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Kill and cure: dietary augmentation of immune defences against colon cancer

Published online by Cambridge University Press:  28 February 2007

Fiona Armstrong*
Affiliation:
Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
J. C. Mathers
Affiliation:
Human Nutrition Research Centre, Department of Biological and Nutritional Sciences, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
*
*Corresponding author: Ms Fiona Armstrong, fax +44 (0) 191 222 8684, email fiona.armstrong@ncl.ac.uk
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Abstract

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At its most fundamental, cancer is a genetic disease resulting from inherited or acquired mutations in tumour suppressor genes and proto-oncogenes. Environmental factors, including ingested food components, interact with genetic inheritance to determine individual cancer risk. There is growing evidence that the immune system exerts selective pressure during neoplastic development. Tumour cells that evade this immunosurveillance because they are non-antigenic or because they defend themselves successfully against immune attack have a survival advantage. Effective chemopreventative agents will include dietary components that enhance the immune system’s ability to identify transformed cells and to target them for apoptosis.

Type
Postgraduate Symposium
Copyright
Copyright © The Nutrition Society 2000

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