Skip to main content
    • Aa
    • Aa
  • Access
  • Cited by 92
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bertoni, Giuseppe Trevisi, Erminio Houdijk, Jos Calamari, Luigi and Athanasiadou, Spiridoula 2016. Nutrition and the Welfare of Farm Animals.

    Chauhan, S. S. Liu, F. Leury, B. J. Cottrell, J. J. Celi, P. and Dunshea, F. R. 2016. Functionality and genomics of selenium and vitamin E supplementation in ruminants. Animal Production Science, Vol. 56, Issue. 8, p. 1285.

    Hobson, Rachel 2016. Vitamin E and wound healing: an evidence-based review. International Wound Journal, Vol. 13, Issue. 3, p. 331.

    Margaritelis, Nikos V. 2016. Antioxidants as therapeutics in the intensive care unit: Have we ticked the redox boxes?. Pharmacological Research, Vol. 111, p. 126.

    Shwter, Abdrabuh N. Abdullah, Nor Azizan Alshawsh, Mohammed A. El-Seedi, Hesham R. Al-Henhena, Nawal A. Khalifa, Shaden A.M. and Abdulla, Mahmood A. 2016. Chemopreventive Effect of Phaleria macrocarpa on Colorectal Cancer Aberrant Crypt Foci In vivo. Journal of Ethnopharmacology,

    Xu, Chenchen Zuo, Zhaoyun Liu, Kun Jia, Huina Zhang, Yuwei and Luo, Hailing 2016. Transcriptome analysis of the Tan sheep testes: Differential expression of antioxidant enzyme-related genes and proteins in response to dietary vitamin E supplementation. Gene, Vol. 579, Issue. 1, p. 47.

    Bertoni, G. Minuti, A. and Trevisi, E. 2015. Immune system, inflammation and nutrition in dairy cattle. Animal Production Science, Vol. 55, Issue. 7, p. 943.

    Cuce, Gokhan Çetinkaya, Seda Koc, Tugba Esen, Hacı Hasan Limandal, Cisem Balcı, Tevfik Kalkan, Serpil and Akoz, Mehmet 2015. Chemoprotective effect of vitamin E in cyclophosphamide-induced hepatotoxicity in rats. Chemico-Biological Interactions, Vol. 232, p. 7.

    Kitajima, Hiroyuki Kanazawa, Tadahiro Mori, Rintaro Hirano, Shinya Ogihara, Tohru and Fujimura, Masanori 2015. Long-term alpha-tocopherol supplements may improve mental development in extremely low birthweight infants. Acta Paediatrica, Vol. 104, Issue. 2, p. e82.

    Moazzami, Ali A. Frank, Sonja Gombert, Antonin Sus, Nadine Bayram, Banu Rimbach, Gerald and Frank, Jan 2015. Non-targeted1H-NMR-metabolomics suggest the induction of master regulators of energy metabolism in the liver of vitamin E-deficient rats. Food Funct., Vol. 6, Issue. 4, p. 1090.

    Rocco, Lucia Mottola, Filomena Santonastaso, Marianna Saputo, Valentina Cusano, Elena Costagliola, Domenico Suero, Teresa Pacifico, Severina and Stingo, Vincenzo 2015. Anti-genotoxic ability of α-tocopherol and Anthocyanin to counteract fish DNA damage induced by musk xylene. Ecotoxicology, Vol. 24, Issue. 9, p. 2026.

    Chauhan, Surinder S. Celi, Pietro Ponnampalam, Eric N. Leury, Brian J. Liu, Fan and Dunshea, Frank R. 2014. Antioxidant dynamics in the live animal and implications for ruminant health and product (meat/milk) quality: role of vitamin E and selenium. Animal Production Science, Vol. 54, Issue. 10, p. 1525.

    Delgado, Francisco J. Cava, Ramón Delgado, Jonathan and Ramírez, Rosario 2014. Tocopherols, fatty acids and cytokines content of holder pasteurised and high-pressure processed human milk. Dairy Science & Technology, Vol. 94, Issue. 2, p. 145.

    Faizan, Mohammad Esatbeyoglu, Tuba Bayram, Banu and Rimbach, Gerald 2014. A Fast and Validated Method for the Determination of Malondialdehyde in Fish Liver Using High-Performance Liquid Chromatography with a Photodiode Array Detector. Journal of Food Science, Vol. 79, Issue. 4, p. C484.

    Korade, Zeljka Xu, Libin Harrison, Fiona E. Ahsen, Refayat Hart, Sarah E. Folkes, Oakleigh M. Mirnics, Károly and Porter, Ned A. 2014. Antioxidant Supplementation Ameliorates Molecular Deficits in Smith-Lemli-Opitz Syndrome. Biological Psychiatry, Vol. 75, Issue. 3, p. 215.

    Menoyo, David Sanz-Bayón, Carmen Nessa, Anna Esatbeyoglu, Tuba Faizan, Mohammad Pallauf, Kathrin De Diego, Nuria Wagner, Anika Ipharraguerre, Ignacio Stubhaug, Ingunn and Rimbach, Gerald 2014. Atlantic Salmon (Salmo salar L.) as a Marine Functional Source of Gamma-Tocopherol. Marine Drugs, Vol. 12, Issue. 12, p. 5944.

    Woo, Hee-Jong Sohn, Soo-In Shin, Kong-Sik Kim, Jae-Kwang Kim, Beom-Gi and Lim, Myung-Ho 2014. Expression of tobacco tocopherol cyclase in rice regulates antioxidative defense and drought tolerance. Plant Cell, Tissue and Organ Culture (PCTOC), Vol. 119, Issue. 2, p. 257.

    Bayram, Banu Nikolai, Sibylle Huebbe, Patricia Ozcelik, Beraat Grimm, Stefanie Grune, Tilman Frank, Jan and Rimbach, Gerald 2013. Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8. AGE, Vol. 35, Issue. 4, p. 1205.

    Ernst, I.M.A. Pallauf, K. Bendall, J.K. Paulsen, L. Nikolai, S. Huebbe, P. Roeder, T. and Rimbach, G. 2013. Vitamin E supplementation and lifespan in model organisms. Ageing Research Reviews, Vol. 12, Issue. 1, p. 365.

    Hanrieder, Jörg Phan, Nhu T. N. Kurczy, Michael E. and Ewing, Andrew G. 2013. Imaging Mass Spectrometry in Neuroscience. ACS Chemical Neuroscience, Vol. 4, Issue. 5, p. 666.

  • Proceedings of the Nutrition Society, Volume 61, Issue 4
  • November 2002, pp. 415-425

Regulation of cell signalling by vitamin E

  • Gerald Rimbach (a1), Anne Marie Minihane (a1), Jonathan Majewicz (a1), Alexandra Fischer (a2), Josef Pallauf (a2), Fabio Virgli (a3) and Peter D. Weinberg (a4)
  • DOI:
  • Published online: 01 March 2007


La vitamine E, l'antioxydant liposoluble le plus important, fut découverte à l'Université de Californie à Berkeley en 1922. Depuis sa découverte, les études sur les tocophérols et les tocotrienols que constitue cette vitamine, ont été centrées pour la plupart sur leurs propriétés antioxydantes. En 1991, le groupe de Angelo Azzi (Boscoboinik et al. 1991a,b) fut le premier à décrire les fonctions autres que les antioxydantes et de transmission de signaux de l'α-tocophérol, en démontrant la régulation par la vitamine E de l'activité de la protéine kinase C dans les cellules de muscle lisse. Au niveau de la transcription, l'²-tocophérol module l'expression de la protéine de transfert hépatique de l'α-tocophérol, ainsi que l'expression du ge`ne alpha1 du collage`ne du foie, du ge`ne de la collagénase et du ge`ne de l'α-tropomyosine. Récemment, un facteur de transcription dépendant du tocophérol (la protéine associée au tocophérol) a été découvert. Il a été démontré sur des cellules cultivées que la vitamine E inhibe l'inflammation, l'adhésion cellulaire, l'agrégation des plaquettes et la prolifération des cellules de muscle lisse. Les avancées récentes de la biologie moléculaire et des techniques génomiques ont conduit à la découverte de nouveaux ge`nes et des mécanismes de transduction des signaux sensibles à la vitamine E.

    • Send article to Kindle

      To send this article to your Kindle, first ensure is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the or variations. ‘’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Regulation of cell signalling by vitamin E
      Available formats
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Regulation of cell signalling by vitamin E
      Available formats
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Regulation of cell signalling by vitamin E
      Available formats
Corresponding author
*Corresponding author: Dr Gerald Rimbach, fax + 44 118 931 0080, email
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

TLG Andersson , J Matz , GAA Ferns & EE Änggård (1994) Vitamin E reverses cholesterol-induced endothelial dysfunction in the rabbit coronary circulation. Atherosclerosis 111, 3945.

E Aratri , SE Spycher , I Breyer & A Azzi (1999) Modulation of alpha-tropomyosin expression by alpha-tocopherol in rat vascular smooth muscle cells. FEBS Letters 447, 9194.

PA Baeuerle & D Baltimore (1996) NF-kappa B: ten years after. Cell 87,13-20.

PA Baeuerle & T Henkel (1996) Function and activation of NF-kappa B in the immune system. Annual Review of Immunology 12, 141179.

CS Baker , RJ Hall , TJ Evans , A Pomerance , J Maclouf , C Creminon , MH Yacoub & JM Polak (1999) Cyclooxygenase-2 is widely expressed in atherosclerotic lesions affecting native and transplanted human coronary arteries and colocalizes with inducible nitric oxide synthase and nitrotyrosine particularly in macrophages. Arteriosclerosis Thrombosis and Vascular Biology 19, 646655.

C Ben Hamida , N Doerflinger , S Belal , C Linder , L Reutenauer , C Dib et al. (1993) Localization of Friedreich ataxia phenotype with selective vitamin E deficiency to chromosome 8q by homozygosity mapping. Nature Genetics 5, 195200.

DH Blatt , SW Leonard & MG Traber (2001) Vitamin E kinetics and the function of tocopherol regulatory proteins. Nutrition 17, 799805.

RH Böger , SM Bode-Böger , L Phivthong-ngam , RP Brandes , E Schwedhelm , A Mügge , D Böhme , D Tsikas & JC Frölich (1998) Dietary l-arginine and a-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanisms. Atherosclerosis 141, 3144.

D Boscoboinik , A Szewczyk & A Azzi (1991a) Alpha-tocopherol (vitamin E) regulates vascular smooth muscle cell proliferation and protein kinase C activity. Archives of Biochemistry and Biophysics 286, 264269.

K Brand , S Page , G Rogler , A Bartsch , R Brandl , R Knuechel , M Page , C Kaltschmidt , PA Baeuerle & D Neumeier (1996) Activated transcription factor nuclear factor-kappa B is present in the atherosclerotic lesion. Journal of Clinical Investigation 97, 17151722.

K Brand , S Page , AK Walli , D Neumeier & PA Baeuerle (1997) Role of nuclear factor-kappa B in atherogenesis. Experimental Physiology 82, 297304.

R Busse & I Fleming (1995) Regulation and functional consequences of endothelial nitric oxide formation. Annals of Medicine 27, 331340.

LE Cardonna-Sanclemente & GVR Born (1995) Effect of inhibition of nitric oxide synthesis on the uptake of LDL and fibrinogen by arterial walls and other organs of the rats. British Journal of Pharmacology 114, 14901494.

GL Catignani & JG Bieri (1977) Rat liver alpha-tocopherol binding protein. Biochimica et Biophysica Acta 497, 349357

DS Celermajer , KE Sorensen , D Georgakopoulos , C Bull , O Thomas , J Robinson & JE Deanfield (1993) Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation 88, 21492155.

CJ Chen , HS Huang , SB Lin & WC Chang (2000) Regulation of cyclooxygenase and 12-lipoxygenase catalysis by phospholipid hydroperoxide glutathione peroxidase in A431 cells. Prostaglandins Leukotrienes and Essential Fatty Acids 62, 261268.

S Clement , A Tasinato , D Boscoboinik & A Azzi (1997) The effect of alpha-tocopherol on the synthesis, phosphorylation and activity of protein kinase C in smooth muscle cells after phorbol 12-myristate 13-acetate down-regulation. European Journal of Biochemistry 246, 745749.

T Collins & MI Cybulski (2001) NF-kB: pivotal mediator or innocent bystander in atherogenesis. Journal of Clinical Investigation 107, 255264.

JP Cooke , AH Singer , P Tsao , P Zera , RA Rowan & ME Bilingam (1992) Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. Journal of Clinical Investigation 90, 11681172.

MI Cybulski & MA Gimbrone (1991) Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788791.

RK Davda , LJ Chandler & NJ Guzman (1994) Protein kinase C modulates receptor-independent activation of endothelial nitric oxide synthase. European Journal of Pharmacology 266, 237244.

R De Caerina , P Libby , HB Peng , VJ Thannickal , TB Rajavashisth , MAJ Gimbrone , WS Shin & JK Liao (1995) Nitric oxide decreases cytokine-induced endothelial activation: nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. Journal of Clinical Investigation 96, 6068.

JC De Graaf , JD Banga , S Moncado , RM Palmer , PG de Groot & JJ Sixma (1992) Nitric oxide functions as an inhibitor of platelet adhesion under flow conditions. Circulation 85, 22842290.

S Devaraj , D Li & I Jialal (1996) The effects of alpha tocopherol supplementation on monocyte function. Decreased lipid oxidation, interleukin 1 beta secretion, and monocyte adhesion to endothelium. Journal of Clinical Investigation 98, 756763.

AK Dutta-Roy (1999) Molecular mechanism of cellular uptake and intracellular translocation of alpha-tocopherol: role of tocopherol-binding proteins. Food and Chemical Toxicology 37, 967971.

H Fechner , M Schlame , F Guthmann , PA Stevens & B Rustow (1998) Alpha- and delta-tocopherol induce expression of hepatic alpha-tocopherol-transfer-protein mRNA. Biochemical Journal 331, 577581.

A Fischer , J Pallauf , K Gohil , SU Weber , L Packer & G Rimbach (2001) Effect of selenium and vitamin E deficiency on differential gene expression in rat liver. Biochemical and Biophysical Research Communications 285, 470475.

JE Freedman , JH Farhat , J Loscalzo & JF Jr Keaney (1996) Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 94, 24342440.

J Freubis , TE Carew & W Palinski (1995) Effect of vitamin E on atherogenesis in LDL receptor-deficient rabbits. Atherosclerosis 117, 217224.

UC Garg & A Hassid (1989) Nitric oxide generation vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. Journal of Clinical Investigation 83, 17741777.

B Halliwell (1996) Antioxidants in human health and disease. Annual Review of Nutrition 16, 3350.

K Hehenberger & A Hansson (1997) High glucose-induced growth factor resistance in human fibroblasts can be reversed by antioxidants and protein kinase C-inhibitors. Cell Biochemistry and Function 15, 197201.

E Herrera & C Barbas (2001) Vitamin E: action, metabolism and perspectives. Journal of Physiology and Biochemistry 57, 4356.

A Hosomi , M Arita , Y Sato , C Kiyose , T Ueda , O Igarashi , H Arai & K Inoue (1997) Affinity for alpha-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Letters 409, 105108.

KU Ingold , AC Webb , D Witter , GW Burton , TA Metcalfe & DP Muller (1987) Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Archives of Biochemistry and Biophysics 259, 224225.

Q Jiang , I Elson-Schwab , C Courtemanche & BN Ames (2000) Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proceedings of the National Academy of Sciences USA 97, 1149411499.

VE Kagan & YY Tyurina (1998) Recycling and redox cycling of phenolic antioxidants. Annals of the New York Academy of Sciences 854, 425434.

T Kanno , T Utsumi , H Kobuchi , Y Takehara , J Akiyama , T Yoshioka , AA Horton & K Utsumi (1995) Inhibition of stimulus-specific neutrophil superoxide generation by alpha-tocopherol. Free Radical Research 22, 431440.

JF Jr Keaney , JM Gaziano , A Xu , B Frei , J Curran-Celtano , GT Shwaery , J Loscalzo & JA Vita (1994) Low dose a-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. Journal of Clinical Investigation 93, 844851.

L Lagrost , C Desrumaux , D Masson , V Deckert & P Gambert (1998) Structure and function of the plasma phospholipid transfer protein. Current Opinion in Lipidology 9, 203209.

CPM Leeson , PH Whincup , DG Cook , AE Donald , O Papacosta , A Lucas & JE Deanfield (1997) Flow mediated dilation in 9- to 11-year old children - the influence of intrauterine and childhood factors. Circulation 96, 22332238.

D Li , T Saldeen , F Romeo & JL Metha (2001) Different isoforms of tocopherols enhance nitric oxide synthase phosphorylation and inhibit human platelet aggregation and lipid peroxidation: implication in therapy with vitamin E. Journal of Cardiovascular Pharmacology and Therapy 6, 155161.

F Liao , A Andalibi , FC deBeer , AM Fogelman & AJ Lusis (1993) Genetic control of inflammatory gene induction and NF-kappa B-like transcription factor activation in response to an atherogenic diet in mice. Journal of Clinical Investigation 91, 25722579.

JR Matthews , CH Botting , M Panico , HR Morris & RT Hay (1996) Inhibition of NF-kappa B DNA binding by nitric oxide. Nucleic Acids Research 24, 22362242.

T Nakamura , M Goto , A Matsumoto & I Tanaka (1998) Inhibition of NF-kappa B transcriptional activity by alpha-tocopheryl succinate. Biofactors 7, 2130.

K Naruse , K Shimizu , M Muramatsu , Y Toki , Y Miyazaki , K Okumura , H Hashimoto & T Ito (1994) Long-term inhibition of NO synthesis promotes atherosclerosis in the hypercholesterolemic rabbit thoracic aorta. PGH2 does not contribute to impaired endothelium-dependent relaxation. Arteriosclerosis and Thrombosis 14, 746752.

NK Özer & A Azzi (2000) Effect of vitamin E on the development of atherosclerosis. Toxicology 148, 179185.

JA Panza , CE Garcia , CM Kilcoyne , AA Quyyumi & 3rd Cannon RO (1995) Impaired endothelium-dependent vasodilation in patients with essential hypertension. Evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation 91, 17321738.

RP Patel , AL Levonen , JH Crawford & VM Darley-Usma (2000) Mechanisms of the pro- and antioxidant actions of nitric oxide in atherosclerosis. Cardiovascular Research 47, 465474.

R Ricciarelli , A Tasinato , S Clement , NK Ozer , D Boscoboinik & A Azzi (1998) alpha-Tocopherol specifically inactivates cellular protein kinase C alpha by changing its phosphorylation state. Biochemical Journal 334, 243249.

R Ricciarelli , JM Zingg & A Azzi (2000) Vitamin E reduces the uptake of oxidized LDL by inhibiting CD36 scavenger receptor expression in cultured aortic smooth muscle cells. Circulation 102, 8287.

G Rimbach , G Valacchi , R Canali & F Virgili (2000) Macrophages stimulated with IFN-gamma activate NF-kB and induce MCP-1 gene expression in primary human endothelial cells. Molecular and Cell Biology Research Communications 3, 238242.

GM Rubanyi (1993) The role of endothelium in cardiovascular homeostasis and diseases. Journal of Cardiovascular Pharmacology 22, 114.

C Saliou , G Valacchi & G Rimbach (2001) Assessing bioflavonoids as regulators of NF-kB acitivity and gene expression in mammalian cells. Methods in Enzymology 335, 380387.

DC Schwenke & SR Behr (1998) Vitamin E combined with selenium inhibits atherosclerosis in hypercholesterolemic rabbits independently of effects on plasma cholesterol concentrations. Circulation Research 83, 366377.

E Serbinova , V Kagan , D Han & L Packer (1991) Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radicals in Biology and Medicine 10, 263275.

AL Stewart-Lee , LA Forster , J Nouroz-Zadeh , GAA Ferns & EE Änggård (1994) Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits. Arteriosclerosis and Thrombosis 14, 494499.

A Stocker , S Zimmer , SE Spycher & A Azzi (1999) Identification of a novel cytosolic tocopherol-binding protein: structure, specificity, and tissue distribution. IUBMB Life 48, 4955.

ES Stroes , HA Koomans , TW de Bruin & TJ Rabelink (1995) Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication. Lancet 346, 467471.

YJ Suzuki & L Packer (1993) Inhibition of NF-kappa B activation by vitamin E derivatives. Biochemical and Biophysical Research Communications 193, 277283.

YJ Suzuki , M Tsuchiya , SR Wassall , YM Choo , G Govil , VE Kagan & L Packer (1993) Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry 32, 1069210699.

H Tada , H Ishii & S Isogai (1997) Protective effect of D-alpha-tocopherol on the function of human mesangial cells exposed to high glucose concentrations. Metabolism 46, 779784.

Y Terasawa , Z Ladha , SW Leonard , JD Morrow , D Newland , D Sanan , L Packer , MG Traber & RV Jr Farese (2000) Increased atherosclerosis in hyperlipidemic mice deficient in alpha-tocopherol transfer protein and vitamin E. Proceedings of the National Academy of Sciences USA 97, 1383013834.

J Thiery , D Teupser , AK Walli , B Ivandic , K Nebendahl , O Stein , Y Stein & D Seidel (1996) Study of causes underlying the low atherosclerotic response to dietary hypercholesterolemia in a selected strain of rabbits. Atherosclerosis 121, 6373.

MG Traber & HJ Kayden (1989) Alpha-tocopherol as compared with gamma-tocopherol is preferentially secreted in human lipoproteins. Annals of the New York Academy of Sciences 570, 95108.

MG Traber , RJ Sokol , GW Burton , KU Ingold , AM Papas , JE Huffaker & HJ Kayden (1990) Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver. Journal of Clinical Investigation 85, 397407.

CM Watanabe , S Wolffram , P Ader , G Rimbach , L Packer , JJ Maguire , PG Schultz & K Gohil (2001) The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Proceedings of the National Academy of Sciences USA 98, 65776580.

FK Welty , AH Lichtenstein , PH Barrett , JL Jenner , GG Dolnikowski & EJ Schaefer (2000) Effects of ApoE genotype on ApoB-48 and ApoB-100 kinetics with stable isotopes in humans. Arteriosclerosis Thrombosis and Vascular Biology 20, 18071810.

RJ Williams , JM Motteram , CH Sharp & PJ Gallagher (1992) Dietary vitamin E and the attenuation of early lesion development in modified Watanabe rabbits. Atherosclerosis 94, 153159.

SB Williams , JA Cusco , MA Roddy , MT Johnstone & MA Creager (1996) Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. Journal of the American College of Cardiology 27, 567574.

J Yamauchi , T Iwamoto , S Kida , S Masushige , K Yamada & T Esashi (2001) Tocopherol-associated protein is a ligand-dependent transcriptional activator. Biochemical and Biophysical Research Communications 285, 295299.

N Yoshida , H Manabe , Y Terasawa , H Nishimura , F Enjo , H Nishino & T Yoshikawa (2000) Inhibitory effects of vitamin E on endothelial-dependent adhesive interactions with leukocytes induced by oxidized low density lipoprotein. Biofactors 13, 279288.

D Zapolska-Downar , A Zapolski-Downar , M Markiewski , A Ciechanowicz , M Kaczmarczyk & M Naruszewicz (2000) Selective inhibition by alpha-tocopherol of vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Biochemical and Biophysical Research Communications 274, 609615.

S Zimmer , A Stocker , MN Sarbolouki , SE Spycher , J Sassoon & A Azzi (2000) A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. Journal of Biological Chemistry 275, 2567225680.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
Please enter your name
Please enter a valid email address
Who would you like to send this to? *