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Phytochemicals and cancer

  • Ian T. Johnson (a1)
  • DOI:
  • Published online: 01 April 2007

Epidemiological studies showing a protective effect of diets rich in fruits and vegetables against cancer have focused attention on the possibility that biologically-active plant secondary metabolites exert anti-carcinogenic activity. This huge group of compounds, now collectively termed ‘phytochemicals’, provides much of the flavour and colour of edible plants and the beverages derived from them. Many of these compounds also exert anti-carcinogenic effects in animal models of cancer, and much progress has been made in defining their many biological activities at the molecular level. Such mechanisms include the detoxification and enhanced excretion of carcinogens, the suppression of inflammatory processes such as cyclooxygenase-2 expression, inhibition of mitosis and the induction of apoptosis at various stages in the progression and promotion of cancer. However, much of the research on phytochemicals has been conducted in vitro, with little regard to the bioavailability and metabolism of the compounds studied. Many phytochemicals present in plant foods are poorly absorbed by human subjects, and this fraction usually undergoes metabolism and rapid excretion. Some compounds that do exert anti-carcinogenic effects at realistic doses may contribute to the putative benefits of plant foods such as berries, brassica vegetables and tea, but further research with human subjects is required to fully confirm and quantify such benefits. Chemoprevention using pharmacological doses of isolated compounds, or the development of ‘customised’ vegetables, may prove valuable but such strategies require a full risk–benefit analysis based on a thorough understanding of the long-term biological effects of what are often surprisingly active compounds.

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Corresponding author: Professor Ian Johnson, fax +44 1603 255330, email
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J Askling , J Grunewald , A Eklund , G Hillerdal & A Ekbom (1999) Increased risk for cancer following sarcoidosis. American Journal of Respiratory and Critical Care Medicine 160, 16681672.

F Balkwill & A Mantovani (2001) Inflammation and cancer: back to Virchow? Lancet 357, 539545.

J Baumann , F von Bruchhausen & G Wurm (1980) Flavonoids and related compounds as inhibition of arachidonic acid peroxidation. Prostaglandins 20, 627639.

P Brennan , CC Hsu , N Moullan , N Szeszenia-Dabrowska , J Lissowska , D Zaridze (2005) Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach. Lancet 366, 15581560.

FP Chou , YC Chu , JD Hsu , HC Chiang & CJ Wang (2000) Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Biochemical Pharmacology 60, 643650.

WM Dashwood , GA Orner & RH Dashwood (2002) Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations. Biochemical and Biophysical Research Communications 296, 584588.

G Davey Smith & S Ebrahim (2005) What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? British Medical Journal 330, 10761079.

ML Daviglus , K Liu , A Pirzada , LL Yan , DB Garside , R Wang (2005) Relationship of fruit and vegetable consumption in middle-aged men to medicare expenditures in older age: the Chicago Western Electric Study. Journal of the American Dietetic Association 105, 17351744.

S Dihlmann , A Siermann & M von Knebel Doeberitz (2001) The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signalling. Oncogene 20, 645653.

A Ekbom , C Helmick , M Zack & HO Adami (1990) Ulcerative colitis and colo-rectal cancer. A population-based study. New England Journal of Medicine 323, 12281233.

JM Gee , H Hara & IT Johnson (2002) Suppression of intestinal crypt cell proliferation and aberrant crypt foci by dietary quercetin in rats. Nutrition and Cancer 43, 193201.

A Gregorieff & H Clevers (2005) Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes and Development 19, 877890.

FJ He , CA Nowson & GA MacGregor (2006) Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367, 320326.

KJ Helzlsouer , TP Erlinger & EA Platz (2006) C-reactive protein levels and subsequent cancer outcomes: results from a prospective cohort study. European Journal of Cancer 42, 704707.

K Itoh , T Chiba , S Takahashi , T Ishii , K Igarashi , Y Katoh (1997) An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochemical and Biophysical Research Communications 236, 313322.

AS Jaiswal , BP Marlow , N Gupta & S Narayan (2002) Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells. Oncogene 21, 84148427.

I Johnson , G Williamson & S Musk (1994) Anticarcinogenic factors in plant foods: a new class of nutrients? Nutrition Research Reviews 7, 175204.

IT Johnson (2005) Cancers of the gut and Western ills. Science 307, 1839.

M Karin , Y Cao , FR Greten & ZW Li (2002) NF-kappaB in cancer: from innocent bystander to major culprit. Nature Reviews Cancer 2, 301310.

TJ Key , N Allen , P Appleby , K Overvad , A Tjonneland , A Miller (2004) Fruits and vegetables and prostate cancer: no association among 1104 cases in a prospective study of 130544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC). International Journal of Cancer 109, 119124.

YC Liang , YT Huang , SH Tsai , SY Lin-Shiau , CF Chen & JK Lin (1999) Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages. Carcinogenesis 20, 19451952.

YC Liang , SH Tsai , DC Tsai , SY Lin-Shiau & JK Lin (2001) Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages. FEBS Letters 496, 1218.

SJ London , JM Yuan , FL Chung , YT Gao , GA Coetzee , RK Ross & MC Yu (2000) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China. Lancet 356, 724729.

R McDanell , AE McLean , AB Hanley , RK Heaney & GR Fenwick (1988) Chemical and biological properties of indole glucosinolates (glucobrassicins): a review. Food and Chemical Toxicology 26, 5970.

C Martin , A Connelly , TO Keku , SB Mountcastle , J Galanko , JT Woosley , B Schliebe , PK Lund & RS Sandler (2002) Nonsteroidal anti-inflammatory drugs, apoptosis, and colo-rectal adenomas. Gastroenterology 123, 17701777.

W Miao , L Hu , PJ Scrivens & G Batist (2005) Transcriptional regulation of NF-E2 p45-related factor (NRF2) expression by the aryl hydrocarbon receptor-xenobiotic response element signaling pathway: direct cross-talk between phase I and II drug-metabolizing enzymes. Journal of Biological Chemistry 280, 2034020348.

KB Michels , G Edward , KJ Joshipura , BA Rosner , MJ Stampfer , CS Fuchs , GA Colditz , FE Speizer & WC Willett (2000) Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers. Journal of the National Cancer Institute 92, 17401752.

RF Mithen , M Dekker , R Verkerk , S Rabot & IT Johnson (2000) The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foods. Journal of the Science of Food and Agriculture 80, 967984.

DR Nelson , T Kamataki , DJ Waxman , FP Guengerich , RW Estabrook , R Feyereisen (1993) The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA and Cell Biology 12, 151.

KA O'Leary , S de Pascual-Tereasa , PW Needs , YP Bao , NM O'Brien & G Williamson (2004) Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription. Mutation Research 551, 245254.

CH Park , JY Chang , ER Hahm , S Park , HK Kim & CH Yang (2005) Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochemical and Biophysical Research Communications 328, 227234.

N Petri , C Tannergren , B Holst , FA Mellon , Y Bao , GW Plumb (2003) Absorption/metabolism of sulforaphane and quercetin, and regulation of phase II enzymes, in human jejunum in vivo. Drug Metabolism and Disposition 31, 805813.

G Rouzaud , SA Young & AJ Duncan (2004) Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiology, Biomarkers and Prevention 13, 125131.

TK Smith , EK Lund , RG Clarke , RN Bennett & IT Johnson (2005) Effects of Brussels sprout juice on the cell cycle and adhesion of human colo-rectal carcinoma cells (HT29) in vitro. Journal of Agricultural and Food Chemistry 53, 38953901.

TK Smith , EK Lund & IT Johnson (1998) Inhibition of dimethylhydrazine-induced aberrant crypt foci and induction of apoptosis in rat colon following oral administration of the glucosinolate sinigrin. Carcinogenesis 19, 267273.

TK Smith , EK Lund , ML Parker , RG Clarke & IT Johnson (2004) Allyl-isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT29 cells. Carcinogenesis 25, 14091415.

TK Smith , R Mithen & IT Johnson (2003) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo. Carcinogenesis 24, 491495.

KA Steinmetz & JD Potter (1996) Vegetables, fruit, and cancer prevention: a review. Journal of the American Dietetic Association 96, 10271039.

L Tang , G Li , L Song & Y Zhang (2006) The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs 17, 297305.

P Terry , JB Terry & A Wolk (2001) Fruit and vegetable consumption in the prevention of cancer: an update. Journal of Internal Medicine 250, 280290.

MJ Tijhuis , PA Wark , JM Aarts , MH Visker , FM Nagengast , FJ Kok & E Kampman (2005) GSTP1 and GSTA1 polymorphisms interact with cruciferous vegetable intake in colo-rectal adenoma risk. Cancer Epidemiology, Biomarkers and Prevention 14, 29432951.

CH van Gils , PH Peeters , HB Bueno-de-Mesquita , HC Boshuizen , PH Lahmann , F Clavel-Chapelon (2005) Consumption of vegetables and fruits and risk of breast cancer. Journal of the American Medical Association 293, 183193.

TL Vaughan , LM Dong , PL Blount , K Ayub , RD Odze , CA Sanchez , PS Rabinovitch & BJ Reid (2005) Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: a prospective study. Lancet Oncology 6, 945952.

AH Wikramanayake , M Hong , PN Lee , K Pang , CA Byrum , JM Bince , R Xu & MQ Martindale (2003) An ancient role for nuclear beta-catenin in the evolution of axial polarity and germ layer segregation. Nature 426, 446450.

D Xiao , JT Pinto , GG Gundersen & IB Weinstein (2005) Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells. Molecular Cancer Therapeutics 4, 13881398.

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