Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
Hostname: page-component-55597f9d44-54jdg Total loading time: 0.524 Render date: 2022-08-19T15:38:27.086Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "useNewApi": true } hasContentIssue true
  • English
Proceedings of the Nutrition Society Proceedings of the Nutrition Society

Article contents

Human and clinical perspectives on leptin

Published online by Cambridge University Press:  28 February 2007

Werner F. Blum ,
Piera Englaro ,
Andrea M. Attanasio ,
Wieland Kiess  and
Wolfgang Rascher
Werner F. Blum*
Affiliation:
University Children's Hospital, Giessen, Germany Lilly Deutschland GmbH, Saalburgstr. 153, D-61350 Bad Homburg, Germany
Piera Englaro
Affiliation:
University Children's Hospital, Giessen, Germany
Andrea M. Attanasio
Affiliation:
Lilly Deutschland GmbH, Saalburgstr. 153, D-61350 Bad Homburg, Germany
Wieland Kiess
Affiliation:
University Children's Hospital, Leipzig, Germany
Wolfgang Rascher
Affiliation:
University Children's Hospital, Giessen, Germany
*
*Corresponding author: Dr Werner F. Blum, fax +49 6172 273 427, email Blum_Werner@Lilly.com
Rights & Permissions[Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Simposium on ‘Leptin: energy regulation and beyond’
Information
Proceedings of the Nutrition Society , Volume 57 , Issue 3 , August 1998 , pp. 477 - 485
Copyright
Copyright © The Nutrition Society 1998

References

Ahima, RS, Dushay, J, Flier, SN, Prabakaran, D & Flier, JS (1997) Leptin accelerates the onset of puberty in normal female mice. Journal of Clinical Investigation 99, 391–395.CrossRefGoogle ScholarPubMed
Ahima, RS, Prabakaran, D, Mantzoros, C, Qu, D, Lowell, B, Maratos-Flier, E & Flier, JS (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382, 250–252.CrossRefGoogle Scholar
Attanasio, AHF, Blum, WF, Englaro, P, Birkett, M, Kiess, W, Rascher, W & Lamberts, SWJ (1996) Effect of growth hormone replacement therapy on serum leptin concentrations in adult growth hormone deficient subjects. 4th International Pituitary Congress, San Diego, p. 24 Abstr.Google Scholar
Barash, IA, Cheung, CC, Weigle, DS, Ren, H, Kabigting, EB, Kuijper, JL, Clifton, DK & Steiner, RA (1996) Leptin is a metabolic signal to the reproductive system. Endocrinology 137, 3144–3147.CrossRefGoogle ScholarPubMed
Blum, WF, Englaro, P, Hanitsch, S, Juul, A, Hertel, NT, Skakkebaek, NE, Birkett, M, Heiman, M, Attanasio, A, Kiess, W & Rascher, W (1997 a) Serum leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. Journal of Clinical Endocrinology and Metabolism 82, 2904–2910.Google Scholar
Blum, WF, Englaro, P, Schmitt, K, Kiess, W, Rascher, W & Ranke, MB (1997 b) Marked and rapid changes of serum leptin levels during fasting and refeeding in humans. Experimental and Clinical Endocrinology and Diabetes 105, Suppl. 1, 34–35 Abstr.Google Scholar
Blum, WF, Jorgensen, JOL, Englaro, P, Heiman, M, Attanasio, A, Kiess, W, Christiansen, JS & Rascher, W (1997 c) Nocturnal serum leptin increases after short-term but not during long-term treatment with growth hormone. Endocrinology and Metabolism 4, Suppl. A, 22 Abstr.Google Scholar
Blum, WF & Juul, A (1997) Reference ranges of serum leptin levels according to body mass index, gender, and developmental stage. In Leptin – The Voice of Adipose Tissue, pp. 318–326 [Blum, WF, Kiess, W and Rascher, W, editors]. Heidelberg: J.A. Barth Verlag.Google ScholarPubMed
Campfield, LA & Smith, FJ (1998) Overview: neurobiology of OB protein (leptin). Proceedings of the Nutrition Society 57, 429–440.CrossRefGoogle Scholar
Caro, JF, Kolaczynski, JW, Nyce, MR, Ohannesian, JP, Opentanova, I, Goldman, WH, Lynn, RB, Zhang, PL, Sinha, MK & Considine, RV (1996) Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 348, 159–161.CrossRefGoogle ScholarPubMed
Carro, E, Senaris, R, Considine, RV, Casanueva, FF & Dieguez, C (1997) Regulation of in vivo growth hormone secretion by leptin. Endocrinology 138, 2203–2205.CrossRefGoogle ScholarPubMed
Chehab, FF, Lim, ME & Lu, R (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genetics 12, 318–320.CrossRefGoogle ScholarPubMed
Chehab, FF, Mounzih, K, Lu, R & Lim, ME (1997) Early onset of reproductive function in normal female mice treated with leptin. Science 275, 88–90.CrossRefGoogle ScholarPubMed
Cheung, CC, Thornton, JE, Kuijper, JL, Weigle, DS, Clifton, DK & Steiner, RA (1997) Leptin is a metabolic gate for the onset of puberty in the female rat. Endocrinology 138, 855–858.CrossRefGoogle ScholarPubMed
Clayton, PE, Gill, MS, Hall, CM, Tillmann, V, Whatmore, AJ & Price, DA (1997) Serum leptin through childhood and adolescence. Clinical Endocrinology 46, 727–733.CrossRefGoogle ScholarPubMed
Clément, K, Vaisse, C, Lahlou, N, Cabrol, S, Pelloux, V, Cassuto, D, Gourmelen, M, Dina, C, Chambaz, J, Lacorte, J-M, Basdevant, A, Bougnéres, P, Lebouc, Y, Froguel, P & Guy-grand, B (1998) A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 392, 398–401.Google ScholarPubMed
Coleman, DL & Hummel, KP (1969) Effects of parabiosis of normal with genetically diabetic mice. American Journal of Physiology 217, 1298–1304.Google ScholarPubMed
Considine, RV, Sinha, MK, Heiman, ML, Kriauciunas, A, Stephens, TW, Nyce, MR, Ohannesian, JP, Marco, CC, Mckee, LJ, Bauer, TL & Caro, JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292–295.CrossRefGoogle ScholarPubMed
Corbetta, S, Englaro, P, Giambona, S, Persani, L, Blum, WF & Beck-peccoz, P (1997) Lack of effects of circulating thyroid hormone levels on serum leptin concentrations. European Journal of Endocrinology 137, 659–663.CrossRefGoogle ScholarPubMed
Daschner, M, Tönshoff, B, Blum, WF, Englaro, P, Wingen, A-M, Schaefer, F, Rascher, W & Mehls, O (1998) Inappropriate elevation of serum leptin levels in children with chronic renal failure. Journal of the American Society of Nephrology (In the Press).Google ScholarPubMed
De-vos, P, Saladin, R, Auwerx, J & Staels, B (1995) Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. Journal of Biological Chemistry 270, 15958–15961.CrossRefGoogle Scholar
Donahoo, WT, Jensen, DR, Yost, TJ & Eckel, RH (1997) Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. Journal of Clinical Endocrinology and Metabolism 82, 4139–4143.Google ScholarPubMed
Eiholzer, U, Gisin, R, Englaro, P, Blum, WF, Rascher, W, Steinert, H, Torresani, T & Prader, A (1997) Fat mass and plasma concentrations of leptin, insulin, IGF-I and IGF-binding proteins in Prader-Willi syndrome. Hormone Research 48, Suppl. 2, 51 Abstr.Google Scholar
Elbers, JMH, Asscheman, H, Seidell, JC, Frölich, M, Meinders, AE & Gooren, LJG (1997) Reversal of the sex difference in serum leptin levels upon cross-sex hormone administration in transsexuals. Journal of Clinical Endocrinology and Metabolism 82, 3267–3270.Google ScholarPubMed
Frederich, RC, Hamann, A, Anderson, S, Lollmann, B, Lowell, BB & Flier, JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nature Medicine 1, 1311–1314.CrossRefGoogle ScholarPubMed
Frisch, RE (1980) Pubertal adipose tissue: is it necessary for normal sexual maturation? Federation Proceedings 39, 2395–2400.Google ScholarPubMed
Gong, DW, Bi, S, Pratley, RE & Weintraub, BD (1996) Genomic structure and promoter analysis of the human obese gene. Journal of Biological Chemistry 271, 3971–3974.CrossRefGoogle ScholarPubMed
Grunfeld, C, Zhao, C, Fuller, J, Pollack, A, Moser, A, Friedman, J & Feingold, KR (1996) Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. Journal of Clinical Investigation 97, 2152–2157.CrossRefGoogle ScholarPubMed
Halaas, JL, Gajiwala, KS, Maffei, M, Cohen, SL, Chait, BT, Rabinowitz, D, Lallone, RL, Burley, SK & Friedman, JM (1995) Weightreducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546.CrossRefGoogle ScholarPubMed
Harris, RB, Ramsay, TG, Smith, SR & Bruch, RC (1996) Early and late stimulation of ob mRNA expression in meal-fed and overfed rats. Journal of Clinical Investigation 97, 2020–2026.CrossRefGoogle Scholar
Hausberger, FX (1958) Parabiosis and transplantation experiments in hereditarily obese mice. Anatomical Record 130, 313.Google Scholar
Hebebrand, J, Blum, WF, Barth, N, Coners, H, Englaro, P, Juul, A, Ziegler, A, Warnke, A, Rascher, W & Remschmidt, H (1997) Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration. Molecular Psychiatry 2, 330–334.CrossRefGoogle ScholarPubMed
Hervey, GR (1959) The effects of lesions in the hypothalamus in parabiotic rats. Journal of Physiology 145, 336–352.CrossRefGoogle ScholarPubMed
Hickey, MS, Israel, RG, Gardiner, SN, Considine, RV, Mccammon, MR, Tyndall, GL, Houmard, JA, Marks, RHL & Caro, JF (1996) Gender difference in serum leptin levels in humans. Biochemical and Molecular Medicine 59, 1–6.CrossRefGoogle ScholarPubMed
Horn, R, Geldszus, R, Pötter, E, von zur Mühlen, A & Brabant, G (1996) Radioimmunoassay for the detection of leptin in human serum. Experimental and Clinical Endocrinology and Diabetes 104, 454–458.CrossRefGoogle ScholarPubMed
Janik, JE, Curti, BD, Rager, HC, Powers, GC, Alvord, WG, Smith, JW II, Gause, BL & Kopp, WC (1997) Interleukin lalpha increases serum leptin concentrations in humans. Journal of Clinical Endocrinology and Metabolism 82, 3084–3086.Google Scholar
Jockenhövel, F, Blum, WF, Vogel, E, Englaro, P, Müller-Wieland, D, Reinwein, D, Rascher, W & Krone, W (1997) Testosterone substitution normalizes elevated leptin serum levels in hypogonadal men. Journal of Clinical Endocrinology and Metabolism 82, 2510–2513.CrossRefGoogle ScholarPubMed
Kennedy, GC (1953) The role of depot fat in the hypothalamic control of food intake in the rat. Proceedings of the Royal Society 140, 578–592.CrossRefGoogle ScholarPubMed
Kiess, W, Anil, M, Blum, WF, Englaro, P, Juul, A, Attanasio, A, Dötsch, J & Rascher, W (1998) Serum leptin levels in children and adolescents with insulin-dependent diabetes mellitus in relation to metabolic control and body mass index. European Journal of Endocrinology 138, 501–509.CrossRefGoogle ScholarPubMed
Kiess, W, Englaro, P, Rascher, W, Blum, WF (1996) High leptin concentrations in serum of very obese children are further stimulated by dexamethasone. Hormone and Metabolic Research 28, 708–710.CrossRefGoogle ScholarPubMed
Kolaczynski, JW, Considine, RV, Ohannesian, J, Marco, C, Opentanova, I, Nyce, MR, Myint, M & Caro, JF (1996 a) Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves. Diabetes 45, 1511–1515.CrossRefGoogle Scholar
Kolaczynski, JW, Nyce, MR, Considine, RV, Boden, G, Nolan, JJ, Henry, R, Mudaliar, SR, Olefsky, J & Caro, JF (1996 b) Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45, 699–701.CrossRefGoogle ScholarPubMed
Kolaczynski, JW, Ohannesian, J, Considine, RV, Marco, C, Caro, JF (1996 c) Response of leptin to short-term and prolonged over-feeding in humans. Journal of Clinical Endocrinology and Metabolism 91, 4162–4165.Google Scholar
Köpp, W, Blum, WF, von prittwitz, S, Ziegler, A, Lüibbert, H, Emons, G, Herzog, W, Deter, H-C, Remschmidt, H & Hebebrand, J (1997) Low leptin levels predict amenorrhea in underweight and eating disordered females. Molecular Psychiatry 2, 335–340.CrossRefGoogle ScholarPubMed
Laron, Z, Silbergeld, A & Blum, WF (1997) Serum leptin levels in untreated and IGF-I treated patients with Laron syndrome. 79th Annual Meeting of the Endocrine Society, Minneapolis, p. 471 Abstr.Google Scholar
Ma, Z, Gingerich, RL, Santiago, JV, Smith, CH & Landt, M (1996) Radioimmunoassay of leptin in human plasma. Clinical Chemistry 42, 942–946.Google ScholarPubMed
Maffei, M, Halaas, J, Ravussin, E, Pratley, RE, Lee, GH, Zhang, Y, Fei, H, Kim, S, Lallone, R, Kern, PA & Friedman, JM (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1, 1155–1161.CrossRefGoogle ScholarPubMed
Malström, R, Taskinen, M-R, Karonen, S-L & Yki-järvinen, H (1996) Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39, 993–996.CrossRefGoogle Scholar
Mantzoros, CS, Flier, JS & Rogol, AD (1997) A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. Journal of Clinical Endocrinology and Metabolism 82, 1066–1070.Google ScholarPubMed
Miell, JP, Englaro, P & Blum, WF (1996) Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Hormone and Metabolic Research 28, 704–707.CrossRefGoogle ScholarPubMed
Moinat, M, Deng, C, Muzzin, P, Assimacopoulos-jeannet, F, Seydoux, J, Dulloo, AG & Giacobino, JP (1995) Modulation of obese gene expression in rat brown and white adipose tissues. FEBS Letters 373, 131–134.CrossRefGoogle Scholar
Montague, CT, Farooqi, IS, Whitehead, JP, Soos, MA, Rau, H, Wareham, NJ, Sewter, CP, Digby, JE, Mohammedi, SN, Hurst, JA, Cheetham, CH, Earley, AR, Barnett, AH, Prins, JB & O'Rahilly, S (1997) Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903–908.CrossRefGoogle ScholarPubMed
Pagano, C, Macor, C, Englaro, P, Granzotto, M, Rella, E, Novo, F, Sagillo, E, Blum, WF & Vettor, R (1997) Does insulin regulate leptin? Studies in rats and humans. In Leptin — The Voice of Adipose Tissue, pp. 83–92 [Blum, WF, Kiess, W and Rascher, W, editors]. Heidelberg: J.A. Barth Verlag.Google Scholar
Pierroz, DD, Heritier, A, Lalaoui, M, d'Allèves, V, Blum, WF & Aubert, ML (1997) Leptm is a metabolic signal for sexual function: reciprocal changes in plasma leptin and arcuate nucleus NPY mRNA in two models with adverse metabolic conditions with hypogonadism. 79th Annual Meeting of the Endocrine Society, Minneapolis, p. 99 Abstr.Google Scholar
Rauch, F, Westermann, F, Englaro, P, Blum, WF & Schöonau, E (1997) Serum Ieptin during growth hormone therapy in growth hormone deficient children. Hormone Research 48, Suppl. 2, 55 Abstr.Google Scholar
Saad, MF, Damani, S, Gingerich, RL, Riad-gabriel, MG, Khan, A, Boyadjiani, R, Jinagouda, SD, El-tawil, K, Rude, RK & Kamdar, V (1997) Sexual dimorphism in plasma leptin concentration. Journal of Clinical Endocrinology and Metabolism 82, 579–584.Google ScholarPubMed
Saladin, R, De-vos, P, Guerre-millo, M, Leturque, A, Girard, J, Staels, B & Auwerx, J (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377, 527–529.CrossRefGoogle ScholarPubMed
Scholz, GH, Englaro, P, Thiele, I, Scholz, M, Klusman, T, Kellner, K, Rascher, W & Blum, WF (1996) Dissociation of serum leptin concentration and body fat content during long term dietary intervention in obese individuals. Hormone and Metabolic Research 28, 718–723.CrossRefGoogle ScholarPubMed
Schwartz, MW, Seeley, RJ, Campfield, LA, Burn, P & Baskin, DG (1996) Identification of targets of leptin action in rat hypothalamus. Journal of Clinical Investigation 98, 1101–1106.CrossRefGoogle ScholarPubMed
Sinha, MK, Ohannesian, JP, Heiman, ML, Kriauciunas, A, Stephens, TW, Magosin, S, Marco, C & Caro, JF (1996) Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. Journal of Clinical Investigation 97, 1344–1347.CrossRefGoogle ScholarPubMed
Slieker, LJ, Sloop, KW, Surface, PL, Kriauciunas, A, LaQuier, F, Manetta, J, Bue-Valleskey, J & Stephens, TW (1996) Regulation of expression of ob mRNA and protein by glucocorticoids and CAMP. Journal of Biological Chemistry 271, 5301–5304.CrossRefGoogle Scholar
Stephens, TW, Basinski, M, Bristow, PK, Bue-valleskey, JM, Burgett, SG, Craft, L, Hale, J, Hoffmann, J, Hsiung, HM, Kriauciunas, A, Mackeller, W, Rosteck, PR, Schöner, B, Smith, D, Tinsley, FC, Zhang, YY & Heiman, M (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377, 530–532.CrossRefGoogle ScholarPubMed
Tanner, JM & Whitehouse, RH (1976) Clinical longitudinal standards for height, weight, height velocity, weight velocity and stages of puberty. Archives of Disease in Childhood 51, 170–179.CrossRefGoogle ScholarPubMed
Vettor, R, De pergola, G, Pagano, C, Englaro, P, Laudadio, E, Giorgino, F, Blum, WF, Giorgino, R & Federspil, G (1997) Relationship between serum leptin and testosterone in obese men. In Leptin — The Voice of Adipose Tissue, pp. 237–245 [Blum, WF, Kiess, W and Rascher, W, editors]. Heidelberg: J.A. Barth Verlag.Google Scholar
Vuagnat, BAM, Pierroz, DD, Lalaoui, M, Englaro, P, Pralong, FP, Blum, WF & Aubert, ML (1998) Evidence for a leptinneuropeptide Y axis for the regulation of growth hormone secretion in the rat. Neuroendocrinology 67, 291–300.CrossRefGoogle Scholar
Wabitsch, M, Blum, WF, Muche, R, Braun, M, Hube, F, Rascher, W, Heinze, E, Teller, W & Hauner, H (1997) Contribution of androgens to the gender difference in leptin production in obese children and adolescents. Journal of Clinical Investigation 100, 808–813.CrossRefGoogle ScholarPubMed
Wabitsch, M, Jensen, PB, Blum, WF, Christoffersen, CT, Englaro, P, Heinze, E, Rascher, W, Teller, W, Tornqvist, H & Hauner, H (1996) Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45, 1435–1438.CrossRefGoogle ScholarPubMed
Zhang, Y, Proenca, R, Maffei, M, Barone, M, Leopold, L & Friedman, JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–432.CrossRefGoogle ScholarPubMed
Zumbach, MS, Boehme, MWJ, Wahl, P, Stremmel, W, Ziegler, R & Nawroth, PP (1997) Tumor necrosis factor increases serum leptin levels in humans. Journal of Clinical Endocrinology and Metabolism 82, 4080–4082.CrossRefGoogle ScholarPubMed
You have Access
30
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Human and clinical perspectives on leptin
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Human and clinical perspectives on leptin
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Human and clinical perspectives on leptin
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *