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Recent advances in the physiology of eating

  • Stephen French (a1) and Kate Castiglione (a2)
Abstract

Since the discovery of the protein product of the ob/ob gene, leptin, knowledge of the neurochemical pathways involved in the regulation of feeding has increased enormously. Our understanding of the mechanisms regulating food intake in man has also progressed greatly over a similar time span. Previous research into the regulation of food intake has largely proceeded through a reductionist approach, defining ever-smaller components of these mechanisms. This research strategy has been very productive and instructive, and has yielded a great deal of information on the specific putative components linking energy status and food intake. However, to fully understand the regulation of feeding it is important that these components are systematically reconstructed to investigate relevant interactions. In the present review recent data relating to interactions between systems proposed to be involved in feeding regulation will be highlighted. The review will be directed predominantly (but not exclusively) towards the regulation of human feeding.

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Corresponding author
*Corresponding author: Dr Stephen French, fax +44 1753 514499, email Stephen.French@eu.effem.com
References
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Anand BK & Brobeck JR (1951) Hypothalamic control of food intake in rats and cats. Yale Journal of Biological Medicine 24, 123140.
Andrews JM, Rayner CK, Doran S, Hebbard GS & Horowitz M (1998) Physiological changes in blood glucose affect appetite and pyloric motility during intraduodenal lipid infusion. American Journal of Physiology 275, G797-G804.
Baskin DG, Breininger JF, Bonigut S & Miller MA (1999a) Leptin binding in the arcuate nucleus is increased during fasting. Brain Research 828, 154158.
Baskin DG, Figlewicz DP, Latterman D, Seeley RJ, Woods SC, Porte D Jr & Schwartz MC (1999b) Insulin and leptin: dual adiposity signals to the brain for the regulation of food intake and body weight. Brain Research 848, 114123.
Beck B (2000) Neuropeptides and obesity. Nutrition 16, 916923.
Campfield LA & Smith FJ (1986) Functional coupling between transient declines in blood glucose and feeding behavior: temporal relationships. Brain Research Bulletin 17, 427433.
Campfield LA, Smith FJ, Rosenbaum M & Hirsch J (1996) Human eating: evidence for a physiological basis using a modified paradigm. Neuroscience and Biobehavioural Reviews 20, 133137.
Castiglione KE, Read NW & French SJ (1998) Food intake responses to upper gastrointestinal lipid infusions in humans. Physiology and Behavior 64, 141145.
Castiglione KE, Read NW & French SJ (2002) Adaptation to high-fat diet accelerates emptying of fat but not carbohydrate test meals in humans. American Journal of Physiology 282, R366-R371.
Corp ES, Conze DB, Smith F & Campfield LA (1996) Regional localization of specific {I-125} leptin binding sites in the rat forebrain. Brain Research 789, 4047.
Covasa M & Ritter RC (1998) Rats maintained on high-fat diets exhibit reduced satiety in response to CCK and bombesin. Peptides 19, 14071415.
Covasa M. & Ritter RC (1999) Reduced sensitivity to the satiation effect of intestinal oleate in rats adapted to a high fat diet. American Journal of Physiology 277, R279-R285.
Covasa M & Ritter RC (2000) Adaptation to a high-fat diet reduces inhibition of gastric emptying by CCK and intestinal oleate. American Journal of Physiology 278, R166-R170.
Cunningham K, Daly J, Horowitz M & Read NW (1991) Gastrointestinal adaptation to diets of differing fat composition in human volunteers. Gut 32, 483486.
Davis JD (1989) The microstructure of ingestive behavior. Annals of the New York Academy of Sciences 575, 106119.
de Castro JM (2000) Eating behavior: lessons from the real world of humans. Nutrition 16, 800813.
Degen L, Matzinger D, Drewe J & Beglinger C (2001) The effect of cholecystokinin in controlling appetite and food intake in humans. Peptides 22, 12651269.
Eaton S (2002) Control of mitochondrial b-oxidation flux. Progress in Lipid Research 41, 197239.
Farooqi IS, Jebb SA, Langmack G, Lawrence E, Cheetham CH, Prentice AM, Hughes IA, McCamish MA & O'Rahilly S (1999) Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 341, 913915.
Feinle C, Grundy D & Read NW (1997) Effects of duodenal nutrients on sensory and motor responses of the human stomach to distension. American Journal of Physiology 273, G721-G726.
Figlewicz DP, Sipols AJ, Seeley RJ, Chavez M, Woods SC & Porte D Jr (1995) Intraventricular insulin enhances the meal-suppressive efficacy of intraventricular cholecystokinin octapeptide in the baboon. Behavioral Neuroscience 109, 565569.
Francis J, Castiglione KE & French SJ (1997) Techniques for gastric distension in humans. In Ingestive Behavior Protocols, pp. 8792 [Wellman PJ and Hoebel B, editors]. New York: SSIB.
Frayn KN, Coppack SW & Humphreys SM (1993) Subcutaneous adipose tissue metabolism studied by local catheterization. International Journal of Obesity 17,Suppl. 3, S18-S21.
Friedman MI (1997) An energy sensor for control of energy intake. Proceedings of the Nutrition Society 56, 4150.
French SJ, Castiglione KE & Francis J (1997) Techniques for intestinal nutrient infusion in humans. In Ingestive Behaviour Protocols, pp. 8186. [Wellman PJ and Hoebel B, editors]. New York: SSIB.
French SJ, Conlon CA, Mutuma ST, Arnold M, Read NW, Meijer G & Francis J (2000) The effects of intestinal infusion of long-chain fatty acids on food intake in humans. Gastroenterology 119, 943948.
French SJ. Murray B, Rumsey RDE, Fadzlin R & Read NW (1995) Adaptation to high-fat diets: effects on eating behaviour and plasma cholecystokinin. British Journal of Nutrition 73, 179189.
Geliebter A (1988) Gastric distension and gastric capacity in relation to food intake in humans. Physiology and Behavior 44, 665668.
Geliebter A & Hashim SA (2001) Gastric capacity in normal, obese, and bulimic women. Physiology and Behavior 74, 743746.
Geliebter A, Melton PM, Gage D, McCray RS & Hashim SA (1992) Gastric capacity, gastric emptying, and test meal intake in normal and bulimic women. American Journal of Clinical Nutrition 56, 656661.
Geliebter A, Schachter S, Lohmann-Walter C, Feldman H & Hashim SA (1996) Reduced stomach capacity in obese subjects after dieting. American Journal of Clinical Nutrition 63, 170173.
Granstrom L & Backman L (1985) Stomach distension in extremely obese and in normal subjects. Acta Chirugica Scandinavica 151, 367370.
Holst JJ (1994) Glucagon like peptide 1: a newly discovered gastrointestinal hormone. Gastroenterology 107, 18481855.
Jequier E & Tappy L (1999) Regulation of body weight in humans. Physiological Reviews 79, 451480.
Kahler A, Zimmermann M & Langhans W (1999) Suppression of hepatic fatty acid oxidation and food intake in men. Nutrition 15, 819828.
Kaiyala KJ, Woods SC & Schartz MW (1995) New model for the regulation of energy balance and adiposity by the central nervous system. American Journal of Clinical Nutrition 62, 1123s1134s.
Kalant D, Phélis S, Fielding BA, Frayn KN, Cianflone K & Sniderman AD (2000) Increased postprandial fatty acid trapping in subcutaneous adipose tissue in obese women. Journal of Lipid Research 41, 19631968.
Kissileff HR, Klingsberg G & Van Itallie TB (1980) Universal eating monitor for continuous recording of solid or liquid consumption in man. American Journal of Physiology 238, R14-R22.
Kovacs EM, Westerterp-Plantenga MS, de Vries M, Brouns F & Saris WH (2001a) Effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety and food intake. Physiology and Behavior 74, 543549.
Kovacs EM, Westerterp-Plantenga MS & Saris WH (2001b) The effects of 2-week ingestion of (-)-hydroxycitrate and (-)-hydroxycitrate combined with medium-chain triglycerides on satiety, fat oxidation, energy expenditure and body weight. International Journal of Obesity 25, 1087-1094.
Lam WF, Gielkens HAJ, de Boer SY, Lamers CBHW & Masclee AAM (1998) Influence of hyperglycemia on the satiating effect of CCK in humans. Physiology and Behavior 65, 505511.
Langhans W (1996) Metabolic and glucostatic control of feeding. Proceedings of the Nutrition Society 55, 497515.
Lavin JH, Palikaridis D, Read NW & French SJ (1997) The effect of carbohydrate utilisation during high intensity exercise on eating behaviour. Appetite 29, 402Abstr.
Lawton CL, Delargy HJ, Brockman J, Smith FC & Blundell JE. (2000) The degree of saturation of fatty acids influences post-ingestive satiety. British Journal of Nutrition 83, 473482.
Leonhardt M, Hrupka B & Langhans W (2001) Effect of hydroxycitrate on food intake and body weight regain after a period of restrictive feeding in male rats. Physiology and Behavior 74, 191196.
McLaughlin J, Grazia Luca M, Jones MN, D'Amato M, Dockray GJ & Thompson DG (1999) Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116, 4653.
Matson CA, Reid DF, Cannon TA & Ritter RC (2000) Cholecystokinin and leptin act synergistically to reduce body weight. American Journal of Physiology 278, R882-R890.
Matson CA, Wiater MF, Kuijper JL & Weigle DS (1997) Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 18, 12751278.
Matson CA & Ritter RC (1999) Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. American Journal of Physiology 276, R1038-R1045.
Mattes RD & Bormann L (2000) Effects of (-)-hydroxycitric acid on appetitive variables. Physiology and Behavior 71, 8794.
Melanson KJ, Westerterp-Plantenga MS, Saris WHM, Smith FJ & Campfield LA (1999) Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat. American Journal of Physiology 46, R337-R345.
Moran TH (2000) Cholecystokinin and satiety: current perspectives. Nutrition 16, 858865.
Oster-Jorgensen E, Qvist N, Pedersen SA, Rasmussen L & Hovendal CP (1992) The influence of induced hyperglycaemia on the characteristics of intestinal motility and bile kinetics in healthy men. Scandinavian Journal of Gastroenterology 27, 285288.
Plata-Salaman CR (2000) Ingestive behavior and obesity. Nutrition 16, 797799.
Reidy CA, Chavez M, Figlewicz DP & Woods SC (1995) Central insulin enhances sensitivity to cholecystokinin. Physiology and Behavior 58, 755760.
Robinson TM, French SJ, Lee MD, Gray RW & Yeomans MR (2001) Effects of test meal palatability on responses to intragastric nutrient preloads. Appetite 37, 159Abstr.
Rolls BJ, Gnizak N, Summerfelt A & Laster LJ (1988) Food intake in dieters and nondieters after a liquid meal containing medium-chain triglycerides. American Journal of Clinical Nutrition 48, 6671.
Russek M (1963) An hypothesis on the participation of hepatic glucoreceptors in the control of food intake. Nature 197, 7980.
Russek M (1970) Demonstration of the influence of an hepatic glucose-sensitive mechanism on food intake. Physiology and Behavior 5, 12071209.
Schvarcz E, Palmer M, Aman J & Berne C (1995) Hypoglycemia increases the gastric emptying rate in healthy subjects. Diabetes Care 18, 674676.
Shvarcz E, Palmer M, Aman J, Horowitz M, Stridsberg M & Berne C (1997) Physiological hyperglycemia slows gastric emptying in normal subjects and patients with insulin-dependent diabetes mellitus. Gastroenterology 113, 6066.
Schvarcz E, Palmer M, Aman J, Lindkvist B & Beckman KW (1993) Hypoglycaemia increases the gastric emptying rate in patients with type 1 diabetes mellitus. Diabetic Medicine 10, 660663.
Schwartz MW, Figlewicz DP, Baskin DG, Woods DC & Porte D Jr (1994) Insulin and the central regulation of energy balance. Endocrine Reviews 2, 109113.
Schwartz MW, Sipols AJ, Grubin CE & Baskin DG (1993) Differential effect of fasting on hypothalamic expression of genes encoding neuropeptide Y, galanin, and glutamic acid decarboxylase. Brain Research Bulletin 31, 361367.
Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A et al. (1992) Inhibition of hypothalamic neuropeptide gene expression by insulin. Endocrinology 130, 36083616.
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ & Baskin DG (2000) Central nervous system control of food intake. Nature 404, 661671.
Shulman RG & Rothman DL (2001) 13C NMR of intermediary metabolism: implications for systemic physiology. Annual Review of Physiology 63, 1548.
Smith FJ & Campfield LA (1993) Meal initiation occurs after experimental induction of transient declines in blood glucose. American Journal of Physiology 265, R1423-R1429.
Stephens TW, Basinski M, Bristow PK, Bue-Valleskey JM, Burgett SG, Craft L et al. (1995) The role of neuropeptide Y in the anti-obesity action of the obese gene product. Nature 377, 530532.
Stubbs RJ & Harbron CG (1996) Covert manipulation of the ratio of medium- to long-chain triglycerides in isoenergetically dense diets: effect on food intake in ad libitum feeding men. International Journal of Obesity and Related Metabolic Disorders 20, 435444.
Watson JA, Fang M & Lowenstein JM (1969) Tricarballylate and hydroxycitrate: Substrate and inhibitors of ATP:citrate oxaloacetate lyase. Archives of Biochemistry and Biophysics 135, 209217.
Yeomans MR (1998) Taste, palatability and the control of appetite. Proceedings of the Nutrition Society 57, 609615.
Yeomans MR, Lee MD, Gray RW & French SJ (2001) Effects of test-meal palatability on compensatory eating following disguised fat and carbohydrate preloads. International Journal of Obesity 25, 12151224.
Zarjevski N, Cusin I, Vettor R, Rohner-Jeanrenaud F & Jenrenaud B (1993) Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity. Endocrinology 133, 17531758.
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