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  • Proceedings of the Nutrition Society, Volume 62, Issue 1
  • February 2003, pp. 193-199

Rye, lignans and human health

  • Göran Hallmans (a1), Jie-Xian Zhang (a1), Eva Lundin (a2), PäR Stattin (a3), Anders Johansson (a1), Ingegerd Johansson (a1), Kerstin Hultén (a1), Anna Winkvist (a1), Per Lenner (a4), Per Åman (a5) and Herman Adlercreutz (a6)
  • DOI:
  • Published online: 05 March 2007

Rye bran contains a high content not only of dietary fibre, but also of plant lignans and other bioactive compounds in the so-called dietary fibre complex. Blood concentrations of lignans such as enterolactone have been used as biomarkers of intake of lignan-rich plant food. At present, evidence from studies in human subjects does not warrant the conclusion that rye, whole grains or phyto-oestrogens protect against cancer. Some studies, however, have pointed in that direction, especially in relation to cancers of the upper digestive tract. A number of prospective epidemiological studies have clearly shown a protective effect of whole-grain cereals against myocardial infarctions. A corresponding protective effect against diabetes and ischaemic stroke (brain infarct) has also been demonstrated. It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex.

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*Corresponding author: Dr Jie-Xian Zhang, fax +46 90 7852642,
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H Adlercreutz , H Markkanen & S Watanabe (1993) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 12091210.

H Adlercreutz & W Mazur (1997) Phyto-oestrogens and Western diseases. Annals of Medicine 29, 95120.

O Bosello , R Ostuzzi , F Armellini , R Micciolo & LA Scuro (1980) Glucose tolerance and blood lipids in bran-fed patients with impaired glucose tolerance. Diabetes Care 3, 4649.

AJ Brodribb & DM Humphreys (1976) Diverticular disease: three studies. Part III – Metabolic effect of bran in patients with diverticular disease. British Medical Journal 1, 428430.

A Bylund , JX Zhang , A Bergh , JE Damber , A Widmark , A Johansson , H Adlercreutz , P Aman , MJ Shepherd & G Hallmans (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42, 304314.

W Demark-Wahnefried , DT Price , TJ Polascik , CN Robertson , EE Anderson , DF Paulson , PJ Walther , M Gannon & RT Vollmer (2001) Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 58, 4752.

CS Fuchs , EL Giovannucci , GA Colditz , DJ Hunter , MJ Stampfer , B Rosner , FE Speizer & WC Willett (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine 340, 69176.

S Heinonen , T Nurmi , K Liukkonen , K Poutanen , K Wähälä , T Deyama , S Nishibe & H Adlercreutz (2001) In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. Journal of Agricultural and Food Chemistry 49, 31783186.

K Hultén , A Winkvist , P Lenner , R Johansson , H Adlercreutz & G Hallmans (2002) An incident case referent study on plasma enterolactone and breast cancer risk. European Journal of Nutrition 41, 168176.

D Ingram , K Sanders , M Kolybaba & D Lopez (1997) Casecontrol study of phyto-oestrogens and breast cancer. Lancet 350, 990994.

TJA Key , PB Silcocks , GK Davey , PN Appleby & DT Bishop (1997) A case control study of diet and prostate cancer. British Journal of Cancer 76, 678687.

KT Khaw , S Bingham , A Welch , R Luben , N Wareham , S Oakes & N Day (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC – Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357, 657663.

RC Kurtz & ZF Zhang (2001) Gastric cardia cancer and dietary fiber. Gastroenterology 120, 568570.

M Landström , JX Zhang , G Hallmans , P Åman , A Berg , JE Damber , W Mazur , K Wähälä & H Adlercreutz (1998) Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate 36, 151161.

AM Linko , K Parikka , K Wähälä & H Adlercreutz (2002) Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma. Analytical Biochemistry 308, 307313.

S Liu , JE Buring , HD Sesso , EB Rimm , WC Willett & JE Manson (2002) A prospective study of dietary fiber intake and risk of cardiovascular disease among women. Journal of the American College of Cardiology 39, 4956.

S Liu , JE Manson , MJ Stampfer , KM Rexrode , FB Hu , EB Rimm & WC Willett (2000) Whole grain consumption and risk of ischemic stroke in women: A prospective study. Journal of the American Medical Association 284, 15341540.

W Mazur (1998) Phytoestrogen content in foods. Bailliere's Clinical Endocrinology and Metabolism 12, 729742.

W Mazur & H Adlercreutz (1998) Naturally occurring oestrogens in food. Pure and Applied Chemistry 70, 17591776.

W Mazur , T Fotsis , K Wähälä , S Ojala , A Salakka & H Adlercreutz (1996) Isotope dilution gas chromatographic–mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Analytical Biochemistry 233, 169180.

F Meyer , I Bairati , R Shadimani , Y Fradet & L Moore (1999) Dietary fat and prostate cancer survival. Cancer Causes and Control 10, 245251.

P Mills , B Beeson , R Phillips & G Fraser (1989) Cohort study of diet, lifestyle and prostate cancer in Adventist men. Cancer 64, 598604.

JN Morris , JW Marr & DG Clayton (1977) Diet and heart: A postscript. British Medical Journal 2, 13071314.

M Nilsson , P Åman , H Härkönen , G Hallmans , KE Bach Knudsen , W Mazur , H Adlercreutz (1997a) Content of nutrients and lignans in roller milled fractions of rye. Journal of the Science of Food and Agriculture 73, 143148.

K Oishi , K Okada , O Yoshida , H Yamabe & Y Ohno (1988) A casecontrol study of prostatic cancer with reference to dietary habit. Prostate 12, 179190.

P Pietinen , N Malila , M Virtanen , TJ Hartman , JA Tangrea , D Albanes & J Virtamo (1999) Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes and Control 10, 387396.

P Pietinen , EB Rimm , P Korhonen , AM Hartman , WC Willett , D Albanes & J Virtamo (1996) Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. Circulation 94, 27202727.

E Riboli & R Kaaks (1997) The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. International Journal of Epidemiology 26, S6S14. Suppl. 1

IR Rowland , H Wiseman , TA Sanders , H Adlercreutz & EA Bowey (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutrition and Cancer 36, 2732.

J Salmeron , JAE Manson , MJ Stampfer , GA Golditz , AL Wing & WC Willett (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Journal of the American Medical Association 277, 472477.

PO Sandman , R Adolfsson , G Hallmans , C Nygren , L Nystrom & B Winblad (1983) Treatment of constipation with high-bran bread in long-term care of severely demented elderly patients. Journal of the American Geriatrics Society 31, 289293.

A Schatzkin , E Lanza , D Corle , P Lance , F Iber , B Caan , M Shike , J Weissfeld , R Burt , MR Cooper , JW Kikendall & J Cahill (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 342, 11491155.

P Stattin , H Adlercreutz , L Tenkanen , E Jellum , S Lumme , G Hallmans , S Harvei , L Teppo , K Stumpf , T Luostarinen , M Lehtinen , J Dillner & M Hakama (2002) Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. International Journal of Cancer 99, 124129.

SS Strom , Y Yamamura , CM Duphrone , MR Spitz , RJ Babaian , PC Pillow & SD Hursting (1999) Phytoestrogen intake and prostate cancer: A case-control study using a new data base. Nutrition and Cancer 33, 2025.

P Terry , E Giovannucci , KB Michels , L Bergkvist , H Hansen , L Holmberg & A Wolk (2001a) Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute 93, 525533.

P Terry , J Lagergren , W Ye , A Wolk & O Nyren (2001b) Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology 120, 387391.

AS Truswell (2002) Cereal grains and coronary heart disease. European Journal of Clinical Nutrition 56, 114.

M Vanharanta , S Voutilainen , TA Lakka , M van der Lee , H Adlercreutz , JT Salonen (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354, 21122115.

M Vanharanta , S Voutilainen , T Nurmi , J Kaikkonen , LJ Roberts , JD Morrow , H Adlercreutz & JT Salonen (2002) Association between low serum enterolactone and increased plasma F2–isoprostanens, a measure of lipid peroxidation. Atherosclerosis 160, 465469.

A Wolk , JE Manson , MJ Stampfer , GA Colditz , FB Hu , FE Speizer , CH Hennekens & WC Willett (1999) Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. Journal of the American Medical Association 281, 19982004.

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