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Micronutrients: dietary intake v. supplement use

  • Jayne V. Woodside (a1), Damian McCall (a1), Claire McGartland (a1) and Ian S. Young (a1)
Abstract

Whilst clinical deficiency of micronutrients is uncommon in the developed world, a suboptimal intake of certain micronutrients has been linked with an increased risk of chronic diseases such as CVD and cancer. Attention has therefore focused on increasing micronutrient status in order to theoretically reduce chronic disease risk. Increasing micronutrient status can involve a number of approaches: increasing dietary intake of micronutrient-rich foods; food fortification; use of supplements. Observational cohort studies have demonstrated an association between high intakes of micronutrients such as vitamin E, vitamin C, folic acid and β-carotene, and lower risk of CHD, stroke and cancer at various sites. However, randomised intervention trials of micronutrient supplements have, to date, largely failed to show an improvement in clinical end points. The discordance between data from cohort studies and the results so far available from clinical trials remains to be explained. One reason may be that the complex mixture of micronutrients found, for example, in a diet high in fruit and vegetables may be more effective than large doses of a small number of micronutrients, and therefore that intervention studies that use single micronutrient supplements are unlikely to produce a lowering of disease risk. Studies concentrating on whole foods (e.g. fruit and vegetables) or diet pattern (e.g. Mediterranean diet pattern) may be more effective in demonstrating an effect on clinical end points. The present review will consider the clinical trial evidence for a beneficial effect of micronutrient supplements on health, and review the alternative approaches to the study of dietary intake of micronutrients.

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Corresponding author
* Corresponding author: Dr Jayne Woodside, fax +44 28 90235900, email j.woodside@qub.ac.uk
References
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Age-Related Eye Disease Study Research Group (2001) A randomised, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta-carotene, and zinc for age-related macular degeneration and vision loss. Archives of Ophthalmology 119, 14171436.
Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN & Manson JE (1998) Fish consumption and risk of sudden cardiac death. Journal of the American Medical Association 279, 2328.
Alpha-Tocopherol, Beta Carotene Cancer Prevention Trial Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. New England Journal of Medicine 330, 10291035.
Alpha-Tocopherol, Beta Carotene Cancer Prevention Trial Study Group (2004) Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. Journal of the American Medical Association 290, 476485.
Ambring A, Friberg P, Axelsen M, Laffrenzen M, Taskinen MR, Basu S & Johansson M (2004) Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects. Clinical Science 106, 519525.
Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM et al. . (1997) A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. New England Journal of Medicine 336, 11171124.
Aviram M & Fuhrman B (1998) Polyphenolic flavonoids inhibit macrophage-mediated oxidation of LDL and attenuate atherogenesis. Atherosclerosis 137, S45S50.
Baker F, Picton D & Blackwood S (2002) Blinded comparison of folic acid and placebo in patients with ischemic heart disease: an outcome trial. Circulation 106, II741S.
Balder HF, Goldbohm RA & van den Brandt PA (2005) Dietary patterns associated with male lung cancer risk in the Netherlands Cohort Study. Cancer Epidemiology Biomarkers and Prevention 14, 483490.
Bazzano LA, He J, Ogden LG, Loria CM, Vapputuri S, Myers L & Whelton PK (2002) Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. American Journal of Clinical Nutrition 76, 9399.
Bjelakovic G, Nikolova D, Simonetti RG & Gluud C (2004) Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis. Lancet 364, 12191228.
Boaz M, Smetana S, Weinstein T, Matas Z, Gafter U, Iaina A, Knecht A, Weissgarten Y, Brunner D, Fainaru M & Green MS (2000) Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet 356, 12131218.
Bostom AG & Garber C (2000) Endpoints for homocysteine-lowering trials. Lancet 355, 511512.
Boushey CJ, Beresford SA, Omenn GS & Motulsky AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. Journal of the American Medical Association 274, 10491057.
Brouwer IA, van Dusseldorp M, West CE, Meyboom S, Thomas CMG, Duran M, van het Hof KH, Eskes TKAB, Hautvast JGAJ & Steegers-Theunissen RPM (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial. Journal of Nutrition 129, 11351139.
Brown AJ (1963) Regional differences in coronary heart disease in Britain: do antioxidant nutrients provide the key? Asia Pacific Journal of Clinical Nutrition 2, Suppl. 1. 3336.
Brown BG & Crowley J (2005) Is there any hope for vitamin E? Journal of the American Medical Association 293, 13871390.
Caballero B (2003) Fortification, supplementation and nutrient balance. European Journal of Clinical Nutrition 57, S76S78.
Cao G, Booth SL, Sadowski JA & Prior RL (1998) Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. American Journal of Clinical Nutrition 68, 10811087.
Chopra M, O'Neill ME, Keogh N, Wortley G, Southon S & Thurnham DI (2000) Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and non-smokers. Clinical Chemistry 46, 18181829.
Daviglus ML, Stamler J, Orencia AJ, Dyer AR, Liu K, Greenland P, Walsh MK, Morris D & Shekelle RB (1997) Fish consumption and the 30-year risk of fatal myocardial infarction. New England Journal of Medicine 336, 10461053.
de Lorgeril M, Renaud S, Mamelle N, Salen P, Martin JL, Monjaud I, Guidollet J, Touboul P & Dleaye J (1994) Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease. Lancet 343, 14541459.
de Lorgeril M, Salen P, Martin J-L, Monjaud I, Boucher P & Mamelle N (1998) Mediterranean dietary pattern in a randomised trial. Prolonged survival and possible reduced cancer rate. Archives of Internal Medicine 158, 11811187.
de Lorgeril M, Salen P, Martin J-L, Monjaud I, Delaye J & Mamelle N (1999) Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction. Final report of the Lyon Diet Heart Study. Circulation 99, 779785.
de Stefani E, Boffetta P, Ronco AL, Correa P, Oreggia F, Deneo-Pellegrini H, Mendilaharsu M & Leiva J (2005) Dietary patterns and risk of cancer of the oral cavity and pharynx in Uruguay. Nutrition and Cancer 51, 132139.
Dragsted LO, Pedersen A, Hermetter A, Basu S, Hansen M, Haren GR et al. . (2004) The 6-a-day study: effects of fruit and vegetables on markers of oxidative stress and antioxidative defense in healthy non-smokers. American Journal of Clinical Nutrition 79, 10601072.
El-Kadiki A & Sutton AJ (2005) Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials. British Medical Journal 330, 871876.
Esposito K, Marfella R, Ciotola M, di Palo C, Giugliano F, Giugliano G, d'Armiento M, d'Andrea F & Giugliano D (2004) Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome. A randomised trial. Journal of the American Medical Association 292, 14401446.
Esposito K, Nappo F, Giugliano F, Giugliano G, Marfella R & Giugliano D (2003) Effect of dietary antioxidants on post-prandial endothelial dysfunction induced by a high fat meal in healthy subjects. American Journal of Clinical Nutrition 77, 139143.
Fairfield KM & Fletcher RH (2002) Vitamins for chronic disease prevention in adults. Journal of the American Medical Association 287, 31163126.
Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Hertzmark E, Essex M & Junter DJ (2004) A randomised trial of multivitamin supplements and HIV disease progression and mortality. New England Journal of Medicine 351, 2332.
Fuentes F, Lopez-Miranda J, Sanchez E, Sanchez F, Paez J, Paz-Rojas E, Marin C, Gomez P, Jimenez-Peraperez J, Ordovas JM & Perez-Jimenez F (2001) Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men. Annals of Internal Medicine 134, 11151119.
Fung TT, Hu FB, Holmes MD, Rosner BA, Hunter DJ, Colditz GA & Willett WC (2005) Dietary patterns and the risk of postmenopausal breast cancer. International Journal of Cancer 116, 116121.
Fung TT, Rimm EB, Spiegelman D, Rifai N, Tofler GH, Willett WC & Hu FB (2001) Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk. American Journal of Clinical Nutrition 73, 6167.
Gardner CD, Coulston A, Chatterjee L, Rigby A, Spiller G & Farquhar JW (2005) The effect of a plant-based diet on plasma lipids in hypercholesterolemic adults: a randomized trial. Annals of Internal Medicine 142, 725733.
GISSI-Prevenzione Trial Group (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico. Lancet 354, 447455.
Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL, Omenn GS, Valanis B, Williams JH Jr (2004) The Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements. Journal of the National Cancer Institute 96, 17431750.
Heart Protection Study Collaborative Group (2002) MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 360, 2333.
Hogg R & Chakravarthy U (2004) AMD and micronutrient antioxidants. Current Eye Research 29, 387401.
Homocysteine Studies Collaboration (2002) Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis. Journal of the American Medical Association 288, 20152022.
Hu FB (2002) Dietary pattern analysis: a new direction in nutritional epidemiology. Current Opinion in Lipidology 13, 39.
Hu FB, Rimm EB, Stampfer MJ, Ascherio A, Spiegelman D & Willett WC (2000) Prospective study of major dietary patterns and risk of coronary heart disease in men. American Journal of Clinical Nutrition 72, 912921.
Hung HC, Joshipura KJ, Jiang R, Hu FB, Hunter D, Smith-Warner SA, Colditz GA, Rosner B, Spiegelman D & Willett WC (2004) Fruit and vegetable intake and risk of major chronic disease. Journal of the National Cancer Institute 96, 15771584.
Huxley RR, Lean M, Crozier A, John JH & Neil HAW (2004) Effect of dietary advice to increase fruit and vegetable consumption on plasma flavonol concentrations: results from a randomised controlled intervention trial. Journal of Epidemiology and Community Health 58, 288289.
Johansen JS, Harris AK, Rychly DJ & Ergul A (2005) Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovascular Diabetology 4, 516.
John JH, Ziebland S, Yudkin P, Roe LS & Neil HA (2002) Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet 359, 19691974.
Joshipura KJ, Ascherio A, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Hennekens CH, Spiegelman D & Willett WC (1999) Fruit and vegetable intake in relation to risk of ischaemic stroke. Journal of the American Medical Association 282, 12331239.
Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D & Willett WC (2001) The effect of fruit and vegetable intake on risk for coronary heart disease. Annals of Internal Medicine 134, 11061114.
Kerver JM, Yang EJ, Bianchi L & Song WO (2003) Dietary patterns associated with risk factors for cardiovascular disease in healthy US adults. American Journal of Clinical Nutrition 78, 11031110.
Key TJ, Fraser GE, Thorogood M, Appleby PN, Beral V, Reeves G et al. . (1999) Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies. American Journal of Clinical Nutrition 70, 516S524S.
Kim MK, Sasaki S, Otani T & Tsugane S (2005) Dietary patterns and subsequent colorectal cancer risk by subsite: a prospective cohort study. International Journal of Cancer 115, 790798.
Knoops KTB, de Groot LCPGM, Kromhout D, Perrin A-E, Moreiras-Varela O, Menotti A & van Staveren WA (2004) Mediterranean diet, lifestyle factors, and 10-year mortality in elderly European men and women. The HALE Project. Journal of the American Medical Association 292, 14331439.
Kris-Etherton P, Eckel RH, Howard BV, St Jeor S & Bazzarre TL (2001) Lyon diet heart study. Benefits of a Mediterranean-style, national cholesterol education program/American Heart Association Step I dietary pattern on cardiovascular disease. Circulation 103, 18231825.
Lanzillotti JS & Tang AM (2005) Micronutrients and HIV disease: a review pre- and post-HAART. Nutrition and Clinical Care 8, 1623.
Leaf A (1999) Dietary prevention of coronary heart disease: the Lyon Diet Heart Study (editorial; comment). Circulation 99, 733735.
Liem AH, van Boven AJ, Veeger NJ, Withagen AJ, Robles de, Medina RM, Tijssen JG & van Veldhuisen DJ (2004) Folic Acid on Risk Diminishment After Acute Myocardial Infarction Study Group. Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction: a randomised pilot trial. International Journal of Cardiology 93, 175179.
Liu S, Manson JE, Lee I-M, Cole SR, Hennekens CH, Willett WC & Buring JE (2000) Fruit and vegetable intake and risk of cardiovascular disease: the Women's Health Study. American Journal of Clinical Nutrition 72, 922928.
Lock K, Pomerleau J, Causer L, Altmann DR & McKee M (2005) The global burden of disease attributable to low consumption of fruit and vegetables: implications for the global strategy on diet. Bulletin of the World Health Organization 83, 100108.
Lonn E, Bosch J, Yusuf S, Sheridan P, Pogue J, Arnold JM, Ross C, Arnold A, Sleight P, Probstfield J & Dagenais GR (2005) Effect of long-term vitamin E supplementation on cardiovascular events and cancer. A randomised controlled trial. Journal of the American Medical Association 293, 13381347.
Lopez-Garcia E, Schulze MB, Fung TT, Meigs JB, Rifai N, Manson JE & Hu FB (2004) Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction. American Journal of Clinical Nutrition 80, 10291035.
Michaud DS, Skinner HG, Wu K, Hu F, Giovannucci E, Willett WC, Colditz GA & Fuchs CS (2005) Dietary patterns and pancreatic cancer risk in men and women. Journal of the National Cancer Institute 97, 518524.
Miller ER, Pastor-Barriuso R, Dalal D & Riemersma RA (2005) Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of Internal Medicine 142, 3746.
MRC Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338, 131137.
Napoli C, Williams-Ignarro S, De Nigris F, Lerman LO, Rossi L, Guarino C et al. . (2004) Long-term combined beneficial effects of physical training and metabolic treatment on atherosclerosis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences USA 101, 87978802.
Ness A, Egger M & Powles J (1999) Fruit and vegetables and ischaemic heart disease: systematic review or misleading meta-analysis? European Journal of Clinical Nutrition 53, 900904.
Nigdikar SV, Williams NR, Griffin BA & Howard AN (1998) Consumption of red wine polyphenols reduces the susceptibility of LDL to oxidation in vivo. American Journal of Clinical Nutrition 8, 258265.
Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A et al. . (1996) Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. New England Journal of Medicine 334, 11501155.
Osler M, Heitmann BL, Gerdes LU, Jorgensen LM & Schroll M (2001) Dietary patterns and mortality in Danish men and women: a prospective observational study. British Journal of Nutrition 85, 219225.
Peto R, Doll R, Buckley JD & Sporn MB (1981) Can dietary beta-carotene materially reduce human cancer rates? Nature 290, 201209.
Rapola JM, Virtamo J, Ripatti S, Huttunen JK, Albanes D, Taylor PR & Heinonen OP (1997) Randomised trial of α-tocopherol and β-carotene supplements on incidence of major coronary events in men with previous myocardial infarction. Lancet 349, 17151720.
Rimm EB, Stampfer MJ, Ascherio A, Giovannucci E, Colditz GA & Willett WC (1993) Vitamin E consumption and the risk of coronary heart disease in men. New England Journal of Medicine 328, 14501456.
Rimm EB, Willett WC, Hu FB, Sampson L, Colditz GA, Manson JE, Hennekens C & Stampfer MJ (1998) Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Journal of the American Medical Association 279, 359364.
Ros E, Nunez I, Perez-Heras A, Serra M, Gilabert R, Casals E & Deulofeu R (2004) A walnut diet improves endothelial function in hypercholesterolaemic subjects: a randomised crossover trial. Circulation 109, 16091614.
Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D et al. . (2001) DASH-Sodium Collaborative Research Group. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. New England Journal of Medicine 344, 310.
Schnyder G, Roffi M, Pin R, Flammer Y, Lange H, Eberli FR, Meier B, Turi ZG & Hess OM (2001) Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. New England Journal of Medicine 345, 15931600.
Segasothy M & Phillips PA (1999) Vegetarian diet: panacea for modern lifestyle diseases? Quarterly Journal of Medicine 92, 531544.
Serdula MK, Byers T, Mokdad AH, Simoes E, Mendlein JM & Coates RJ (1996) The association between fruit and vegetable intake and chronic disease risk factors. Epidemiology 7, 161165.
Singh RB, Dubnov G, Niaz MA, Ghosh S, Singh R, Rastogi SS, Manor O, Pella D & Berry EM (2002) Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients (Indo-Mediterranean Diet Heart Study): a randomised single-blind trial. Lancet 360, 14551461.
Singh RB, Rastogi SS, Niaz MA, Ghosh S, Singh R & Gupta S (1992a) Effect of fat-modified and fruit-enriched and vegetable-enriched diets on blood lipids in the Indian Diet Heart Study. American Journal of Cardiology 70, 869874.
Singh RB, Rastogi SS, Verma R, Laxmi B, Singh R, Ghosh S & Niaz MA (1992b) Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of a one year follow up. British Medical Journal 304, 10151019.
Slattery ML, Jacobs DR, Dyer A, Benson J, Hilmer JE & Caan BJ (1995) Dietary antioxidants and plasma lipids: the CARDIA study. Journal of the American College of Nutrition 14, 635642.
Sommer A, Tarwotjo I, Djunaedi E, West KP, Loeden AA & Tilden R (1986) Impact of vitamin A supplementation on childhood mortality. Lancet i, 11691173.
Sondergaard E, Moller JE & Egstrup K (2003) Effect of dietary intervention and lipid-lowering treatment on brachialvasoreactivity in patients with ischaemic heart disease and hypercholesterolaemia. American Heart Journal 145 E19.
Stampfer MJ, Hennekens CH, Manson JE, Colditz GA, Rosner B & Willett WC (1993) Vitamin E consumption and the risk of coronary heart disease in women. New England Journal of Medicine 328, 14441449.
Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH & Stampfer M (2004) Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. Journal of the American Medical Association 291, 565575.
Trichopoulou A, Costacou T, Bamia C & Trichopoulos D (2003) Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 348, 25992608.
Trichopoulou A, Orfanos P, Norat T, Bueno-de-Mesquita B, Ocke MC, Peeters PH et al. . (2005) Modified Mediterranean diet and survival: EPIC-elderly prospective cohort study. British Medical Journal 330, 991998.
Tucker KL, Chen H, Hannan MT, Cupples LA, Wilson PWF, Felson D & Kiel DP (2002) Bone mineral density and dietary patterns in older adults: the Framingham Osteoporosis Study. American Journal of Clinical Nutrition 76, 245252.
Tucker KL, Hallfrisch J, Qiao N, Muller D, Andres R & Fleg JL (2005) The combination of high fruit and vegetable and low saturated fat intakes is more protective against mortality in ageing men than is either alone: the Baltimore Longitudinal Study of Ageing. Journal of Nutrition 135, 556561.
Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E & Amouyel P (1999) Contribution of trends in survival and coronary-event rate to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations: monitoring trends and determinants in cardiovascular disease. Lancet 353, 15471557.
Vermeulen EJ, Stehouwer CA, Twisk JR, van den Berg, M de, Jong SC, Mackaay AJ, van Campen CM, Visser FC, Jakobs CA, Bulterjis EJ & Rauwerda JA (2000) Effect of homocysteine-lowering treatment with folic acid plus vitamin B-6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet 355, 517522.
Vivekananthan DP, Penn MS, Sapp SK, Hsu A & Topol EJ (2003) Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 361, 20172023.
Vogel RA, Corretti MC & Plotnick GD (2000) The postprandial effect of components of the Mediterranean diet on endothelial function. Journal of the American College of Cardiology 36, 14551460.
Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT & Kuopio Ischemic Heart Disease Risk Factor Study (2001) Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 103, 26742680.
Wald DS, Law M & Morris JK (2002) Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. British Medical Journal 325, 1202.
Walker M, Aronson KJ, King W, Wilson JW, Fan W, Heaton JP, MacNeily A, Nickel JC & Morales A (2005) Dietary patterns and risk of prostate cancer in Ontario, Canada. International Journal of Cancer 116, 592598.
Wise JA, Morin RJ, Sanderson R & Blum K (1996) Changes in plasma carotenoid, alpha-tocopherol, and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts – a pilot study. Current Therapeutic Research Clinical and Experimental 57, 445461.
Zino S, Skeaff M, Williams S & Mann J (1997) Randomised controlled trial of effect of fruit and vegetable consumption on plasma concentrations of lipids and antioxidants. British Medical Journal 314, 17871791.
Zureik M, Galan P, Bertrais S, Mennen L, Czernichow S, Blacher J, Ducimetiere P & Hercberg S (2004) Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 14851491.
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