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Optimal vitamin D levels in Crohn's disease: a review

  • Tara Raftery (a1) and Maria O'Sullivan (a1)


Vitamin D deficiency is common among patients with Crohn's disease. Serum 25-hydroxyvitamin D (25(OH)D) is the best measure of an individual's vitamin D status and current cut-off ranges for sufficiency are debatable. Several factors contribute to vitamin D deficiency in Crohn's disease. These include inadequate exposure to sunlight, inadequate dietary intake, impaired conversion of vitamin D to its active metabolite, increased catabolism, increased excretion and genetic variants in vitamin D hydroxylation and transport. The effects of low 25(OH)D on outcomes other than bone health are understudied in Crohn's disease. The aim of the present review is to discuss the potential roles of vitamin D and the possible levels required to achieve them. Emerging evidence suggests that vitamin D may have roles in innate and adaptive immunity, in the immune-pathogenesis of Crohn's disease, prevention of Crohn's disease-related hospitalisations and surgery, in reducing disease severity and in colon cancer prevention. The present literature appears to suggest that 25(OH)D concentrations of ≥75 nmol/l may be required for non-skeletal effects; however, further research on optimal levels is required.

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* Corresponding author: Professor M. O'Sullivan, fax +353 1 896 2988, email


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1. Xavier, RJ & Podolsky, DK (2007) Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427434.
2. Abraham, C & Cho, JH (2009) Inflammatory bowel disease. N Engl J Med 361, 20662078.
3. Khor, B, Gardet, A & Xavier, RJ (2011) Genetics and pathogenesis of inflammatory bowel disease. Nature 474, 307317.
4. Jostins, L, Ripke, S, Weersma, RK et al. (2012) Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 491, 119124.
5. Ananthakrishnan, AN (2013) Environmental triggers for inflammatory bowel disease. Curr Gastroenterol Rep 15, 302.
6. Holick, MF (2007) Vitamin D deficiency. N Engl J Med 357, 266281.
7. Holick, MF (2004) Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 80, 6 Suppl., 1678S1688S.
8. Rosen, CJ (2011) Clinical practice. Vitamin D insufficiency. N Engl J Med 364, 248254.
9. Leslie, WD, Miller, N, Rogala, L et al. (2008) Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study. Am J Gastroenterol 103, 14511459.
10. Laakso, S, Valta, H, Verkasalo, M et al. (2012) Impaired bone health in inflammatory bowel disease: a case-control study in 80 pediatric patients. Calcif Tissue Int 91, 121130.
11. Mowat, C, Cole, A, Windsor, A et al. (2011) Guidelines for the management of inflammatory bowel disease in adults. Gut 60, 571607.
12. Ananthakrishnan, AN, Khalili, H, Higuchi, LM et al. (2012) Higher predicted vitamin D status is associated with reduced risk of Crohn's disease. Gastroenterology 142, 482489.
13. Cantorna, MT & Mahon, BD (2004) Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med (Maywood) 229, 11361142.
14. Cantorna, MT, Zhu, Y, Froicu, M et al. (2004) Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 80, 6 Suppl., 1717S1720S.
15. Jørgensen, SP, Agnholt, J, Glerup, H et al. (2010) Clinical trial: vitamin D3 treatment in Crohn's disease – a randomized double-blind placebo-controlled study. Aliment Pharmacol Ther 32, 377383.
16. Raftery, T, O'Morain, CA & O'Sullivan, M (2012) Vitamin D: new roles and therapeutic potential in inflammatory bowel disease. Curr Drug Metab 13, 12941302.
17. Institute of Medicine (2010) Report Brief: Dietary Reference Intakes for Calcium and Vitamin D.
18. Alkhouri, RH, Hashmi, H, Baker, RD et al. (2013) Vitamin and mineral status in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 56, 8992.
19. Blank, S, Scanlon, KS, Sinks, TH et al. (1995). An outbreak of hypervitaminosis D associated with the overfortification of milk from a home-delivery dairy. Am J Public Health 85, 656659.
20. Souberbielle, JC, Body, JJ, Lappe, JM et al. (2010) Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: recommendations for clinical practice. Autoimmun Rev 9, 709715.
21. Vieth, R (1999). Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69, 842856.
22. Vieth, R (2006) Critique of the considerations for establishing the tolerable upper intake level for vitamin D: critical need for revision upwards. J Nutr 136, 11171122.
23. Jones, G (2008) Pharmacokinetics of vitamin D toxicity. Am J Clin Nutr 88, 582S586S.
24. Maalouf, J, Nabulsi, M, Vieth, R et al. (2008) Short- and long-term safety of weekly high-dose vitamin D3 supplementation in school children. J Clin Endocrinol Metab 93, 26932701.
25. Haddock, L & Corcino, J, Vazques, MD (1982) V. 25(OH)D serum levels in the normal Puerto Rican population and in subjects with tropical sprue and parathyroid disease. Puerto Rico Health Sci J 1, 8591.
26. Yang, L, Weaver, V, Smith, JP et al. (2013) Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patients. Clin Transl Gastroenterol 4, e33.
27. Hanley, DA, Cranney, A, Jones, G et al. (2010) Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada. CMAJ 182, E610E618.
28. Siffledeen, JS, Siminoski, K, Steinhart, H et al. (2003) The frequency of vitamin D deficiency in adults with Crohn's disease. Can J Gastroenterol 17, 473478.
29. McCarthy, D, Duggan, P, O'Brien, M et al. (2005) Seasonality of vitamin D status and bone turnover in patients with Crohn's disease. Aliment Pharmacol Ther 21, 10731083.
30. Harries, AD, Brown, R, Heatley, RV et al. (1985) Vitamin D status in Crohn's disease: association with nutrition and disease activity. Gut 26, 11971203.
31. Gilman, J, Shanahan, F & Cashman, KD (2006) Determinants of vitamin D status in adult Crohn's disease patients, with particular emphasis on supplemental vitamin D use. Eur J Clin Nutr 60, 889896.
32. Driscoll, RH, Meredith, SC, Sitrin, M et al. (1982) Vitamin D deficiency and bone disease in patients with Crohn's disease. Gastroenterology 83, 12521258.
33. de Bruyn, JR, van Heeckeren, R, Ponsioen, CY et al. (2014) Vitamin D deficiency in Crohn's disease and healthy controls: a prospective case-control study in the Netherlands. J Crohns Colitis 8, 1287–1273.
34. Raftery, T, Lee, C, Cox, G et al. (2013) Supplemental vitamin D in quiescent Crohn's disease – effects on quality of life, fatigue and muscle strength: results from a double blind placebo controlled study. Proc Nutr Soc 72, OCE3, E177.
35. Suibhne, TN, Cox, G, Healy, M et al. (2012) Vitamin D deficiency in Crohn's disease: prevalence, risk factors and supplement use in an outpatient setting. J Crohns Colitis 6, 182188.
36. Vogelsang, H, Klamert, M, Resch, H et al. (1995) Dietary vitamin D intake in patients with Crohn's disease. Wien Klin Wochenschr 107, 578581.
37. Filippi, J, Al-Jaouni, R, Wiroth, JB et al. (2006) Nutritional deficiencies in patients with Crohn's disease in remission. Inflamm Bowel Dis 12, 185191.
38. Bin, CM, Flores, C, Alvares-da-Silva, MR et al. (2010) Comparison between handgrip strength, subjective global assessment, anthropometry, and biochemical markers in assessing nutritional status of patients with Crohn's disease in clinical remission. Dig Dis Sci 55, 137144.
39. Hollander, D & Truscott, TC (1976) Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations. Am J Clin Nutr 29, 970975.
40. Leichtmann, GA, Bengoa, JM, Bolt, MJ et al. (1991) Intestinal absorption of cholecalciferol and 25-hydroxycholecalciferol in patients with both Crohn's disease and intestinal resection. Am J Clin Nutr 54, 548552.
41. Ulitsky, A, Ananthakrishnan, AN, Naik, A et al. (2011) Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. JPEN J Parenter Enteral Nutr 35, 308316.
42. Hassan, V, Hassan, S, Seyed-Javad, P et al. (2013) Association between serum 25 (OH) vitamin D concentrations and inflammatory bowel diseases (IBDs) activity. Med J Malaysia 68, 3438.
43. Jørgensen, SP, Hvas, CL, Agnholt, J et al. (2013) Active Crohn's disease is associated with low vitamin D levels. J Crohns Colitis 7, e407e413.
44. Ham, M, Longhi, MS, Lahiff, C et al. (2014) Vitamin d levels in adults with Crohn's disease are responsive to disease activity and treatment. Inflamm Bowel Dis 20, 856860.
45. Farraye, FA, Nimitphong, H, Stucchi, A et al. (2011) Use of a novel vitamin D bioavailability test demonstrates that vitamin D absorption is decreased in patients with quiescent Crohn's disease. Inflamm Bowel Dis 17, 21162121.
46. Mouli, VP & Ananthakrishnan, AN (2014) Review article: vitamin D and inflammatory bowel diseases. Aliment Pharmacol Ther 39, 125136.
47. Wang, TJ, Zhang, F, Richards, JB et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, 180188.
48. Simpson, S, Blizzard, L, Otahal, P et al. (2011) Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry 82, 11321141.
49. Peyrin-Biroulet, L, Oussalah, A & Bigard, MA (2009) Crohn's disease: the hot hypothesis. Med Hypotheses 73, 9496.
50. Frolkis, A, Dieleman, LA, Barkema, H et al. (2013) Environment and the inflammatory bowel diseases. Can J Gastroenterol 27, e18e24.
51. Spehlmann, ME, Begun, AZ, Burghardt, J et al. (2008) Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis 14, 968976.
52. Khalili, H, Huang, ES, Ananthakrishnan, AN et al. (2012) Geographical variation and incidence of inflammatory bowel disease among US women. Gut 61, 16861692.
53. Shivananda, S, Lennard-Jones, J, Logan, R et al. (1996) Incidence of inflammatory bowel disease across Europe: is there a difference between north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD). Gut 39, 690697.
54. Loftus, EV & Sandborn, WJ (2002) Epidemiology of inflammatory bowel disease. Gastroenterol Clin North Am 31, 120.
55. Schultz, M & Butt, AG (2012) Is the north to south gradient in inflammatory bowel disease a global phenomenon?. Expert Rev Gastroenterol Hepatol 6, 445447.
56. Burisch, J, Pedersen, N, Cukovic-Cavka, S et al. (2013) Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe – An ECCO-EpiCom study. J Crohns Colitis 8, 607616
57. Pinsk, V, Lemberg, DA, Grewal, K et al. (2007) Inflammatory bowel disease in the South Asian pediatric population of British Columbia. Am J Gastroenterol 102, 10771083.
58. Sewell, JL, Yee, HF & Inadomi, JM (2010) Hospitalizations are increasing among minority patients with Crohn's disease and ulcerative colitis. Inflamm Bowel Dis 16, 204207.
59. Limketkai, BN, Bayless, TM, Brant, SR et al. (2014) Lower regional and temporal ultraviolet exposure is associated with increased rates and severity of inflammatory bowel disease hospitalisation. Aliment Pharmacol Ther 40, 508517.
60. Cantorna, MT & Mahon, BD (2005). D-hormone and the immune system. J Rheumatol Suppl 76, 1120.
61. Jäger, S, Stange, EF & Wehkamp, J (2013) Inflammatory bowel disease: an impaired barrier disease. Langenbecks Arch Surg 398, 112.
62. Tollin, M, Bergman, P, Svenberg, T et al. (2003) Antimicrobial peptides in the first line defence of human colon mucosa. Peptides 24, 523530.
63. Otte, JM, Zdebik, AE, Brand, S et al. (2009) Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity. Regul Pept 156, 104117.
64. Gombart, AF, Borregaard, N & Koeffler, HP (2005) Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3 . FASEB J 19, 10671077.
65. Daniel, C, Sartory, NA, Zahn, N et al. (2008) Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile. J Pharmacol Exp Ther 324, 2333.
66. Tang, J, Zhou, R, Luger, D et al. (2009) Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol 182, 46244632.
67. Jeffery, LE, Burke, F, Mura, M et al. (2009) 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 183, 54585467.
68. Cantorna, MT (2012) Vitamin D, multiple sclerosis and inflammatory bowel disease. Arch Biochem Biophys 523, 103106.
69. Froicu, M & Cantorna, MT (2007) Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury. BMC Immunol 8, 5.
70. Froicu, M, Weaver, V, Wynn, TA et al. (2003) A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases. Mol Endocrinol 17, 23862392.
71. Cantorna, MT, Munsick, C, Bemiss, C et al. (2000) 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr 130, 26482652.
72. Henderson, P, van Limbergen, JE et al. (2011) Function of the intestinal epithelium and its dysregulation in inflammatory bowel disease. Inflamm Bowel Dis 17, 382395.
73. Marchiando, AM, Graham, WV & Turner, JR (2010) Epithelial barriers in homeostasis and disease. Annu Rev Pathol 5, 119144.
74. Cantorna, MT, McDaniel, K, Bora, S et al. (2014) Vitamin D, immune regulation, the microbiota, and inflammatory bowel disease. Exp Biol Med (Maywood) 239, 15241530.
75. D'Incà, R, Di Leo, V, Corrao, G et al. (1999) Intestinal permeability test as a predictor of clinical course in Crohn's disease. Am J Gastroenterol 94, 29562960.
76. Wyatt, J, Vogelsang, H, Hübl, W et al. (1993) Intestinal permeability and the prediction of relapse in Crohn's disease. Lancet 341, 14371439.
77. Kong, J, Zhang, Z, Musch, MW et al. (2008) Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol 294, G208G216.
78. Ooi, JH, Li, Y, Rogers, CJ et al. (2013) Vitamin D regulates the gut microbiome and protects mice from dextran sodium sulfate-induced colitis. J Nutr 143, 16791686.
79. Zhang, Y, Leung, DY, Richers, BN et al. (2012) Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol 188, 21272135.
80. Hewison, M (2010) Vitamin D and the immune system: new perspectives on an old theme. Endocrinol Metab Clin North Am 39, 365379; table of contents.
81. El-Matary, W, Sikora, S & Spady, D (2011) Bone mineral density, vitamin D, and disease activity in children newly diagnosed with inflammatory bowel disease. Dig Dis Sci 56, 825829.
82. Joseph, AJ, George, B, Pulimood, AB et al. (2009) 25 (OH) vitamin D level in Crohn's disease: association with sun exposure & disease activity. Indian J Med Res 130, 133137.
83. Ananthakrishnan, AN, Cagan, A, Gainer, VS et al. (2013) Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis 19, 19211927.
84. Boyd, CA & Limdi, JK (2013) Vitamin D deficiency and disease outcomes in South Asian patients with IBD. Dig Dis Sci 58, 21242125.
85. Miheller, P, Muzes, G, Hritz, I et al. (2009) Comparison of the effects of 1,25 dihydroxyvitamin D and 25 hydroxyvitamin D on bone pathology and disease activity in Crohn's disease patients. Inflamm Bowel Dis 15, 16561662.
86. Raftery, T, Martineau, A, Greiller, C et al. (2013) Does vitamin D supplementation impact plasma cathelicidin, human beta defensin 2 and intestinal permeability in stable Crohn's disease? – Results from a randomised, double blind placebo controlled study. Proc Nutr Soc 72, OCE3, E176.
87. Schneider, SM, Al-Jaouni, R, Filippi, J et al. (2008) Sarcopenia is prevalent in patients with Crohn's disease in clinical remission. Inflamm Bowel Dis 14, 15621568.
88. Wiroth, JB, Filippi, J, Schneider, SM et al. (2005) Muscle performance in patients with Crohn's disease in clinical remission. Inflamm Bowel Dis 11, 296303.
89. Geerling, BJ, Badart-Smook, A, Stockbrügger, RW et al. (1998) Comprehensive nutritional status in patients with long-standing Crohn disease currently in remission. Am J Clin Nutr 67, 919926.
90. van Langenberg, DR, Della Gatta, P, Warmington, SA et al. (2014) Objectively measured muscle fatigue in Crohn's disease: correlation with self-reported fatigue and associated factors for clinical application. J Crohns Colitis 8, 137146.
91. Jelsness-Jorgensen, LP, Bernklev, T, Henriksen, M et al. (2012) Chronic fatigue is associated with increased disease-related worries and concerns in inflammatory bowel disease. World J Gastroenterol 18, 445452.
92. Casati, J, Toner, BB, de Rooy, EC, Drossman, DA et al. (2000) Concerns of patients with inflammatory bowel disease: a review of emerging themes. Dig Dis Sci 45, 2631.
93. Drossman, DA, Patrick, DL, Mitchell, CM et al. (1989) Health-related quality of life in inflammatory bowel disease. Functional status and patient worries and concerns. Dig Dis Sci 34, 13791386.
94. Maunder, RG, de Rooy, EC, Toner, BB et al. (1997) Health-related concerns of people who receive psychological support for inflammatory bowel disease. Can J Gastroenterol 11, 681685.
95. Minderhoud, IM, Oldenburg, B, van Dam, PS et al. (2003) High prevalence of fatigue in quiescent inflammatory bowel disease is not related to adrenocortical insufficiency. Am J Gastroenterol 98, 10881093.
96. Reimund, JM, Wittersheim, C, Dumont, S et al. (1996) Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease. J Clin Immunol 16, 144150.
97. Cominelli, F (2004) Cytokine-based therapies for Crohn's disease–new paradigms. N Engl J Med 351, 20452048.
98. Visser, M, Pahor, M, Taaffe, DR et al. (2002) Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. J Gerontol A Biol Sci Med Sci 57, M326M332.
99. Schaap, LA, Pluijm, SM, Deeg, DJ et al. (2006) Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am J Med 119, e9e17.
100. Al-Shoha, A, Qiu, S, Palnitkar, S et al. (2009) Osteomalacia with bone marrow fibrosis due to severe vitamin D deficiency after a gastrointestinal bypass operation for severe obesity. Endocr Pract 15, 528533.
101. Schott, GD & Wills, MR (1976) Muscle weakness in osteomalacia. Lancet 1, 626629.
102. Mawer, EB, Backhouse, J, Holman, CA et al. (1972). The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 43, 413431.
103. Boillon, R, Gielen, E & Vanderschueren, D (2014) Vitamin D receptor and vitamin D action in muscle. Endocrinology 155, 32103213.
104. Pfeifer, M, Begerow, B, Minne, HW et al. (2009) Effects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 20, 315322.
105. van Langenberg, DR, Gatta, PD, Hill, B et al. (2013) Delving into disability in Crohn's disease: dysregulation of molecular pathways may explain skeletal muscle loss in Crohn's disease. J Crohns Colitis 8, 626634.
106. Salacinski, AJ, Regueiro, MD, Broeder, CE et al. (2013) Decreased neuromuscular function in Crohn's disease patients is not associated with low serum vitamin D levels. Dig Dis Sci 58, 526533.
107. Wacker, M & Holick, MF (2013) Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients 5, 111148.
108. Feskanich, D, Ma, J, Fuchs, CS et al. (2004) Plasma vitamin D metabolites and risk of colorectal cancer in women. Cancer Epidemiol Biomarkers Prev 13, 15021508.
109. Giovannucci, E (2007) Strengths and limitations of current epidemiologic studies: vitamin D as a modifier of colon and prostate cancer risk. Nutr Rev 65,Pt 2, S77S79.
110. Giovannucci, E (2009) Vitamin D and cancer incidence in the Harvard cohorts. Ann Epidemiol 19, 8488.
111. Giovannucci, E, Liu, Y, Rimm, EB et al. (2006) Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst 98, 451459.
112. Lappe, JM, Travers-Gustafson, D, Davies, KM et al. (2007) Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr 85, 15861591.
113. Cannell, JJ & Hollis, BW (2008) Use of vitamin D in clinical practice. Altern Med Rev 13, 620.
114. Heaney, RP, Davies, KM, Chen, TC et al. (2003) Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77, 204210.
115. Heaney, RP, Horst, RL, Cullen, DM et al. (2009) Vitamin D3 distribution and status in the body. J Am Coll Nutr 28, 252256.
116. Grant, WB & Holick, MF (2005) Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev 10, 94111.
117. Hollis, BW (2005) Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 135, 317322.
118. Bischoff-Ferrari, HA, Willett, WC, Orav, EJ et al. (2012) A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 367, 4049.
119. Hall, LM, Kimlin, MG, Aronov, PA et al. (2010) Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations. J Nutr 140, 542550.
120. Vieth, R (2006) What is the optimal vitamin D status for health? Prog Biophys Mol Biol 92, 2632.
121. Whiting, SJ & Calvo, MS (2010) Correcting poor vitamin D status: do older adults need higher repletion doses of vitamin D3 than younger adults? Mol Nutr Food Res 54, 10771084.
122. Garrett-Mayer, E, Wagner, CL, Hollis, BW et al. (2012) Vitamin D3 supplementation (4000 IU/d for 1 y) eliminates differences in circulating 25-hydroxyvitamin D between African American and white men. Am J Clin Nutr 96, 332336.
123. Holick, MF (2012) Vitamin D: extraskeletal health. Rheum Dis Clin North Am 38, 141160.
124. Barger-Lux, MJ & Heaney, RP (2002) Effects of above average summer sun exposure on serum 25-hydroxyvitamin D and calcium absorption. J Clin Endocrinol Metab 87, 49524956.
125. Azizi, E, Pavlotsky, F, Kudish, A et al. (2012) Serum levels of 25-hydroxy-vitamin D3 among sun-protected outdoor workers in Israel. Photochem Photobiol 88, 15071512.
126. Luxwolda, MF, Kuipers, RS, Kema, IP et al. (2012) Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr 108, 15571561.
127. Hathcock, JN, Shao, A, Vieth, R et al. (2007) Risk assessment for vitamin D. Am J Clin Nutr 85, 618.
128. Tajika, M, Matsuura, A, Nakamura, T et al. (2004) Risk factors for vitamin D deficiency in patients with Crohn's disease. J Gastroenterol 39, 527533.
129. Jahnsen, J, Falch, JA, Mowinckel, P et al. (2002) Vitamin D status, parathyroid hormone and bone mineral density in patients with inflammatory bowel disease. Scand J Gastroenterol 37, 192199.
130. Wingate, KE, Jacobson, K, Issenman, R et al. (2014) 25-Hydroxyvitamin D concentrations in children with Crohn's disease supplemented with either 2000 or 400 IU daily for 6 months: a randomized controlled study. J Pediatr 164, 860865.
131. Sentongo, TA, Semaeo, EJ, Stettler, N et al. (2002) Vitamin D status in children, adolescents, and young adults with Crohn disease. Am J Clin Nutr 76, 10771081.
132. Pappa, HM, Gordon, CM, Saslowsky, TM et al. (2006) Vitamin D status in children and young adults with inflammatory bowel disease. Pediatrics 118, 19501961.
133. Vagianos, K, Bector, S, McConnell, J et al. (2007) Nutrition assessment of patients with inflammatory bowel disease. JPEN J Parenter Enteral Nutr 31, 311319.
134. Fu, YT, Chatur, N, Cheong-Lee, C et al. (2012) Hypovitaminosis D in adults with inflammatory bowel disease: potential role of ethnicity. Dig Dis Sci 57, 21442148.
135. Ananthakrishnan, AN, Cheng, SC, Cai, T et al. (2013) Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 12, 821827.
136. Garg, M, Rosella, O, Lubel, JS et al. (2013) Association of circulating vitamin D concentrations with intestinal but not systemic inflammation in inflammatory bowel disease. Inflamm Bowel Dis 19, 26342643.
137. Grunbaum, A, Holcroft, C, Heilpern, D et al. (2013) Dynamics of vitamin D in patients with mild or inactive inflammatory bowel disease and their families. Nutr J 12, 145.
138. Abraham, BP, Prasad, P & Malaty, HM (2014) Vitamin D deficiency and corticosteroid use are risk factors for low bone mineral density in inflammatory bowel disease patients. Dig Dis Sci. 59, 18781884.
139. Dumitrescu, G, Mihai, C, Dranga, M et al. (2014) Serum 25-hydroxyvitamin D concentration and inflammatory bowel disease characteristics in Romania. World J Gastroenterol 20, 23922396.
140. Ananthakrishnan, AN, Cheng, SC, Cai, T et al. (2014) Association between reduced plasma 25-hydroxy vitamin d and increased risk of cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol 12, 821827.


Optimal vitamin D levels in Crohn's disease: a review

  • Tara Raftery (a1) and Maria O'Sullivan (a1)


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