Hostname: page-component-76dd75c94c-t6jsk Total loading time: 0 Render date: 2024-04-30T07:39:57.969Z Has data issue: false hasContentIssue false
  • English
  • Français

Postprandial lipid metabolism: an overview

Published online by Cambridge University Press:  28 February 2007

Richard J. Havel
Richard J. Havel
Affiliation:
Cardiovascular Research Institute and Department of Medicine, University of California, San Francisco, California, USA
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Guest Lecture
Information
Proceedings of the Nutrition Society , Volume 56 , Issue 2 , July 1997 , pp. 659 - 666
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Bergeron, N. & Havel, R. J. (1995). Influence of diets rich in saturated and omega-6 polyunsaturated fatty acids on the postprandial responses of apolipoproteins B-48, B-100, E and lipids in triglyceride-rich lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology 15, 2111–2121.CrossRefGoogle Scholar
Bergeron, N. & Havel, R. J. (1996). Prolonged postprandial response of lipids and apolipoproteins in triglyceride-rich lipoproteins of individuals expressing an apolipoprotein ε4 allele. Journal of Clinical Investigation 97, 65–72.CrossRefGoogle Scholar
Bergeron, N. & Havel, R. J. (1997). Assessment of postprandial lipemia: nutritional influences. Current Opinion in Lipidology (In the Press).CrossRefGoogle ScholarPubMed
Bergeron, N., Kotite, L. & Havel, R.J. (1996). Simultaneous quantification of apolipoproteins B-100, B-48 and E separated by SDS-PAGE. Methods in Enzymology 263, 82–94.CrossRefGoogle Scholar
Bergman, E.N., Havel, R.J., Wolfe, B.M. & Bøhmer, T. (1971). Quantitative studies of the metabolism of chylomicron triglycerides and cholesterol by liver and extrahepatic tissues of sheep and dogs. Journal of Clinical Investigation 50, 1831–1839.CrossRefGoogle Scholar
Berr, F. (1992). Characterization of chylomicron remnant clearance by retinyl palmitate label in normal humans. Journal of Lipid Research 33, 915–930.CrossRefGoogle ScholarPubMed
Bjorkegren, J., Packard, C. J., Hamsten, A., Bedford, D., Caslake, M., Foster, L., Shepherd, J., Steward, P. & Karpe, F. (1996). Accumulation of large very low density lipoprotein in plasma during intravenous infusion of a chylomicron-like triglyceride emulsion reflects competition for a common lipolytic pathway. Journal of Lipid Research 37, 76–86.CrossRefGoogle ScholarPubMed
Campos, E., Nakajima, K., Tanaka, K. & Havel, R. J. (1992). Properties of an apolipoprotein E-enriched fraction of triglyceride-rich lipoproteins isolated from human blood plasma with a monoclonal antibody to apolipoprotein B-100. Journal of Lipid Research 33, 369–380.CrossRefGoogle ScholarPubMed
Castro, G. R. & Fielding, C. J. (1985). Effects of postprandial lipemia on plasma cholesterol metabolism. Journal of Clinical Investigation 75, 874–882.CrossRefGoogle ScholarPubMed
Connelly, P.W., Vezina, C. & Maguire, G. F. (1996). Quantification of apolipoprotein C-II by immunochemical and chromatographic methods. Methods in Enzymology 263, 188–208.CrossRefGoogle ScholarPubMed
Dubois, C., Armand, M., Ferezou, J., Beaumier, G., Portugal, H., Pauli, A.-M., Bernard, P.-M., Becue, T., Lafont, H. & Lairon, D. (1996). Postprandial appearance of dietary deuterated cholesterol in the chylomicron fraction and whole plasma in healthy subjects. American Journal of Clinical Nutrition 64, 47–52.CrossRefGoogle ScholarPubMed
Fielding, B. A., Callow, J., Owen, R. M., Samra, J. S., Matthews, D. R. & Frayn, K. N. (1995). Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. American Journal of Clinical Nutrition 63, 36–41.CrossRefGoogle Scholar
Fielding, C. J., Havel, R. J., Todd, K. M., Yco, K. E., Schloetter, M. C., Weinberg, V. & Frost, P. H. (1995). Effects of dietary cholesterol and fat saturation on plasma lipoproteins in an ethnically diverse population of healthy young men. Journal of Clinical Investigation 95, 611–618.CrossRefGoogle Scholar
Frayn, K. N., Shadid, S., Roohi, H., Humphreys, S. M., Clark, M. L., Fielding, B. A., Boland, O. & Coppack, S. W. (1994). Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. American Journal of Physiology 266, E308–E317.Google ScholarPubMed
Gage, S. H. & Fish, P. A. (1924). Fat digestion, absorption, and assimilation in man and animals as determined by the dark-field microscope, and a fat-soluble dye. American Journal of Anatomy 34, 1–85.CrossRefGoogle Scholar
Gofman, J. W., Lindgren, F. T. & Elliott, H. (1949). Ultracentrifugal studies of lipoproteins of human serum. Journal of Biological Chemistry 179, 973–979.CrossRefGoogle ScholarPubMed
Havel, R. J. (1957). Early effects of fat ingestion on lipids and lipoproteins of serum in man. Journal of Clinical Investigation 36, 848–854.CrossRefGoogle ScholarPubMed
Havel, R. J. (1965). Metabolism of lipids in chylomicrons and very low-density lipoproteins. In Handbook of Physiology. Section 5, Adipose Tissue, pp. 499–507 [Renold, A. E. and Cahill, G. F. Jr., editors] Baltimore: Williams and Wilkins.Google Scholar
Havel, R. J. (1972). Caloric homeostasis and disorders of fuel transport. New England Journal of Medicine 287, 1186–1192.CrossRefGoogle ScholarPubMed
Havel, R. J. (1974). Lipid transport and the availability of insulin. Hormone and Metabolic Research Suppl. 4, 51–53.Google ScholarPubMed
Havel, R. J. (1989). Contrasts and similarities between the metabolism of intestinal and hepatic lipoproteins: the role of particle size. In Intestinal Lipid and Lipoprotein 8:31 Metabolism, pp. 168–173 [Windler, E. and Greten, H., editors]. Munich: W. Zuckschwerdt Verlag.Google Scholar
Havel, R. J. (1994). Postprandial hyperlipidemia and remnant lipoproteins. Current Opinion in Lipidology 5, 102–109.CrossRefGoogle ScholarPubMed
Havel, R. J. (1996). Dissection of steps mediating the hepatic uptake and catabolism of chylomicron remnants in rodents – removal from the blood and endocytosis into hepatocytes. Zeitschrift für Gastroenterologie 34, Suppl. 3, 99–102.Google ScholarPubMed
Havel, R. J., Eder, H. & Bragdon, J. (1955). The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. Journal of Clinical Investigation 34, 1345–1353.CrossRefGoogle ScholarPubMed
Havel, R. J., Fielding, C. J., Olivecrona, T., Shore, V. G., Fielding, P. E. & Egelrud, T. (1973 a). Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoprotein lipase from different sources. Biochemistry 12, 1828–1833.CrossRefGoogle ScholarPubMed
Havel, R. J. & Fredrickson, D. (1956). The metabolism of chylomicra. I. The removal of palmitic acid-1-C14 labeled chylomicra from dog plasma. Journal of Clinical Investigation 35, 1025–1032.CrossRefGoogle Scholar
Havel, R. J. & Gordon, R. Jr (1960). Idiopathic hyperlipemia. Metabolic studies in an affected family. Journal of Clinical Investigation 39, 1777–1790.CrossRefGoogle Scholar
Havel, R. J., Kane, J. P., Balasse, E. O., Segel, N. & Basso, L. V. (1970). Splanchnic metabolism of free fatty acids and production of triglyceride of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humans. Journal of Clinical Investigation 49, 2017–2035.CrossRefGoogle ScholarPubMed
Havel, R. J., Kane, J. P. & Kashyap, M. D. (1973 b). Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. Journal of Clinical Investigarion 52, 32–38.CrossRefGoogle ScholarPubMed
Hoeg, J. M., Sviridov, D. D., Tennyson, D. E., Demosky, S. J., Meng, M. S., Bojanovski, D., Safonova, D., Safonova, I. G., Repin, V. S., Kuberger, M. B., Smimov, V. N., Higuchi, K., Gregg, R. E. & Brewer, H. B. (1990). Both apolipoprotein B-48 and B-100 are synthesized and secreted by the human intestine. Journal of Lipid Research 31, 1761–1769.CrossRefGoogle ScholarPubMed
Imaizumi, K., Havel, R. J., Fainaru, M. & Vigne, J.-L. (1978). Origin and transport of the A-1 and arginine-rich apolipoproteins in mesenteric lymph of rats. Journal of Lipid Research 19, 1038–104CrossRefGoogle Scholar
Jäckle, S., Runquist, E., Brady, S., Hamilton, R. L. & Havel, R. J. (1991). Isolation and characterization of three endosomal fractions from the liver of normal rats after lipoprotein loading. Journal of Lipid Research 32, 485–498.CrossRefGoogle ScholarPubMed
Jones, A. L., Hradek, G. T., Hornick, C., Renaud, G., Windler, E. E. T. & Havel, R. J. (1984). Uptake and processing of remnants of chylomicrons and very low density lipoproteins by rat liver. Journal of Lipid Research 25, 1151–1158.CrossRefGoogle ScholarPubMed
Kane, J. P., Hardman, D. A. & Paulus, H. E. (1980). Heterogeneity of apolipoprotein B: Isolation of a new species from human chylomicrons. Proceedings of the National Academy of Sciences USA 77, 2465–2469.CrossRefGoogle ScholarPubMed
Karpe, F. & Hamsten, A. (1995). Postprandial lipoprotein metabolism and atherosclerosis. Current Opinion in Lipidology 6, 123–129.CrossRefGoogle ScholarPubMed
Karpe, F., Hamsten, A., Uffelman, K. & Steiner, G. (1996). Apolipoprotein B-48. Methods in Enzymology 263, 95–104.CrossRefGoogle ScholarPubMed
Korn, E. D. (1955). Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart. Journal of Biological Chemistry 215, 1–14.CrossRefGoogle ScholarPubMed
Krasinski, S. D., Cohn, J. S., Russell, R. M. & Schaefer, E. J. (1990). Postprandial plasma vitamin A metabolism in humans: A reassessment of the use of plasma retinyl esters as markers for intestinally derived chylomicrons and their remnants. Metabolism 39, 357–365.CrossRefGoogle ScholarPubMed
Mendeloff, A. L. (1954). The effects of eating and of sham feeding upon the absorption of vitamin A palmitate in man. Journal of Clinical Investigation 33, 1015–1021.CrossRefGoogle ScholarPubMed
Mjøs, O. D., Faergeman, O., Hamilton, R. L. & Havel, R. J. (1975). Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat. Journal of Clinical Investigation 56, 603–615.CrossRefGoogle Scholar
Nakajima, K., Saito, T., Tamura, A., Suzuki, M., Nakano, T., Adachi, M., Tanaka, A., Tada, N., Nakamura, H., Campos, E. & Havel, R. J. (1993). Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100 and anti apo A-I immunoaffinity mixed gels. Clinica Chimica Acta 223, 53–71.CrossRefGoogle ScholarPubMed
Nestel, P., Havel, R. J. & Bezman, A. (1963). Metabolism of constituent lipids of dog chylomicrons. Journal of Clinical Investigation 42, 1313–1321.CrossRefGoogle ScholarPubMed
Pagnan, A., Havel, R. J., Kane, J. P. & Kotite, L. (1977). Characterization of human very low density lipoproteins containing two electrophoretic populations: double pre-beta lipoproteinemia and primary dysbetalipoproteinemia. Journal of Lipid Research 18, 613–622.CrossRefGoogle ScholarPubMed
Peterson, J., Bihain, B. E., Bengtsson-Olivecrona, G., Deckelbaum, R. J., Carpentier, Y. A. & Olivecrona, T. (1990). Fatty acid control of lipoprotein lipase: A link between energy metabolism and lipid transport. Proceedings of the National Academy of Sciences USA 87, 909–913.CrossRefGoogle ScholarPubMed
Redgrave, T. G. (1970). Formation of cholesteryl ester-rich particulate lipid during metabolism of chylomicrons. Journal of Clinical Investigation 49 465–47.CrossRefGoogle ScholarPubMed
Schneeman, B. O., Kotite, L., Todd, K. M. & Havel, R. J. (1993). Relationships between the responses of triglyceride-rich lipoproteins in blood plasma containing apolipoproteins B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proceedings of the National Academy of Sciences USA 90, 2069–2073.CrossRefGoogle ScholarPubMed
Stalenhoef, A. F. H., Malloy, M. J., Kane, J. P. & Havel, R. J. (1986). Metabolism of apolipoproteins B-48 and B-100 of triglyceride-rich lipoproteins in patients with familial dysbetalipoproteinemia. Journal of Clinical Investigation 78, 722–728.CrossRefGoogle ScholarPubMed
van't Hooft, F. M., Hardman, D. A., Kane, J. P. & Havel, R. J. (1982). Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins. Proceedings of the National Academy of Sciences USA 79, 179–182.CrossRefGoogle Scholar
Vigne, J.-L. & Havel, R. J. (1981). Metabolism of apolipoprotein A-1 of chylomicrons in rats and humans. Canadian Journal of Biochemistry 59, 613–618.CrossRefGoogle ScholarPubMed
Weintraub, M. S., Eisenberg, S. & Breslow, J. L. (1987). Dietary fat clearance in normal subjects is regulated by genetic variation in apolipoprotein E. Journal of Clinical Investigation 80, 1571–1577.CrossRefGoogle ScholarPubMed