Andersson TLG, Matz J, Ferns GAA & Änggård EE (1994) Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation. Atherosclerosis 111, 39–45.
Aratri E, Spycher SE, Breyer I & Azzi A (1999) Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat vascular smooth muscle cells. FEBS Letters 447, 91–94.
Azzi A, Breyer I, Feher M, Ricciarelli R, Stocker A, Zimmer S & Zingg J (2001) Nonantioxidant functions of alpha-tocopherol in smooth muscle cells. Journal of Nutrition 131, 378S-381S.
Baeuerle PA & Baltimore D (1996) NF-kappa B: ten years after. Cell 87,13-20.
Baeuerle PA & Henkel T (1996) Function and activation of NF-kappa B in the immune system. Annual Review of Immunology 12, 141–179.
Baker CS, Hall RJ, Evans TJ, Pomerance A, Maclouf J, Creminon C, Yacoub MH & Polak JM (1999) Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. Arteriosclerosis Thrombosis and Vascular Biology 19, 646–655.
Behrens WA, Thompson JN & Madere R (1982) Distribution of alpha-tocopherol in human plasma lipoproteins. American Journal of Clinical Nutrition 35, 691–696.
Ben Hamida C, Doerflinger N, Belal S, Linder C, Reutenauer L, Dib C et al. (1993) Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nature Genetics 5, 195–200.
Blatt DH, Leonard SW & Traber MG (2001) Vitamin E kinetics and the function of tocopherol regulatory proteins. Nutrition 17, 799–805.
Böger RH, Bode-Böger SM, Phivthong-ngam L, Brandes RP, Schwedhelm E, Mügge A, Böhme D, Tsikas D & Frölich JC (1998) Dietary l-arginine and a-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms. Atherosclerosis 141, 31–44.
Boscoboinik D, Szewczyk A & Azzi A (1991a) Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Archives of Biochemistry and Biophysics 286, 264–269.
Boscoboinik D, Szewczyk A, Hensey C & Azzi A (1991b) Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. Journal of Biological Chemistry 266, 6188–6194.
Brand K, Page S, Rogler G, Bartsch A, Brandl R, Knuechel R, Page M, Kaltschmidt C, Baeuerle PA & Neumeier D (1996) Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. Journal of Clinical Investigation 97, 1715–1722.
Brand K, Page S, Walli AK, Neumeier D & Baeuerle PA (1997) Role of nuclear factor-kappa B in atherogenesis. Experimental Physiology 82, 297–304.
Brigelius-Flohe R & Traber MG (1999) Vitamin E: function and metabolism. FASEB Journal 13, 1145–1155.
Busse R & Fleming I (1995) Regulation and functional consequences of endothelial nitric oxide formation. Annals of Medicine 27, 331–340.
Cardonna-Sanclemente LE & Born GVR (1995) Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the rats. British Journal of Pharmacology 114, 1490–1494.
Catignani GL & Bieri JG (1977) Rat liver alpha-tocopherol binding protein. Biochimica et Biophysica Acta 497, 349–357
Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J & Deanfield JE (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88, 2149–2155.
Chen CJ, Huang HS, Lin SB & Chang WC (2000) Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells. Prostaglandins Leukotrienes and Essential Fatty Acids 62, 261–268.
Clement S, Tasinato A, Boscoboinik D & Azzi A (1997) The effect of alpha-tocopherol on the synthesis, phosphorylation and activity of protein kinase C in smooth muscle cells after phorbol 12-myristate 13-acetate down-regulation. European Journal of Biochemistry 246, 745–749.
Cohn W, Gross P, Grun H, Loechleiter F, Muller DP & Zulauf M (1992) Tocopherol transport and absorption. Proceedings of the Nutrition Society 51, 179–188.
Collins T & Cybulski MI (2001) NF-kB: pivotal mediator or innocent bystander in atherogenesis. Journal of Clinical Investigation 107, 255–264.
Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA & Bilingam ME (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. Journal of Clinical Investigation 90, 1168–1172.
Cybulski MI & Gimbrone MA (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788–791.
Davda RK, Chandler LJ & Guzman NJ (1994) Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase. European Journal of Pharmacology 266, 237–244.
De Caerina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MAJ, Shin WS & Liao JK (1995) Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. Journal of Clinical Investigation 96, 60–68.
De Graaf JC, Banga JD, Moncado S, Palmer RM, de Groot PG & Sixma JJ (1992) Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation 85, 2284–2290.
Devaraj S, Li D & Jialal I (1996) The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. Journal of Clinical Investigation 98, 756–763.
Dutta-Roy AK (1999) Molecular mechanism of cellular uptake and intracellular translocation of alpha-tocopherol: role of tocopherol-binding proteins. Food and Chemical Toxicology 37, 967–971.
Fazzio A, Marilley D & Azzi A (1997) The effect of alpha-tocopherol and beta-tocopherol on proliferation, protein kinase C activity and gene expression in different cell lines. Biochemistry and Molecular Biology International 41, 93–101.
Fechner H, Schlame M, Guthmann F, Stevens PA & Rustow B (1998) Alpha- and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA. Biochemical Journal 331, 577–581.
Fischer A, Pallauf J, Gohil K, Weber SU, Packer L & Rimbach G (2001) Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochemical and Biophysical Research Communications 285, 470–475.
Fosslien E (2001) Review: molecular pathology of cyclooxygenase-2 in cancer-induced angiogenesis. Annals of Clinical and Laboratory Science 31, 325–348.
Freedman JE, Farhat JH, Loscalzo J & Keaney JF Jr (1996) Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94, 2434–2440.
Freubis J, Carew TE & Palinski W (1995) Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbits. Atherosclerosis 117, 217–224.
Garg UC & Hassid A (1989) Nitric oxide generation vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Journal of Clinical Investigation 83, 1774–1777.
Godfried SL, Combs GF Jr, Saroke JM & Dillingham LA (1989) Potentiation of atherosclerotic lesions in rabbits by high dietary levels of vitamin E. British Journal of Nutrition 61, 607–617.
Halliwell B (1996) Antioxidants in human health and disease. Annual Review of Nutrition 16, 33–50.
Hehenberger K & Hansson A (1997) High glucose-induced growth factor resistance in human fibroblasts can be reversed by antioxidants and protein kinase C-inhibitors. Cell Biochemistry and Function 15, 197–201.
Herrera E & Barbas C (2001) Vitamin E: action, metabolism and perspectives. Journal of Physiology and Biochemistry 57, 43–56.
Hosomi A, Arita M, Sato Y, Kiyose C, Ueda T, Igarashi O, Arai H & Inoue K (1997) Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Letters 409, 105–108.
Ingold KU, Webb AC, Witter D, Burton GW, Metcalfe TA & Muller DP (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Archives of Biochemistry and Biophysics 259, 224–225.
Jiang Q, Elson-Schwab I, Courtemanche C & Ames BN (2000) Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences USA 97, 11494–11499.
Kagan VE & Tyurina YY (1998) Recycling and redox cycling of phenolic antioxidants. Annals of the New York Academy of Sciences 854, 425–434.
Kanno T, Utsumi T, Kobuchi H, Takehara Y, Akiyama J, Yoshioka T, Horton AA & Utsumi K (1995) Inhibition of stimulus-specific neutrophil superoxide generation by alpha-tocopherol. Free Radical Research 22, 431–440.
Kayden HJ & Traber MG (1993) Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans. Journal of Lipid Research 34, 343–358.
Keaney JF Jr, Gaziano JM, Xu A, Frei B, Curran-Celtano J, Shwaery GT, Loscalzo J & Vita JA (1994) Low dose a-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. Journal of Clinical Investigation 93, 844–851.
Kocher O, Gabbiani F, Gabbiani G, Reidy MA, Cokay MS, Peters H & Huttner I (1991) Phenotypic features of smooth muscle cells during the evolution of experimental carotid artery intimal thickening. Biochemical and morphologic studies. Laboratory Investigation 65, 459–470.
Lagrost L, Desrumaux C, Masson D, Deckert V & Gambert P (1998) Structure and function of the plasma phospholipid transfer protein. Current Opinion in Lipidology 9, 203–209.
Leeson CPM, Whincup PH, Cook DG, Donald AE, Papacosta O, Lucas A & Deanfield JE (1997) Flow mediated dilation in 9- to 11-year old children - the influence of intrauterine and childhood factors. Circulation 96, 2233–2238.
Li D, Saldeen T, Romeo F & Metha JL (2001) Different isoforms of tocopherols enhance nitric oxide synthase phosphorylation and inhibit human platelet aggregation and lipid peroxidation: implication in therapy with vitamin E. Journal of Cardiovascular Pharmacology and Therapy 6, 155–161.
Liao F, Andalibi A, deBeer FC, Fogelman AM & Lusis AJ (1993) Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. Journal of Clinical Investigation 91, 2572–2579.
Lindner V & Collins T (1996) Expression of NF-kappa B and I kappa B-alpha by aortic endothelium in an arterial injury model. American Journal of Pathology 148, 427–438.
Malins DC, Johnson PM, Wheeler TM, Barker EA, Polissar NL & Vinson MA (2001) Age-related radical-induced DNA damage is linked to prostate cancer. Cancer Research 61, 6025–6028.
Matthews JR, Botting CH, Panico M, Morris HR & Hay RT (1996) Inhibition of NF-kappa B DNA binding by nitric oxide. Nucleic Acids Research 24, 2236–2242.
Matz RL, Schott C, Stoclet JC & Andriantsitohaina R (2000) Age-related endothelial dysfunction with respect to nitric oxide, endothelium-dependent hyperpolarizing factor and cyclooxygenase products. Physiological Research 49, 11–18.
Nakamura T, Goto M, Matsumoto A & Tanaka I (1998) Inhibition of NF-kappa B transcriptional activity by alpha-tocopheryl succinate. Biofactors 7, 21–30.
Naruse K, Shimizu K, Muramatsu M, Toki Y, Miyazaki Y, Okumura K, Hashimoto H & Ito T (1994) Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation. Arteriosclerosis and Thrombosis 14, 746–752.
Özer NK & Azzi A (2000) Effect of vitamin E on the development of atherosclerosis. Toxicology 148, 179–185.
Packer L, Weber SU & Rimbach G (2001) Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. Journal of Nutrition 131, 369S-373S..
Panza JA, Garcia CE, Kilcoyne CM, Quyyumi AA & Cannon RO 3rd (1995) Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 91, 1732–1738.
Parthasarathy S, Santanam N, Ramachandran S & Meilhac O (1999) Oxidants and antioxidants in atherogenesis. An appraisal. Journal of Lipid Research 40, 2143–2157.
Patel RP, Levonen AL, Crawford JH & Darley-Usma VM (2000) Mechanisms of the pro- and antioxidant actions of nitric oxide in atherosclerosis. Cardiovascular Research 47, 465–474.
Raisanen SR, Lehenkari P, Tasanen M, Rahkila P, Harkonen PL & Vaananen HK (1999) Carbonic anhydrase III protects cells from hydrogen peroxide-induced apoptosis. FASEB Journal 13, 513–522.
Ricciarelli R, Tasinato A, Clement S, Ozer NK, Boscoboinik D & Azzi A (1998) alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state. Biochemical Journal 334, 243–249.
Ricciarelli R, Zingg JM & Azzi A (2000) Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 102, 82–87.
Rimbach G, Saliou C, Canali R & Virgili F (2001) Interaction between cultured endothelial cells and macrophages: in vitro model for studying flavonoids in redox-dependent gene expression. Methods in Enzymology 335, 238–242.
Rimbach G, Valacchi G, Canali R & Virgili F (2000) Macrophages stimulated with IFN-gamma activate NF-kB and induce MCP-1 gene expression in primary human endothelial cells. Molecular and Cell Biology Research Communications 3, 238–242.
Rubanyi GM (1993) The role of endothelium in cardiovascular homeostasis and diseases. Journal of Cardiovascular Pharmacology 22, 1–14.
Saliou C, Valacchi G & Rimbach G (2001) Assessing bioflavonoids as regulators of NF-kB acitivity and gene expression in mammalian cells. Methods in Enzymology 335, 380–387.
Schwenke DC & Behr SR (1998) Vitamin E combined with selenium inhibits atherosclerosis in hypercholesterolemic rabbits independently of effects on plasma cholesterol concentrations. Circulation Research 83, 366–377.
Serbinova E, Kagan V, Han D & Packer L (1991) Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radicals in Biology and Medicine 10, 263–275.
Stewart-Lee AL, Forster LA, Nouroz-Zadeh J, Ferns GAA & Änggård EE (1994) Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits. Arteriosclerosis and Thrombosis 14, 494–499.
Stocker A, Zimmer S, Spycher SE & Azzi A (1999) Identification of a novel cytosolic tocopherol-binding protein: structure, specificity, and tissue distribution. IUBMB Life 48, 49–55.
Stroes ES, Koomans HA, de Bruin TW & Rabelink TJ (1995) Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 346, 467–471.
Suzuki YJ & Packer L (1993) Inhibition of NF-kappa B activation by vitamin E derivatives. Biochemical and Biophysical Research Communications 193, 277–283.
Suzuki YJ, Tsuchiya M, Wassall SR, Choo YM, Govil G, Kagan VE & Packer L (1993) Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32, 10692–10699.
Tada H, Ishii H & Isogai S (1997) Protective effect of D-alpha-tocopherol on the function of human mesangial cells exposed to high glucose concentrations. Metabolism 46, 779–784.
Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG & Farese RV Jr (2000) Increased atherosclerosis in hyperlipidemic mice deficient in alpha-tocopherol transfer protein and vitamin E. Proceedings of the National Academy of Sciences USA 97, 13830–13834.
Thiery J, Teupser D, Walli AK, Ivandic B, Nebendahl K, Stein O, Stein Y & Seidel D (1996) Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits. Atherosclerosis 121, 63–73.
Traber MG & Kayden HJ (1989) Alpha-tocopherol as compared with gamma-tocopherol is preferentially secreted in human lipoproteins. Annals of the New York Academy of Sciences 570, 95–108.
Traber MG, Sokol RJ, Burton GW, Ingold KU, Papas AM, Huffaker JE & Kayden HJ (1990) Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. Journal of Clinical Investigation 85, 397–407.
Watanabe CM, Wolffram S, Ader P, Rimbach G, Packer L, Maguire JJ, Schultz PG & Gohil K (2001) The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Proceedings of the National Academy of Sciences USA 98, 6577–6580.
Welty FK, Lichtenstein AH, Barrett PH, Jenner JL, Dolnikowski GG & Schaefer EJ (2000) Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans. Arteriosclerosis Thrombosis and Vascular Biology 20, 1807–1810.
Williams RJ, Motteram JM, Sharp CH & Gallagher PJ (1992) Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis 94, 153–159.
Williams SB, Cusco JA, Roddy MA, Johnstone MT & Creager MA (1996) Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. Journal of the American College of Cardiology 27, 567–574.
Wu D, Hayek MG & Meydani S (2001) Vitamin E and macrophage cyclooxygenase regulation in the aged. Journal of Nutrition 131, 382S-388S.
Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K & Esashi T (2001) Tocopherol-associated protein is a ligand-dependent transcriptional activator. Biochemical and Biophysical Research Communications 285, 295–299.
Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D & Stern D (1994) Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. Journal of Biological Chemistry 269, 9889–9897.
Yoshida N, Manabe H, Terasawa Y, Nishimura H, Enjo F, Nishino H & Yoshikawa T (2000) Inhibitory effects of vitamin E on endothelial-dependent adhesive interactions with leukocytes induced by oxidized low density lipoprotein. Biofactors 13, 279–288.
Zapolska-Downar D, Zapolski-Downar A, Markiewski M, Ciechanowicz A, Kaczmarczyk M & Naruszewicz M (2000) Selective inhibition by alpha-tocopherol of vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Biochemical and Biophysical Research Communications 274, 609–615.
Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J & Azzi A (2000) A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. Journal of Biological Chemistry 275, 25672–25680.