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Recent advances in the physiology of eating

  • Stephen French (a1) and Kate Castiglione (a2)

Since the discovery of the protein product of the ob/ob gene, leptin, knowledge of the neurochemical pathways involved in the regulation of feeding has increased enormously. Our understanding of the mechanisms regulating food intake in man has also progressed greatly over a similar time span. Previous research into the regulation of food intake has largely proceeded through a reductionist approach, defining ever-smaller components of these mechanisms. This research strategy has been very productive and instructive, and has yielded a great deal of information on the specific putative components linking energy status and food intake. However, to fully understand the regulation of feeding it is important that these components are systematically reconstructed to investigate relevant interactions. In the present review recent data relating to interactions between systems proposed to be involved in feeding regulation will be highlighted. The review will be directed predominantly (but not exclusively) towards the regulation of human feeding.

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*Corresponding author: Dr Stephen French, fax +44 1753 514499, email
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DG Baskin , JF Breininger , S Bonigut & MA Miller (1999a) Leptin binding in the arcuate nucleus is increased during fasting. Brain Research 828, 154158.

DG Baskin , DP Figlewicz , D Latterman , RJ Seeley , SC Woods , D Jr Porte & MC Schwartz (1999b) Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Research 848, 114123.

B Beck (2000) Neuropeptides and obesity. Nutrition 16, 916923.

LA Campfield & FJ Smith (1986) Functional coupling between transient declines in blood glucose and feeding behavior: temporal relationships. Brain Research Bulletin 17, 427433.

LA Campfield , FJ Smith , M Rosenbaum & J Hirsch (1996) Human eating: evidence for a physiological basis using a modified paradigm. Neuroscience and Biobehavioural Reviews 20, 133137.

KE Castiglione , NW Read & SJ French (1998) Food intake responses to upper gastrointestinal lipid infusions in humans. Physiology and Behavior 64, 141145.

ES Corp , DB Conze , F Smith & LA Campfield (1996) Regional localization of specific {I-125} leptin binding sites in the rat forebrain. Brain Research 789, 4047.

M Covasa & RC Ritter (1998) Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides 19, 14071415.

K Cunningham , J Daly , M Horowitz & NW Read (1991) Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 32, 483486.

JD Davis (1989) The microstructure of ingestive behavior. Annals of the New York Academy of Sciences 575, 106119.

JM de Castro (2000) Eating behavior: lessons from the real world of humans. Nutrition 16, 800813.

L Degen , D Matzinger , J Drewe & C Beglinger (2001) The effect of cholecystokinin in controlling appetite and food intake in humans. Peptides 22, 12651269.

S Eaton (2002) Control of mitochondrial b-oxidation flux. Progress in Lipid Research 41, 197239.

IS Farooqi , SA Jebb , G Langmack , E Lawrence , CH Cheetham , AM Prentice , IA Hughes , MA McCamish & S O'Rahilly (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 341, 913915.

DP Figlewicz , AJ Sipols , RJ Seeley , M Chavez , SC Woods & D Jr Porte (1995) Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon. Behavioral Neuroscience 109, 565569.

MI Friedman (1997) An energy sensor for control of energy intake. Proceedings of the Nutrition Society 56, 4150.

SJ French , CA Conlon , ST Mutuma , M Arnold , NW Read , G Meijer & J Francis (2000) The effects of intestinal infusion of long-chain fatty acids on food intake in humans. Gastroenterology 119, 943948.

B French SJ. Murray , RDE Rumsey , R Fadzlin & NW Read (1995) Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin. British Journal of Nutrition 73, 179189.

A Geliebter (1988) Gastric distension and gastric capacity in relation to food intake in humans. Physiology and Behavior 44, 665668.

A Geliebter & SA Hashim (2001) Gastric capacity in normal, obese, and bulimic women. Physiology and Behavior 74, 743746.

JJ Holst (1994) Glucagon like peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology 107, 18481855.

A Kahler , M Zimmermann & W Langhans (1999) Suppression of hepatic fatty acid oxidation and food intake in men. Nutrition 15, 819828.

EM Kovacs , MS Westerterp-Plantenga , M de Vries , F Brouns & WH Saris (2001a) Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake. Physiology and Behavior 74, 543549.

WF Lam , HAJ Gielkens , SY de Boer , CBHW Lamers & AAM Masclee (1998) Influence of hyperglycemia on the satiating effect of CCK in humans. Physiology and Behavior 65, 505511.

W Langhans (1996) Metabolic and glucostatic control of feeding. Proceedings of the Nutrition Society 55, 497515.

M Leonhardt , B Hrupka & W Langhans (2001) Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats. Physiology and Behavior 74, 191196.

J McLaughlin , M Grazia Luca , MN Jones , M D'Amato , GJ Dockray & DG Thompson (1999) Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116, 4653.

CA Matson , MF Wiater , JL Kuijper & DS Weigle (1997) Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 18, 12751278.

RD Mattes & L Bormann (2000) Effects of (-)-hydroxycitric acid on appetitive variables. Physiology and Behavior 71, 8794.

TH Moran (2000) Cholecystokinin and satiety: current perspectives. Nutrition 16, 858865.

E Oster-Jorgensen , N Qvist , SA Pedersen , L Rasmussen & CP Hovendal (1992) The influence of induced hyperglycaemia on the characteristics of intestinal motility and bile kinetics in healthy men. Scandinavian Journal of Gastroenterology 27, 285288.

CR Plata-Salaman (2000) Ingestive behavior and obesity. Nutrition 16, 797799.

CA Reidy , M Chavez , DP Figlewicz & SC Woods (1995) Central insulin enhances sensitivity to cholecystokinin. Physiology and Behavior 58, 755760.

M Russek (1963) An hypothesis on the participation of hepatic glucoreceptors in the control of food intake. Nature 197, 7980.

M Russek (1970) Demonstration of the influence of an hepatic glucose-sensitive mechanism on food intake. Physiology and Behavior 5, 12071209.

E Schvarcz , M Palmer , J Aman & C Berne (1995) Hypoglycemia increases the gastric emptying rate in healthy subjects. Diabetes Care 18, 674676.

E Shvarcz , M Palmer , J Aman , M Horowitz , M Stridsberg & C Berne (1997) Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113, 6066.

E Schvarcz , M Palmer , J Aman , B Lindkvist & KW Beckman (1993) Hypoglycaemia increases the gastric emptying rate in patients with type 1 diabetes mellitus. Diabetic Medicine 10, 660663.

MW Schwartz , AJ Sipols , CE Grubin & DG Baskin (1993) Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Research Bulletin 31, 361367.

MW Schwartz , AJ Sipols , JL Marks , G Sanacora , JD White , A et al Scheurink . (1992) Inhibition of hypothalamic neuropeptide gene expression by insulin. Endocrinology 130, 36083616.

RG Shulman & DL Rothman (2001) 13C NMR of intermediary metabolism: implications for systemic physiology. Annual Review of Physiology 63, 1548.

TW Stephens , M Basinski , PK Bristow , JM Bue-Valleskey , SG Burgett , L et al Craft . (1995) The role of neuropeptide Y in the anti-obesity action of the obese gene product. Nature 377, 530532.

JA Watson , M Fang & JM Lowenstein (1969) Tricarballylate and hydroxycitrate: Substrate and inhibitors of ATP:citrate oxaloacetate lyase. Archives of Biochemistry and Biophysics 135, 209217.

MR Yeomans (1998) Taste, palatability and the control of appetite. Proceedings of the Nutrition Society 57, 609615.

MR Yeomans , MD Lee , RW Gray & SJ French (2001) Effects of test-meal palatability on compensatory eating following disguised fat and carbohydrate preloads. International Journal of Obesity 25, 12151224.

N Zarjevski , I Cusin , R Vettor , F Rohner-Jeanrenaud & B Jenrenaud (1993) Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133, 17531758.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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