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Personalised nutrition: ready for practice?

  • Baukje de Roos (a1)
Abstract

The efficacy by which dietary interventions influence risk markers of multi-factorial diseases is mainly determined by taking population-based approaches. However, there exists considerable inter-individual variation in response to dietary interventions, and some interventions may benefit certain individuals or population subgroups more than others. This review evaluates the application of nutrigenomic technologies to further the concept of personalised nutrition, as well as the process to take personalised nutrition to the marketplace. The modulation of an individual's response is influenced by both genetic and environmental factors. Many nutrigenetics studies have attempted to explain variability in responses based on a single or a few genotypes so that a genotype may be used to define personalised dietary advice. It has, however, proven very challenging to define an individual's responsiveness to complex diets based on common genetic variations. In addition, there is a limited understanding of what constitutes an optimal response because we lack key health biomarkers and signatures. In conclusion, advances in nutrigenomics will undoubtedly further the understanding of the complex interplay between genotype, phenotype and environment, which are required to enhance the development of personalised nutrition in the future. At the same time, however, issues relating to consumer acceptance, privacy protection as well as marketing and distribution of personalised products need to be addressed before personalised nutrition can become commercially viable.

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Corresponding author
Corresponding author: Dr Baukje de Roos, fax +44 1224 438629, email b.deroos@abdn.ac.uk
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3. MT Cooney , A Dudina , P Whincup (2009) Re-evaluating the Rose approach: comparative benefits of the population and high-risk preventive strategies. Eur J Cardiovasc Prev Rehabil 16, 541549.

4. G Rose (1985) Sick individuals and sick populations. Int J Epidemiol 14, 3238.

6. AM Minihane , S Khan , EC Leigh-Firbank (2000) ApoE polymorphism and fish oil supplementation in subjects with an atherogenic lipoprotein phenotype. Arterioscler Thromb Vasc Biol 20, 19901997.

7. AM Minihane (2010) Fatty acid-genotype interactions and cardiovascular risk. Prostaglandins Leukot Essent Fatty Acids 82, 259264.

9. J Madden , CM Williams , PC Calder (2011) The impact of common gene variants on the response of biomarkers of cardiovascular disease (CVD) risk to increased fish oil fatty acids intakes. Annu Rev Nutr 31, 203234.

10. E Olano-Martin , E Anil , MJ Caslake (2010) Contribution of apolipoprotein E genotype and docosahexaenoic acid to the LDL-cholesterol response to fish oil. Atherosclerosis 209, 104110.

11. C Bouchard , A Tremblay , JP Despres (1990) The response to long-term overfeeding in identical twins. N Engl J Med 322, 14771482.

13. J Hesketh , I Wybranska , Y Dommels (2006) Nutrient-gene interactions in benefit-risk analysis. Br J Nutr 95, 12321236.

14. SB Matthews , JP Waud , AG Roberts (2005) Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J 81, 167173.

15. G Rimbach & AM Minihane (2009) Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there? Proc Nutr Soc 68, 162172.

16. B van Ommen (2007) Personalized nutrition from a health perspective: luxury or necessity? Genes Nutr 2, 34.

17. J Kaput , JM Ordovas , L Ferguson (2005) The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr 94, 623632.

18. A O'Sullivan , MJ Gibney , AO Connor (2011) Biochemical and metabolomic phenotyping in the identification of a vitamin D responsive metabotype for markers of the metabolic syndrome. Mol Nutr Food Res 55, 679690.

19. CM Phillips , L Goumidi , S Bertrais (2009) Complement component 3 polymorphisms interact with polyunsaturated fatty acids to modulate risk of metabolic syndrome. Am J Clin Nutr 90, 16651673.

20. HG Joost , MJ Gibney , KD Cashman (2007) Personalised nutrition: status and perspectives. Br J Nutr 98, 2631.

21. PJ Curtis , AJ Adamson & JC Mathers (2012) Effects on nutrient intake of a family-based intervention to promote increased consumption of low-fat starchy foods through education, cooking skills and personalised goal setting: the Family Food and Health Project. Br J Nutr 107, 18331844.

22. LI Bouwman & MA Koelen (2007) Communication on personalised nutrition: individual–environment interaction. Genes Nutr 2, 8183.

23. T Caulfield , NM Ries , PN Ray (2010) Direct-to-consumer genetic testing: good, bad or benign? Clin Genet 77, 101105.

25. S Tamir (2010) Direct-to-consumer genetic testing: ethical-legal perspectives and practical considerations. Med Law Rev 18, 213238.

27. CM Phillips , L Goumidi , S Bertrais (2010) Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components. J Clin Endocrinol Metab 95, 13861394.

28. JF Ferguson , CM Phillips , AC Tierney (2010) Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr 91, 794801.

29. BJ Stewart-Knox , BP Bunting , S Gilpin (2009) Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers. Br J Nutr 101, 982989.

30. A Ronteltap , JC van Trijp & RJ Renes (2009) Consumer acceptance of nutrigenomics-based personalised nutrition. Br J Nutr 101, 132144.

31. A Ronteltap , JC van Trijp , RJ Renes (2007) Consumer acceptance of technology-based food innovations: lessons for the future of nutrigenomics. Appetite 49, 117.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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