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  • Proceedings of the Nutrition Society, Volume 70, Issue 4
  • November 2011, pp. 426-438

Pathogenic obesity and nutraceuticals

  • K. P. Conroy (a1), I. M. Davidson (a1) and M. Warnock (a1)
  • DOI: http://dx.doi.org/10.1017/S0029665111001662
  • Published online: 22 August 2011
Abstract

Over a decade of intense research in the field of obesity has led to the knowledge that chronic, excessive adipose tissue expansion leads to an increase in the risk for CVD, type 2 diabetes mellitus and cancer. This is primarily thought to stem from the low-grade, systemic inflammatory response syndrome that characterises adipose tissue in obesity, and this itself is thought to arise from the complex interplay of factors including metabolic endotoxaemia, increased plasma NEFA, hypertrophic adipocytes and localised hypoxia. Plasma concentrations of vitamins and antioxidants are lower in obese individuals than in the non-obese, which is hypothesised to negatively affect the development of inflammation and disease in obesity. This paper provides a review of the current literature investigating the potential of nutraceuticals to ameliorate the development of oxidative stress and inflammation in obesity, thereby limiting the onset of obesity complications. Research has found nutraceuticals able to positively modulate the activity of adipocyte cell lines and further positive effects have been found in other aspects of pathogenic obesity. While their ability to affect weight loss is still controversial, it is clear that they have a great potential to reverse the development of overweight and obesity-related comorbidities; this, however, still requires much research especially that utilising well-structured randomised controlled trials.

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*Corresponding author: K. P. Conroy, fax +44 131 4740000, email kconroy@qmu.ac.uk
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2.D Guh , W Zhang , N Bansback (2009) The incidence of co-morbidities related to obesity and overweight: A systematic review and meta-analysis. BMC Public Health 9, 88.

3.KD Bertakis & R Azari (2005) Obesity and the use of health care services. Obesity 13, 372379.

6.DB Panagiotakos , C Pitsavos , M Yannakoulia (2005) The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study. Atherosclerosis 183, 308315.

7.C Chrysohoou , DB Panagiotakos , C Pitsavos (2007) The implication of obesity on total antioxidant capacity in apparently healthy men and women: The ATTICA study. Nutr Metab Cardiovasc Dis. 17, 590597.

8.ES Wintergerst , S Maggini & DH Hornig (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Metab 51, 301323.

9.SL DeFelice (1995) The nutraceutical revolution: Its impact on food industry R&D. Trends Food Sci Technol 6, 5961.

10.OP Gulati & P Berry Ottaway (2006) Legislation relating to nutraceuticals in the European Union with a particular focus on botanical-sourced products. Toxicology 221, 7587.

11.S Ramos (2008) Cancer chemoprevention and chemotherapy: Dietary polyphenols and signalling pathways. Mol Nutr Food Res 52, 507526.

12.C Ramassamy (2006) Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets. Eur J Pharmacol 545, 5164.

13.E Maury & S Brichard (2010) Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol 314, 116.

14.G Fantuzzi (2005) Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 115, 911919.

15.F Lago , C Dieguez , J Gomez-Reino (2007) Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheum 3, 716724.

16.J Friedman (2002) The function of leptin in nutrition, weight and physiology. Nutr Rev 60, s1s14.

17.RV Considine , MK Sinha , ML Heiman (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334, 292295.

18.M Maffei , J Halaas , E Ravussin (1995) Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1, 11551161.

19.BS Hamilton , D Paglia , AYM Kwan (1995) Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1, 953956.

20.F Lonnqvist , P Arner , L Nordfors (1995) Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1, 950953.

21.MF Saad , S Damani , RL Gingerich (1997) Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 82, 579584.

22.RE Ostlund Jr, JW Yang , S Klein (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81, 39093913.

24.M Otero , Rcaa Lago , F Lago (2005) Leptin, from fat to inflammation: Old questions and new insights. FEBS Lett 579, 295301.

25.V Sanchez-Margalet , C Martin-Romero , J Santos-Alvarez (2003) Role of leptin as an immunomodulator of blood mononuclear cells: Mechanisms of action. Clin Exp Immunol 133, 1119.

26.K Sugiura , K Tamakoshi , H Yatsuya (2008) Contribution of adipocytokines to low-grade inflammatory state as expressed by circulating C-reactive protein in Japanese men: Comparison of leptin and adiponectin. Int J Cardiol 130, 159164.

27.Y Arita , S Kihara , N Ouchi (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257, 7983.

28.H Tilg & AR Moschen (2008) Role of adiponectin and PBEF/visfatin as regulators of inflammation: Involvement in obesity-associated diseases. Clin Sci 114, 275288.

29.JM Bruun , AS Lihn , C Verdich (2003) Regulation of adiponectin by adipose tissue-derived cytokines: In vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285, E527E533.

30.N Maeda , M Takahashi , T Funahashi (2001) PPARγ ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 50, 20942099.

31.N Ouchi , S Kihara , T Funahashi (2003) Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue. Circulation 107, 671674.

32.K Matsushita , H Yatsuya , K Tamakoshi (2006) Inverse association between adiponectin and C-reactive protein in substantially healthy Japanese men. Atherosclerosis 188, 184189.

33.N Maeda , I Shimomura , K Kishida (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8, 731.

34.T Nishihara , M Matsuda , H Araki (2006) Effect of adiponectin on murine colitis induced by dextran sulfate sodium. Gastroenterology 131, 853861.

35.R Shibata , K Sato , DR Pimentel (2005) Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nat Med 11, 10961103.

36.K Spalding , E Arner , P Westermark (2008) Dynamics of fat cell turnover in humans. Nature 453, 783787.

37.V van Harmelen , T Skurk , K Rohrig (2003) Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women. Int J Obes Relat Metab Disord 27, 889895.

38.N Stefan , K Kantartzis , J Machann (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168, 16091616.

39.M Zeyda & TM Stulnig (2007) Adipose tissue macrophages. Immunol Lett 112, 6167.

40.AN Margioris (2009) Fatty acids and postprandial inflammation. Curr Opin Clin Nutr Metab Care 12, 129137.

41.C Patel , H Ghanim , S Ravishankar (2007) Prolonged reactive oxygen species generation and nuclear factor-{kappa}B activation after a high-fat, high-carbohydrate meal in the obese. J Clin Endocrinol Metab 92, 44764479.

42.H Ghanim , S Abuaysheh , CL Sia (2009) Increase in plasma endotoxin concentrations and the expression of Toll-like receptors and suppressor of cytokine signaling-3 in mononuclear cells after a high-fat, high-carbohydrate meal. Diabetes Care 32, 22812287.

43.C Erridge (2011) Accumulation of stimulants of Toll-like receptor (TLR)-2 and TLR4 in meat products stored at 5C. J Food Sci 76, H72H79.

44.F Backhed , H Ding , T Wang (2004) The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci USA 101, 1571815723.

45.PD Cani , J Amar , MA Iglesias (2007) Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 17611772.

48.Z Hassanali , BN Ametaj , CJ Field (2010) Dietary supplementation of n-3 PUFA reduces weight gain and improves postprandial lipaemia and the associated inflammatory response in the obese JCR:LA-cp rat. Diabetes Obes Metab 12, 139147.

49.L Sun , Z Yu , X Ye (2010) A marker of endotoxemia is associated with obesity and related metabolic disorders in apparently healthy Chinese. Diabetes Care 33, 19251932.

50.P Cani , R Bibiloni , C Knauf (2008) Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57, 14701481.

51.MD Neal , C Leaphart , R Levy (2006) Enterocyte TLR4 mediates phagocytosis and translocation of bacteria across the intestinal barrier. J Immunol 176, 30703079.

52.R Deopurkar , H Ghanim , J Friedman (2010) Differential effects of cream, glucose, and orange juice on inflammation, endotoxin, and the expression of Toll-like receptor-4 and suppressor of cytokine signaling-3. Diabetes Care 33, 991997.

53.P Brun , I Castagliuolo , VD Leo (2007) Increased intestinal permeability in obese mice: New evidence in the pathogenesis of nonalcoholic steatohepatitis. Am J Physiol Gastrointest Liver Physiol 292, G518G525.

55.G Korte , A Dreiseitel , P Schreier (2010) Tea catechins’ affinity for human cannabinoid receptors. Phytomedicine 17, 1922.

56.G Korte , A Dreiseitel , P Schreier (2009) An examination of anthocyanins’ and anthocyanidins’ affinity for cannabinoid receptors. J Med Food 12, 14071410.

57.H Ghanim , CL Sia , M Upadhyay (2010) Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Am J Clin Nutr 91, 940949.

58.H Ghanim , CL Sia , K Korzeniewski (2011) A resveratrol and polyphenol preparation suppresses oxidative and inflammatory stress response to a high-fat, high-carbohydrate meal. J Clin Endocrinol Metab 96, 14091414.

61.OI Vitseva , K Tanriverdi , TT Tchkonia (2008) Inducible Toll-like receptor and NF-[kappa]B regulatory pathway expression in human adipose tissue. Obesity 16, 932937.

62.SJ Creely , PG McTernan , CM Kusminski (2007) Lipopolysaccharide activates an innate immune system response in human adipose tissue in obesity and type 2 diabetes. Am J Physiol Endocrinol Metab 292, E740E747.

63.S Bes-Houtmann , R Roche , L Hoareau (2007) Presence of functional TLR2 and TLR4 on human adipocytes. Histochem Cell Biol 127, 131137.

64.JE Davis , NK Gabler , J Walker-Daniels (2008) Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity 16, 12481255.

65.A Bumrungpert , RW Kalpravidh , C Chitchumroonchokchai (2009) Xanthones from mangosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J Nutr 139, 11851191.

66.F Lira , J Rosa , C Cunha (2011) Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids Health Dis 10, 37.

67.Y Zhang , F Lian , Y Zhu (2010) Cyanidin-3-O-β-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IκBα phosphorylation in THP-1 cells. Inflamm Res 59, 723730.

68.E Hong Byun , Y Fujimura , K Yamada (2010) TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor. J Immunol 185, 3345.

69.S Nielsen , Z Guo , M Johnson (2004) Splanchnic lipolysis in human obesity. J Clin Invest 113, 15821588.

70.P Arner (2005) Human fat cell lipolysis: Biochemistry, regulation and clinical role. Best Pract Res Clin Endocrinol Metab 19, 471482.

71.J Yin , Z Gao , Q He (2009) Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. Am J Physiol Endocrinol Metab 296, E333E342.

72.LH Opie & PG Walfish (1963) Plasma free fatty acid concentrations in obesity. New Engl J Med 268, 757760.

73.E Fraze , CC Donner , ALM Swislocki (1985) Ambient plasma free fatty acid concentrations in noninsulin-dependent diabetes mellitus: Evidence for insulin resistance. J Clin Endocrinol Metab 61, 807811.

74.M Charles , A Fontbonne , N Thibult (2001) High plasma nonesterified fatty acids are predictive of cancer mortality but not of coronary heart disease mortality: Results from the Paris prospective study. Am J Epidemiol 153, 292298.

75.VT Samuel , KF Petersen & GI Shulman (2010) Lipid-induced insulin resistance: Unravelling the mechanism. Lancet 375, 22672277.

76.ZF Zhang , Q Li , J Liang (2010) Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition. Phytomedicine 17, 1418.

77.K Zygmunt , B Faubert , J MacNeil (2010) Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK. Biochem Biophys Res Commun 398, 178183.

78.CN Vishnu Prasad , T Anjana , A Banerji (2010) Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells. FEBS Lett 584, 531536.

79.P Strobel , C Allard , T Perez-Acle (2005) Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes. Biochem J 386, 471478.

80.LY Wu , CC Juan , L Hwang (2004) Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model. Eur J Nutr 43, 116124.

81.Y Li , S Zhao , W Zhang (2011) Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo. Diabetes Res Clin Pract (In the Press).

82.SE McQuaid , L Hodson , MJ Neville (2011) Downregulation of adipose tissue fatty acid trafficking in obesity. Diabetes 60, 4755.

83.JF Liu , Y Ma , Y Wang (2011) Reduction of lipid accumulation in HepG2 cells by luteolin is associated with activation of AMPK and mitigation of oxidative stress. Phytother Res 25, 588596.

84.J Shang , L Chen , F Xiao (2008) Resveratrol improves non-alcoholic fatty liver disease by activating AMP-activated protein kinase1. Acta Pharmacol Sin 29, 698706.

85.CL Lin , HC Huang & JK Lin (2007) Theaflavins attenuate hepatic lipid accumulation through activating AMPK in human HepG2 cells. J Lipid Res 48, 23342343.

86.T Kim , J Davis , AJ Zhang (2009) Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem Biophys Res Comm 388, 377382.

87.QF Collins , HY Liu , J Pi (2007) Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, suppresses hepatic gluconeogenesis through 5′-AMP-activated protein kinase. J Biol Chem 282, 3014330149.

88.D Carling (2004) The AMP-activated protein kinase cascade – a unifying system for energy control. Trends Biochem Sci 29, 1824.

89.J Chen , M Ma , Y Lu (2009) Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice. Planta Medica 75, 472477.

91.H Poudyal , F Campbell & L Brown (2010) Olive leaf extract attenuates cardiac, hepatic, and metabolic changes in high carbohydrate-, high fat-fed rats. J Nutr 140, 946953.

92.L Bujanda , E Hijona , M Larzabal (2008) Resveratrol inhibits nonalcoholic fatty liver disease in rats. BMC Gastroenterol 8, 40.

93.H Staiger , K Staiger , N Stefan (2004) Palmitate-induced interleukin-6 expression in human coronary artery endothelial cells. Diabetes 53, 32093216.

94.SJ van Dijk , EJ Feskens , MB Bos (2009) A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome. Am J Clin Nutr 90, 16561664.

95.P Laine , E Schwartz , Y Wang (2007) Palmitic acid induces IP-10 expression in human macrophages via NF-κB activation. Biochem Biophys Res Commun 358, 150155.

96.L Haversen , KN Danielsson , L Fogelstrand (2009) Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages. Atherosclerosis 202, 382393.

98.AR Subauste & CF Burant (2007) Role of FoxO1 in FFA-induced oxidative stress in adipocytes. Am J Physiol Endocrinol Metab 293, E159E164.

99.K Takahashi , S Yamaguchi , T Shimoyama (2008) JNK- and I{kappa}B-dependent pathways regulate MCP-1 but not adiponectin release from artificially hypertrophied 3T3-L1 adipocytes preloaded with palmitate in vitro. Am J Physiol Endocrinol Metab 294, E898E909.

100.HH Zhang , M Halbleib , F Ahmad (2002) Tumor necrosis factor stimulates lipolysis in differentiated human adipocytes through activation of extracellular signal-related kinase and elevation of intracellular cAMP. Diabetes 51, 29292935.

101.PA Permana , C Menge & PD Reaven (2006) Macrophage-secreted factors induce adipocyte inflammation and insulin resistance. Biochem Biophys Res Commun 341, 507514.

102.CC Lien , LC Au , YL Tsai (2009) Short-term regulation of tumor necrosis factor-{alpha}-induced lipolysis in 3T3-L1 adipocytes is mediated through the inducible nitric oxide synthase/nitric oxide-dependent pathway. Endocrinology 150, 48924900.

103.EA Schwartz , WY Zhang , SK Karnik (2010) Nutrient modification of the innate immune response: A novel mechanism by which saturated fatty acids greatly amplify monocyte inflammation. Arterioscler Thromb Vasc Biol 30, 802808.

104.T Suganami , J Nishida & Y Ogawa (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor {alpha}. Arterioscler Thromb Vasc Biol 25, 20622068.

105.H Shi , M Kokoeva , K Inouye (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116, 30153025.

106.MTA Nguyen , S Favelyukis , AK Nguyen (2007) A Subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 282, 3527935292.

107.T Suganami , X Yuan , Y Shimoda (2009) Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-Like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105, 2532.

108.CY Han , AY Kargi , M Omer (2010) Differential effect of saturated and unsaturated free fatty acids on the generation of monocyte adhesion and chemotactic factors by adipocytes. Diabetes 59, 386396.

109.C Erridge & NJ Samani (2009) Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 29, 19441949.

110.A Kennedy , K Martinez , CC Chuang (2009) Saturated fatty acid-mediated inflammation and insulin resistance in adipose tissue: Mechanisms of action and implications. J Nutr 139, 14.

111.G Berglund , S Ljungman , M Hartford (1982) Type of obesity and blood pressure. Hypertension 4, 692696.

112.M Lonn , K Mehlig , C Bengtsson (2010) Adipocyte size predicts incidence of type 2 diabetes in women. FASEB J 24, 326331.

113.S Cinti , G Mitchell , G Barbatelli (2005) Adipocyte death defines macrophage localisation and function in adipose tissue of obese mice and humans. J Lipid Res 46, 23472355.

114.R Cancello , C Henegar , N Viguerie (2005) Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes 54, 22772286.

115.SP Weisberg , D McCann , M Desai (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112, 17961808.

116.YH Lee , S Nair , E Rousseau (2005) Microarray profiling of isolated abdominal subcutaneous adipocytes from obese vs non-obese Pima Indians: Increased expression of inflammation-related genes. Diabetologia 48, 17761783.

117.M Jernas , J Palming , K Sjoholm (2006) Separation of human adipocytes by size: Hypertrophic fat cells display distinct gene expression. FASEB J 20, 15401542.

118.T Skurk , C Alberti-Huber , C Herder (2007) Relationship between adipocyte size and adipokine expression and secretion. J Clin Endocrinol Metab 92, 10231033.

120.B Gustafson , A Hammarstedt , CX Andersson (2007) Inflamed adipose tissue: A culprit underlying the metabolic syndrome and atherosclerosis. Arterioscler Thromb Vasc Biol 27, 22762283.

121.ED Rosen & OA MacDougald (2006) Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 7, 885896.

122.Z Wu , ED Rosen , R Brun (1999) Cross-regulation of C/EBP[alpha] and PPAR[gamma] controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 3, 151158.

123.S Weisberg , R Leibel & D Tortoriello (2008) Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 149, 35493558.

124.A Ejaz , D Wu , P Kwan (2009) Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 139, 919925.

126.YK Lee , WS Lee , JT Hwang (2008) Curcumin exerts antidifferentiation effect through AMPKα-PPARγ in 3T3-L1 adipocytes and antiproliferatory effect through AMPKα-COX-2 in cancer cells. J Agric Food Chem 57, 305310.

128.S Wolfram , Y Wang & F Thielecke (2006) Anti-obesity effects of green tea: From bedside to bench. Mol Nutr Food Res 50, 176187.

129.S Wolfram , D Raederstorff , Y Wang (2005) TEAVIGO (epigallocatechin gallate) supplementation prevents obesity in rodents by reducing adipose tissue mass. Ann Nutr Metab 49, 5463.

131.N Chen , R Bezzina , E Hinch (2009) Green tea, black tea, and epigallocatechin modify body composition, improve glucose tolerance, and differentially alter metabolic gene expression in rats fed a high-fat diet. Nutr Res 29, 784793.

132.T Furuyashiki , H Nagayasu , Y Aoki (2004) Tea catechin suppresses adipocyte differentiation accompanied by down-regulation of PPARgamma2 and C/EBPalpha in 3T3-L1 cells. Biosci Biotechnol Biochem 68, 23532359.

133.HS Moon , CS Chung , HG Lee (2007) Inhibitory effect of (−)-epigallocatechin-3-gallate on lipid accumulation of 3T3-L1 cells. Obesity 15, 25712582.

134.J Lin , MA Della-Fera & CA Baile (2005) Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obesity 13, 982990.

135.N Sakurai , K Mochizuki , H Kameji (2009) (−)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation. Nutrition 25, 10471056.

138.T McLaughlin , A Deng , G Yee (2010) Inflammation in subcutaneous adipose tissue: Relationship to adipose cell size. Diabetologia 53, 369377.

139.G Charriere , B Cousin , E Arnaud (2003) Preadipocyte conversion to macrophage. J Biol Chem 278, 98509855.

140.P Isakson , A Hammarstedt , B Gustafson (2009) Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-α, and inflammation. Diabetes 58, 15501557.

141.D Lacasa , S Taleb , M Keophiphath (2007) Macrophage-secreted factors impair human adipogenesis: Involvement of proinflammatory state in preadipocytes. Endocrinology 148, 868877.

142.B Cousin , M Andre , L Casteilla (2001) Altered macrophage-like functions of preadipocytes in inflammation and genetic obesity. J Cell Physiol 186, 380386.

144.S Chung , K LaPoint , K Martinez (2006) Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes. Endocrinology 147, 53405351.

146.O Poulain-Godefroy & P Froguel (2007) Preadipocyte response and impairment of differentiation in an inflammatory environment. Biochem Biophys Res Commun 356, 662667.

147.JM Lehmann , LB Moore , TA Smith-Oliver (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J Biol Chem 270, 1295312956.

148.A Okuno , H Tamemoto , K Tobe (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest 101, 13541361.

150.M Hassan , CE Yazidi , JF Landrier (2007) Phloretin enhances adipocyte differentiation and adiponectin expression in 3T3-L1 cells. Biochem Biophys Res Commun 361, 208213.

151.T Saito , D Abe & K Sekiya (2007) Nobiletin enhances differentiation and lipolysis of 3T3-L1 adipocytes. Biochem Biophys Res Commun 357, 371376.

152.M Pasarica , O Sereda , L Redman (2009) Reduced adipose tissue oxygenation in human obesity: Evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response. Diabetes 58, 718.

153.N Hosogai , A Fukuhara , K Oshima (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56, 901911.

154.ME Rausch , S Weisberg , P Vardhana (2007) Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes 32, 451463.

155.S Patel & M Simon (2008) Biology of hypoxia-inducible factor-2a in development and disease. Cell Death Differ 15, 628634.

156.A Weidemann & R Johnson (2008) Biology of HIF-1a. Cell Death Differ 15, 621627.

157.M Maumus , C Sengenes , P Decaunes (2008) Evidence of in situ proliferation of adult adipose tissue-derived progenitor cells: Influence of fat mass microenvironment and growth. J Clin Endocrinol Metab 93, 40984106.

158.C Regazzetti , P Peraldi , T Gremeaux (2009) Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 58, 95–103.

159.B Wang , IS Wood & P Trayhurn (2008) Hypoxia induces leptin gene expression and secretion in human preadipocytes: Differential effects of hypoxia on adipokine expression by preadipocytes. J Endocrinol 198, 127134.

160.J Ye , Z Gao , J Yin (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293, E1118E1128.

161.KH Kim , MJ Song , J Chung (2005) Hypoxia inhibits adipocyte differentiation in a HDAC-independent manner. Biochem Biophys Res Commun 333, 11781184.

162.K Lolmede , V Dunand de Saint Front , J Galitzhy (2003) Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442A adipocytes. Int J Obes 27, 11871195.

163.B Wang , I Wood & P Trayhurn (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Archiv 455, 479492.

164.JV Silha , M Krsek , P Sucharda (2005) Angiogenic factors are elevated in overweight and obese individuals. Int J Obes 29, 13081314.

165.C Pang , Z Gao , J Yin (2008) Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity. Am J Physiol Endocrinol Metab 295, E313E322.

166.S Nishimura , I Manabe , M Nagasaki (2007) Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56, 15171526.

167.R Singh & R Agarwal (2003) Tumor angiogenesis: A potential target in cancer control by phytochemicals. Curr Cancer Drug Targets 3:205217.

168.SAM Paul , JW Simons & NJ Mabjeesh (2004) HIF at the crossroads between ischemia and carcinogenesis. J Cell Physiol 200, 2030.

169.M Hatanaka , S Shimba , M Sakaue (2009) Hypoxia-inducible factor-3α functions as an accelerator of 3T3-L1 adipose differentiation. Biol Pharm Bull 32, 11661172.

170.U Ozcan , Q Cao , E Yilmaz (2004) Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457461.

171.NK Sharma , SK Das , AK Mondal (2008) Endoplasmic reticulum stress markers are associated with obesity in nondiabetic subjects. J Clin Endocrinol Metab 93, 45324541.

172.G Boden , X Duan , C Homko (2008) Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals. Diabetes 57, 24382444.

173.M Gregor , L Yang , E Fabbrini (2009) Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss. Diabetes 58, 693700.

174.EH Koh , JY Park , HS Park (2007) Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes 56, 29732981.

175.MF Gregor & GS Hotamisligil (2007) Thematic review series: Adipocyte biology. Adipocyte stress: The endoplasmic reticulum and metabolic disease. J Lipid Res 48, 19051914.

176.D Ron & P Walter (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8, 519529.

177.C Xu , B Bailly-Maitre & J Reed (2005) Endoplasmic reticulum stress: Cell life and death decisions. J Clin Invest 115, 26562664.

178.CM Haynes , EA Titus & AA Cooper (2004) Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death. Mol Cell 15, 767776.

179.K Zhang & R Kaufman (2008) From endoplasmic reticulum stress to the inflammatory response. Nature 454, 455462.

180.R Kaufman (2002) Orchestrating the unfolded protein reponse in health and disease. J Clin Invest 110, 13891398.

181.Y Wei , D Wang , F Topczewski (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291, E275E281.

182.E Karaskov , C Scott , L Zhang (2006) Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic {beta}-cell apoptosis. Endocrinology 147, 33983407.

183.SK Das , WS Chu , AK Mondal (2008) Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines. Am J Physiol Endocrinol Metab 295, E393E400.

184.RA Parker , OP Flint , R Mulvey (2005) Endoplasmic reticulum stress links dyslipidemia to inhibition of proteasome activity and glucose transport by HIV protease inhibitors. Mol Pharmacol 67, 19091919.

185.J Malhotra , H Miao , K Zhang (2008) Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci USA 105, 1852518530.

186.M Sheikh-Ali , S Sultan , AR Alamir (2010) Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells. Diabetes Res Clin Pract 87, 161166.

187.Y Natsume , S Ito , H Satsu (2009) Protective effect of quercetin on ER stress caused by calcium dynamics dysregulation in intestinal epithelial cells. Toxicology 258, 164175.

188.R Pal , EA Cristan , K Schnittker (2010) Rescue of ER oxidoreductase function through polyphenolic phytochemical intervention: Implications for subcellular traffic and neurodegenerative disorders. Biochem Biophys Res Commun 392, 567571.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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