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The regulation of mineral absorption in the gastrointestinal tract

  • J. J. Powell (a1), R. Jugdaohsingh (a1) and R. P. H. Thompson (a1)
Abstract

The absorption of metal ions in the mammalian single-stomached gut is fortunately highly selective, and both luminal and tissue regulation occur. Initially, assimilation of metal ions in an available form is facilitated by the intestinal secretions, chiefly soluble mucus (mucin) that retards hydrolysis of ions such as Cu, Fe and Zn. Metal ions then bind and traverse the mucosally-adherent mucus layer with an efficiency M+ > M2+ > M3+. At the mucosa Fe3+ is probably uniquely reduced to Fe2+, and all divalent cations (including Fe2+) are transported by a membrane protein (such as divalent cation transporter 1) into the cell. This minimizes absorption of toxic trivalent metals (e.g. A13+). Intracellular metal-binding molecules (such as mobilferrin) may be present at the intracellular side of the apical membrane, anchored to a transmembrane protein such as an integrin complex. This mobilferrin would receive the metal ion from divalent cation transporter 1 and, with part of the integrin molecule, transport the metal to the cytosol for safe sequestration in a larger complex such as ferritin or‘paraferritin’. β2-Microglobulin and HFE (previously termed human leucocyte antigen H) may be involved in stabilizing metal mobilferrin-integrin to form this latter complex. Finally, a systemic metal-binding protein such as transferrin may enter the antiluminal (basolateral) side of the cell for binding of the sequestered metal ion and delivery to the circulation. Regulatory proteins, such as HFE, may determine the degree of ion transport from intestinal cells to the circulation. Gradients in pH and perhaps pCa or even pNa could allow the switching of ions between the different transporters throughout this mechanism.

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Corresponding author
*Corresponding author: Lh Jonathan J. Powell, fax +1 530 753 3545, email jonpowel@ucdavis.edu
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Department of Immunology, TB192, Internal Medicine, University of California at Davis, Davis, CA 95616, USA

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References
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Bates GW (1973) Complex formation, polymerization, and autoreduction in the ferric fructose system. Bioinorganic Chemistry 2, 311327.
Bates GW, Boyer J, Hegenauer JC & Saltman P (1972) Facilitation of iron absorption by ferric fructose. American Journal of Clinical Nutrition 25, 983986.
Champagne ET (1989) Low gastric hydrochloric acid secretion and mineral bioavailability. In Advances in Experimental Medicine and Biology, vol. 249, Mineral Absorption in the Monogastric GI Tract, pp. 173184 [Dintzis F and Laszlo J, editors]. New York: Plenum Press.
Chrichton RR & Ward RJ (1998) Iron Homeostasis. Basel, Switzerland: Marcel Dekker.
Conrad ME, Umbreit JN & Moore EG (1991) A role for mucin in the absorption of inorganic iron and other metal cations: a study in rats. Gastroenterology 100, 129136.
Conrad ME, Umbreit JN & Moore EG (1993 a) Rat duodenal iron-binding protein mobilferrin is a homologue of calreticulin. Gastroenterology 104, 17001704.
Conrad ME, Umbreit JN, Moore EG & Heiman D (1996) Mobilferrin is an intermediate in iron transport between transferrin and haemoglobin in K562 cells. Journal of Clinical Investigation 98, 14491454.
Conrad ME, Umbreit JN, Moore EG, Peterson RDA & Jones MB (1990) A newly identified iron binding protein in duodenal mucosa of rats: purification and characterization of mobilferrin. Journal of Biological Chemistry 265, 52735279.
Conrad ME, Umbreit JN, Moore EG, Uzel C & Berry MR (1994) Alternate iron transport pathway: Mobilferrin and integrin in K562 cells. Journal of Biological Chemistry 269, 71697173.
Conrad ME, Umbreit JN, Peterson RDA, Moore EG & Harper KP (1993 b) Function of integrin in duodenal mucosal uptake of iron. Blood 81, 517521.
Crowther RS (1982) Cation induced changes in the biophysical properties of mucus glycoproteins. PhD Thesis, University of London.
Crowther RS & Marriott C (1984) Counter-ion binding to mucus glycoproteins. Journal of Pharmacy and Pharmacology 36, 2126.
Danielsen EM & Deurs BV (1995) A transferrin-like GPI-linked iron-binding protein in detergent-insoluble noncaveolar microdomains at the apical surface of fetal intestinal epithelial cells. Journal of Cell Biology 131, 939950.
Davis PS, Multani JS, Cepeeneek CP & Saltman P (1969) Isolation of gastroferrin from human gastric juice. Biochemical and Biophysical Research Communications 37, 532537.
Davis SR, McMahon RJ & Cousins RJ (1998) Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. Journal of Nutrition 128, 825831.
Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, Dormishian F, Domingo R Jr, Ellis MC, Fullan A, Hinton LM, Jones NL, Kimmel BE, Kronmal GS, Lauer P, Lee VK, Loeb DB, Mapa FA, McClelland E, Meyer NC, Mintier GA, Moeller N, Moore T, Morikang E, Prass CE, Quintana L, Starnes SM, Schatzman RC, Brunke KJ, Drayna DT, Risch NJ, Bacon BR & Wolff RK (1996) A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nature Genetics 13, 399408.
Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, Tsuchihashi Z, Sigal E, Bjorkman PJ & Schatzman RC (1998) The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proceedings of the National Academy of Sciences USA 95, 14721477.
Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, Nussberger S, Gollan JL & Hediger MA (1997) Cloning and characterisation of a mammalian proton-coupled metal-ion transporter. Nature 388, 482488.
Hunter AC, Allen A & Garner A (1989) Studies on mucus biosynthesis in the gastrointestinal tract. In Symposia of the Society for Experimental Biology, no. 43, Mucus and Related Topics, pp. 2736 [Chantler E and Ratcliffe N, editors]. Cambridge: Cambridge Society for Experimental Biology.
Lebron JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, Feder JN & Bjorkman PJ (1998) Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 93, 111123.
Lucas ML & Blair JA (1978) The magnitude and distribution of the acid microclimate in proximal jejenum and its relation to luminal acidification. Proceedings of the Royal Society London A200 2741.
McMahon RJ & Cousins R (1998) Mammalian zinc transporters. Journal of Nutrition 128, 667670.
Ota H & Katsuyama T (1992) Alternating laminated array of two types of mucin in the human gastric surface mucous layer. Histochemical Journal 24, 8692.
Pountney DJ, Raja KB, Bottwood MJ, Wrigglesworth JM & Simpson RJ (1996) Mucosal surface ferricyanide reductase activity in mouse duodenum. Biometals 9, 1520.
Powell JJ (1994) Aluminium in the gastrointestinal tract. PhD Thesis, United Medical and Dental Schools, University of London.
Powell JJ, Gartland KPR, Nicholson JK, Ainley CC & Thompson RPH (1990) Bile, pancreatic juice and small bowel secretions contain endogenous metal binding ligands. Gut 31, A1197.
Powell JJ & Thompson RPH (1993) The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption. Proceedings of the Nutrition Society 52, 241253.
Powell JJ, Whitehead MW, Lee S & Thompson RPH (1994) Mechanisms of gastrointestinal absorption: dietary minerals and the influence of beverage ingestion. Food Chemistry 51, 381388.
Quarterman J (1987) Metal absorption and the intestinal mucus layer. Digestion 37, 19.
Rhodes JM (1989) Colonic mucus and mucosal glycoproteins: The key to colitis and cancer. Gut 30, 16601666.
Riedal HD, Remus AJ, Fitscher BA & Stremmel W (1995) Characterization and partial purification of a ferrireductase from human duodenal microvillus membranes. Biochemical Journal 309, 745748.
Rudzki Z, Baker RJ & Deller DJ (1973) The iron-binding glycoprotein of human gastri juice: II nature of the interaction of the glycoprotein with iron. Digestion 8, 5367.
Rudzki Z & Deller DJ (1973) The iron binding glycoprotein of human gastric juice: I isolation and characterization. Digestion 8, 3552.
Shimizu T, Akamatsu T, Sugiyama A, Ota H & Katsuyama T (1996) Helicobacter pylori and the surface mucous gel layer of the human stomach. Helicobacter 1, 207217.
Song R & Harding CV (1996) Roles of proteasomes, transporter for antigen presentation (TAP), and β2-microglobulin in the processing of bacterial or particulate antigens via an alternative class I MHC processing pathway. Journal of Immunology 156, 41824190.
Stewart WK (1989) Aluminium toxicity in individuals with chronic renal disease. In Aluminium in Food and the Environment, pp. 719 [Massey R and Taylor D, editors]. London: Royal Society of Chemistry.
Umbreit JN, Conrad ME, Moore EG, Desai MP & Turrens J (1996) Paraferritin: A protein complex with ferrireductase activity is associated with iron absorption in rats. Biochemistry 35, 64606469.
Umbreit JN, Conrad ME, Moore EG & Latour LF (1998) Iron absorption and cellular transport: the mobilferrin/paraferritin paradigm. Seminars in Haematology 35, 1326.
Whitehead MW, Farrar G, Christie G, Blair JA, Thompson RPH & Powell JJ (1997) Mechanisms of aluminium absorption in the rat. American Journal of Clinical Nutrition 65, 14461452.
Whitehead MW, Powell JJ & Thompson RPH (1995) The gut mucus layer regulates metal absorption? Gut 36, A48.
Whitehead MW, Thompson RPH & Powell JJ (1996) Regulation of metal absorption in the gastrointestinal tract. Gut 39, 625628.
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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
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