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Session 1: Feeding and infant development Breast-feeding and immune function: Symposium on ‘Nutrition in early life: new horizons in a new century’

  • Lars Å. Hanson (a1)
Abstract

The newborn receives, via the placenta, maternal IgG antibodies against the microbes present in its surroundings, but such antibodies have a pro-inflammatory action, initiating the complement system and phagocytes. Although the host defence mechanisms of the neonate that involve inflammatory reactivity are somewhat inefficient, this defence system can still have catabolic effects. Breast-feeding compensates for this relative inefficiency of host defence in the neonate by providing considerable amounts of secretory IgA antibodies directed particularly against the microbial flora of the mother and her environment. These antibodies bind the microbes that are appearing on the infant's mucosal membranes, preventing activation of the pro-inflammatory defence. The major milk protein lactoferrin can destroy microbes and reduce inflammatory responses. The non-absorbed milk oligosaccharides block attachment of microbes to the infant's mucosae, preventing infections. The milk may contain anti-secretory factor, which is anti-inflammatory, preventing mastitis in mothers and diarrhoea in infants. Numerous additional factors in the milk are of unknown function, although IL-7 is linked to the larger size of the thymus and the enhanced development of intestinal Tγδ lymphocytes in breast-fed compared with non-breast-fed infants. Several additional components in the milk may help to explain why breast-feeding can reduce infant mortality, protecting against neonatal septicaemia and meningitis. It is therefore important to start breast-feeding immediately. Protection is also apparent against diarrhoea, respiratory infections and otitis media. There may be protection against urinary tract infections and necrotizing enterocolitis, and possibly also against allergy and certain other immunological diseases, and tumours. In conclusion, breast-feeding provides a very broad multifactorial anti-inflammatory defence for the infant.

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Corresponding author
Corresponding author: Professor Lars Å. Hanson, fax +46 31 342 46 21, email lars.a.hanson@immuno.gu.se
References
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Aaby P, Marx C, Trautner S, Rudaa D, Hasselbalch H, Jensen H & Lisse I (2002) Thymus size at birth is associated with infant mortality: a community study from Guinea-Bissau. Acta Paediatrica 91, 698703.
Adinolfi M, Glynn AA, Lindsay M & Milne CM (1966) Serological properties of gamma-A antibodies to Escherichia coli present in human colostrum. Immunology 10, 517526.
Adlerberth I, Hanson & Wold AE (1999) Ontogeny of the intestinal flora. In Development of the Gastrointestinal Tract, pp. 279292 [Sanderson IR and Walker WA editors]. Hamilton, Ontario: BC Dexter Inc.
Ahrne S, Lonnermark E, Wold AE, Aberg N, Hesselmar B, Saalman R, Strannegard IL, Molin G & Adlerberth I (2005) Lactobacilli in the intestinal microbiota of Swedish infants. Microbes and Infection 7, 12561262.
Alm B, Wennergren G, Norvenius SG, Skjaerven R, Lagercrantz H, Helweg-Larsen K & Irgens LM (2002) Breast feeding and the sudden infant death syndrome in Scandinavia, 1992–95. Archives of Disease in Childhood 86, 400402.
Andersson B, Porras O, Hanson , Lagergård T & Svanborg Edén C (1986) Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk. Journal of Infectious Diseases 153, 232237.
Araujo CL, Victora CG, Hallal PC & Gigante DP (2006) Breastfeeding and overweight in childhood: evidence from the Pelotas 1993 birth cohort study. International Journal of Obesity 30, 500506.
Arenz S & von Kries R (2005) Protective effect of breastfeeding against obesity in childhood. Can a meta-analysis of observational studies help to validate the hypothesis? Advances in Experimental Medicine and Biology 569, 4048.
Bahl R, Frost C, Kirkwood BR, Edmond K, Martines J, Bhandari N & Arthur P (2005) Infant feeding patterns and risks of death and hospitalization in the first half of infancy: multicentre cohort study. Bulletin of the World Health Organization 83, 418426.
Bogen DL, Hanusa BH & Whitaker RC (2004) The effect of breast-feeding with and without formula use on the risk of obesity at 4 years of age. Obesity Research 12, 15271535.
Bollinger RR, Everett ML, Palestrant D, Love SD, Lin SS & Parker W (2003) Human secretory immunoglobulin A may contribute to biofilm formation in the gut. Immunology 109, 580587.
Brandtzaeg P, Carlsen HS & Farstad IN (2005) The human mucosal B-cell system. In Mucosal Immunology, 3rd ed., pp. 617654 [Mestecky J, Bienenstock J, Lamm M, Strober W, McGhee J and Mayer L editors]. Amsterdam: Elsevier Academic Press.
Burke V, Beilin LJ, Simmer K, Oddy WH, Blake KV, Doherty D, Kendall GE, Newnham JP, Landau LI & Stanley FJ (2005) Breastfeeding and overweight: longitudinal analysis in an Australian birth cohort. Journal of Pediatrics 147, 5661.
Cesar JA, Victora CG, Barros FC, Santos IS & Flores JA (1999) Impact of breast feeding on admission for pneumonia during postneonatal period in Brazil: nested case-control study. British Medical Journal 318, 13161320.
Chantry CJ, Howard CR & Auinger P (2006) Full breastfeeding duration and associated decrease in respiratory tract infection in US children. Pediatrics 117, 425432.
Chen A & Rogan WJ (2004) Breastfeeding and the risk of postneonatal death in the United States. Pediatrics 113, e435e439.
Clemens J, Rao M, Eng M, Ahmed F, Ward R, Huda S et al. (1993) Breast-feeding and the risk of life-threatening rotavirus diarrhea: Prevention or postponement? Pediatrics 92, 680685.
Coppa GV, Zampini L, Galeazzi T, Facinelli B, Ferrante L, Capretti R & Orazio G (2006) Human milk oligosaccharides inhibit the adhesion to Caco-2 Cells of diarrheal pathogens: Escherichia coli, Vibrio cholerae, and Salmonella fyris. Pediatric Research 59, 377382.
Cruz JR, Gil L, Cano F, Caceres P & Pareja G (1988) Breast-milk anti-Escherichia coli heatlabile toxin IgA antibodies protect against toxin-induced infantile diarrhoea. Acta Paediatrica Scandinavica 77, 658662.
Cushing AH, Samet JM, Lambert WE, Skipper BJ, Hunt WC, Young SA & McLaren LC (1998) Breastfeeding reduces risk of respiratory illness in infants. American Journal of Epidemiology 147, 863870.
Decker MD, Edwards KM, Bradley R & Palmer P (1992) Comparative trial in infants of four conjugate Haemophilus influenzae type b vaccines. Journal of Pediatrics 120, 184189.
Der G, Batty GD & Deary IJ (2006) Effect of breastfeeding on intelligence in children: prospective study, sibling pairs analysis, and meta-analysis. British Medical Journal 333, 945951.
de Silva A, Jones PW & Spencer SA (2004) Does human milk reduce infection rates in preterm infants? A systematic review. Archives of Disease in Childhood 89, F509F513.
Dewey KG, Heinig MJ & Nommsen-Rivers LA (1995) Differences in morbidity between breast-fed and formula-fed infants. Journal of Pediatrics 126, 696702.
Duffy LC, Byers TE, Riepenhoff-Talty M, La Scolea LJ, Zielezny M & Ogra PL (1986) The effects of infant feeding on rotavirus-induced gastroenteritis: A prospective study. American Journal of Public Health 76, 259263.
Duncan B, Ey J, Holberg CJ, Wright AL, Martinez FD & Taussig LM (1993) Exclusive breast-feeding for at least 4 months protects against otitis media. Pediatrics 91, 867872.
Edde L, Hipolito RB, Hwang FF, Headon DR, Shalwitz RA & Sherman MP (2001) Lactoferrin protects neonatal rats from gut-related systemic infection. American Journal of Physiology 281, G1140G1150.
Edmond K, Zandoh C, Quigley M, Amenga-Etego S, Owusu-Agyei S & Kirkwood B (2006) Delayed breastfeeding initiation increases risk of neonatal mortality. Pediatrics 117, e380e386.
Ellison RT (1994) The effects of lactoferrin on gram-negative bacteria. In Advances in Experimental Medicine and Biology. Lactoferrin: Structure and Function, pp. 7190 [Hutchens TW, Rumballand SV and Lönnerdal B editors]. New York: Plenum Press.
Espinoza F, Paniagua M, Hallander H, Svensson L & Strannegård Ö (1997) Rotavirus infections in young Nicaraguan children. Pediatric Infectious Disease Journal 16, 564571.
Filteau S (2003) The influence on mastitis on antibody transfer to infants through breast milk. Vaccine 21, 33773381.
Fituch CC, Palkowetz KH, Goldman AS & Schanler RJ (2004) Concentrations of IL-10 in preterm human milk and in milk from mothers of infants with necrotizing enterocolitis. Acta Paediatrica 93, 14961500.
Ford K & Labbok M (1993) Breast-feeding and child health in the United States. Journal of Biosocial Science 25, 187194.
Fornarini B, Iacobelli S, Tinari N, Natoli C, De Martino M & Sabatino G (1999) Human milk 90K (Mac-2 BP): possible protective effects against acute respiratory infections. Clinical and Experimental Immunology 115, 9194.
Furukawa M, Narahara H, Yasuda K & Johnston JM (1993) Presence of platelet-activating factor-acetylhydrolase in milk. Journal of Lipid Research 34, 16031609.
Garofalo RP & Goldman AS (1999) Expression of functional immunomodulatory and anti-inflammatory factors in human milk. Clinics in Perinatology 26, 361377.
Gartner LM, Morton J, Lawrence RA, Naylor AJ, O'Hare D, Schanler RJ & Eidelman AI (2005) Breastfeeding and the use of human milk. Pediatrics 115, 496506.
Gianino P, Mastretta E, Longo P, Laccisaglia A, Sartore M, Russo R & Mazzaccara A (2002) Incidence of nosocomial rotavirus infections, symptomatic and asymptomatic, in breast-fed and non-breast-fed infants. Journal of Hospital Infection 50, 1317.
Gillin FD, Reiner DS & Gault MJ (1985) Cholate-dependent killing of Giardia lamblia by human milk. Infection and Immunity 47, 619622.
Gillman MW, Rifas-Shiman SL, Berkey CS, Frazier AL, Rockett HR, Camargo CA Jr, Field AE & Colditz GA (2006) Breast-feeding and overweight in adolescence. Epidemiology 17, 112114.
Glass RI & Stoll BJ (1989) The protective effect of human milk against diarrhoea: a review of studies from Bangladesh. Acta Paediatrica Scandinavica 351, 131136.
Glass RI, Svennerholm AM, Stoll BJ, Khan SR, Hassain KMB, Huq MI & Holmgren J (1983) Protection against cholera in breast-fed children by antibodies in breast-milk. New England Journal of Medicine 308, 13891392.
Goldblum R, Ahlstedt S, Carlsson B, Hanson L, Jodal U & Lidin-Janson G (1975) Antibody-forming cells in human colostrum after oral immunization. Nature 257, 797799.
Goldblum RM, Schanler RJ, Garza C & Goldman AS (1989) Human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. Pediatric Research 25, 184188.
Goldman AS, Garza C, Nichols BL & Goldblum RM (1982) Immunologic factors in human milk during the first year of lactation. Journal of Pediatrics 100, 563567.
Gomez HF, Herrera-Insua I, Siddiqui MM, Diaz-Gonzalez VA, Caceres E, Newburg DS & Cleary TG (2001) Protective role of human lactoferrin against invasion of Shigella flexneri M90T. Advances in Experimental Medicine and Biology 501, 457467.
Gothefors L, Olling S & Winberg J (1975) Breast feeding and biological properties of faecal E. coli strains. Acta Paediatrica Scandinavica 64, 807812.
Grummer-Strawn LM & Mei Z (2004) Does breastfeeding protect against pediatric overweight? Analysis of longitudinal data from the Centers for Disease Control and Prevention Pediatric Nutrition Surveillance System. Pediatrics 113, e81e86.
Hahn-Zoric M, Fulconis F, Minoli I, Moro M, Carlsson B, Böttiger M, Räihä N & Hanson L (1990) Antibody responses to parenteral and oral vaccines are impaired by conventional and low protein formulas as compared to breast-feeding. Acta Paediatrica Scandinavica 79, 11371142.
Hanson L, Ashraf R, Zaman S, Karlberg J, Khan SR, Lindblad B & Jalil F (1994) Breastfeeding is a natural contraceptive and prevents disease and death in infants, linking infant mortality and birth rates. Acta Paediatrica 83, 36.
Hanson (1961) Comparative immunological studies of the immune globulins of human milk and blood serum. International Archives of Allergy and Applied Immunology 18, 241267.
Hanson (1998) Non-breastfeeding – The most common immunodeficiency. Hong Kong Journal of Paediatrics 3, 58.
Hanson (2004) Immunobiology of Human Milk. How Breastfeeding Protects Babies. Amarillo, TX: Pharmasoft Publishing.
Hanson (2007) The role of breastfeeding in the defense of the child. In Textbook of Breastfeeding [Hale T and Hartmann P editors]. Amarillo, TX: Hale Publishing (In the Press).
Hanson & Johansson BG (1962) Immunological characterization of chromatographically separated protein fractions from human colostrum. International Archives of Allergy and Applied Immunology 20, 6579.
Harder T, Bergmann R, Kallischnigg G & Plagemann A (2005) Duration of breastfeeding and risk of overweight: a meta-analysis. American Journal of Epidemiology 162, 397403.
Hasselbalch H, Engelmann MD, Ersboll AK, Jeppesen DL & Fleischer-Michaelsen K (1999) Breast-feeding influences thymic size in late infancy. European Journal of Pediatrics 158, 964967.
Haversen LA, Baltzer L, Dolphin G, Hanson & Mattsby-Baltzer I (2003) Anti-inflammatory activities of human lactoferrin in acute dextran sulphate-induced colitis in mice. Scandinavian Journal of Immunology 57, 210.
Haversen LA, Engberg I, Baltzer L, Dolphin G, Hanson & Mattsby-Baltzer I (2000) Human lactoferrin and peptides derived from a surface-exposed helical region reduce experimental Escherichia coli urinary tract infection in mice. Infection and Immunity 68, 58165823.
Hayani KC, Guerrero ML, Morrow AL, Gomez HF, Winsor DK, Ruiz-Palacios GM & Cleary TG (1992) Concentration of milk secretory immunoglobulin A against Shigella virulence plasmid-associated antigens as a predictor of symptom status in Shigella-infected breast-fed infants. Journal of Pediatrics 121, 852856.
Hendrixson DR, Qii J, Shewry SC, Fink Dl, Petty AG, Baker EN, Plat AG & St Gem JW III (2003) Human milk lactoferrin is a serine protease that cleaves Haemophilus surface proteins at arginine-rich sites. Molecular Microbiology 47, 607617.
Hernell O, Ward H, Blackberg L & Pereira ME (1986) Killing of Giardia lamblia by human milk lipases: an effect mediated by lipolysis of milk lipids. Journal of Infectious Diseases 153, 715720.
Holmgren J, Svennerholm AM & Lindblad M (1983) Receptor-like glycocompounds in human milk that inhibit classical and El Tor Vibrio cholerae cell adherence (hemagglutination). Infection and Immunity 39, 147154.
Howie PW, Forsyth JS, Ogston SA, Clark A & Florey CV (1990) Protective effect of breast feeding against infection. British Medical Journal 300, 1116.
Huffman SL, Zehner ER & Victora C (2001) Can improvements in breast-feeding practices reduce neonatal mortality in developing countries? Midwifery 17, 8092.
Hvas CL, Kelsen J, Agnholt J, Hollsberg P, Tvede M, Moller JK & Dahlerup JF (2007) Crohn's disease intestinal CD4+ T cells have impaired interleukin-10 production which is not restored by probiotic bacteria. Scandinavian Journal of Gastroenterology 42, 592601.
Kawakami H & Lonnerdal B (1991) Isolation and function of a receptor for human lactoferrin in human fetal intestinal brush-border membranes. American Journal of Physiology 261, G841G846.
Kersey M, Lipton R, Sanchez-Rosado M, Kumar J, Thisted R & Lantos JD (2005) Breast-feeding history and overweight in Latino preschoolers. Ambulatory Pediatrics 5, 355358.
Kimbrell DA & Beutler BB (2001) The evolution and genetics of innate immunity. Nature Reviews Genetics 2, 256267.
Korhonen TK, Valtonen MV, Parkkinen J, Vaisanen-Rhen V, Finne J, Orskov F, Orskov I, Svenson SB & Makela PH (1985) Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infection and Immunity 48, 486491.
Kramer MS, Chalmers B, Hodnett ED, Sevkovskaya Z, Dzikovich I, Shapiro S et al. (2001) Promotion of Breastfeeding Intervention Trial (PROBIT): a randomized trial in the Republic of Belarus. Journal of the American Medical Association 285, 413420.
Kramer MS, Guo T, Platt RW, Sevkovskaya Z, Dzikovich I, Collet JP et al. (2003) Infant growth and health outcomes associated with 3 compared with 6 mo of exclusive breastfeeding. American Journal of Clinical Nutrition 78, 291295.
Kunz C & Rudloff S (1993) Biological functions of oligosaccharides in human milk. Acta Paediatrica 82, 903912.
Kvaavik E, Tell GS & Klepp KI (2005) Surveys of Norwegian youth indicated that breast feeding reduced subsequent risk of obesity. Journal of Clinical Epidemiology 58, 849855.
Labbok MH, Clark D & Goldman AS (2004) Breastfeeding: Maintaining an irreplaceable immunological resource. Nature Reviews Immunology 4, 565573.
Labbok MH, Hight-Laukaran V, Peterson AE, Fletcher V, von Hertzen H & Van Look PF (1997) Multicenter study of the Lactational Amenorrhea Method (LAM): I. Efficacy, duration, and implications for clinical application. Contraception 55, 327336.
Labeta MO, Vidal K, Nores JE, Arias M, Vita N, Morgan BP et al. (2000) Innate recognition of bacteria in human milk is mediated by a milk-derived highly expressed pattern recognition receptor, soluble CD14. Journal of Experimental Medicine 191, 18071812.
Laegreid A, Otnaess AB & Fuglesang J (1986) Human and bovine milk: comparison of ganglioside composition and enterotoxin-inhibitory activity. Pediatric Research 20, 416421.
Laky K, Lewis JM, Tigelaar RE & Puddington L (2003) Distinct requirements for IL-7 in development of TCR gamma delta cells during fetal and adult life. Journal of Immunology 170, 40874094.
Lange S & Lönnroth I (2001) The antisecretory factor: synthesis, anatomical and cellular distribution, and biological action in experimental and clinical studies. International Review of Cytology 210, 3975.
Lawlor DA, Najman JM, Sterne J, Williams GM, Ebrahim S & Davey Smith G (2004) Associations of parental, birth, and early life characteristics with systolic blood pressure at 5 years of age: findings from the Mater-University study of pregnancy and its outcomes. Circulation 110, 24172423.
Leitch EC & Willcox MD (1998) Synergic antistaphylococcal properties of lactoferrin and lysozyme. Journal of Medical Microbiology 47, 837842.
Letterio JJ, Geiser AG, Kulkarni AB, Roche NS, Sporn MB & Roberts AB (1994) Maternal rescue of transforming growth factor-b1 null mice. Science 264, 19361938.
Lewis DB (2006) Developmental immunology and role of host defenses in fetal and neonatal susceptibility to infection. In Infectious Diseases of the Fetus and the Newborn Infant, pp. 87210 [Remington JS, Klein JO, Wilson CB and Baker CJ editors]. Philadelphia, PA: Elsevier Saunders.
Long K, Vasquez-Garibay E, Mathewson J, de la Cabada J & DuPont H (1999) The impact of infant feeding patterns on infection and diarrheal disease due to enterotoxigenic Escherichia coli. Salud Publica de Mexico 41, 263270.
Lotz M, Gutle D, Walther S, Menard S, Bogdan C & Hornef MW (2006) Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. Journal of Experimental Medicine 203, 973984.
Lucas A & Cole TJ (1990) Breast milk and neonatal necrotising enterocolitis. Lancet 336, 15191523.
McGuire W & Anthony MY (2003) Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Archives of Disease in Childhood 88, F11F14.
Mårild S, Hansson S, Jodal U, Oden A & Svedberg K (2004) Protective effect of breastfeeding against urinary tract infections. Acta Paediatrica 93, 164168.
Martin RM, Gunnell D, Owen CG & Smith GD (2005a) Breast-feeding and childhood cancer: A systematic review with metaanalysis. International Journal of Cancer 117, 10201031.
Martin RM, Gunnell D & Smith GD (2005b) Breastfeeding in infancy and blood pressure in later life: systematic review and meta-analysis. American Journal of Epidemiology 161, 1526.
Martin RM, Middleton N, Gunnell D, Owen CG & Smith GD (2005c) Breast-feeding and cancer: the Boyd Orr cohort and a systematic review with meta-analysis. Journal of the National Cancer Institute 97, 14461457.
Mata LJ, Urrutia JJ, García RF & Béhar M (1969) Shigella infection in breast-fed Guatemalan Indian neonates. American Journal of Diseases of Children 117, 142146.
Montgomery SM, Ehlin A & Sacker A (2006) Breastfeeding and resilience against psychosocial stress Archives of Disease in Childhood 91, 990994.
Morrow AL, Reves RR, West MS, Guerrero ML, Ruiz-Palacios GM & Pickering LK (1992) Protection against infection with Giardia lamblia by breast-feeding in a cohort of Mexican infants. Journal of Pediatrics 121, 363370.
Morrow AL, Ruiz-Palacios GM, Altaye M, Jiang X, Guerrero ML, Meinzen-Derr JK, Farkas T, Chaturvedi P, Pickering LK & Newburg DS (2004) Human milk oligosaccharides are associated with protection against diarrhea in breast-fed infants. Journal of Pediatrics 145, 297303.
Nafstad P & Jaakola JJK (2003) Breastfeding, passive smoking, and asthma and wheeze in children. Journal of Allergy and Clinical Immunology 112, 807808.
Narayanan I, Prakash K, Prabhakar AK & Gujral VV (1982) A planned prospective evaluation of the anti-infective property of varying quantities of expressed human milk. Acta Paediatrica Scandinavica 71, 441445.
Neeser JR, Chambaz A, Del Vedovo S, Prigent MJ & Guggenheim B (1988) Specific and nonspecific inhibition of adhesion of oral actinomyces and streptococci to erythrocytes and polystyrene by caseinoglycopeptide derivatives. Infection and Immunity 56, 32013208.
Nelson MC, Gordon-Larsen P & Adair LS (2005) Are adolescents who were breast-fed less likely to be overweight? Analyses of sibling pairs to reduce confounding. Epidemiology 16, 247253.
Newburg DS (1997) Do the binding properties of oligosaccharides in milk protect human infants from gastrointestinal bacteria? Journal of Nutrition 127, 980S984S.
Newburg DS (1999) Human milk glycoconjugates that inhibit pathogens. Current Medicinal Chemistry 6, 117127.
Newburg DS, Peterson JA, Ruiz-Palacios GM, Matson DO, Morrow AL, Shults J et al. (1998) Role of human-milk lactadherin in protection against symptomatic rotavirus infection. Lancet 351, 11601164.
Newburg DS, Ruiz-Palacios GM & Morrow AL (2005) Human milk glycans protect infants against enteric pathogens. Annual Review of Nutrition 25, 3758.
Ngom PT, Collinson A, Pido-Lopez J, Henson S, Prentice A & Aspinall R (2004) Improved thymic function in exclusively breast-fed babies is associated with higher breast milk IL-7. American Journal of Clinical Nutrition 80, 722728.
Nikawa H, Samaranayake LP, Tenovuo J & Hamada T (1994) The effect of antifungal agents on the in vitro susceptibility of Candida albicans to apo-lactoferrin. Archives of Oral Biology 39, 921923.
Noverr MC & Huffnagle GB (2005) The ‘microflora hypothesis’ of allergic diseases. Clinical and Experimental Allergy 35, 15111520.
Nowrouzian FL, Monstein HJ, Wold AE & Adlerberth I (2005) Effect of human milk on type 1 and P-fimbrial mRNA expression in intestinal Escherichia coli strains. Letters in Applied Microbiology 40, 7480.
Ochoa TJ, Noguera-Obenza M, Ebel F, Guzman CA, Gomez HF & Cleary TG (2003) Lactoferrin impairs type III secretory system function in enteropathogenic Escherichia coli. Infection and Immunity 71, 51495155.
Oddy WH, Sly PD, de Klerk NH, Landau LI, Kendall GE, Holt PG & Stanley FJ (2003) Breast feeding and respiratory morbidity in infancy: a birth cohort study. Archives of Disease in Childhood 88, 224228.
Ogundele MO (1999) Inhibitors of complement activity in human breast-milk: a proposed hypothesis of their physiological significance. Mediators of Inflammation 8, 6975.
Otnaess AB, Laegreid A & Ertresvag K (1983) Inhibition of enterotoxin from Escherichia coli and Vibrio cholerae by gangliosides from human milk. Infection and Immunity 40, 563569.
Owen CG, Martin RM, Whincup PH, Davey-Smith G, Gillman MW & Cook DG (2005) The effect of breastfeeding on mean body mass index throughout life: a quantitative review of published and unpublished observational evidence. American Journal of Clinical Nutrition 82, 12981307.
Pabst HF & Spady DW (1990) Effect of breast-feeding on antibody response to conjugate vaccine. Lancet 336, 269270.
Pettersson J, Mossberg AK & Svanborg C (2006) alpha-Lactalbumin species variation HAMLET formation, and tumor cell death. Biochemical and Biophysical Research Communications 345, 260270.
Pisacane A, Graziano L, Mazzarella G, Scarpellino B & Zona G (1992) Breastfeeding and urinary tract infection. Journal of Pediatrics 120, 8789.
Plaut AG (1978) Microbial IgA proteases. New England Journal of Medicine 298, 14591463.
Quigley MA, Cumberland P, Cowden JM & Rodrigues LC (2006) How protective is breastfeeding against diarrhoeal disease in infants in 1990s England? A case-control study. Archives of Disease in Childhood 91, 245250.
Ronnestad A, Abrahamsen TG, Medbo S, Reigstad H, Lossius K, Kaaresen PI, Egeland T, Engelund IE, Irgens LM & Markestad T (2005) Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding. Pediatrics 115, e269e276.
Roux M, McWilliams M, Phillips-Quagliata J, Weisz-Carrington P & Lamm M (1977) Origin of IgA-secreting plasma cells in the mammary gland. Journal of Experimental Medicine 146, 13111322.
Rudloff S, Pohlentz G, Diekmann L, Egge H & Kunz C (1996) Urinary excretion of lactose and oligosaccharides in preterm infants fed human milk or infant formula. Acta Paediatrica 85, 598603.
Ruiz-Palacios GM, Calva JJ, Pickering LK, Lopez-Vidal Y, Volkow P, Pezzarossi H & West MS (1990) Protection of breast-fed infants against Campylobacter diarrhea by antibodies in human milk. Journal of Pediatrics 116, 707713.
Ruiz-Palacios GM, Cervantes LE, Ramos P, Chavez-Munguia B & Newburg DS (2003) Campylobacter jejuni binds intestinal H(O) antigen (Fuca1,2Galb1,4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection. Journal of Biological Chemistry 278, 1411214120.
Ruiz-Palacios GM, Torres J, Torres NI, Escamilla E, Ruiz-Palacios BR & Tamayo J (1983) Cholera-like enterotoxin produced by Campylobacter jejuni. Characterisation and clinical significance. Lancet ii, 250253.
Salminen SJ, Gueimonde M & Isolauri E (2005) Probiotics that modify disease risk. Journal of Nutrition 135, 12941298.
Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R & Silvestro L (2005) Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. Acta Paediatrica 94, 531537.
Schanler RJ, Shulman RJ, Lau C, Smith EO & Heitkemper MM (1999) Feeding strategies for premature infants: randomized trial of gastrointestinal priming and tube-feeding method. Pediatrics 103, 434439.
Schroten H, Hanisch FG, Plogmann R, Hacker J, Uhlenbruck G, Nobis-Bosch R & Wahn V (1992) Inhibition of adhesion of S-fimbriated Escherichia coli to buccal epithelial cells by human milk fat globule membrane components: a novel aspect of the protective function of mucins in the nonimmunoglobulin fraction. Infection and Immunity 60, 28932899.
Shahani KM, Herper WJ, Jensen RG, Parry RM Jr & Zittle CA (1973) Enzymes in bovine milk: a review. Journal of Dairy Science 56, 531543.
Silfverdal SA, Bodin L, Ulanova M, Hahn-Zoric M, Hanson LA & Olcen P (2002) Long term enhancement of the IgG2 antibody response to Haemophilus influenzae type b by breast-feeding. Pediatric Infectious Disease Journal 21, 816821.
Silfverdal SA, Ekholm L & Bodin L (2007) Breastfeeding enhances the antibody response to Hib and Pneumococcal serotype 6B and 14 after vaccination with conjugate vaccines. Vaccine 25, 14971502.
Silfverdal SA & Montgomery SM (2007) Breastfeeding protects against more severe manifestations of clinical measles infection. Proceedings of the 12th International Conference of the International Society for Research of Human Milk and Lactation (ISRHML), Cambridge 2004. (In the Press.)
Singhal A, Cole TJ, Fewtrell M & Lucas A (2004) Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised study. Lancet 363, 15711578.
Singhal A & Lucas A (2004) Early origins of cardiovascular disease: is there a unifying hypothesis? Lancet 363, 16421645.
Stephens S, Kennedy CR, Lakhani PK & Brenner MK (1984) In vivo immune responses of breast- and bottle-fed infants to tetanus toxoid antigen and to normal gut flora. Acta Paediatrica Scandinavica 73, 426432.
Stoll B (2006) Neonatal infections: a global perspective. In Infectious Diseases of the Fetus and the Newborn Infant, pp. 2757 [Remington JS, Klein JO, Wilson CB and Baker CJ editors]. Philadelphia, PA: Elsevier Saunders.
Strömqvist M, Falk P, Bergström S, Hansson L, Lönnerdal B, Normark S & Hernell O (1995) Human milk kappa-casein and inhibition of Helicobacter pylori adhesion to human gastric mucosa. Journal of Pediatrics 21, 288296.
Svanborg C, Ågerstam H, Aronson A, Bjerkvist R, Duringer C, Fischer W et al. (2003) HAMLET kills tumor cells by an apoptosis-like mechanism – cellular, molecular and therapeutic aspects. Advances in Cancer Research 88, 129.
Svensson K, Lange S, Lönnroth I, Widström A-M & Hanson (2004) Induction of anti-secretory factor in human milk may prevent mastitis. Acta Paediatrica 93, 12281231.
Talayero JMP, Liza'n-Garcia M, Puime AO, Muncharaz MJB, Soto BB, Sanchez-Palomares M, Serrano LS & Rivera LL (2006) Full breastfeeding and hospitalization as a result of infections in the first year of life. Pediatrics 118, e92e99.
Togawa J, Nagase H, Tanaka K, Inamori M, Umezawa T, Nakajima A, Naito M, Sato S, Saito T & Sekihara H (2002) Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance. American Journal of Physiology 283, G187G195.
Toschke AM, Vignerova J, Lhotska L, Osancova K, Koletzko B & Von Kries R (2002) Overweight and obesity in 6- to 14-year-old Czech children in 1991: protective effect of breast-feeding. Journal of Pediatrics 141, 764769.
Tunzi CR, Harper PA, Bar-Oz B, Valore EV, Semple JL, Watson-MacDonell J, Ganz T & Ito S (2000) Beta-defensin expression in human mammary gland epithelia. Pediatric Research 48, 3035.
Uauy R & Araya M (2004) Novel oligosaccharides in human milk: understanding mechanisms may lead to better prevention of enteric and other infections. Journal of Pediatrics 145, 283285.
Victora CG (1990) Case-control studies of the influence of breast-feeding on child morbidity and mortality: methodological issues. In Human Lactation 4. Breastfeeding Nutrition Infection and Infant Growth in Developed and Emerging Countries, pp. 405418 [Atkinson SA, Hanson LA and Chandra RK editors]. St John's, Newfoundland: ARTS Biomedical Publisher.
Victora CG, Smith PG, Vaughan JP, Nobre LC, Lombardi C, Teixeira AM, Fuchs SM, Moreira LB, Gigante LP & Barros FC (1987) Evidence for protection by breast-feeding against infant deaths from infectious diseases in Brazil. Lancet 2, 319322.
Vidal K, Labeta MO, Schiffrin EJ & Donnet-Hughes A (2001) Soluble CD14 in human breast milk and its role in innate immune responses. Acta Odontologica Scandinavica 59, 330334.
Vohr BR, Poindexter BB, Dusick AM, McKinley LT, Wright LL, Langer JC & Poole WK for the NICHD Neonatal Research Network (2006) Beneficial effects of breast milk in the neonatal intensive care unit on the developmental outcome of extremely low birth weight infants at 18 months of age. Pediatrics 118, e115e123.
von Kries R, Koletzko B, Sauerwald T, von Mutius E, Barnert D, Grunert V & von Voss H (1999) Breast feeding and obesity: cross sectional study. British Medical Journal 319, 147150.
Vorbach C, Capecchi MR & Penninger JM (2006) Evolution of the mammary gland from the innate immune system? BioEssays 28, 606616.
Walterspiel JN, Morrow AL, Guerrero ML, Ruiz-Palacios GM & Pickering LK (1994) Secretory anti-Giardia lamblia antibodies in human milk: protective effect against diarrhea. Pediatrics 93, 2831.
Watemberg N, Dagan R, Arbelli Y, Belmaker I, Morag A, Hessel L, Fritzell B, Bajard A & Peyron L (1991) Safety and immunogenicity of Haemophilus type b-tetanus protein conjugate vaccine, mixed in the same syringe with diphtheria-tetanus-pertussis vaccine in young infants. Pediatric Infectious Diseases 10, 758761.
World Health Organization (1995) Factors affecting the immunogenicity of oral poliovirus vaccine: a prospective evaluation in Brazil and the Gambia. WHO Collaborative Study Group on Oral Poliovirus Vaccination. Journal of Infectious Diseases 95, 10971106.
Wright AL, Holberg CJ, Martinez FD, Morgan WJ & Taussig LM (1989) Breast-feeding and lower respiratory tract illness in the first year of life. British Medical Journal 299, 946949.
Zajac AJ, Amphlett EM, Rowlands DJ & Sangar DV (1991) Parameters influencing the attachment of hepatitis A virus to a variety of continuous cell lines. Journal of General Virology 72, 16671675.
Zaman S, Mannan J, Lange S, Lönnroth I & Hanson (2007) Efficacy of anti-secretory factor in reducing severity and duration of acute and prolonged diarrhoeal illness in children 6–24 months of age – a placebo controlled trial. Acta Paediatrica (In the Press).
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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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