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The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis?

  • Angela Hague (a1), Alison J. Butt (a1) and Christos Paraskeva (a1)

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Arends, M. J. & Wyllie, A. H. (1991). Apoptosis: mechanisms and role in pathology. International Review of Experimental Pathology 32, 223254.
Augeron, C. & Laboisse, C. L. (1984). Emergence of permanently differentiated cell clones in a human colonic cancer cell line after treatment with sodium butyrate. Cancer Research 44, 39613969.
Berry, R. D. & Paraskeva, C. (1988). Expression of carcinoembryonic antigen by adenoma and carcinoma derived epithelial cell lines: possible marker of tumour progression and modulation of expression by sodium butyrate. Carcinogenesis 9, 447450.
Bicknell, G. R. & Cohen, G. M. (1995). Cleavage of DNA to large kilobase pair fragments occurs in some forms of necrosis as well as apoptosis. Biochemical and Biophysical Research Communications 207, 4047.
Bracey, T. S., Miller, J. C., Preece, A. & Paraskeva, C. (1995) γ-Radiation-induced apoptosis in human colorectal adenoma and carcinoma cell-lines can occur in the absence of wild type p53. Oncogene 10, 23912396.
Burkitt, D. P. (1971). Epidemiology of cancer of the colon and rectum. Cancer 28, 313.
Chadwick, R. W. & George, S. E. (1992). Role of the gastrointestinal mucosa and microflora in the bioactivation of dietary and environmental mutagens or carcinogens. Drug Metabolism Reviews 24, 425492.
Clarke, A. R., Gledhill, S., Hooper, M. L., Bird, C. C. & Wyllie, A. H. (1994). p53 dependence of early apoptotic and proliferative responses within the mouse intestinal epithelium following γ-irradiation. Oncogene 9, 17671773.
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P. E. & Macfarlane, G. T. (1987). Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 12211227.
Deng, G., Liu, G., Hu, L., Gum, J. R. & Kim, Y. S. (1992). Transcriptional regulation of the human placental-like alkaline phosphatase gene and mechanisms involved in its induction by sodium butyrate. Cancer Research 52, 33783383.
Garnet, L., Daviaud, D., Denis-Pouxviel, C., Remesy, C. & Murat, J. C. (1992). Effects of short chain fatty acids on growth and differentiation of the human colon cancer cell line HT29. International Journal of Cancer 52, 286289.
Gavrieli, Y., Sherman, Y. & Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. Journal of Cell Biology 119, 493501.
Hague, A., Elder, D. J. E., Hicks, D. J. & Paraskeva, C. (1995). Apoptosis in colorectal tumour cells: induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate. International Journal of Cancer 60, 400406.
Hague, A., Manning, A. M., Hanlon, K. A., Huschtscha, L. I., Hart, D. & Paraskeva, C. (1993). Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53-independent pathway: implications for the possible role of dietary fibre in the prevention of large bowel cancer. International Journal of Cancer 55, 498505.
Hague, A., Moorghen, M., Hicks, D., Chapman, M. & Paraskeva, C (1994). Bcl-2 expression in human colorectal adenomas and carcinomas. Oncogene 9, 33673370.
Hall, P. A., Coates, P. J., Ansari, B. & Hopwood, D. (1994). Regulation of cell number in the mammalian gastrointestinal tract: importance of apoptosis. Journal of Cell Science 107, 35693577.
Heerdt, B. G., Houston, M. A. & Augenlicht, L. H. (1994). Potentiation by short chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines. Cancer Research 54, 32883294.
Hockenbery, D. M., Zutter, M., Hickey, W., Nahm, M. & Korsmeyer, S. J. (1991). Bcl-2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proceedings of the National Academy of Sciences, USA 88, 69616965.
Howe, G. R., Benito, E., Castelleto, R., Cornée, J., Estève, J., Gallagher, R. P., Iscovich, J. M., Deng-ao, J., Kaaks, R., Kune, G. A., Kune, S., L'Abb´, K. A., Lee, H. P., Lee, M., Miller, A. B., Peters, R. K., Potter, J. D., Riboli, E., Slattery, K. L., Trichopoulos, D., Tuyns, A., Tzonou, A., Whittemore, A. S., Wu-Williams, A. H. & Zheng, S. (1992). Dietary intake of fibre and decreased risk of cancers of the colon and rectum – evidence from the combined analysis of 13 case-control studies. Journal of the National Cancer Institute 84, 18871896.
Jass, J. R. (1985). Diet, butyric acid and differentiation of gastrointestinal tract tumours. Medical Hypotheses 18, 113118.
Kashtan, H., Stem, H. S., Jenkins, D. J. A., Jenkins, A. L., Thompson, L. U., Hay, K., Marcon, N., Minkin, S. & Bruce, W. R. (1992). Colonic fermentation and markers of colorectal cancer risk. American Journal of Clinical Nutrition 55, 723728.
Krajewski, S., Bodrug, S., Krajewska, M., Shabaik, A., Gascoyne, R., Berean, K. & Reed, J. C. (1995). Immunohistochemical analysis of mcl-1 protein in human tissues – differential regulation of mcl-1 and bcl-2 protein-production suggests a unique role for mcl-1 in control of programmed cell-death in vivo. American Journal of Pathology 146, 13091319.
Krajewski, S., Krajewska, M., Shabaik, A., Miyashita, T., Wang, H.-G. & Reed, J. C. (1994 a). Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. American Journal of Pathology 145, 13231336.
Krajewski, S., Krajewska, M., Shabaik, A., Wang, H.-G., Irie, S., Fong, L. & Reed, J. C. (1994 b). Immunohistochemical analysis of in vivo patterns of Bcl-x expression. Cancer Research 54, 55015507.
Levin, B. (1992). Nutrition and colorectal cancer. Cancer 70, 17231726.
Mclntyre, A., Gibson, P. R. & Young, G. P. (1993). Butyrate protection from dietary fibre and protection against large bowel cancer in a rat model. Gut 34, 386391.
Merritt, A. J., Potten, C. S., Kemp, C. J., Hickman, J. A., Balmain, A., Lane, D. P. & Hall, P. A. (1994). The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Research 54, 614617.
Otaka, M., Singhal, A. & Hakomori, S. (1989). Antibody-mediated targeting of differentiation inducers to tumor cells: inhibition of colonic cancer cell growth in vitro and in vivo. Biochemical and Biophysical Research Communications 158, 202208.
Paraskeva, C. (1992). Colorectal cancer and dietary intervention. Lancet 339, 869870.
Potten, C. S., Li, Y. Q., O'Connor, P. J. O. & Winton, D. J. (1992). A possible explanation for the differential cancer incidence in the intestine, based on distribution of the cytotoxic effects of carcinogens in the murine large bowel. Carcinogenesis 13, 23052312.
Raff, M. C. (1992). Social controls on cell survival and death: an extreme view. Nature 356, 397400.
Roediger, W. E. W. (1982). Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology 83, 424429.
Rogers, A. E., Zeisel, S. H. & Groopman, J. (1993). Diet and carcinogenesis. Carcinogenesis 14, 22052217.
Sandler, R. S., Lyles, C. M., Peipins, L. A., McAuliffe, C. A., Woosley, J. T. & Kupper, L. L. (1993). Diet and risk of colorectal adenomas: macronutrients, cholesterol, and fiber. Journal of the National Cancer Institute 85, 884891.
Scheppach, W. (1994). Effects of short chain fatty acids in gut morphology and function. Gut 35, Suppl. 1, S35S38.
Scheppach, W., Bartram, H. P. & Richter, E. (1995). Role of short chain fatty acids in the prevention of colorectal cancer. European Journal of Cancer 31A, 10771080.
Scheppach, W., Sommer, H., Kirchner, T., Paganelli, G.-M., Bartram, P., Christl, S., Richter, F., Dusel, G. & Kasper, H. (1992). Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103, 5156.
Silvester, K. R., Englyst, H. N. & Cummings, J. H. (1995). lleal recovery of starch from whole diets containing resistant starch measured in vitro and fermentation of ileal effluent. American Journal of Clinical Nutrition 62, 403411.
Tsujimoto, Y., Cossman, J., Jaffe, E. & Croce, C. M. (1985). Involvement of the bcl-2 gene in human follicular lymphoma. Science 228, 14401443.
Whitehead, R. H., Young, G. P. & Bhathal, P. S. (1986). Effects of short chain fatty acids on a new colon carcinoma cell line (LIM 1215). Gut 27, 14571463.
Williams, A. C., Harper, S. J. & Paraskeva, C. (1990). Neoplastic transformation of a human colonic epithelial cell line: in vitro vidence for the adenoma to carcinoma sequence. Cancer Research 50, 47244730.
Wyllie, A. H. (1980). Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284, 555556.

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