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Physical activity, immunity and infection

  • J. Romeo (a1), J. Wärnberg (a2) (a3), T. Pozo (a1) and A. Marcos (a1)
Abstract

During the last few decades, scientific evidence has confirmed a wide range of health benefits related to regular physical activity. How physical activity affects the immune function and infection risk is, however, still under debate. Commonly, intensive exercise suppresses the activity and levels of several immune cells, while other immune functions may be stimulated by moderate physical activity. With this knowledge, the understanding of the relationship between different levels of physical activity on the immune function has been raised as a potential tool to protect health not only in athletes but also in the general population; the mechanisms that translate a physically active lifestyle into good health continue to be investigated. Reviewing the literature, although several outcomes (i.e. the mechanisms by which different levels and duration of physical activity programmes affect numerous cell types and responses) remain unclear, given that the additional benefits encompass healthy habits including exercise, the use of physical activity programmes may result in improved health of elderly populations. Moderate physical activity or moderate–regulated training may enhance the immune function mainly in less fit subjects or sedentary population and the pre-event fitness status also seems to be an important individual factor regarding this relationship. Although adequate nutrition and regular physical activity habits may synergistically improve health, clinical trials in athletes using nutritional supplements to counteract the immune suppression have been inconclusive so far.

Further research is necessary to find out to what extent physical activity training can exert an effect on the immune function.

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Corresponding author
*Corresponding author: Dr J. Romeo, fax +34 91 5493627, email jromeo@if.csic.es
References
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1.Caspersen CJ, Powell KE & Christenson GM (1985) Physical activity, exercise, and physical fitness: definitions and distinctions for health-related research. Public Health Rep 100, 126131.
2.Ainsworth BE, Haskell WL, Leon AS et al. (1993) Compendium of physical activities, classification of energy costs of human physical activities. Med Sci Sports Exerc 25, 7180.
3.Hambrecht R, Wolf A, Gielen S et al. (2000) Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 342, 454460.
4.Blair SN, Cheng Y & Holder JS (2001) Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 33, Suppl. 6, S379S399 discussion S419S420.
5.Thompson PD, Buchner D & Pina IL et al. (2003) Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107, 31093116.
6.Melzer K, Kayser B & Pichard C (2004) Physical activity: the health benefits outweigh the risks. Curr Opin Clin Nutr Metab Care 7, 641647.
7.Braith RW & Stewart KJ (2006) Resistance exercise training: its role in the prevention of cardiovascular disease. Circulation 113, 26422650.
8.Manini TM, Everhart JE, Patel KV et al. (2006) Daily activity energy expenditure and mortality among older adults. JAMA 296, 171179.
9.Booth FW, Gordon SE, Carlson CJ et al. (2000) Waging war on modern chronic diseases: primary prevention through exercise biology. J Appl Physiol 88, 774787.
10.Senchina DS & Kohut ML (2007) Immunological outcomes of exercise in older adults. Clin Interv Aging 2, 3–16.
11.Timmons BW & Cieslak T (2008) Human natural killer cell subsets and acute exercise: a brief review. Exerc Immunol Rev 14, 8–23.
12.Brolinson PG & Elliott D (2007) Exercise and the immune system. Clin Sports Med 26, 311319.
13.Klentrou P, Cieslak T, McNeil M et al. (2002) Effect of moderate exercise on salivary IgA and infection risk in humans. Eur J Appl Physiol 87, 153158.
14.Matthews CE, Ockene IS, Freedson PS et al. (2002) Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc 34, 12421248.
15.Nieman DC (1998) Influence of carbohydrate on the immune responses to intensive, prolonged exercise. Exerc Immunol Rev 4, 6476.
16.Chubak J, McTiernan A, Sorensen B et al. (2006) Moderate-intensity exercise reduces the incidence of colds among postmenopausal women. Am J Med 119, 937942.
17.Moreira A, Kekkonen RA, Delgado L et al. (2007) Nutritional modulation of exercise-induced immunodepression in athletes: a systematic review and meta-analysis. Eur J Clin Nutr 61, 443460.
18.Woods JA, Davis JM, Smith JA et al. (1999) Exercise and cellular innate immune function. Med Sci Sports Exerc 31, 5766.
019 19.MacKinnon LT (1999) Advances in Exercise Immunology. p. 159. Champaign, IL: Human Kinetics.
20.Mooren FC, Bloming D, Lechtermann A et al. (2002) Lymphocyte apoptosis after exhaustive and moderate exercise. J Appl Physiol 93, 147153.
21.MacKinnon LT (1994) Current challenges and future expectations in exercise immunology: back to the future. Med Sci Sports Exerc 26, 191194.
22.Pedersen BK & Nieman DC (1998) Exercise and immunology: integration and regulation. Immunol Today 19, 204206.
23.Lim CL, Byrne C, Chew SA et al. (2005) Leukocyte subset response during exercise under heat stress with carbohydrate or water intake. Aviat Space Environ Med 76, 726732.
24.Walsh NP & Whitham M (2006) Exercising in environmental extremes a greater threat to immune function? Sports Med 36, 941976.
25.Romeo J, Jiménez-Pavón D, Cervantes-Borunda M et al. (2008) Immunological changes after a single bout of moderate-intensity exercise in a hot environment. J Physiol Biochem 64, 197204.
26.Pyne DB (1994) Regulation of neutrophil function during exercise. Sports Med 17, 245258.
27.Nieman DC & Pedersen BK (1999) Exercise and immune function. Recent developments. Rev Sports Med 27, 7380.
28.Pedersen BK & Ullum H (1994) NK cell response to physical activity: possible mechanisms of action. Med Sci Sports Exerc 26, 140146.
29.Nieman DC, Henson DA, Gusewitch G et al. (1993) Physical activity and immune function in elderly women. Med Sci Sports Exerc 25, 823831.
30.Starkie RL, Hargreaves M, Rolland J et al. (2005) Heat stress, cytokines, and the immune response to exercise. Brain Behav Immun 19, 404412.
31.Kusaka Y, Kondou H & Morimoto K (1992) Healthy lifestyles are associated with higher natural killer cell activity. Prev Med 21, 602615.
32.Fehrenbach E & Schneider ME (2006) Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects. Sports Med 36, 373384.
33.Pedersen B (1996) Immune Responses to Acute Exercise. pp. 7992. New York: CRC Press.
34.Pedersen BK & Hoffman-Goetz L (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol Rev 80, 10551081.
35.Gleeson M (2007) Immune function in sport and exercise. J Appl Physiol 103, 693699.
36.Castell LM, Poortmans JR, Leclercq R et al. (1997) Some aspects of the acute phase response after a marathon race, and the effects of glutamine supplementation. Eur J Appl Physiol Occup Physiol 75, 4753.
37.Nieman DC, Henson DA, Smith LL et al. (2001) Cytokine changes after a marathon race. J Appl Physiol 91, 109114.
38.Suzuki K, Nakaji S, Yamada M et al. (2002) Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 8, 6–48.
39.Malaguarnera L, Cristaldi E, Vinci M et al. (2008) The role of exercise on the innate immunity of the elderly. Eur Rev Aging Phys Act 5, 4349.
40.Moraska A & Fleshner M (2001) Voluntary physical activity prevents stressinduced behavioral depression and anti-KLH antibody suppression. Am J Physiol Regul Integr Comp Physiol 281, R484R489.
41.Elphick GF, Greenwood BN, Campisi J et al. (2003) Increased serum nIgM in voluntarily physically active rats: a potential role for B-1 cells. J Appl Physiol 94, 660667.
42.Elphick GF, Wieseler-Frank J, Greenwood BN et al. (2003) B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary rats. J Appl Physiol 95, 199206.
43.MacNeil B & Hoffman-Goetz L (1993) Chronic exercise enhances in vivo and in vitro cytotoxic mechanisms of natural immunity in mice. J Appl Physiol 74, 388395.
44.MacNeil B & Hoffman-Goetz L (1993) Effect of exercise on natural cytotoxicity and pulmonary tumor metastases in mice. Med Sci Sports Exerc 25, 922928.
45.Rogers CJ, Zaharoff DA, Hance KW et al. (2008) Exercise enhances vaccine-induced antigen-specific T-cell responses. Vaccine 26, 54075415.
46.Shimizu K, Kimura F, Akimoto T et al. (2008) Effect of moderate exercise training on T-helper cell subpopulations in elderly people. Exerc Immunol Rev 14, 2437.
47.Nasrullah I & Mazzeo RS (1992) Age-related immunosenescence in Fischer 344 rats: Influence of exercise training. J Appl Physiol 73, 19321938.
48.Chen P, Li H, Xu F et al. (2003) Heavy load exercise induced dysfunction of immunity and neuroendocrine responses in rats. Life Sci 72, 22552262.
49.Giraldo E, Garcia JJ, Hinchado MD et al. (2009) Exercise intensity-dependent changes in the inflammatory response in sedentary women: role of neuroendocrine parameters in the neutrophil phagocytic process and the pro-/anti-inflammatory cytokine balance. Neuroimmunomodulation 16, 237244.
50.Kasapis C & Thompson PD (2005) The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 45, 15631569.
51.Brenner IKM, Shek PN & Shephard RJ (1994) Infection in athletes. Sports Med 17, 86–107.
52.Pyne DB & Gleeson M (1998) Effects of intensive exercise training on immunity in athletes. Int J Sports Med 19, 183191.
53.Shephard RJ & Shek PN (1999) Exercise, immunity and susceptibility to infection. A J-shaped relationship? Phys Sportsmed 27, 4771.
54.Reid VL, Gleeson M, Williams N et al. (2004) Clinical investigation of athletes with persistent fatigue and/or recurrent infections. Br J Sports Med 38, 4245.
55.Castle SC (2000) Clinical relevance of age-related immune dysfunction. Clin Infect Dis 31, 578585.
56.Bauer ME, Jeckel CM, & Luz C (2009) The role of stress factors during aging of the immune system. Ann N Y Acad Sci 1153, 139152.
57.Bender BS (2003) Infectious disease risk in the elderly. Immunol Allergy Clin North Am 23, 5764.
58.Falsey AR & Walsh EE (2005) Respiratory syncytial virus infection in elderly adults. Drugs Aging 22, 577587.
59.High KP, Bradley S, Loeb M et al. (2005) A new paradigm for clinical investigation of infectious syndromes in older adults: Assessment of functional status as a risk factor and outcome measure. Clin Infect Dis 40, 114122.
60.Meunier N, Feillet-Coudray C, Rambeau M et al. (2005) Impact of micronutrient dietary intake and status on intestinal zinc absorption in late middle-aged men: the ZENITH study. Eur J Clin Nutr 59, S48S52.
61.Oldewage-Theron WH, Samuel FO & Venter CS (2008) Zinc deficiency among the elderly attending a care centre in Sharpeville, South Africa. J Hum Nutr Diet 21, 566574.
62.Unkiewicz-Winiarczyk A, Bagniuk A, Gromysz-Kałkowska K et al. (2009) Calcium, magnesium, iron, zinc and copper concentration in the hair of tobacco smokers. Biol Trace Elem Res 128, 152160.
63.Solana R & Pawelec G (1998) Molecular and cellular basis of immunosenescence. Mech Aging Dev 102, 115129.
64.Franceschi C, Bonafe M & Valensin S (2000a) Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of the immunological space. Vaccine 18, 17171720.
65.Linton P & Thoman ML (2001) T-cell senescence. Front Biosci 6, D248D261.
66.Tannahill GM, Elliott J, Barry AC et al. (2005) ‘SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation’. Mol Cell Biol 25, 91159126.
67.Hong MS, Dan JM, Choi J-Y et al. (2004) Age-associated changes in the frequency of naive, memory, and effector CD8+ T cells. Mech Aging Dev 125l, 615618.
68.Naylor K, Li G, Vallejo AN et al. (2005) The influence of age on T cell generation and TCR diversity. J Immunol 174, 74467452.
69.Schwab R, Russo C & Weksler ME (1992) Altered major histocompatibility complex-restricted antigen recognition by T cells from elderly humans. Eur J Immunol 22, 29892993.
70.Xu X, Beckman I, Dimopoulos K et al. (1992) Age-related changes in the expression of T cell activation antigens following phytohaemagglutinin stimulation. Exp Clin Immunogenet 9, 203211.
71.Miller RA, Jacobson B, Weil G et al. (1987) Diminished calcium influx in lectin-stimulated T cells from old mice. J Cell Physiol 132, 337342.
72.Ohkusu K, Du J, Isobe K-I et al. (1997) Protein kinase Cα-mediated chronic signal transduction for immunosenescence. J Immunol 159, 20822084.
73.Gupta S (2000) Molecular steps of cell suicide: an insight into immune senescence. J Clin Immunol 20, 229239.
74.McLeod JD (2000) Apoptotic capability in aging T cells. Mech Aging Dev 121, 151159.
75.Froelich CJ, Burkett JS, Guiffaut S et al. (1988) Phytohemagglutinin induced proliferation by aged lymphocytes: Reduced expression of high affinity interleukin-2 receptors and interleukin-2 secretion. Life Sci 43, 15831590.
76.Castle SC, Uyemara K, Crawford W et al. (1999) Age-related impaired proliferation of peripheral blood mononuclear cells is associated with an increase in IL-10 and IL-12. Exp Gerontol 34, 243252.
77.Castle S, Uyemara K, Wong W et al. (1997) Evidence of enhanced type 2 immune response and impaired upregulation of a type 1 response in frail elderly nursing home residents. Mech Aging Dev 94, 7–16.
78.Rink L, Cakman I & Kirchner H (1998) Altered cytokine production in the elderly. Mech Aging Dev 102, 199209.
79.Fagiolo U, Cossarizza A, Scala E et al. (1993) Increased cytokine production in mononuclear cells of healthy elderly people. Eur J Immunol 23, 23752378.
80.Riancho JA, Zarrabeitia MT, Amado JA et al. (1994) Age-related differences in cytokine secretion. Gerontology 40, 8–12.
81.Gardner EM & Murasko DM (2002) Age-related changes in Type 1 and Type 2 cytokine production in humans. Biogerontol 3, 271289.
82.Whisler RL & Newhouse YG (1985) Immunosenescence of the human B cell system: Impaired activation/proliferation in response to autologous monocytes pulsed with Staph protein A and the effects of interleukins 1 and 2 compared to interferon. Lymphokine Res 4, 331337.
83.Zheng B, Han S, Takahashi Y et al. (1997) Immunosenescence and germinal center reaction. Immunol Rev 160, 6377.
84.Frasca D, Riley RL, & Blomberg BB (2005) Humoral immune response and B cell functions including immunoglobulin class switch are downregulated in aged mice and humans. Semin Immunol 17, 378384.
85.Ennist DL, Jones KH, St Pierre RL et al. (1986) Functional analysis of the immunosenescence of the human B cell system: Dissociation of normal activation and proliferation from impaired terminal differentiation into IgM immunoglobulin-secreting cells. J Immunol 136, 99–105.
86.Spencer NFL & Daynes RA (1997) IL-12 directly stimulates expression of IL-10 by CD5+ B cells and IL-6 by both CD5+ and CD5– B cells: Possible involvement in age-associated cytokine dysregulation. Int Immunol 9, 745754.
87.Whisler RL & Grants IS (1993) Age-related alterations in the activation and expression of phosphotyrosine kinases and protein kinase C (PKC) among human B cells. Mech Aging Dev 71, 3146.
88.Leveille SG, Gray S, LaCroix AZ et al. (2000) Physical inactivity and smoking increase risk for serious infections in older women. J Am Geriatr Soc 48, 15821588.
89.Bruunsgaard H & Pedersen BK (2000) Effects of exercise on the immune system in the elderly population. Immunol Cell Biol 78, 523531.
90.Drela N, Kozdron E & Szczypiorski P (2004) Moderate exercise may attenuate some aspects of immunosenescence. BMC Geriatr 29, 48.
91.Kohut ML & Senchina DS (2004) Reversing age-associated immunosenescence via exercise. Exerc Immunol Rev 10, 6–41.
92.McFarlin BK, Flynn MG, Campbell WW et al. (2006) Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. J Gerontol A Biol Sci Med Sci 61, 388393.
93.Kostka T, Berthouze SE, Lacour J-R et al. (2000) The symptomatology of upper respiratory tract infections and exercise in elderly people. Med Sci Sports Exerc 32, 4651.
94.Fahlman M, Boardley D, Flynn MG et al. (2000) Effects of endurance training on selected parameters of immune function in elderly women. Gerontology 46, 97–104.
95.Raso V, Benard G, Da Silva Duarte AJ et al. (2007) Effect of resistance training on immunological parameters of healthy elderly women. Med Sci Sports Exerc 39, 21522159.
96.Smith JK, Dykes R, Douglas JE et al. (1999) Long-term exercise and atherogenic activity of blood mononuclear cells in persons at risk of developing ischemic heart disease. JAMA 281, 17221727.
97.Esposito K, Pontillo A, Di Palo C et al. (2003) Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial. JAMA 289, 17991804.
98.Goldhammer E, Tanchilevitch A, Maor I et al. (2005) Exercise training modulates cytokines activity in coronary heart disease patients. Int J Cardiol 10, 9399.
99.Vuori IM (2001) Health benefits of physical activity with special reference to interaction with diet. Public Health Nutr 4, 517528.
100.Romeo J, Wärnberg J, Gómez-Martínez S et al. (2008) Neuroimmunomodulation by nutrition in stress situations. Neuroimmunomodulation 15, 165169.
101.Wärnberg J, Gomez-Martinez S, Romeo J et al. (2009) Nutrition, inflammation, and cognitive function. Ann N Y Acad Sci 1153, 164175.
102.Moreira A, Delgado L, Moreira P et al. (2009) Does exercise increase the risk of upper respiratory tract infections? Br Med Bull 90, 111131.
103.Grimble RF (2001) Nutritional modulation of immune function. Proc Nutr Soc 60, 389397.
104.Marcos A, Nova E & Montero A (2003) Changes in the immune system are conditioned by nutrition. Eur J Clin Nutr 57, Suppl. 1, S66S69.
105.Grimble RF (1997) Effect of antioxidative vitamins on immune function with clinical applications. Int J Vitam Nutr Res 67, 312320.
106.Victor VM & De la Fuente M (2002) N-acetylcysteine improves in vitro the function of macrophages from mice with endotoxin-induced oxidative stress. Free Radic Res 36, 3345.
107.Chandra RK (2002) Nutrition and the immune system from birth to old age. Eur J Clin Nutr 56, S73S76.
108.Gleeson M (2000) The scientific basis of practical strategies to maintain immunocompetence in elite athletes. Exerc Immunol Rev 6, 75–101.
109.Gleeson M, Nieman DC & Pedersen BK (2004) Exercise, nutrition and immune function. J Sports Sci 22, 115125.
110.Bishop NC, Blannin AK, Robson PJ et al. (1999) The effects of carbohydrate supplementation on immune responses to a soccer-specific exercise protocol. J Sports Sci 17, 787796.
111.Bishop NC, Blannin AK, Walsh NP et al. (2001) Carbohydrate beverage ingestion and neutrophil degranulation responses following cycling to fatigue at 75% VO2max. Int J Sports Med 22, 226231.
112.Bishop NC, Walsh NP, Haines DL et al. (2001) Pre-exercise carbohydrate status and immune responses to prolonged cycling: I. Effect on neutrophil degranulation. Int J Sport Nutr Exerc Metab 11, 490502.
113.Bishop NC, Walsh NP, Haines DL et al. (2001c) Pre-exercise carbohydrate status and immune responses to prolonged cycling: II. Effect on plasma cytokine concentration. Int J Sport Nutr Exerc Metab 11, 503512.
114.Bishop NC, Blannin AK, Armstrong E et al. (2000) Carbohydrate and fluid intake affect the saliva flow rate and IgA response to cycling. Med Sci Sports Exerc 32, 20462051.
115.Henson DA, Nieman DC, Parker JC et al. (1998) Carbohydrate supplementation and the lymphocyte proliferative response to long endurance running. Int J Sports Med 19, 574580.
116.Nieman DC, Henson DA, Garner EB et al. (1997c) Carbohydrate affects natural killer cell redistribution but not activity after running. Med Sci Sports Exerc 29, 13181324.
117.Nieman DC, Davis JM, Henson DA et al. (2003) Carbohydrate ingestion influences skeletal muscle cytokine mRNA and plasma cytokine levels after a 3-h run. J Appl Physiol 94, 19171925.
118.Nieman DC, Davis JM, Brown VA et al. (2004) Influence of carbohydrate ingestion on immune changes after 2 h of intensive resistance training. J Appl Physiol 96, 12921298.
119.Starkie RL, Angus DJ, Rolland J et al. (2000) Effect of prolonged, submaximal exercise and carbohydrate ingestion on monocyte intracellular cytokine production in humans. J Physiol 528, 647655.
120.Starkie RL, Arkinstall MJ, Koukoulas I et al. (2001) Carbohydrate ingestion attenuates the increase in plasma interleukin-6, but not skeletal muscle interleukin-6 mRNA, Turing exercise in humans. J Physiol 533, 585591.
121.Mitchell JB, Pizza FX, Paquet A et al. (1998) Influence of carbohydrate status on immune responses before and after endurance exercise. J Appl Physiol 84, 19171925.
122.Chen YJ, Wong SH, Wong CK et al. (2008) The effect of a pre-exercise carbohydrate meal on immune responses to an endurance performance run. Br J Nutr 100, 12601268.
123.Koch AJ, Potteiger JA, Chan MA et al. (2001) Minimal influence of carbohydrate ingestion on the immune Minimal influence of carbohydrate ingestion on the immune response following acute resistance exercise. J Sport Nutr Exerc Metab 11, 149161.
124.Bacurau RF, Bassit RA, Sawada L et al. (2002) Carbohydrate supplementation during intense exercise and the immune response of cyclists. Clin Nutr 21, 423429.
125.McAnulty SR, McAnulty LS, Nieman DC et al. (2003) Influence of carbohydrate ingestion on oxidative stress and plasma antioxidant potential following a 3 h run. Free Radic Res 37, 835840.
126.Chan MA, Koch AJ, Benedict SH et al. (2003) Influence of carbohydrate ingestion on cytokine responses following acute resistance exercise. Int J Sport Nutr Exerc Metab 13, 454465.
127.Packer L, Cadenas E, Davies KJ (2008) Free radicals and exercise: an introduction. Free Radic Biol Med 44, 123125.
128.Mena P, Maynar M, Gutierrez JM et al. (1991) Erythrocyte free radical scavenger enzymes in bicycle professional racers. Adaptation to training. Int J Sports Med 12, 563566.
129.Tauler P, Aguilo A, Fuentespina E et al. (2002) Diet supplementation with vitamin E, vitamin C and beta-carotene cocktail enhances basal neutrophil antioxidant enzymes in athletes. Pflugers Arch 443, 791797.
130.Radak Z, Pucsuk J, Boros S et al. (2000) Changes in urine 8-hydroxydeoxyguanosine levels of super-marathon runners during a four-day race period. Life Sci 66, 17631767.
131.Nieman DC, Henson DA, Butterworth DE et al. (1997b) Vitamin C supplementation does not alter the immune response to 2·5 hours of running. Int J Sport Nutr 7, 173184.
132.Nieman DC, Peters EM, Henson DA et al. (2000b) Influence of vitamin C supplementation on cytokine changes following an ultramarathon. J Interferon Cytokine Res 20, 10291035.
133.Nieman DC, Henson DA, McAnulty SR et al. (2002b) Influence of vitamin C supplementation on oxidative and immune changes after an ultramarathon. J Appl Physiol 92, 19701977.
134.Peters EM, Anderson R, Nieman DC et al. (2001a) Vitamin C supplementation attenuates the increases in circulating cortisol, adrenaline and anti-inflammatory polypeptides following ultramarathon running. Int J Sports Med 22, 537543.
135.Peters EM, Anderson R, & Theron AJ (2001b) Attenuation of increase in circulating cortisol and enhancement of the acute phase protein response in vitamin C-supplemented ultramarathoners. Int J Sports Med 22, 120126.
136.Himmelstein S, Robergs R, Koehler K et al. (1998) Vitamin C supplementation and upper respiratory tract infections in marathon runners. J Exerc Physiol (online) 1, 117.
137.Fischer CP, Hiscock NJ, Penkowa M et al. (2004) Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol 558, 633645.
138.Singh A, Papanicolaou DA, Lawrence LL et al. (1999) Neuroendocrine responses to running in women after zinc and vitamin E supplementation. Med Sci Sports Exerc 31, 536542.
139.Krzywkowski K, Petersen EW, Ostrowski K et al. (2001a) Effect of glutamine supplementation on exercise-induced changes in lymphocyte function. Am J Physiol Cell Physiol 281, C1259C1265.
140.Krzywkowski K, Petersen EW, Ostrowski K et al. (2001b) Effect of glutamine and protein supplementation on exercise-induced decreases insalivary IgA. J Appl Physiol 91, 832838.
141.Walsh NP, Blannin AK, Bishop NC et al. (2000) Effect of oral glutamine supplementation on human neutrophil lipopolysaccharide-stimulated degranulation following prolonged exercise. Int J Sport Nutr Exerc Metab 10, 3950.
142.Hiscock N, Petersen EW, Krzywkowski K et al. (2003) Glutamine supplementation further enhances exercise-induced plasma IL-6. J Appl Physiol 95, 145148.
143.Venkatraman JT, Leddy J & Pendergast D (2000) Dietary fats and immune status in athletes: clinical implications. Med Sci Sports Exerc 32, Suppl. 7, S389S395.
144.Toft AD, Thorn M, Ostrowski K et al. (2000) N-3 polyunsaturated fatty acids do not affect cytokine response to strenuous exercise. J Appl Physiol 89, 24012406.
145.Kwon DK, Hwang KH, Kim YK et al. (2008) Effects of swimming exercise and soybean supplementation on the immune functions of rats fed a high-fat diet. Clin Exp Pharmacol Physiol 35, 638642.
146.Nichols AW (2007) Probiotics and athletic performance: a systematic review. Curr Sports Med Rep 6, 269273.
147.Erickson KL & Hubbard NE (2000) Probiotics immunomodulation in health and disease. J Nutr 130, Suppl. 2S, 403S409S.
148.Kekkonen RA, Vasankari TJ, Vuorimaa T et al. (2007) The effect of probiotics on respiratory infections and gastrointestinal symptoms during training in marathon runners. Int J Sport Nutr Exerc Metab 17, 352363.
149.Crooks CV, Wall CR, Cross ML et al. (2006) The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab 16, 4764.
150.Biondo PD, Robbins SJ, Walsh JD et al. (2008) A randomized controlled crossover trial of the effect of ginseng consumption on the immune response to moderate exercise in healthy sedentary men. Appl Physiol Nutr Metab 33, 966975.
151.Hammett CJ, Oxenham HC, Baldi JC et al. (2004) Effect of six months' exercise training on C-reactive protein levels in healthy elderly subjects. J Am Coll Cardiol 44, 24112413.
152.Kohut ML, McCann DA, Russell DW et al. (2006) Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of beta-blockers, BMI, and psychosocial factors in older adults. Brain Behav Immun 20, 201209.
153.Chin A, Paw MJ, de Jong N et al. (2000) Immunity in frail elderly: a randomized controlled trial of exercise and enriched foods. Med Sci Sports Exerc 32, 20052011.
154.Lancaster GI, Halson SL, Khan Q et al. (2004) Effects of acute exhaustive exercise and chronic exercise trainingon type 1 and type 2 T lymphocytes. Exerc Immunol Rev 10, 91–106.
155.Ceddia MA & Woods JA (1999) Exercise suppresses macrophage antigen presentation. JAppl Physiol 87, 22532258.
156.Gannon GA, Rhind S, Shek PN et al. (2002) Naive and memory T cell subsets are differentially mobilized during physical stress. Int J Sports Med 23, 223229.
157.Fischer CP, Plomgaard P, Hansen AK et al. (2004) Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Physiol Endocrinol Metab 287, E1189E1194.
158.Nicklas BJ, Hsu FC, Brinkley TJ et al. (2008) Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 56, 20452052.
159.Sari-Sarraf V, Reilly T & Doran DA (2006) Salivary IgA response to intermittent and continuous exercise. Int J Sports Med 27, 849855.
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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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