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NMR of glycogen in exercise

Published online by Cambridge University Press:  12 June 2007

Thomas B. Price ,
Douglas L. Rothman  and
Robert G. Shulman
Thomas B. Price*
Affiliation:
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
Douglas L. Rothman
Affiliation:
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
Robert G. Shulman
Affiliation:
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
*
*Corresponding Author: Dr Thomas B. Price, fax +1 203 785 6534, email price@boreas.med.yale.edu
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Abstract

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Natural-abundance 13CNMR spectroscopy is a non-invasive technique that enables in vivo assessments of muscle and/or liver glycogen concentrations. Over the last several years, 13C NMR has been developed and used to obtain information about human glycogen metabolism with diet and exercise. Since NMR is non-invasive, more data points are available over a specified time course, dramatically improving the time resolution. This improved time resolution has enabled the documentation of subtleties of muscle glycogen re-synthesis following severe glycogen depletion that were not previously observed. Muscle and liver glycogen concentrations have been tracked in several different human populations under conditions that include: (1) muscle glycogen recovery from intense localized exercise with normal insulin and with insulin suppressed; (2) muscle glycogen recovery in an insulin-resistant population; (3) muscle glycogen depletion during prolonged low-intensity exercise; (4) effect of a mixed meal on postprandial muscle and liver glycogen synthesis. The present review focuses on basic 13C NMR and gives results from selected studies.

Keywords

Muscle metabolismNMRGlycogenExerciseInsulin
Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 4 , November 1999 , pp. 851 - 859
Copyright
The Nutrition Society

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