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Is there a potential therapeutic value of copper and zinc for osteoporosis?

  • Nicola M Lowe (a1), William D Fraser (a2) and Malcolm J Jackson (a3)

Osteoporosis is almost universal in very old age, and is a major cause of morbidity and mortality in the elderly of both sexes. Bone is lost at a rate of 0·2–0·5 %/year in both men and women after the age of 40–45 years. The causes of age-related changes in bone mass are multifactorial and include genetic predisposition, nutritional factors, endocrine changes, habitual exercise levels and body weight. Bone loss is accelerated to 2–5 % year immediately before and for up to 10 years post-menopause (Heaney, 1986). In women hormone-replacement therapy is effective in reducing the rate of bone loss caused by this peri-menopausal decrease in hormone levels (Smith & Studd, 1993); however, in men and older women (>10 years post-menopause) nutrition plays a key role in the rate of bone loss. One factor contributing to bone loss in the elderly may be a subclinical Zn and/or Cu deficiency, due to a reduced dietary intake of micronutrients and reduced absorption (Thomson & Keelan, 1986). Zn and Cu are essential cofactors for enzymes involved in the synthesis of various bone matrix constituents. Paradoxically, Ca supplementation may accentuate the problem of reduced Zn and Cu levels by impairing the absorption of simultaneously-ingested Zn and the retention of Cu (Snedeker et al. 1982; Grekas et al. 1988). The present paper will review the current literature on the potential benefits of Cu and Zn supplementation in reducing bone loss, and present new information on the effect of Ca supplementation on Zn and Cu status in post-menopausal women with osteoporosis.

Corresponding author
*Dr Nicola Lowe, fax +44 1772 892929, email
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OS Atik (1983) Zinc in senile osteoporosis. Journal of the American Geriatrics Society 31 790791.

D Conlan , R Korula & D Tallentire , (1990) Serum copper levels in elderly patients with femoral-neck fractures Age and Ageing 19, 212214.

M Delmi , C-H Rapin , J-M Bengoa , PD Delmas , H Vasey & J-P Bonjour , (1990) Dietary supplementation in elderly patients with fractured neck of femur. Lancet 335, 10131016.

J Eberle , S Schindmayer , RG Erben , M Stangassinger & HP Roth , (1999) Skeletal effects of zinc deficiency in growing rats. Journal of Trace Elements in Medicine and Biology 13, 2126.

Guigliano & DJ Milward , (1984) Growth and zinc homeostasis in the severely zinc deficient rat. British Journal of Nutrition 52, 545560.

TR Helliwell , SA Kelly , HPJ Walsh , L Klenerman , J Haines , R Clark & NB Roberts , (1996) Elemental analysis of femoral bone from patients with fractured neck of femur or osteoarthritis Bone 18, 151157.

S Kishi & M Yamaguchi , (1994) Inhibitory effect of zinc compounds on osteoclast-like cell formation in mouse marrow cultures. Biochemical Pharmacology 48, 12251230.

NM Lowe , I Bremner & MJ Jackson , (1991) Plasma65Zn kinetics in the rat. British Journal of Nutrition 65, 445455.

TDB Lyon , GS Fell , D Gaffney , BA McGaw , RI Russell , RHR Park , AD Beattie , G Curry , RJ Crofton , I Gunn , GS Sturniolo , R D'Inca & M Patriarca , (1995) Use of stable copper isotope (65Cu) in the differential diagnosis of Wilson's disease. Clinical Science 88, 727732.

A Pecoud , P Donzel & JL Schelling , (1975) Effect of foodstuffs on the absorption of zinc sulphates. Clinical Pharmacology and Therapeutics 17, 469474.

P Relea , M Revilla , E Ripoll , I Arribas , LF Villa & H Rico , (1995) Zinc, biochemical markers of nutrition and type 1 osteoporosis. Age and Ageing 24, 303307.

H Rico , (1991) Minerals and osteoporosis Osteoporosis International 2, 2025.

PD Saltman & LG Strause , (1993) The role of trace minerals in osteoporosis. Journal of the American College of Nutrition 12, 384389.

JJ Strain , (1988) A reassessment of diet and osteoporosis: possible role of copper. Medical Hypotheses 27, 333338.

ABR Thomson & M Keelan , (1986) The aging gut. Canadian Journal of Physiology and Pharmacology 64, 3038.

M Yamaguchi , (1995) β-Alanyl-L-histidinato zinc and bone resorption. General Pharmacology 26, 11791183.

M Yamaguchi , (1998) Role of zinc in bone formation and bone resorption. Journal of Trace Elements in Experimental Medicine 11, 119135.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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