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Use of nutrigenomics endpoints in dietary interventions

  • Henk F. J. Hendriks (a1)
  • DOI:
  • Published online: 28 May 2013

In this paper, the nutrigenomics approach is discussed as a research tool to study the physiological effects of nutrition and consequently how nutrition affects health and disease (endpoints). Nutrigenomics is the study of the effects of foods and food constituents on gene expression; the analyses include analysis of mRNA, proteins and metabolites. Nutrigenomics may be useful in dealing with the challenges that nutrition research is facing; by integrating the description of numerous active genes and metabolic pathways stronger evidence and new biomarkers for subtle nutritional effects may be obtained. Also, a new definition of disease and health may be needed. The use of tests challenging homoeostasis is being proposed to help define health. Challenge tests may be able to demonstrate in a better way subtle beneficial effects of nutrition on health. The paper describes some basic concepts relevant to nutrition research as well as some of the possibilities that are offered by nutrigenomics technology. Some of its applications are described.

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Corresponding author: Henk F. J. Hendriks, email
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2.B van Ommen , J Keijer , R Kleemann (2008) The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes Nutr 3, 5159.

3.B van Ommen , J Keijer , SG Heil (2009) Challenging homeostasis to define biomarkers for nutrition related health. Mol Nutr Food Res 53, 795804.

6.LA Afman & M Müller (2012) Human nutrigenomics of gene regulation by dietary fatty acids. Prog Lipid Res. 51, 6370.

9.GCM Bakker , MJ van Erk , L Pellis (2010) An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am J Clin Nutr 91, 10441059.

11.GS Hotamisligil (2006) Inflammation and metabolic disorders. Nature 444, 860867.

13.MB Schulze , EB Rimm , I Shai (2004) Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabetes Care 27, 16801687.

14.J Danesh , JG Wheeler , GM Hirschfield (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N Eng J Med 350, 13871397.

15.K Esposito , R Marfella , M Ciotola (2004) Effect of a Mediterranean-style diet on endothelial cell dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA, J Am Med Assoc 292, 14401446.

16.LM Havekes , BJ van Vlijmen , MC Jong (1997) Use of transgenic mice in lipoprotein metabolism and atherosclerosis research. Prostaglandins Leukot Essent Fatty Acids 57, 463466.

17.JH Lardenoye , DJ Delsing , MR de Vries (2000) Accelerated atherosclerosis by placement of a perivascular cuff and a cholesterol-rich diet in ApoE*3-Leiden transgenic mice. Circ Res. 87, 248253.

18.R Kleemann , L Verschuren , BJ de Rooij (2004) Evidence for anti-inflammatory activity of statins and PPARalpha activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro. Blood 103, 41884194.

19.L Verschuren , PY Wielinga , W van Duyvenvoorde (2011) A dietary mixture containing fish oil, resveratrol, lycopene, catechins, and vitamins E and C reduces atherosclerosisin transgenic mice. J Nutr 141, 863869.

20.S Wopereis , CM Rubingh , MJ van Erk (2009) Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. PLoS ONE 4, 143149.

21.L Pellis , MJ van Erk , B van Ommen (2012) Plasma metabolomics and proteomics profiling after a postprandial challenge reveal subtle diet effects on human metabolic status. Metabolomics 8, 347359.

22.J Bouwman , JTWE Vogels , S Wopereis (2012) Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes. BMC Med Genomics 5, 19.

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Proceedings of the Nutrition Society
  • ISSN: 0029-6651
  • EISSN: 1475-2719
  • URL: /core/journals/proceedings-of-the-nutrition-society
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