Ashkenazi, A & Dixit, VM (1998) Death receptors: signaling and modulation. Science 281 1305–1308.
Brusewitz, G, Cameron, BD, Chasseaud, LF, Gorler, K, Hawkins, DR, Koch, H & Mennicke, WH (1977) The metabolism of benzyl isothiocyanate and its cysteine conjugate. Biochemical Journal 162 99–107.
Buttke, TM & Sandstrom, PA (1994) Oxidative stress as a mediator of apoptosis. Immunology Today 15 7–10.
Callaway, EC, Zhang, Y, Chew, W & Chow, HHS (2004) Cellular accumulation of dietary anticarcinogenic isothiocyanates is followed by transporter-mediated export as dithiocarbamates. Cancer Letters 204 23–31.
Chen, YR, Wang, W, Kong, AN & Tan, TH (1998) Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates. Journal of Biological Chemistry 273 1769–1775.
Chiao, JW, Chung, FL, Kancherla, R, Ahmed, T, Mittelman, A & Conaway, CC (2002) Sulforaphane and its metabolite mediate growth arrest and apoptosis in human prostate cancer cells. International Journal of Oncology 20 631–636.
Chiao, JW, Chung, FL, Krzeminski, J, Amin, S, Arshad, R, Ahmed, T & Conaway, CC (2000) Modulation of growth of human prostate cancer cells by the N-acetylcysteine conjugate of phenethyl isothiocyanate. International Journal of Oncology 16 1215–1219.
Chiao, JW, Wu, H, Ramaswamy, G, Conaway, CC, Chung, FL, Wang, L & Liu, D (2004) Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest. Carcinogenesis 25 1403–1408.
Choi, S & Singh, SV (2005) Bax and Bak are required for apoptosis induction by sulforaphane, a cruciferous vegetable-derived cancer chemopreventive agent. Cancer Research 65 2035–2043.
Conaway, CC, Krzeminski, J, Amin, S & Chung, FL (2001) Decomposition rates of isothiocyanate conjugates determine their activity as inhibitors of cytochrome p450 enzymes. Chemical Research in Toxicology 14 1170–1176.
Conaway, CC, Yang, YM & Chung, FL (2002) Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans. Current Drug Metabolism 3 233–255.
Fahey, JW, Zhang, Y & Talalay, P (1997) Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences USA 94 10367–10372.
Fenwick, GR, Heaney, RK & Mullin, WJ (1983) Glucosinolates and their breakdown products in food and food plants. Critical Reviews in Food Science and Nutrition 18 123–201.
Fowke, JH, Chung, FL, Jin, F, Qi, D, Cai, Q, Conaway, C, Cheng, JR, Shu, XO, Gao, YT & Zheng, W (2003) Urinary isothiocyanate levels, Brassica, and human breast cancer. Cancer Research 63 3980–3986.
Gamet-Payrastre, L, Lumeau, S, Gasc, N, Cassar, G, Rollin, P & Tulliez, J (1998) Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human colon cancer cells in vitro. Anti-Cancer Drugs 9 141–148.
Hall, AG (1999) The role of glutathione in the regulation of apoptosis. European Journal of Clinical Investigation 29 238–245.
Hasegawa, T, Nishino, H & Iwashima, A (1993) Isothiocyanates inhibit cell cycle progression of HeLa cells at G2/M phase. Anti-Cancer Drugs 4 273–279.
Hecht, SS (2000) Inhibition of carcinogenesis by isothiocyanates. Drug Metabolism Reviews 32 395–411.
Hu, R, Kim, BR, Chen, C, Hebbar, V & Kong, AN (2003) The role of JNK and apoptotic signaling pathways in PEITC-mediated responses in human HT-29 colon adenocarcinoma cells. Carcinogenesis 24 1361–1367.
Hu, K & Morris, ME (2004) Effects of benzyl-, phenethyl-, and alpha-naphthyl isothiocyanate on P-glycoprotein- and MRP1-mediated transport. Journal of Pharmaceutical Sciences 93 1901–1911.
Huang, C, Ma, W, Li, J, Hecht, SS & Dong, Z (1998) Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Research 58 4102–4106.
Hudson, TS, Stoner, GD, Morse, MA, Young, H & Mallery, SR (2005) Comparison of phenethyl and 6-phenylhexyl isothiocyanate-induced toxicity in rat esophageal cell lines with and without glutathione depletion. Toxicology Letter 155 427–436.
Insinga, A, Monestiroli, S, Ronzoni, S, Gelmetti, V, Marchesi, F, Viale, A, Altucci, L, Nervi, C, Minucci, S & Pelicci, PG (2005) Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway. Nature Medicine 11 71–76.
Ioannou, YM, Burka, LT & Matthews, HB (1984) Allyl isothiocyanate: comparative disposition in rats and mice. Toxicology and Applied Pharmacology 75 173–181.
Jackson, SJ & Singletary, KW (2004 a) Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization. Carcinogenesis 25 219–227.
Jackson, SJT & Singletary, KW (2004 b) Sulforaphane inhibits human MCF-7 mammary cancer cell mitotic progression and tubulin polymerization. Journal of Nutrition 134 2229–2236.
Ji, Y & Morris, ME (2003) Determination of phenethyl isothiocyanate in human plasma and urine by ammonia derivatization and liquid chromatography-tandem mass spectrometry. Analytical Biochemistry 323 39–47.
Ji, Y & Morris, ME (2004) Effect of organic isothiocyanates on breast cancer resistance protein (ABCG-2)-mediated transport. Pharmaceutical Research 21 2261–2269.
Kaum, YS, Jeong, WS & Kong, ANT (2004) Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms. Mutation Research 555 191–202.
Kim, BR, Hu, R, Keum, YS, Hebbar, V, Shen, G, Nair, SS & Kong, ANT (2003) Effects of glutathione on antioxidant response element-mediated gene expression and apoptosis elicited by sulforaphane. Cancer Research 64 7520–7525.
Lea, MA, Randolph, VM, Lee, JE, Des Bordes, C (2001) Induction of histone acetylation in mouse erythroleukemia cells by some organosulfur compounds including allyl isothiocyanate. International Journal of Cancer 92 784–789.
Li, H, Zhu, H, Xu, CJ & Yuan, J (1998) Cleavage of BID by caspase-8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 491–501.
Li, J, Yao, S & Zhang, Y (2005) The role of c-Jun in the AP-1 activation induced by naturally occurring isothiocyanates. Food and Chemical Toxicology 43 1373–1380.
London, SJ, Yuan, JM, Chung, FL, Gao, YT, Coetzee, GA, Rose, RK & Yu, MC (2000) Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: A prospective study of men in Shanghai, China. Lancet 356 724–729.
Lui, VWY, Wentzel, AL, Xiao, D, Lew, KL, Singh, SV & Grandis, JR (2003) Requirement of a carbon spacer in benzyl isothiocyanate-mediated cytotoxicity and MAPK activation in head and neck squamous cell carcinoma. Carcinogenesis 24 1705–1712.
Miko, M & Chance, B (1975) Isothiocyanates: a new class of uncouplers. Biochimica et Biophysica Acta 396 165–174.
Miyashita, T & Reed, JC (1995) Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80 293–299.
Miyoshi, N, Uchida, K, Osawa, T & Nakamura, Y (2004) A link between benzyl isothiocyanate-induced cell cycle arrest and apoptosis: involvement of mitogen-activated protein kinases in the Bcl-2 phosphorylation. Cancer Research 64 2134–2142.
Musk, SRR & Johnson, IT (1993) Allyl isothiocyanate is selectively toxic to transformed cells of the human colorectal tumour line HT29. Carcinogenesis 14 2079–2083.
Myzak, MC, Karplus, PA, Chung, FL & Dashwood, RH (2004) A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase. Cancer Research 64 5767–5774.
Nakamura, Y, Kawakami, M, Yoshihiro, A, Miyoshi, N, Ohigashi, H, Kawai, K, Osawa, T & Uchida, K (2002) Involvement of the mitochondrial death pathway in chemopreventive benzyl isothiocyanate-induced apoptosis. Journal of Biological Chemistry 277 8492–8499.
Nakamura, Y, Ohigashi, H, Masuda, S, Murakami, A, Morimitsu, Y, Kawamoto, Y, Osawa, T, Imagawa, M & Uchida, K (2000) Redox regulation of glutathione S-transferase induction by benzyl isothiocyanate: correlation of enzyme induction with the formation of reactive oxygen intermediates. Cancer Research 60 219–225.
Nebbioso, A, Clarke, N, Voltz, E, Germain, E, Ambrosino, C, Bontempo, P et al. (2005) Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Medicine 11 77–84.
Payen, L, Courtois, A, Loewert, M, Guillouzo, A & Fardel, Q (2001) Reactive oxygen species-related induction of multidrug resistance-associated protein 2 expression in primary hepatocytes exposed to sulforaphane. Biochemical and Biophysical Research Communications 282 257–263.
Pham, NA, Jacobberger, JW, Schimmer, AD, Cao, P, Gronda, M & Hedley, DW (2004) The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice. Molecular Cancer Therapeutics 3 1239–1248.
Rose, P, Armstrong, JS, Chua, YL, Ong, CN & Whiteman, M (2005) β-phenylethyl isothiocyanate mediated apoptosis; contribution of Bax and the mitochondrial death pathway. International Journal of Biochemistry and Cell Biology 37 100–119.
Rose, P, Whiteman, M, Huang, SH, Halliwell, B & Ong, CN (2003) β-phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells. Cellular and Molecular Life Sciences 60 1489–1503.
Sasaki, S (1963) Inhibitory effects by α-naphthyl-isothiocyanate on development of hepatoma in rats treated with 3-methyl-4-dimethyl-aminoazobenzene. Journal of Nara Medical Association 14 101–115.
Scheid, MP, Schubert, KM & Duronio, V (1999) Regulation of Bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase. Journal of Biological Chemistry 274 31108–31113.
Seow, A, Yuan, JM, Sun, CL, van Den Berg, D, Lee, HP & Yu, MC (2002) Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23 2055–2061.
Shackelford, RE, Kaufmann, WK & Paules, RS (2000) Oxidative stress and cell cycle checkpoint function. Free Radical Biology and Medicine 28 1387–1404.
Sidransky, H, Ito, N & Verney, E (1966) Influence of alpha-naphthyl-isothiocyanate on liver tumorigenesis in rats ingesting ethionine and N-2-fluorenylacetamide. Journal of the National Cancer Institute 37 677–686.
Singh, AV, Xiao, D, Lew, KL, Dhir, R & Singh, SV (2004) Sulforaphane induces caspase-mediated apoptosis in cultured PC-3 human prostate cancer cells and retards growth of PC-3 xenografts in vivo. Carcinogenesis 25 83–90.
Singh, SV, Herman-Antosiewicz, A, Singh, AV, Lew, KL, Srivastava, SK, Kamath, R, Brown, KD, Zhang, L & Baskaran, R (2004) Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C. Journal of Biological Chemistry 279 25813–25822.
Singh, SV, Srivastava, SK, Choi, S, Lew, KL, Antosiewicz, J, Xiao, D et al. (2005) Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species. Journal of Biological Chemistry 280 19911–19924.
Smith, TK, Lund, EK, Parker, ML, Clarke, RG & Johnson, IT (2004) Allyl isothiocyanate causes mitotic block, loss of cell adhesion and disrupted cytoskeletal structure in HT-29 cells. Carcinogenesis 25 1409–1415.
Spitz, MR, Duphorne, CM, Detry, MA, Pillow, PC, Amos, CI, Lei, L, de Andrade, M, Gu, X, Hong, WK & Wu, X (2000) Dietary intake of isothiocyanates: Evidence of a joint effect with glutathione S-transferase polymorphisms in lung cancer risk. Cancer Epidemiology, Biomarkers & Prevention 9 1017–1020.
Srivastava, SK & Singh, SV (2004) Cell cycle arrest, apoptosis induction and inhibition of nuclear factor kappa B activation in anti-proliferative activity of benzyl isothiocyanate against human pancreatic cancer cells. Carcinogenesis 25 1701–1709.
Srivastava, SK, Xiao, D, Lew, KL, Hershberger, P, Kokkinakis, DM, Johnson, CS, Trump, DL & Singh, SV (2003) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo. Carcinogenesis 24 1665–1670.
Tang, L & Zhang, Y (2004) Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. Journal of Nutrition 134 2004–2010.
Tang, L & Zhang, Y (2005) Mitochondria are the primary target in ITC-induced apoptosis in human bladder cancer UM-UC-3 cells. Molecular Cancer Therapeutics 4 1250–1259.
Thornberry, NA & Lazebnik, Y (1998) Caspases: enemies within. Science 281 1312–1316.
Xiao, D, Johnson, CS, Trump, DL & Singh, SV (2004) Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cycle arrest in PC-3 human prostate cancer cells. Molecular Cancer Therapeutics 3 567–576.
Xiao, D & Singh, SV (2002) Phenethyl isothiocyanate-induced apoptosis in P53-deficient PC-3 human prostate cancer cell line is mediated by extracellular signal-regulated kinases. Cancer Research 62 3615–3619.
Xiao, D, Srivastava, SK, Lew, KL, Zeng, Y, Hershberger, P, Johnson, CS, Trump, DL & Singh, SV (2003) Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis. Carcinogenesis 24 891–897.
Xiao, D, Zeng, Y, Choi, S, Lew, KL, Nelson, JB & Singh, SV (2005) Caspase-dependent apoptosis induction by phenethyl isothiocyanate, a cruciferous vegetables-derived cancer chemopreventive agents, is mediated by Bak and Bax. Clinical Cancer Research 11 2670–2679.
Xu, K & Thornalley, PJ (2000) Studies on the mechanism of the inhibition of human leukemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochemical Pharmacology 60 221–231.
Xu, K & Thornalley, PJ (2001 a) Involvement of glutathione metabolism in the cytotoxicity of the phenethyl isothiocyanate and its cysteine conjugate to human leukemia cells in vitro. Biochemical Pharmacology 61 165–177.
Xu, K & Thornalley, PJ (2001 b) Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNK. British Journal of Cancer 84 670–673.
Ye, L, Dinkova-Kostova, A, Wade, KL, Zhang, Y, Shapiro, TA & Talalay, P (2002) Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans. Clinica Chimica Acta 316 43–52.
Ye, L & Zhang, Y (2001) Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of phase 2 detoxification enzymes. Carcinogenesis 22 1987–1992.
Zhang, Y (2000) Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells. Carcinogenesis 21 1175–1182.
Zhang, Y (2001) Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates. Carcinogenesis 22 425–431.
Zhang, Y (2004) Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutation Research 555 173–190.
Zhang, Y & Callaway, EC (2002) High cellular accumulation of sulphoraphane, a dietary anticarcinogen, is followed by rapid transporter-mediated export as a glutathione conjugate. Biochemical Journal 364 301–307.
Zhang, Y, Gonzalez, V & Xu, MJ (2002) Expression and regulation of glutathione S-transferase P1–1 in cultured human epidermal cells. Journal of Dermatological Science 30 205–214.
Zhang, Y, Li, J & Tang, L (2005) Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress. Free Radical Biology and Medicine 38 70–77.
Zhang, Y & Talalay, P (1994) Anticarcinogenic activities of organic isothiocyanates: chemistry and mechanism. Cancer Research 54 1976S–1981S.
Zhang, Y & Talalay, P (1998) Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic phase 2 enzymes. Cancer Research 58 4632–4639.
Zhang, Y & Tang, L (2004) Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. Journal of Nutrition 134 2004–2010.
Zhang, Y, Tang, L & Gonzalez, V (2003) Selected isothiocyanates rapidly induce growth inhibition of cancer cells. Molecular Cancer Therapeutics 2 1045–1052.
Zhao, B, Seow, A, Lee, EJ, Poh, WT, The, M, End, P, Wang, YT, Tan, WC, Yu, MC & Lee, HP (2001) Dietary isothiocyanates, glutathione S-transferase-M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore. Cancer Epidemiology, Biomarkers & Prevention 10 1063–1067.