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Rye, lignans and human health

  • Göran Hallmans (a1), Jie-Xian Zhang (a1), Eva Lundin (a2), PäR Stattin (a3), Anders Johansson (a1), Ingegerd Johansson (a1), Kerstin Hultén (a1), Anna Winkvist (a1), Per Lenner (a4), Per Åman (a5) and Herman Adlercreutz (a6)...
Abstract

Rye bran contains a high content not only of dietary fibre, but also of plant lignans and other bioactive compounds in the so-called dietary fibre complex. Blood concentrations of lignans such as enterolactone have been used as biomarkers of intake of lignan-rich plant food. At present, evidence from studies in human subjects does not warrant the conclusion that rye, whole grains or phyto-oestrogens protect against cancer. Some studies, however, have pointed in that direction, especially in relation to cancers of the upper digestive tract. A number of prospective epidemiological studies have clearly shown a protective effect of whole-grain cereals against myocardial infarctions. A corresponding protective effect against diabetes and ischaemic stroke (brain infarct) has also been demonstrated. It seems reasonable to assume that these protective effects are associated with one or more factors in the dietary fibre complex.

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Corresponding author
*Corresponding author: Dr Jie-Xian Zhang, fax +46 90 7852642, Jie-Xian.Zhang@nutrires.umu.se
References
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Adlercreutz H, Honjo H, Higashi A, Fotsis T, Hämäläinen E, Hasegawa T & Okada H (1991) Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet. American Journal of Clinical Nutrition 54, 10931100.
Adlercreutz H, Markkanen H & Watanabe S (1993) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 12091210.
Adlercreutz H & Mazur W (1997) Phyto-oestrogens and Western diseases. Annals of Medicine 29, 95120.
Berglund O, Hallmans G, Nygren C & Taljedal IB (1982) Effects of diets rich and poor in fibres on the development of hereditary diabetes in mice. Acta Endocrinologia (Copenhagen) 100, 556564.
Bosello O, Ostuzzi R, Armellini F, Micciolo R & Scuro LA (1980) Glucose tolerance and blood lipids in bran-fed patients with impaired glucose tolerance. Diabetes Care 3, 4649.
Brodribb AJ & Humphreys DM (1976) Diverticular disease: three studies. Part III – Metabolic effect of bran in patients with diverticular disease. British Medical Journal 1, 428430.
Bylund A, Zhang JX, Bergh A, Damber JE, Widmark A, Johansson A, Adlercreutz H, Aman P, Shepherd MJ & Hallmans G (2000) Rye bran and soy protein delay growth and increase apoptosis of human LNCaP prostate adenocarcinoma in nude mice. Prostate 42, 304314.
Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M & Vollmer RT (2001) Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology 58, 4752.
den Tonkelaar I, Keinan-Boker L, Veer PV, Arts CJ, Adlercreutz H, Thijssen JH, Peeters PHM (2001) Urinary phytoestrogens and postmenopausal breast cancer risk. Cancer Epidemiology, Biomarkers and Prevention 10, 223228.
Fuchs CS, Giovannucci EL, Colditz GA, Hunter DJ, Stampfer MJ, Rosner B, Speizer FE & Willett WC (1999) Dietary fiber and the risk of colorectal cancer and adenoma in women. New England Journal of Medicine 340, 69176.
Hallmans G, Zhang JX, Lundin E, Bergh A, Sylvan A, Bylund A, Widmark A, Stattin P, Damber JE, Åman P, Johansson A & Adlercreutz H (1999) Metabolism of lignans and their relation to prostate cancer. In Phytoestrogens: Exposure, Bioavailability, Health Benefits and Safety Concerns. Proceedings of International Symposium, COST 916, Bioactive Plant Cell Wall Components in Nutrition and Health, pp 6572 [Bausch-Goldbohm S, Kardinaal A and Serra F, editors]. Doorweth, The Netherlands: Commission of European Communities
Heinonen S, Nurmi T, Liukkonen K, Poutanen K, Wähälä K, Deyama T, Nishibe S & Adlercreutz H (2001) In vitro metabolism of plant lignans: new precursors of mammalian lignans enterolactone and enterodiol. Journal of Agricultural and Food Chemistry 49, 31783186.
Hirayama T (1979) Epidemiology of prostate cancer with special reference to the role of diet. National Cancer Institute Monographs 53, 149155.
Hultén K, Winkvist A, Lenner P, Johansson R, Adlercreutz H & Hallmans G (2002) An incident case referent study on plasma enterolactone and breast cancer risk. European Journal of Nutrition 41, 168176.
Ingram D, Sanders K, Kolybaba M & Lopez D (1997) Casecontrol study of phyto-oestrogens and breast cancer. Lancet 350, 990994.
Jacobs DR (2001) The health relevance of whole grain Whole Grain and Human Health, Proceedings of International Symposium VTT 213, Espoo, Finland, pp.1718 [Liukkonen K, Kuokka A and Poutanen K, editors]. Espoo, Finland: VTT
Jacobs DR Jr, Meyer KA, Kushi LH, Folsom AR (1998) Wholegrain intake may reduce the risk of ischemic heart disease death in postmenopausal women: The Iowa Women's Health Study. American Journal of Clinical Nutrition 68, 248257.
Juntunen K, Witold M, Liukkonen K, Mariko U, Poutanen K, Adlercreutz H, Mykkänen H (2000) Consumption of wholemeal rye bread increases serum concentrations and urinary excretion of enterolactone compared with wheat bread in healthy Finnish men and women. British Journal of Nutrition 84, 839846.
Key TJA, Silcocks PB, Davey GK, Appleby PN & Bishop DT (1997) A case control study of diet and prostate cancer. British Journal of Cancer 76, 678687.
Khaw KT, Bingham S, Welch A, Luben R, Wareham N, Oakes S & Day N (2001) Relation between plasma ascorbic acid and mortality in men and women in EPIC – Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 357, 657663.
Kilkkinen A, Stumpf K, Pietinen P, Valsta LM, Tapanainen H & Adlercreutz H (2001) Determinants of serum enterolactone concentration. American Journal of Clinical Nutrition 73, 10941100.
Kleemola P, Virtanen M & Pietinen P (1994) The 1992 Dietary Survey of Finnish Adults. Helsinki, Finland: Helsinki National Public Health Institute, Department of Nutrition
Kurtz RC & Zhang ZF (2001) Gastric cardia cancer and dietary fiber. Gastroenterology 120, 568570.
Landström M, Zhang JX, Hallmans G, Åman P, Berg A, Damber JE, Mazur W, Wähälä K & Adlercreutz H (1998) Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats. Prostate 36, 151161.
Linko AM, Parikka K, Wähälä K & Adlercreutz H (2002) Gas chromatographic-mass spectrometric method for the determination of alkylresorcinols in human plasma. Analytical Biochemistry 308, 307313.
Liu S, Buring JE, Sesso HD, Rimm EB, Willett WC & Manson JE (2002) A prospective study of dietary fiber intake and risk of cardiovascular disease among women. Journal of the American College of Cardiology 39, 4956.
Liu S, Manson JE, Stampfer MJ, Rexrode KM, Hu FB, Rimm EB & Willett WC (2000) Whole grain consumption and risk of ischemic stroke in women: A prospective study. Journal of the American Medical Association 284, 15341540.
Lundin E, Adlercreutz H, Bianchini F, Stenling R, Riboli E, Kaaks R, Hallmans G & Palmqvist R (2001a) No association between plasma enterolactone and colorectal cancer risk in a prospective study. In The Dietary Fiber Complex, Intestinal Function and Metabolic Effects. Experimental and Epidemiology Studies. Umeå University Medical Dissertation. Umeå, Sweden: Umeå University.
Lundin E, Nygren C, Berglund O, Zhang JX, Höstedt P, Hallmans G & Stenling R (2001b) Effects of a rye bran diet and a fiber free diet on the morphology of the small intestine of diabetic and control mice. A scanning and transmission electron microscopy study. In The Dietary Fiber Complex, Intestinal Function and Metabolic Effects. Experimental and Epidemiology Studies. Umeå University Medical Dissertation. Umeå, Sweden: Umeå University.
Mazur W (1998) Phytoestrogen content in foods. Bailliere's Clinical Endocrinology and Metabolism 12, 729742.
Mazur W & Adlercreutz H (1998) Naturally occurring oestrogens in food. Pure and Applied Chemistry 70, 17591776.
Mazur W, Fotsis T, Wähälä K, Ojala S, Salakka A & Adlercreutz H (1996) Isotope dilution gas chromatographic–mass spectrometric method for the determination of isoflavonoids, coumestrol, and lignans in food samples. Analytical Biochemistry 233, 169180.
Meyer F, Bairati I, Shadimani R, Fradet Y & Moore L (1999) Dietary fat and prostate cancer survival. Cancer Causes and Control 10, 245251.
Meyer KA, Kushi LH, Jacobs DR Jr, Slavin J, Sellers TA & Folsom AR (2000) Carbohydrates, dietary fiber, and incident type 2 diabetes in older women. American Journal of Clinical Nutrition 71, 921930.
Mills P, Beeson B, Phillips R & Fraser G (1989) Cohort study of diet, lifestyle and prostate cancer in Adventist men. Cancer 64, 598604.
Morris JN, Marr JW & Clayton DG (1977) Diet and heart: A postscript. British Medical Journal 2, 13071314.
Nilsson M, Åman P, Härkönen H, Hallmans G, Bach Knudsen KE, Mazur W, Adlercreutz H (1997a) Content of nutrients and lignans in roller milled fractions of rye. Journal of the Science of Food and Agriculture 73, 143148.
Nilsson M, Åman P, Härkönen H, Hallmans G, Bach Knudsen KE, Mazur W, Adlercreutz H (1997b) Nutrient and lignan content, dough properties and baking performance of rye samples used in Scandinavia. Acta Agriculturae Scandinavica 47, 2634.
Normén AL, Brants HA, Voorrips LE, Andersson HA, van denBrandt PA & Goldbohm RA (2001) Plant sterol intakes and colorectal cancer risk in the Netherlands Cohort Study on Diet and Cancer. American Journal of Clinical Nutrition 74, 141148.
Nygren C, Hallmans G & Lithner F (1981) Long term effects of dietary fibre in bread on weight, blood glucose, glucosuria and faecal fat excretion in alloxan diabetic rats. Diabete et Metabolisme 7, 115120.
Nygren C, Hallmans G & Lithner F (1984) Effect of high-bran bread on blood glucose control in insulin-dependent diabetic patients. Diabete et Metabolisme 10, 3943.
Oishi K, Okada K, Yoshida O, Yamabe H & Ohno Y (1988) A casecontrol study of prostatic cancer with reference to dietary habit. Prostate 12, 179190.
Pereira MA, Jacobs DR Jr, Pins JJ, Raatz KS, Gross MD, Slavin JL & Seaquist ER (2002) Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. American Journal of Clinical Nutrition 75, 848855.
Pettersson D, Åman P, Bach Knudsen, KE Lundin, E Zhang, JX Hallmans, G Härkönen, H Adlercreutz H (1996) Intake of rye bread by ileostomists increases ileal excretion of fiber polysaccharide components and organic acids but does not increase plasma or urine lignans and isoflavonoids. Journal of Nutrition 126, 15941600.
Pietinen P, Malila N, Virtanen M, Hartman TJ, Tangrea JA, Albanes D & Virtamo J (1999) Diet and risk of colorectal cancer in a cohort of Finnish men. Cancer Causes and Control 10, 387396.
Pietinen P, Rimm EB, Korhonen P, Hartman AM, Willett WC, Albanes D & Virtamo J (1996) Intake of dietary fiber and risk of coronary heart disease in a cohort of Finnish men. Circulation 94, 27202727.
Pietinen P, Stumpf K, Mannisto S, Kataja V, Uusitupa M & Adlercreutz H (2001) Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland. Cancer Epidemiology, Biomarkers and Prevention 10, 339344.
Pukkala E, Gustavsson N & Teppom L (1987) Atlas of Cancer Incidence in Finland, p. 37 Helsinki, Finland: Offset/PKK Oy
Riboli E & Kaaks R (1997) The EPIC Project: rationale and study design. European Prospective Investigation into Cancer and Nutrition. International Journal of Epidemiology 26, S6S14. Suppl. 1
Ross AB, Kamal-Eldin A, Åman P, Lundin E, Zhang JX & Hallmans G (2001) Alkylresorcinols are absorbed by humans Whole Grain and Human Health. Proceedings of International Symposium, VTT 213, Espoo, Finland, p. 93 [Liukkonen K, Kuokka A and Poutanen K, editor] Espoo, Finland: VTT
Rowland IR, Wiseman H, Sanders TA, Adlercreutz H & Bowey EA (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutrition and Cancer 36, 2732.
Salmeron J, Manson JAE, Stampfer MJ, Golditz GA, Wing AL & Willett WC (1997) Dietary fiber, glycemic load, and risk of non-insulin-dependent diabetes mellitus in women. Journal of the American Medical Association 277, 472477.
Sandman PO, Adolfsson R, Hallmans G, Nygren C, Nystrom L & Winblad B (1983) Treatment of constipation with high-bran bread in long-term care of severely demented elderly patients. Journal of the American Geriatrics Society 31, 289293.
Schatzkin A, Lanza E, Corle D, Lance P, Iber F, Caan B, Shike M, Weissfeld J, Burt R, Cooper MR, Kikendall JW & Cahill J (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 342, 11491155.
Severson R, Nomura A, Grove J & Stemmermann G (1989) A prospective study of demographies, diets and prostatic cancer among man of Japanese ancestry in Hawaii. Cancer Research 49, 18571860.
Stattin P, Adlercreutz H, Tenkanen L, Jellum E, Lumme S, Hallmans G, Harvei S, Teppo L, Stumpf K, Luostarinen T, Lehtinen M, Dillner J & Hakama M (2002) Circulating enterolactone and prostate cancer risk: a Nordic nested case-control study. International Journal of Cancer 99, 124129.
Strom SS, Yamamura Y, Duphrone CM, Spitz MR, Babaian RJ, Pillow PC & Hursting SD (1999) Phytoestrogen intake and prostate cancer: A case-control study using a new data base. Nutrition and Cancer 33, 2025.
Stumpf K, Pietinen P, Puska P & Adlercreutz H (2000) Changes in serum enterolactone, genistein, and daidzein in a dietary intervention study in Finland. Cancer Epidemiology Biomarkers and Prevention 9, 13691372.
Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L & Wolk A (2001a) Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute 93, 525533.
Terry P, Lagergren J, Ye W, Wolk A & Nyren O (2001b) Inverse association between intake of cereal fiber and risk of gastric cardia cancer. Gastroenterology 120, 387391.
Thompson LU (1995) Flaxseed, lignans, and cancer Flaxseed in Human Nutrition, pp.219236 [Cunnane SC and Thompson LU, editors]. Champaign, IL: AOCS Press
Truswell AS (2002) Cereal grains and coronary heart disease. European Journal of Clinical Nutrition 56, 114.
Vanharanta M, Voutilainen S, Lakka TA, van der Lee M, Adlercreutz H, Salonen JT (1999) Risk of acute coronary events according to serum concentrations of enterolactone: a prospective population-based case-control study. Lancet 354, 21122115.
Vanharanta M, Voutilainen S, Nurmi T, Kaikkonen J, Roberts LJ, Morrow JD, Adlercreutz H & Salonen JT (2002) Association between low serum enterolactone and increased plasma F2–isoprostanens, a measure of lipid peroxidation. Atherosclerosis 160, 465469.
Willett WC (1998) The Dietary Pyramid: does the foundation need repair?. American Journal of Clinical Nutrition 68, 218219.
Wolk A, Manson JE, Stampfer MJ, Colditz GA, Hu FB, Speizer FE, Hennekens CH & Willett WC (1999) Long-term intake of dietary fiber and decreased risk of coronary heart disease among women. Journal of the American Medical Association 281, 19982004.
World Cancer Research Fund and the American Institute for Cancer Research (1997) Food, Nutrition and The Prevention. of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research
Zheng W, Dai Q, Custer LJ, Shu XO, Wen WQ, Jin F & Franke AA (1999) Urinary excretion of isoflavonoids and the risk of breast cancer. Cancer Epidemiology, Biomarkers and Prevention 8, 3540.
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