigation into Cancer and Nutrition). Public Health Nutr 11, 10541062.
35. Shatenstein, B, Ferland, G, Belleville, S et al. (2012) Diet quality and cognition among older adults from the NuAge study. Exp Gerontol 47, 353360.
36. Akbaraly, TN, Sabia, S, Shipley, MJ et al. (2013) Adherence to healthy dietary guidelines and future depressive symptoms: evidence for sex differentials in the Whitehall II study. Am J Clin Nutr 97, 419427.
37. Sánchez-Villegas, A, Henríquez-Sánchez, P, Ruíz-Canela, M et al. (2015) A longitudinal analysis of diet quality scores and the risk of incident depression in the SUN Project. BMC Med 13, 197.
38. Rienks, J, Dobson, AJ & Mishra, GD (2013) Mediterranean dietary pattern and prevalence and incidence of depressive symptoms in mid-aged women: results from a large community-based prospective study. Eur J Clin Nutr 67, 7582.
39. Akbaraly, TN, Brunner, EJ, Ferrie, JE et al. (2009) Dietary pattern and depressive symptoms in middle age. Br J Psychiatry 195, 408413.
40. Ruusunen, A, Lehto, SM, Mursu, J et al. (2014) Dietary patterns are associated with the prevalence of elevated depressive symptoms and the risk of getting a hospital discharge diagnosis of depression in middle-aged or older Finnish men. J Affect Disord 159, 16.
41. Jacka, FN, Cherbuin, N, Anstey, KJ et al. (2014) Dietary patterns and depressive symptoms over time: examining the relationships with socioeconomic position, health behaviours and cardiovascular risk. PLoS ONE 9, e87657.
42. Le Port, A, Gueguen, A, Kesse-Guyot, E et al. (2012) Association between dietary patterns and depressive symptoms over time: a 10-year follow-up study of the GAZEL cohort. PLoS ONE 7, e51593.
43. Chan, R, Chan, D & Woo, J (2014) A prospective cohort study to examine the association between dietary patterns and depressive symptoms in older Chinese people in Hong Kong. PLoS ONE 9, e105760.
44. Chocano-Bedoya, PO, O'Reilly, EJ, Lucas, M et al. (2013) Prospective study on long-term dietary patterns and incident depression in middle-aged and older women. Am J Clin Nutr 98, 813820.
45. Lucas, M, Chocano-Bedoya, P, Schulze, MB et al. (2014) Inflammatory dietary pattern and risk of depression among women. Brain Behav Immun 36, 4653.
46. Sánchez-Villegas, A, Ruíz-Canela, M, de la Fuente-Arrillaga, C et al. (2015) Dietary inflammatory index, cardio-metabolic conditions and depression in the Seguimiento Universidad de Navarra cohort study. Br J Nutr 114, 14711479.


Food patterns and the prevention of depression

  • Miguel A. Martínez-González (a1) (a2) (a3) and Almudena Sánchez-Villegas (a2) (a3) (a4)


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