1.World Health Organization (2000) Obesity: preventing and managing the global epidemic. . Geneva: World Health Organization.
2.Ng, M, Fleming, T, Robinson, M et al. (2014) Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 384, 766–781.
3.Wells, JCK & Siervo, M (2011) Obesity and energy balance: is the tail wagging the dog? Eur J Clin Nutr 65, 1173–1189.
4.Hall, KD, Heymsfield, SB, Kemnitz, JW et al. (2012) Energy balance and its components: implications for body weight regulation. Am J Clin Nutr 95, 989–994.
5.Hill, JO, Wyatt, HR & Peters, JC (2012) Energy balance and obesity. Circulation 126, 126–132.
6.Abbott, WG, Howard, BV, Christin, L et al. (1988) Short-term energy balance: relationship with protein, carbohydrate, and fat balances. Am J Physiol 255, 332–337.
7.Galgani, J & Ravussin, E (2008) Energy metabolism, fuel selection and body weight regulation. Int J Obes 32(Suppl. 7), S109–S119.
8.Sun, K, Kusminski, CM & Scherer, PE (2011) Adipose tissue remodeling and obesity. J Clin Invest 121, 2094–2101.
9.Cho, KW & Lumeng, CN (2011) SIRT1: a guardian at the gates of adipose tissue inflammation. Diabetes 60, 3100–3102.
10.Rutkowski, JM, Stern, JH & Scherer, PE (2015) The cell biology of fat expansion. J Cell Biol 208, 501–512.
11.Jung, UJ & Choi, M-S (2014) Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Sci 15, 6184–6223.
12.Martyn, JAJ, Kaneki, M & Yasuhara, S (2008) Obesity-induced insulin resistance and hyperglycemia: etiologic factors and molecular mechanisms. Anesthesiology 109, 137–148.
13.Wensveen, FM, Valentić, S, Šestan, M et al. (2015) The “Big Bang” in obese fat: events initiating obesity-induced adipose tissue inflammation. Eur J Immunol 45, 2446–2456.
14.McArdle, MA, Finucane, OM, Connaughton, RM et al. (2013) Mechanisms of obesity-induced inflammation and insulin resistance: insights into the emerging role of nutritional strategies. Front Endocrinol 4, 52.
15.Hill, AA, Reid Bolus, W & Hasty, AH (2014) A decade of progress in adipose tissue macrophage biology. Immunol Rev 262, 134–152.
16.Alberti, KG & Zimmet, PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications – Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15, 539–553.
17.Rocha, VZ & Libby, P (2009) Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 6, 399–409.
18.Hall, KD & Chung, ST (2018) Low-carbohydrate diets for the treatment of obesity and type 2 diabetes. Curr Opin Clin Nutr Metab Care 21, 308–312.
19.Most, J, Tosti, V & Redman, LM (2017) Calorie restriction in humans: an update. Ageing Res Rev 39, 36–45.
20.Westerterp, KR (2018) Exercise, energy balance and body composition. Eur J Clin Nutr 72, 1246–1250.
21.Muller, MJ, Enderle, J, Pourhassan, M et al. (2015) Metabolic adaptation to caloric restriction and subsequent refeeding: the Minnesota Starvation Experiment revisited. Am J Clin Nutr 102, 807–819.
22.Martin, CK, Das, SK, Lindblad, L et al. (2011) Effect of calorie restriction on the free-living physical activity levels of nonobese humans: results of three randomized trials. J Appl Physiol 110, 956–963.
23.Dansinger, ML, Gleason, JA, Griffith, JL et al. (2005) Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 293, 43–53.
24.Ahern, AL, Olson, AD, Aston, LM et al. (2011) Weight Watchers on prescription: an observational study of weight change among adults referred to Weight Watchers by the NHS. BMC Public Health 11, 434.
25.Franz, MJ, VanWormer, JJ, Crain, AL et al. (2007) Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc 107, 1755–1767.
26.Barte, JCM, Ter Bogt, NCW, Bogers, RP et al. (2010) Maintenance of weight loss after lifestyle interventions for overweight and obesity, a systematic review. Obes Rev 11, 899–906.
27.Patterson, RE & Sears, DD (2017) Metabolic effects of intermittent fasting. Annu Rev Nutr 37, 371–393.
28.Anton, SD, Moehl, K, Donahoo, WT et al. (2018) Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity 26, 254–268.
29.Arble, DM, Bass, J, Laposky, AD et al. (2009) Circadian timing of food intake contributes to weight gain. Obesity 17, 2100–2102.
30.Ekmekcioglu, C & Touitou, Y (2011) Chronobiological aspects of food intake and metabolism and their relevance on energy balance and weight regulation. Obes Rev 12, 14–25.
31.Dibner, C & Schibler, U (2018) Body clocks: time for the Nobel Prize. Acta Physiol 222, e13024.
32.Varady, KA, Bhutani, S, Church, EC et al. (2009) Short-term modified alternate-day fasting: a novel dietary strategy for weight loss and cardioprotection in obese adults. Am J Clin Nutr 90, 1138–1143.
33.Scheer, FAJL, Morris, CJ & Shea, SA (2013) The internal circadian clock increases hunger and appetite in the evening independent of food intake and other behaviors. Obesity 21, 421–423.
34.Heilbronn, LK, Smith, SR, Martin, CK et al. (2005) Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr 81, 69–73.
35.Klempel, MC, Bhutani, S, Fitzgibbon, M et al. (2010) Dietary and physical activity adaptations to alternate day modified fasting: implications for optimal weight loss. Nutr J 9, 35.
36.Johnstone, A (2015) Fasting for weight loss: an effective strategy or latest dieting trend? Int J Obes 39, 727–733.
37.Yates, L & Warde, A (2015) The evolving content of meals in Great Britain. Results of a survey in 2012 in comparison with the 1950s. Appetite 84, 299–308.
38.Lhuissier, A, Tichit, C, Caillavet, F et al. (2013) Who still eats three meals a day? Findings from a quantitative survey in the Paris area. Appetite 63, 59–69.
39.Frayn, KN (2016) Living with lipids: reflections of a fat physiologist. Nutr Bull 41, 104–107.
40.Travers, RL, Motta, AC, Betts, JA et al. (2017) Adipose tissue metabolic and inflammatory responses to a mixed meal in lean, overweight and obese men. Eur J Nutr 56, 375–385.
41.Coppack, SW, Fisher, RM, Gibbons, GF et al. (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clin Sci 79, 339–348.
42.Frayn, KN, Coppack, SW, Humphreys, SM et al. (1993) Periprandial regulation of lipid metabolism in insulin-treated diabetes mellitus. Metabolism 42, 504–510.
43.Gonzalez, JT (2014) Paradoxical second-meal phenomenon in the acute postexercise period. Nutrition 30, 961–967.
44.Ahmed, M, Gannon, MC & Nuttall, FQ (1976) Postprandial plasma glucose, insulin, glucagon and triglyceride responses to a standard diet in normal subjects. Diabetologia 12, 61–67.
45.Ruge, T, Hodson, L, Cheeseman, J et al. (2009) Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metab 94, 1781–1788.
46.McQuaid, SE, Hodson, L, Neville, MJ et al. (2011) Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition? Diabetes 60, 47–55.
47.Halberg, N, Henriksen, M, Söderhamn, N et al. (2005) Effect of intermittent fasting and refeeding on insulin action in healthy men. J Appl Physiol 99, 2128–2136.
48.Soeters, MR, Soeters, PB, Schooneman, MG et al. (2012) Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation. Am J Physiol Metab 303, E1397–E1407.
49.Fabry, P, Fodor, J, Hejl, Z et al. (1964) The frequency of meals. Its relation to overweight, hypercholesterolaemia, and decreased glucose-tolerance. Lancet 2, 614–615.
50.Murakami, K & Livingstone, MBE (2015) Eating frequency is positively associated with overweight and central obesity in US adults. J Nutr 145, 2715–2724.
51.Canuto, R, da Silva Garcez, A, Kac, G et al. (2017) Eating frequency and weight and body composition: a systematic review of observational studies. Public Health Nutr 20, 2079–2095.
52.Raynor, HA, Goff, MR, Poole, SA et al. (2015) Eating frequency, food intake, and weight: a systematic review of human and animal experimental studies. Front Nutr 2, 38.
53.St-Onge, M-P, Ard, J, Baskin, ML et al. (2017) Meal timing and frequency: implications for cardiovascular disease prevention: a scientific statement from the American Heart Association. Circulation 135, e96–121.
54.Stote, KS, Baer, DJ, Spears, K et al. (2007) A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr 85, 981–988.
55.Carlson, O, Martin, B, Stote, KS et al. (2007) Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metab – Clin Exp 56, 1729–1734.
56.Dhurandhar, NV, Schoeller, D, Brown, AW et al. (2015) Energy balance measurement: when something is not better than nothing. Int J Obes 39, 1109–1113.
57.Mattson, MP, Allison, DB, Fontana, L et al. (2014) Meal frequency and timing in health and disease. Proc Natl Acad Sci USA 111, 16647–16653.
58.Carter, S, Clifton, PM & Keogh, JB (2016) The effects of intermittent compared to continuous energy restriction on glycaemic control in type 2 diabetes; a pragmatic pilot trial. Diabetes Res Clin Pract 122, 106–112.
59.Conley, M, Le Fevre, L, Haywood, C et al. (2018) Is two days of intermittent energy restriction per week a feasible weight loss approach in obese males? A randomised pilot study. Nutr Diet 75, 65–72.
60.Sundfør, TM, Svendsen, M & Tonstad, S (2018) Effect of intermittent versus continuous energy restriction on weight loss, maintenance and cardiometabolic risk: a randomized 1-year trial. Nutr Metab Cardiovasc Dis 28, 698–706.
61.Harvie, MN, Pegington, M, Mattson, MP et al. (2011) The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes 35, 714–727.
62.Antoni, R, Johnston, KL, Collins, AL et al. (2018) Intermittent v. continuous energy restriction: differential effects on postprandial glucose and lipid metabolism following matched weight loss in overweight/obese participants. Br J Nutr 119, 507–516.
63.Bhutani, S, Klempel, MC, Berger, RA et al. (2010) Improvements in coronary heart disease risk indicators by alternate-day fasting involve adipose tissue modulations. Obesity 18, 2152–2159.
64.Varady, KA, Bhutani, S, Klempel, MC et al. (2013) Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial. Nutr J 12, 146.
65.Hoddy, KK, Kroeger, CM, Trepanowski, JF et al. (2014) Meal timing during alternate day fasting: impact on body weight and cardiovascular disease risk in obese adults. Obesity 22, 2524–2531.
66.Klempel, MC, Kroeger, CM & Varady, KA (2013) Alternate day fasting (ADF) with a high-fat diet produces similar weight loss and cardio-protection as ADF with a low-fat diet. Metab – Clin Exp 62, 137–143.
67.Trepanowski, J, Kroeger, C, Barnosky, A et al. (2017) Effect of alternate-day fasting on weight loss, weight maintenance, and cardioprotection among metabolically healthy obese adults. JAMA – Intern Med 177, 930–938.
68.Trepanowski, J, Kroeger, C, Barnosky, A et al. (2018) Effects of alternate-day fasting or daily calorie restriction on body composition, fat distribution, and circulating adipokines: secondary analysis of a randomized controlled trial. Clin Nutr 37, 1871–1878.
69.Kroeger, CM, Trepanowski, JF, Klempel, MC et al. (2018) Eating behavior traits of successful weight losers during 12 months of alternate-day fasting: an exploratory analysis of a randomized controlled trial. Nutr Health 24, 5–10.
70.Sutton, EF, Beyl, R, Early, KS et al. (2018) Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab 27, 1212–1221.
71.Gonzalez, JT, Richardson, JD, Chowdhury, EA et al. (2018) Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults. J Physiol 596, 609–622.
72.Chowdhury, EA, Richardson, JD, Holman, GD et al. (2016) The causal role of breakfast in energy balance and health: a randomized controlled trial in obese adults. Am J Clin Nutr 103, 747–756.
73.Betts, JA, Richardson, JD, Chowdhury, EA et al. (2014) The causal role of breakfast in energy balance and health: a randomized controlled trial in lean adults. Am J Clin Nutr 100, 539–547.
74.Betts, JA, Chowdhury, EA, Gonzalez, JT et al. (2016) Is breakfast the most important meal of the day? Proc Nutr Soc 75, 464–474.
75.Moro, T, Tinsley, G, Bianco, A et al. (2016) Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. J Transl Med 14, 290.
76.Gabel, K, Hoddy, KK, Haggerty, N et al. (2018) Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: a pilot study. Nutr Health Aging 4, 345–353.
77.Soeters, MR, Lammers, NM, Dubbelhuis, PF et al. (2009) Intermittent fasting does not affect whole-body glucose, lipid, or protein metabolism. Am J Clin Nutr 90, 1244–1251.
78.Heilbronn, LK, Civitarese, AE, Bogacka, I et al. (2005) Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting. Obes Res 13, 574–581.
79.Henique, C, Mansouri, A, Fumey, G et al. (2010) Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem 285, 36818–36827.
80.Church, T & Martin, CK (2018) The obesity epidemic: a consequence of reduced energy expenditure and the uncoupling of energy intake? Obesity 26, 14–16.
81.Catenacci, VA, Pan, Z, Ostendorf, D et al. (2016) A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity. Obesity 24, 1874–1883.
82.Barnosky, AR, Hoddy, KK, Unterman, TG et al. (2014) Intermittent fasting vs daily calorie restriction for type 2 diabetes prevention: a review of human findings. Transl Res 164, 302–311.
83.Rostom, H & Shine, B (2018) Basic metabolism: proteins. Surg 36, 153–158.
84.Felig, P (1975) Amino acid metabolism in man. Annu Rev Biochem 44, 933–955.
85.Atherton, PJ & Smith, K (2012) Muscle protein synthesis in response to nutrition and exercise. J Physiol 590, 1049–1057.
86.Dickinson, JM & Rasmussen, BB (2013) Amino acid transporters in the regulation of human skeletal muscle protein metabolism. Curr Opin Clin Nutr Metab Care 16, 638–644.
87.Tipton, KD, Hamilton, DL & Gallagher, IJ (2018) Assessing the role of muscle protein breakdown in response to nutrition and exercise in humans. Sport Med. 48(Suppl. 1), 53–64.
88.Vendelbo, MH, Møller, AB, Christensen, B et al. (2014) Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling. PLoS ONE 9, e102031.
89.Varady, KA (2011) Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Obes Rev 12, E593–E601.
90.Alhamdan, BA, Garcia-Alvarez, A, Alzahrnai, AH et al. (2016) Alternate-day versus daily energy restriction diets: which is more effective for weight loss? A systematic review and meta-analysis. Obes Sci Pract 2, 293–302.
91.Johnstone, AM, Murison, SD, Duncan, JS et al. (2005) Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine. Am J Clin Nutr 82, 941–948.
92.Hopkins, M, Finlayson, G, Duarte, C et al. (2016) Modelling the associations between fat-free mass, resting metabolic rate and energy intake in the context of total energy balance. Int J Obes 40, 312–318.
93.Lam, YY & Ravussin, E (2016) Analysis of energy metabolism in humans: a review of methodologies. Mol Metab 5, 1057–1071.
94.Sumithran, P, Prendergast, LA, Delbridge, E et al. (2011) Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 365, 1597–1604.
95.Varady, KA, Hoddy, KK, Kroeger, CM et al. (2016) Determinants of weight loss success with alternate day fasting. Obes Res Clin Pract 10, 476–480.
96.Klempel, MC, Kroeger, CM, Bhutani, S et al. (2012) Intermittent fasting combined with calorie restriction is effective for weight loss and cardio-protection in obese women. Nutr J 11, 98.
97.Borai, A, Livingstone, C, Kaddam, I et al. (2011) Selection of the appropriate method for the assessment of insulin resistance. BMC Med Res Methodol 11, 158.
98.Antoni, R, Johnston, KL, Collins, AL et al. (2017) Effects of intermittent fasting on glucose and lipid metabolism. Proc Nutr Soc 76, 361–368.
99.Public Health England (2016) Government Dietary Recommendations: Government Recommendations for Energy and Nutrients for Males and Females Aged 1–18 Years and 19+ Years. London: Public Health England.
100.Public Health England (2018) The Eatwell Guide: Helping You Eat a Healthy, Balanced Diet. London: Public Health England.