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The role of iodine in brain development

  • François Delange (a1)

Abstract

I is required for the synthesis of thyroid hormones. These hormones, in turn, are required for brain development, which occurs during fetal and early postnatal life. The present paper reviews the impact of I deficiency (1) on thyroid function during pregnancy and in the neonate, and (2) on the intellectual development of infants and children. All extents of I deficiency (based on I intake (μg/d); mild 50–99, moderate 20–49, severe > 20) affect the thyroid function of the mother and neonate, and the mental development of the child. The damage increases with the extent of the deficiency, with overt endemic cretinism as the severest consequence. This syndrome combines irreversible mental retardation, neurological damage and thyroid failure. Maternal hypothyroxinaemia during early pregnancy is a key factor in the development of the neurological damage in the cretin. Se deficiency superimposed on I deficiency partly prevents the neurological damage, but precipitates severe hypothyroidism in cretins. I deficiency results in a global loss of 10–15 intellectual quotient points at a population level, and constitutes the world’s greatest single cause of preventable brain damage and mental retardation.

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Copyright

Corresponding author

*Corresponding author: Professor F. Delange, fax +32 2 675 18 98, email fdelange@ulb.ac.be

References

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Aghini-Lombardi, F, Pinchera, A, Antonangeli, L, Rago, T, Chiovato, L, Bargagna, S, Bertucelli, B, Ferretti, G, Sbrana, B, Marcheschi, M & Vitti, P (1995) Mild iodine deficiency during fetal/neonatal life and neuropsychological impairment in Tuscany. Journal of Endocrinological Investigation 18, 5762.
Bernal, J & Nunez, J (1995) Thyroid hormones and brain development. European Journal of Endocrinology 133, 390398.
Bleichrodt, N & Born, MP (1994) A metaanalysis of research on iodine and its relationship to cognitive development. In The Damaged Brain of Iodine Deficiency, pp. 195200 [Stanbury, JB, editor]. New York: Cognizant Communication.
Boyages, SC & Halpern, JP (1993) Endemic cretinism: toward a unifying hypothesis. Thyroid 3, 5969.
Burrow, GN (1972) The Thyroid Gland in Pregnancy. Philadelphia, PA: Saunders.
Choufoer, JC, Van Rhijn, M & Querido, A (1965) Endemic goiter in Western New Guinea. II. Clinical picture, incidence and pathogenesis of endemic cretinism. Journal of Clinical Endocrinology and Metabolism 25, 385402.
Contempré, B, Dumont, JE, Bebe, N, Thilly, CH, Diplock, AT & Vanderpas, J (1991) Effect of selenium supplementation in hypothyroid subjects of an iodine and selenium deficient area: the possible danger of indiscriminate supplementation of iodine deficient subjects with selenium. Journal of Clinical Endocrinology and Metabolism 73, 213215.
Delange, F (1994) The disorders induced by iodine deficiency. Thyroid 4, 107128.
Delange, F (1998) Screening for congenital hypothyroidism used as an indicator of IDD control. Thyroid 8, 11851192.
Delange, F (2000) Endemic cretinism. In The Thyroid. A Fundamental and Clinical Text, 8th ed. [Braverman, LE and Utiger, RD, editors]. Philadelphia, PA: Lippincott. (In the Press).
Delange, F, Bourdoux, P, Ketelbant-Balasse, P, Van Humskerken, A, Glinoer, D & Ermans, AM (1983) Transient primary hypothyroidism in the newborn. In Congenital Hypothyroidism, pp. 275301 [Dussault, JH and Walker, P, editors]. New York: M. Dekker.
Delange, F, Bourdoux, P, Laurence, M, Peneva, L, Walfish, P & Willgerodt, H (1993) Neonatal thyroid function in iodine deficiency. In Iodine Deficiency in Europe. A Continuing Concern, pp. 199210 [Delange, F, Dunn, JT and Glinoer, D, editors]. New York: Plenum Press.
Delange, F, Iteke, FB & Ermans, AM (1982) Nutritional Factors Involved in the Goitrogenic Action of Cassava. Ottawa, Ont.: International Development Research Centre.
De, Long G, Robbins, J & Condliffe, PG (1989) Iodine and the Brain. New York: Plenum Press.
Fierro-Benitez, R, Ramirez, I, Estrella, E & Stanbury, JB (1974) The role of iodine deficiency in intellectual development in an area of endemic goiter. In Endemic Goiter and Cretinism: Continuing Threats to World Health Pan American Health Organization Publication no. 292, pp. 135142 [Dunn, J and Medeiros-Neto, GA, editors]. Washington, DC: Pan American Health Organization.
Fisher, DA & Klein, AH (1981) Thyroid development and disorders of thyroid function in the newborn. New England Journal of Medicine 304, 702712.
Glinoer, D (1997a) The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 18, 404433.
Glinoer, D (1997b) Maternal and fetal impact of chronic iodine deficiency. Clinical Obstetrics and Gynecology 40, 102116.
Glinoer, D, De, Nayer P, Delange, F, Toppet, V, Spehl, M, Grun, JP, Kinthaert, J & Lejeune, B (1995) A randomized trial for the treatment of excessive thyroid stimulation in pregnancy: maternal and neonatal effects. Journal of Clinical Endocrinology and Metabolism 80, 258269.
Hetzel, BS (1983) Iodine deficiency disorders (IDD) and their eradication. Lancet ii, 11261129.
Morreale, de Escobar G, Obregon, MJ, Calvo, R, Pedraza, P & Escobar, del Rey F (1997) Iodine deficiency, the hidden scourge: the rat model of human neurological cretinism. In Neuroendocrinology, pp. 5570 [Hendrich, CH, editor]. Trivandrum, India: Research/Signpost.
Obregon, MJ, Calvo, RM, Escobar, del Rey F & Morreale, de Escobar G (1998) Thyroid hormones and fetal development. In The Thyroid and Age, pp. 4973 [Pinchera, A, Mann, K and Hostalek, U, editors]. Stuttgart: Schattauer.
Pharoah, POD, Connolly, KJ, Ekins, RP & Harding, AG (1984) Maternal thyroid hormone levels in pregnancy and the subsequent cognitive and motor performance of the children. Clinical Endocrinology 21, 265270.
Rajatanavin, R, Chailurkit, L, Winichakoon, P, Mahachoklertwattana, P, Soranasataporn, S, Wacharasin, R, Chaisongkram, V, Amatyakul, P & Wanarata, L (1997) Endemic cretinism in Thailand: a multidisciplinary survey. European Journal of Endocrinology 137, 349355.
Stanbury, JB (1994) The Damaged Brain of Iodine Deficiency. New York: Cognizant Communication.
Stanbury, JB, Delange, F, Dunn, JT & Pandav, CS (1998) Iodine in Pregnancy. New Delhi: Oxford University Press.
Thilly, CH, Delange, F, Lagasse, R, Bourdoux, P, Ramioul, L, Berquist, H & Ermans, AM (1978) Fetal hypothyroidism and maternal thyroid status in severe endemic goiter. Journal of Clinical Endocrinology and Metabolism 47, 354360.
Vanderpas, JB, Contempré, B, Duale, NL, Goossens, W, Bebe, N, Thorpe, R, Ntambue, K, Dumont, J, Thilly, CH & Diplock, AT (1990) Iodine and selenium deficiency associated with cretinism in Northern Zaire. American Journal of Clinical Nutrition 52, 10871093.
Van, Vliet G (1998) Treatment and outcome of neonatal hypothyroidism. In The Thyroid and Age, pp. 109120 [Pinchera, A, Mann, K and Hostalek, U, editors], Stuttgart: Schattauer.
Vermiglio, F, Lo Presti, VP, Scaffidi Argentina, G, Finocchiaro, MO, Gullo, D, Squatrito, S & Trimarchi, F (1995) Maternal hypothyroxinemia during the first half of gestation in an iodine deficient area with endemic cretinism and related disorders. Clinical Endocrinology 42, 409415.
Vulsma, T (1998) Transplacental transfer of thyroid hormones. In The Thyroid and Age, pp. 3948 [A, Pinchera, K, Mann and U, Hostalek, editors]. Stuttgart: Schattauer.
World, Health Organization (1996) Iodine. Trace Elements in Human Nutrition and Health, pp. 4971.Geneva: WHO.
World Health Organization/United Nations for Children's Fund/ International Council for Control of Iodine Deficiency Disorders (1994) Indicators for Assessing Iodine Deficiency Disorders and their Control Through Salt Iodization. WHO/NUT/94.6. Geneva: WHO.

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