Skip to main content
×
Home
    • Aa
    • Aa

Genetics, calcium intake and osteoporosis

  • John A. Eisman (a1)
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Genetics, calcium intake and osteoporosis
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Genetics, calcium intake and osteoporosis
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Genetics, calcium intake and osteoporosis
      Available formats
      ×
Abstract
Copyright
Corresponding author
Corresponding author: Professor J. A. Eisman, fax + 61 2 9295 8241, email j.eisman@garvan.unsw.edu.au
References
Hide All
Alahari KD, Lobaugh B & Econs MJ (1997) Vitamin D receptor alleles do not correlate with bone mineral density in premenopausal Caucasian women from the southeastern United States. Metabolism 46, 224226.
Angus R & Eisman JA (1988) Osteoporosis: the role of calcium intake and supplementation. Medical Journal of Australia 148, 630633.
Angus RM, Pocock N & Eisman JA (1988 a) Nutritional intake of pre- and postmenopausal Australian women with special reference to calcium. European Journal of Clinical Nutrition 42, 617625.
Angus RM, Sambrook PN, Pocock N & Eisman JA (1988) Dietary intake and bone density. Bone and Mineral 4, 265277.
Barger-Lux MJ, Heaney RP, Davies KM, Johnson M & Gong G (1995 a) Vitamin D receptor (VDR) gene polymorphism: relationship to adult bone expansion, bone loss, and body size, in longitudinal data. Journal of Bone and Mineral Research 10, Suppl. 1, S184.
Barger-Lux MJ, Heaney RP, Hayes J, DeLuca HF, Johnson M & Gong G (1995 b) Vitamin D receptor gene polymorphism, bone mass, body size, and vitamin D receptor density. Calcified Tissue International 57, 161162.
Carbon R, Sambrook PN, Deakin V, Fricker P, Eisman JA, Kelly PJ, Maguire K & Yeates MG (1990) Bone density in elite female athletes with stress fractures. Medical Journal of Australia 150, 313376.
Carling T, Kindmark A, Hellman P, Holmberg L, Akerstrom G & Rastad J (1997) Vitamin D receptor alleles B, A, and T-risk factors for sporadic primary hyperparathyroidism (HPT) but not HPT of uremia or MEN 1. Biochemical and Biophysical Research Communications 231, 329332.
Carling T, Kindmark A, Hellman P, Lundgren E, Ljunghall S, Rastad J, Akerstrom G & Melhus H (1995) Vitamin D receptor genotypes in primary hyperparathyroidism. Nature Medicine 1, 13091311.
Christian JC, Yu P-L, Slemenda C & Johnston CC Jr (1989) Heritability of bone mass: a longitudinal study in aging male twins. American Journal of Human Genetics 44, 429433.
Cooper C, Campion G & Melton LJ III (1992) Hip fractures in the elderly: A world-wide projection. Osteoporosis International 2, 285289.
Cooper G & Umbach DM (1996) Are vitamin D receptor polymorphisms associated with bone mineral density – a meta-analysis. Journal of Bone and Mineral Research 11, 18411849.
Cummings SR, Nevitt MC, Browner WS, Stone K, Fox KM, Ensrud KE, Cauley JC, Black D & Vogt TM (1995) Risk factors for hip fracture in white women. New England Journal of Medicine 332, 767773.
Dawson-Hughes B, Hanis S & Finneran S (1995) Calcium absorption on high and low calcium intakes in relation to vitamin D receptor genotype. Journal of Clinical Endocrinology and Metabolism 80, 36573661.
Dequeker J, Nijs J, Verstaeten A, Geusen P & Gevars G (1987) Genetic determinants of bone mineral content at the spine and radius: a twin study. Bone 8, 207209.
Eisman JA (1993) Vitamin D and cancer: new insight into vitamin D physiology and potential for cancer therapy. In Bone & Mineral Research, vol. 8, pp. 4576 [Peck WA, Heersche J and Kanis JA, editors]. Amsterdam, New York and Oxford: Elsevier.
Eisman JA (1995) Vitamin D receptor gene alleles and osteoporosis: An affirmative view. Journal of Bone and Mineral Research 10, 12891293.
Eisman JA (1996) Genetics of Osteoporosis. In Osteoporosis '96. International Congress Series 1118, pp. 131135 [Papapoulos SE, Lips P, Pols HAP, Johnston CC and Delmas PD, editors]. Amsterdam: Excerpta Medica.
Eisman JA, Sambrook PN, Kelly P & Pocock NA (1991) Exercise and its interaction with genetic influences in determination of bone mineral density. American Journal of Medicine 91, 5B9B.
Evans RA, Marel GM, Lancaster EK, Kos S, Evans M & Wong SYP (1988) Bone mass is low in relatives of osteoporotic patients. Annals of Internal Medicine 109, 870873.
Ferrari S, Rizzoli R, Chevalley T, Slosman D, Eisman J & Bonjour J-P (1995) Vitamin D receptor gene polymorphisms and the rate of change of lumbar spine bone mineral density in elderly men and women. Lancet 345, 423424.
Fleet JC, Harris SS, Wood R & Dawson-Hughes B (1995) The BsmI vitamin D receptor restriction length polymorphism (BB) predicts low bone density in premenopausal black and white women. Journal of Bone and Mineral Research 10, 985990.
Francis RM, Harrington F, Turner E, Papiha S & Datta HK (1997) Vitamin D receptor gene polymorphism in men and its effect on bone density and calcium absorption. Clinical Endocrinology 4, 8386.
Gallagher JC, Goldgar D, Kinyamu H & Fannon P (1994) Vitamin D receptor genotypes in type 1 osteoporosis. Journal of Bone and Mineral Research 9, Suppl. 1, 143.
Garnero P, Borel O, Sornay-Rendu E, Arlot M & Delmas PD (1996) Vitamin D receptor gene polymorphisms are not related to bone turnover, rate of bone loss and bone mass in postmenopausal women: The OFELY study. Journal of Bone and Mineral Research 11, 827834.
Garnero P, Borel O, Sornay-Rendu E & Delmas PD (1995) Vitamin D receptor gene polymorphisms do not predict bone turnover and bone mass in healthy premenopausal women. Journal of Bone and Mineral Research 10, 12831288.
Grant SFA, Reid DM, Blake G, Herd R, Fogelman I & Ralston SH (1996) Reduced bone density and osteoporosis associated with a polymorphic Sp1 binding site in the collagen type Ia1 gene. Nature Genetics 14, 203205.
Grisso JA, Kelsey JL, Strom BL, Chiu GY, Maislin G, O'Brien LA, Hoffman S & Kaplan F (1991) Risk factors for falls as a cause of hip fracture in women. New England Journal of Medicine 324, 13261331.
Grisso JA, Kelsey JL, Strom BL, O'Brien LA, Maislin G, La Pann, Samelson L, Hoffman S and the Northeast Hip Fracture Study Group (1994) Risk factors for hip fracture in black women. New England Journal of Medicine 330, 15551559.
Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R & Feldman D (1996) The presence of a polymorphism at the translation initiation site of the Vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. Journal of Bone and Mineral Research 11, 18501855.
Gunnes M, Berg JP, Halse J & Lehmann EH (1997) Lack of relationship between vitamin D receptor genotype and forearm bone gain in healthy children, adolescents, and young adults. Journal of Clinical Endocrinology and Metabolism 82, 851855.
Hopper J & Seeman E (1994) The bone density of female twins discordant for tobacco use. New England Journal of Medicine 330, 387392.
Houston LA, Grant SFA, Reid D & Ralston SH (1996) Vitamin D polymorphism, bone mineral density and osteoporotic vertebral fracture: Studies in a UK population. Bone 18, 249252.
Hustmyer FG, Peacock M, Hui S, Johnston C & Christian JC (1994) Bone mineral density in relation to polymorphisms at the vitamin D receptor locus. Journal of Clinical Investigation 94, 21302134.
Ingles SA, Ross RK, Yu MC, Irvine RA, Lapera G, Haile R & Coetzee GA (1997) Association of prostate cancer risk with genetic polymorphisms in Vitamin D receptor and androgen receptor. Journal of the National Cancer Institute 89, 166170.
Jones G, Nguyen TV, Sambrook PN, Kelly P & Eisman JA (1994 a) Progressive femoral neck bone loss: Longitudinal findings from the Dubbo Osteoporosis Epidemiology Study. British Medical Journal 309, 691695.
Jones G, Nguyen TV, Sambrook PN, Kelly P & Eisman JA (1994 b) Symptomatic fracture incidence in elderly men and women: The Dubbo Osteoporosis Epidemiology Study. Osteoporosis International 4, 277282.
Jorgensen HL, Scholler J, Sand JC, Bjuring M, Hassager C & Christiansen C (1996) Relation of common allelic variation at vitamin D receptor locus to bone mineral density and postmenopausal bone loss: Cross sectional and longitudinal population study. British Medical Journal 313, 586590.
Keen RW, Egger P, Fall C, Major PJ, Lanchbury JS, Spector T & Cooper C (1997) Polymorphisms of the vitamin D receptor, infant growth, and adult bone mass. Calcijied Tissue International 60, 233235.
Keen RW, Major PJ, Lanchbury J & Spector TD (1995) Vitamin D receptor gene polymorphism and bone loss. Lancet 345, 990.
Kelly PJ, Eisman J & Sambrook PN (1990 a) Interaction of genetic and environmental influences on peak bone density. Osteoporosis International 1, 15.
Kelly PJ, Eisman JA, Stuart MC, Pocock NA, Sambrook P & Gwinn T (1990 b) Somatomedin-C, physical fitness and bone density. Journal of Clinical Endocrinology and Metabolism 70, 718723.
Kelly PJ, Hopper JL, Macaskill GT, Pocock NA, Sambrook P & Eisman JA (1991) Genetic factors in bone turnover. Journal of Clinical Endocrinology and Metabolism 72, 808813.
Kelly PJ?, Nguyen T, Pocock N, Hopper J, Sambrook P & Eisman JA (1993) Genetic determination of changes in bone density with age: a twin study. Journal of Bone and Mineral Research 8, 1117.
Kinyamu HK, Gallagher JC, Knezetic JA, DeLuca HF, Prahl J & Lanspa SJ (1997) Effect of vitamin D receptor genotypes on calcium absorption, duodenal vitamin D receptor concentration, and serum 1,25 dihydroxyvitamin D levels in normal women. Calcified Tissue International 60, 491495.
Koshiyama H, Sone T & Nakao K (1995) Vitamin D receptor gene polymorphism and bone loss. Lancet 345, 990991.
Krall EA, Pany P, Lichter J & Dawson-Hughes B (1995) Vitamin D receptor alleles and rates of bone loss: Influences of years since menopause and calcium intake. Journal of Bone and Mineral Research 10, 978984.
Kroger H, Mahonen A, Ryhanen S, Turunen AM, Alhava E & Maenpaa P (1995) Vitamin D receptor genotypes and bone mineral density. Lancet 345 1239.
Kroger H, Tuppurainen M, Honkanen R, Alhava E & Saarikoski S (1994) Bone mineral density and risk factors of osteoporosis a population based study of 1600 perimenopausal women. Calcified Tissue International 55, 17.
Looney JE, Yoon HK, Fischer M, Farley SM, Farley JR, Wergedal J & Baylink DJ (1995) Lack of a high prevalence of the BB vitamin D receptor genotype in severely osteoporotic women. Journal of Clinical Endocrinology and Metabolism 80, 21582162.
McClure L, Eccleshall TR, Gross C, Villa ML, Lin N, Ramaswamy V, Kohlmeier L, Kelsey JL, Marcus R & Feldman D (1997) Vitamin D receptor polymorphisms, bone mineral density, and bone metabolism in postmenopausal Mexican-American women. Journal of Bone and Mineral Research 12, 234240.
McKay HA, Bailey DA, Wilkinson A & Houston CS (1994) Familial comparison of bone mineral density at the proximal femur and lumbar spine. Bone Mineral 24, 95110.
Matsuyama T, Ishii S, Tokita A, Yabuta K, Yamamori S, Morrison N & Eisman JA (1995) VDR gene polymorphisms and vitamin D analog treatment in Japanese. Lancet 345, 12381239.
Melhus H, Kindmark A, Amer S, Wilen B, Lindh E & Ljunghall S (1994) Vitamin D receptor genotypes in osteoporosis. Lancet 344, 949.
Mocharla H, Butch AW, Pappas AA, Flick J, Weinstein RS, De Togni P, Jilka RL, Roberson PK, Parfitt A & Manolagas SC (1997) Quantification of vitamin D receptor mRNA by competitive polymerase chain reaction in PBMC: Lack of correspondence with common allelic variants. Journal of Bone and Mineral Research 12, 726733.
Moller M, Horsman A, Harvald B, Hauage M, Henningsen K & Nordin BEC (1978) Metacarpal morphometry in monozygotic and dizygotic twins. Calcified Tissue International 25, 197201.
Morrison NA, Qi JC, Tokita A, Kelly PJ, Croft L, Nguyen TV, Sambrook P & Eisman JA (1994) Prediction of bone density by vitamin D receptor alleles. Nature 367, 284287.
Morrison NA, Qi JC, Tokita A, Kelly PJ, Croft L, Nguyen TV, Sambrook P & Eisman JA (1997) Prediction of bone density by vitamin D receptor alleles (correction). Nature 387, 106.
Morrison NA, Yeoman R, Kelly P & Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: Vitamin D receptor gene polymorphisms and circulating osteocalcin. Proceedings of the National Academy of Sciences USA 89, 66656669.
Nakamura T (1997) The importance of genetic and nutritional factors in responses to vitamin D and its analogs in osteoporotic patients. Calcified Tissue International 60, 119123.
Nguyen TV, Kelly PJ, Morrison NA, Sambrook PN & Eisman JA (1994) Vitamin D receptors genotypes in osteoporosis. Lancer 344, 15801581.
Nguyen TV, Sambrook PN, Kelly PJ, Jones G, Lord SR, Freund J & Eisman JA (1993) Prediction of osteoporotic fractures by postural instability and bone density. British Medical Journal 307, 11111115.
Peacock M (1995) Vitamin D receptor gene alleles and osteoporosis: Contrasting view. Journal of Bone and Mineral Research 10, 12941297.
Pocock NA, Eisman JA, Gwinn TH, Sambrook PN, Kelly P, Freund J & Yeates MG (1989 a) Muscle strength, physical fitness and weight but not age predict femoral neck bone mass. Journal of Bone and Mineral Research 4, 441448.
Pocock NA, Eisman JA, Kelly PJ, Sambrook P & Yeates MG (1989 b) Effects of tobacco use on axial and appendicular bone mineral density. Bone 10, 329331.
Pocock NA, Eisman JA, Yeates MG, Sambrook P & Eberl S (1986) Physical fitness is a major determinant of femoral neck and lumbar spine bone mineral density. Journal of Clinical Investigation 78, 618621.
Pocock NA, Eisman JA, Yeates MG, Sambrook P & Eberl S (1987) Genetic determinants of bone mass in adults: a twin study. Journal of Clinical Investigation 80, 706710.
Riggs BL, Nguyen TV, Melton LJ III, Monison NA, O'Fallon WM, Kelly PJ, Egan KS, Sambrook PN, Muhs J & Eisman JA (1995) Contribution of vitamin D receptor gene alleles to the determination of bone mineral density in normal and osteoporotic women. Journal of Bone and Mineral Research 10, 991996.
Salamone LM, Ferell R, Black DM, Palermo L, Epstein RS, Petro N, Steadman N, Kuller L & Cauley JA (1996) The association between vitamin receptor gene polymorphisms and bone mineral density at the spine, hip and total body in premenopausal women. Osteoporosis International 6, 6368.
Seeman E, Tsalamandris C, Formica C, Hopper J & McKay J (1994) Reduced femoral neck bone density in the daughters of women with hip fractures: The role of low bone density in the pathogenesis of osteoporosis. Journal of Bone and Mineral Research 9, 739743.
Slemenda CW, Christian JC, Williams CJ, Norton J & Johnston CC Jr (1991) Genetic determinants of bone mass in adult women; a re-evaluation of the model and the potential importance of gene interaction on heritability estimates. Journal of Bone and Mineral Research 6, 561567.
Smith DM, Nance WE, Kang KW, Christian J & Johnston CC Jr (1973) Genetic factors in determining bone mass. Journal of Clinical Investigation 52, 28002808.
Soroko SB, Barrett-Connor E, Edelstein S & Kritz-Siverstein D (1994) Family history of osteoporosis and bone mineral density at the axial skeleton: The Rancho Bernardo study. Journal of Bone and Mineral Research 9, 761769.
Spector TD, Keen RW, Arden NK, Major PJ, Baker JR, Monison NA, Nguyen TV, Kelly PJ, Sambrook PN, Lanchbury J & Eisman JA (1995) Vitamin D receptor gene (VDR) alleles and bone density in post menopausal women; a UK twin study. British Medical Journal 310, 13571360.
Spotila LD, Colige A, Sereda L, Constantinou-Deltas CD, Whyte MP, Riggs BL, Shaker JL, Spector TD, Hume E, Olsen N, Attie M, Tenenhouse A, Shane E, Briney W & Prockop DJ (1994) Mutation analysis of coding sequences for type I procollagen in individuals with low bone density. Journal of Bone and Mineral Research 9, 923932.
Spotila LD, Constantinou CD, Sereda L, Ganguly A, Riggs B & Prockop DJ (1991) Mutation in a gene for type I procollagen (COL1A2) in a woman with postmenopausal osteoporosis: Evidence for phenotypic and genotypic overlap with mild osteogenesis imperfecta. Proceedings of the National Academy of Sciences USA 88, 54235427.
Tamai M, Yokouchi M, Mochizuki K, Hidaka S, Narita S, Inoue A & Itoh K (1997) Correlation between vitamin D receptor genotypes and bone mineral density in Japanese patients with osteoporosis. Calcified Tissue International 60, 229232.
Taylor JA, Hirvonen A, Watson M, Pittman G, Mohler J & Bell DA (1996) Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Research 56, 41084110.
Teegarden D, Proulx WR, Martin BR, Zhao J, McCabe GP, Lyle RM, Peacock M, Slemenda C, Johnston C & Weaver CM (1995) Peak bone mass in young women. Journal of Bone and Mineral Research 10, 711715.
Tokita A, Kelly PJ, Nguyen TV, Qi J-C, Morrison NA, Risteli L, Risteli J, Sambrook P & Eisman JA (1994) Genetic determinants of type I collagen synthesis and degradation: Further evidence for genetic regulation of bone turnover. Journal of Clinical Endocrinology and Metabolism 78, 14611466.
Tokita A, Matsumoto H, Morrison NA, Tawa T, Miura Y, Fukamauchi K, Mitsuhashi N, Irimoto M, Yamamori S, Miura M, Watanabe T, Kuwabara Y, Yabuta K & Eisman JA (1996) Vitamin D receptor alleles, bone mineral density and turnover in premenopausal Japanese women. Journal of Bone and Mineral Research 11, 10031009.
Uitterlinden AG, Pols HAP, Burger H, van Daele PLA, van Duijn CM, Hofman A, Birkenhager J & van Leeuwen JPTM (1996) Haplotypes at the vitamin D receptor gene locus are associated with bone mineral density. Journal of Bone and Mineral Research 11, 12411248.
Vandevyver C, Wylin T, Cassiman JJ, Raus J & Geusens P (1997) Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. Journal of Bone and Mineral Research 12, 241247.
Wishart JM, Horowitz M, Need AG, Scopacasa F, Moms HA, Clifton P & Nordin BEC (1997) Relations betwen calcium intake, calcitriol, polymorphisms of the vitamin D receptor gene, and calcium absorption in premenopausal women. American Journal of Clinical Nutrition 65, 798802.
Yamagata Z, Miyamura T, Iijima S, Asaka A, Sasaki M, Kato J & Koizumi K (1994) Vitamin D receptor gene polymorphism and bone mineral density in healthy Japanese women. Lancet 344, 102.
Young D, Hopper JL, Nowson CA, Green RM, Sherwin AJ, Kaymacki B, Smid M, Guest CS, Larkins R & Wark JD (1995) Determinants of bone mass in 10- to 26-year old females: A twin study. Journal of Bone and Mineral Research 10, 558567.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 29 *
Loading metrics...

Abstract views

Total abstract views: 57 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 23rd October 2017. This data will be updated every 24 hours.