1. Stubbs CD & Smith AD (1984) The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function. Biochim Biophys Acta 779, 89–137.
2. Schoonjans K, Staels B & Auwerx J (1996) The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1302, 93–109.
3. Sampath H & Ntambi JM (2004) Polyunsaturated fatty acid regulation of gene expression. Nutr Rev 62, 333–339.
4. Lewis RA, Austen KF & Soberman RJ (1990) Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med 323, 645–655.
5. Tilley SL, Coffman TM & Koller BH (2001) Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes. J Clin Invest 108, 15–23.
6. Calder PC (2003) N-3 polyunsaturated fatty acids and inflammation: from molecular biology to the clinic. Lipids 38, 343–352.
7. Calder PC (2006) n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr 83, 1505s–1519s.
8. Levy BD, Clish CB, Schmidt B, Gronert K & Serhan CN (2001) Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol 2, 612–619.
9. Serhan CN, Arita M, Hong S & Gotlinger K (2004) Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 39, 1125–1132.
10. Liu J, Yeo HC, Doniger SJ & Ames BN (1997) Assay of aldehydes from lipid peroxidation: gas chromatography-mass spectrometry compared to thiobarbituric acid. Anal Biochem 245, 161–166.
11. British Nutrition Foundation (1999) n-3 Fatty Acids and Health. London: British Nutrition Foundation.
12. Henderson L, Gregory J, Swan G & Ruston D (2002) The National Diet and Nutrition Survey: Adults Aged 19 to 64 Years. London: The Stationery Office.
13. Scientific Advisory Committee on Nutrition (2004) Advice on Fish Consumption: Benefits and Risks. London: The Stationery Office.
14. Ruxton CHS, Calder PC, Reed SC & Simpson MJA (2005) The impact of long-chain n-3 polyunsaturated fatty acids on human health. Nutr Res Rev 18, 113–129.
15. Burdge GC & Calder PC (2006) Dietary alpha-linolenic acid and health related outcomes: a metabolic perspective. Nutr Res Rev 19, 26–52.
16. Kris-Etherton PM, Harris WS & Appel LJ (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 2747–2757.
17. Calder PC (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 107, 1–11.
18. Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, Jordan HS & Lau J (2006) Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 84, 5–17.
19. GISSI-Prevenzione (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354, 447–455.
20. Calder PC (2006) Use of fish oil in parenteral nutrition: Rationale and reality. Proc Nutr Soc 65, 264–277.
21. Farquharson J, Jamieson EC, Logan RW, Patrick WJ, Howatson AG & Cockburn F (1995) Age- and dietary-related distributions of hepatic arachidonic and docosahexaenoic acid in early infancy. Pediatr Res 38, 361–365.
22. Lauritzen L, Hansen HS, Jorgensen MH & Michaelsen KF (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40, 1–94.
23. SanGiovanni JP, Parra-Cabrera S, Colditz GA, Berkey CS & Dwyer JT (2000) Meta-analysis of dietary essential fatty acids and long-chain polyunsaturated fatty acids as they relate to visual resolution acuity in healthy preterm infants. Pediatrics 105, 1292–1298.
24. Cheatham CL, Colombo J & Carlson SE (2006) N-3 fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. Am J Clin Nutr 83, 1458s–1466s.
25. Richardson AJ (2006) Omega-3 fatty acids in ADHD and related neurodevelopmental disorders. Int Rev Psychiatry 18, 155–172.
26. Freeman MP, Hibbeln JR, Wisner KL et al. (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. J Clin Psychiatry 67, 1954–1967.
27. Appleton KM, Hayward RC, Gunnell D, Peters TJ, Rogers PJ, Kessler D & Ness AR (2006) Effects of n-3 long-chain polyunsaturated fatty acids on depressed mood: systematic review of published trials. Am J Clin Nutr 84, 1308–1316.
28. Leonard AE, Pereira SL, Sprecher H & Huang YS (2004) Elongation of long-chain fatty acids. Prog Lipid Res 43, 36–54.
29. Arterburn LM, Hall EB & Oken H (2006) Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 83, 1467S–1476S.
30. Cleland LG, Gibson RA, Pedler J & James MJ (2005) Paradoxical effect of n-3 containing vegetable oils on long-chain n-3 fatty acids in rat heart. Lipids 40, 995–998.
31. Francois CA, Connor SL, Bolewicz LC & Connor WE (2003) Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 77, 226–233.
32. Burdge GC, Jones AE & Wootton SA (2002) Eicosapentaenoic and docosapentaenoic acids are the principal products of alpha-linolenic acid metabolism in young men. Br J Nutr 88, 355–363.
33. Burdge GC & Wootton SA (2002) Conversion of alpha-linolenic acid to eicosapentaenoic, docosapentaenoic and docosahexaenoic acids in young women. Br J Nutr 88, 411–420.
34. Pawlosky RJ, Hibbeln JR, Novotny JA & Salem N Jr (2001) Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 42, 1257–1265.
35. Pawlosky RJ, Hibbeln JR, Lin Y, Goodson S, Riggs P, Sebring N, Brown GL & Salem N Jr (2003) Effects of beef- and fish-based diets on the kinetics of n-3 fatty acid metabolism in human subjects. Am J Clin Nutr 77, 565–572.
36. Pawlosky R, Hibbeln J, Lin Y & Salem N Jr (2003) n-3 Fatty acid metabolism in women. Br J Nutr 90, 993–994.
37. Burdge GC, Finnegan YE, Minihane AM, Williams CM & Wootton SA (2003) Effect of altered dietary n-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]α-linolenic acid to longer-chain fatty acids and partitioning towards β-oxidation in older men. Br J Nutr 90, 311–321.
38. Nikkari T, Luukkainen P, Pietinen P & Puska P (1995) Fatty acid composition of serum lipid fractions in relation to gender and quality of dietary fat. Ann Med 27, 491–498.
39. Giltay EJ, Gooren LJ, Toorians AW, Katan MB & Zock PL (2004) Docosahexaenoic acid concentrations are higher in women than in men because of estrogenic effects. Am J Clin Nutr 80, 1167–1174.
40. Bakewell L, Burdge GC & Calder PC (2006) Polyunsaturated fatty acid concentrations in young men and women consuming their habitual diets. Br J Nutr 96, 93–99.
41. Crowe FL, Skeaff CM & Green TJ (2008) Serum n-3 long-chain PUFA differ by sex and age in a population-based survey of New Zealand adolescents and adults. Br J Nutr (In the Press).
42. Jones AE, Murphy JL, Stolinski M & Wootton SA (1998) The effect of age and gender on the metabolic disposal of [1–13C] palmitic acid. Eur J Clin Nutr 52, 22–28.
43. Tavendale R, Lee AJ, Smith WC & Tunstall-Pedoe H (1992) Adipose tissue fatty acids in Scottish men and women: results from the Scottish Heart Health Study. Atherosclerosis 94, 161–169.
44. Raclot T, Langin D, Lafontan M & Groscolas R (1997) Selective release of human adipocyte fatty acids according to molecular structure. Biochem J 324, 911–915.
45. Raclot T (2003) Selective mobilization of fatty acids from adipose tissue triacylglycerols. Prog Lipid Res 42, 257–288.
46. Sumino H, Ichikawa S, Murakami M, Nakamura T, Kanda T, Sakamaki T, Mizunuma H & Kurabayashi M (2003) Effects of hormone replacement therapy on circulating docosahexaenoic acid and eicosapentaenoic acid levels in postmenopausal women. Endocr J 50, 51–59.
47. Giltay EJ, Duschek EJ, Katan MB, Zock PL, Neele SJ & Netelenbos JC (2004) Raloxifene and hormone replacement therapy increase arachidonic acid and docosahexaenoic acid levels in postmenopausal women. J Endocrinol 182, 399–408.
48. Mattsson LA, Silfverstolpe G & Samsioe G (1985) Fatty acid composition of serum lecithin and cholesterol ester in the normal menstrual cycle. Horm Metab Res 17, 414–417.
49. Ocke MC, Bueno-de-Mesquita HB, Goddijn HE, Jansen A, Pols MA, Van Staveren WA & Kromhout D (1997) The Dutch EPIC food frequency questionnaire. I. Description of the questionnaire, and relative validity and reproducibility for food groups. Int J Epidemiol 26, Suppl. 1, S37–S48.
50. Marra CA, de Alaniz MJ & Brenner RR (1988) Effect of various steroids on the biosynthesis of arachidonic acid in isolated hepatocytes and HTC cells. Lipids 23, 1053–1058.
51. Gonzalez S, Nervi AM & Peluffo RO (1986) Effects of estradiol and environmental temperature changes on rat liver delta 6 microsomal desaturase activity. Lipids 21, 440–443.
52. Marra CA & de Alaniz MJ (1989) Influence of testosterone administration on the biosynthesis of unsaturated fatty acids in male and female rats. Lipids 24, 1014–1019.