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Glycaemic index, appetite and body weight

  • Heather Ford (a1) and Gary Frost (a1)
Abstract

Much interest has been focused on the relationship between glycaemic index and body-weight loss, some of which is fuelled by popular media. However, there is a number of potential mechanisms that could be triggered by reducing the glycaemic index of the carbohydrate consumed in the diet. For example, the effect of foods on the gastrointestinal tract and the effect on blood glucose both could lead to potential appetite effects. Acute meal studies seem to point to an effect of glycaemic index on appetite regulation. However, the results of longer-term studies of weight loss are not as clear. In the present review a possible reason for this variation in outcome from the weight-loss studies will be discussed. The present review focuses on the possibility that the fermentable fibre content of the low-glycaemic-index diet may be important in weight-loss efficacy. A novel receptor that binds SCFA, the products of carbohydrate fermentation, has recently been described on the enteroendocrine L-cell in the colon. This cell releases a number of anorectic hormones and could offer an explanation of the appetite suppressant effects of fermentable carbohydrates. It could also explain the variability in the results of glycaemic-index weight-loss studies.

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Corresponding author
*Corresponding author: Professor Gary Frost, fax +44 20 8383 8320, email g.frost@imperial.ac.uk
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2. D Thomas & EJ Elliott (2009) Low glycaemic index, or low glycaemic load, diets for diabetes mellitus. Cochrane Database of Systematic Reviews 2009, issue 1, CD006296. Chichester, West Sussex: John Wiley and Sons, Ltd.

3. G Livesey (2005) Low-glycaemic diets and health: implications for obesity. Proc Nutr Soc 64, 105113.

4. DE Thomas , EJ Elliott & L Baur (2007) Low glycaemic index or low glycaemic load diets for overweight and obesity. Cochrane Database of Systematic Reviews 2007, issue 3, CD005105. Chichester, West Sussex: John Wiley and Sons, Ltd.

5. J Mann , JH Cummings , HN Englyst (2007) FAO/WHO scientific update on carbohydrates in human nutrition: conclusions. Eur J Clin Nutr 61, Suppl. 1, S132S137.

6. S Kelly , G Frost , V Whittaker (2004) Low glycaemic index diets for coronary heart disease. Cochrane Database of Systematic Reviews 2004, issue 4, CD004467. Chichester, West Sussex: John Wiley and Sons, Ltd.

7. GH Anderson & D Woodend (2003) Effect of glycemic carbohydrates on short-term satiety and food intake. Nutr Rev 61, S17S26.

8. JM Warren , CJ Henry & V Simonite (2003) Low glycemic index breakfasts and reduced food intake in preadolescent children. Pediatrics 112, e414.

9. FR Bornet , AE Jardy-Gennetier , N Jacquet (2007) Glycaemic response to foods: impact on satiety and long-term weight regulation. Appetite 49, 535553.

10. LM Aston , CS Stokes & SA Jebb (2008) No effect of a diet with a reduced glycaemic index on satiety, energy intake and body weight in overweight and obese women. Int J Obes (Lond) 32, 160165.

11. CJ Henry , HJ Lightowler & CM Strik (2007) Effects of long-term intervention with low- and high-glycaemic-index breakfasts on food intake in children aged 8–11 years. Br J Nutr 98, 636640.

12. F Brouns , I Bjorck , KN Frayn (2005) Glycaemic index methodology. Nutr Res Rev 18, 145171.

14. M Lerer-Metzger , SW Rizkalla , J Luo (1996) Effects of long-term low-glycaemic index starchy food on plasma glucose and lipid concentrations and adipose tissue cellularity in normal and diabetic rats. Br J Nutr 75, 723732.

15. DB Pawlak , JA Kushner & DS Ludwig (2004) Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet 364, 778785.

16. PW So , WS Yu , YT Kuo (2007) Impact of resistant starch on body fat patterning and central appetite regulation. PLoS ONE 2, e1309.

17. G Frost , B Keogh , D Smith (1996) The effect of low-glycemic carbohydrate on insulin and glucose response in vivo and in vitro in patients with coronary heart disease. Metabolism 45, 669672.

18. G Frost , A Leeds , G Trew (1998) Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic diet. Metabolism 47, 12451251.

19. C Bouche , SW Rizkalla , J Luo (2002) Five-week, low-glycemic index diet decreases total fat mass and improves plasma lipid profile in moderately overweight nondiabetic men. Diabetes Care 25, 822828.

20. SB Eaton , SB Eaton 3rd & MJ Konner (1997) Paleolithic nutrition revisited: a twelve-year retrospective on its nature and implications. Eur J Clin Nutr 51, 207216.

21. PN Appleby , M Thorogood , JI Mann (1998) Low body mass index in non-meat eaters: the possible roles of animal fat, dietary fibre and alcohol. Int J Obes Relat Metab Disord 22, 454460.

22. DS Ludwig , MA Pereira , CH Kroenke (1999) Dietary fiber, weight gain, and cardiovascular disease risk factors in young adults. JAMA 282, 15391546.

23. G Maskarinec , Y Takata , I Pagano (2006) Trends and dietary determinants of overweight and obesity in a multiethnic population. Obesity (Silver Spring) 14, 717726.

24. LH Nelson & LA Tucker (1996) Diet composition related to body fat in a multivariate study of 203 men. J Am Diet Assoc 96, 771777.

25. D Kromhout , B Bloemberg , JC Seidell (2001) Physical activity and dietary fiber determine population body fat levels: the Seven Countries Study. Int J Obes Relat Metab Disord 25, 301306.

28. LA Tucker & KS Thomas (2009) Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr 139, 576581.

29. PD Cani , C Dewever & NM Delzenne (2004) Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats. Br J Nutr 92, 521526.

30. SA Abrams , IJ Griffin , KM Hawthorne (2007) Effect of prebiotic supplementation and calcium intake on body mass index. J Pediatr 151, 293298.

31. F Backhed , H Ding , T Wang (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101, 1571815723.

32. RE Ley , PJ Turnbaugh , S Klein (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444, 10221023.

33. PJ Turnbaugh , RE Ley , MA Mahowald (2006) An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 10271031.

34. RE Ley , F Backhed , P Turnbaugh (2005) Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102, 1107011075.

35. B Kleessen , L Hartmann & M Blaut (2001) Oligofructose and long-chain inulin: influence on the gut microbial ecology of rats associated with a human faecal flora. Br J Nutr 86, 291300.

37. A Cresci , C Orpianesi , S Silvi (1999) The effect of sucrose or starch-based diet on short-chain fatty acids and faecal microflora in rats. J Appl Microbiol 86, 245250.

38. PD Cani , CA Daubioul , B Reusens (2005) Involvement of endogenous glucagon-like peptide-1(7–36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats. J Endocrinol 185, 457465.

39. KR Freeland , C Wilson & TM Wolever (2010) Adaptation of colonic fermentation and glucagon-like peptide-1 secretion with increased wheat fibre intake for 1 year in hyperinsulinaemic human subjects. Br J Nutr 103, 8290; Epublication 7 August 2009.

40. E Le Poul , C Loison , S Struyf (2003) Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem 278, 2548125489.

41. S Karaki , R Mitsui , H Hayashi (2006) Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine. Cell Tissue Res 324, 353360.

42. SI Karaki , H Tazoe , H Hayashi (2008) Expression of the short-chain fatty acid receptor, GPR43, in the human colon. J Mol Histol 39, 135142; Epublication 27 Sep 2007.

43. AJ Brown , SM Goldsworthy , AA Barnes (2003) The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem 278, 1131211319.

44. H Ge , X Li , J Weiszmann (2008) Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. Endocrinology 149, 45194526.

45. M Druce & SR Bloom (2006) The regulation of appetite. Arch Dis Child 91, 183187.

46. B Olivan , J Teixeira , M Bose (2009) Effect of weight loss by diet or gastric bypass surgery on peptide YY3–36 levels. Ann Surg 249, 948953.

47. PD Cani , S Hoste , Y Guiot (2007) Dietary non-digestible carbohydrates promote L-cell differentiation in the proximal colon of rats. Br J Nutr 98, 3237.

49. HJ Willis , AL Eldridge , J Beiseigel (2009) Greater satiety response with resistant starch and corn bran in human subjects. Nutr Res 29, 100105.

50. PD Cani , E Joly , Y Horsmans (2006) Oligofructose promotes satiety in healthy human: a pilot study. Eur J Clin Nutr 60, 567572.

52. JA Parnell & RA Reimer (2009) Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr 89, 17511759.

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