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Vitamin D modulates adipose tissue biology: possible consequences for obesity?

  • Jean-François Landrier (a1) (a2) (a3), Esma Karkeni (a1) (a2) (a3), Julie Marcotorchino (a1) (a2) (a3), Lauriane Bonnet (a1) (a2) (a3) and Franck Tourniaire (a1) (a2) (a3)...

Cross-sectional studies depict an inverse relationship between vitamin D (VD) status reflected by plasma 25-hydroxy-vitamin D and obesity. Furthermore, recent studies in vitro and in animal models tend to demonstrate an impact of VD and VD receptor on adipose tissue and adipocyte biology, pointing to at least a part-causal role of VD insufficiency in obesity and associated physiopathological disorders such as adipose tissue inflammation and subsequent insulin resistance. However, clinical and genetic studies are far less convincing, with highly contrasted results ruling out solid conclusions for the moment. Nevertheless, prospective studies provide interesting data supporting the hypothesis of a preventive role of VD in onset of obesity. The aim of this review is to summarise the available data on relationships between VD, adipose tissue/adipocyte physiology, and obesity in order to reveal the next key points that need to be addressed before we can gain deeper insight into the controversial VD–obesity relationship.

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* Corresponding author: J.-F. Landrier, fax +33 4 91 78 21 01, email
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1. Holick, MF (2007) Vitamin D deficiency. N Engl J Med 357, 266281.
2. Holick, MF, Binkley, NC, Bischoff-Ferrari, HA et al. (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 96, 19111930.
3. Schmid, A & Walther, B (2013) Natural vitamin d content in animal products. Adv Nutr 4, 453462.
4. Holick, MF (2011) Vitamin D: a D-lightful solution for health. J Investig Med 59, 872880.
5. Heaney, RP, Armas, LA & French, C (2013) All-source basal vitamin d inputs are greater than previously thought and cutaneous inputs are smaller. J Nutr 143, 571575.
6. Mawer, EB, Backhouse, J, Holman, CA et al. (1972) The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 43, 413431.
7. Blum, M, Dolnikowski, G, Seyoum, E et al. (2008) Vitamin D(3) in fat tissue. Endocrine 33, 9094.
8. Pramyothin, P, Biancuzzo, RM, Lu, Z et al. (2011) Vitamin D in adipose tissue and serum 25-hydroxyvitamin D after roux-en-Y gastric bypass. Obesity (Silver Spring) 19, 22282234.
9. Landrier, JF, Marcotorchino, J & Tourniaire, F (2012) Lipophilic micronutrients and adipose tissue biology. Nutrients 4, 16221649.
10. Marcotorchino, J, Tourniaire, F & Landrier, JF (2013) Vitamin D, adipose tissue, and obesity. Horm Mol Biol Clin Investig 15, 123128.
11. Beckman, LM, Earthman, CP, Thomas, W et al. (2013) Serum 25(OH) vitamin D concentration changes after Roux-en-Y gastric bypass surgery. Obesity (Silver Spring) 21, E599–606.
12. Heaney, RP, Horst, RL, Cullen, DM et al. (2009) Vitamin D3 distribution and status in the body. J Am Coll Nutr 28, 252256.
13. Piccolo, BD, Dolnikowski, G, Seyoum, E et al. (2013) Association between subcutaneous white adipose tissue and serum 25-hydroxyvitamin D in overweight and obese adults. Nutrients 5, 33523366.
14. Heaney, RP, Armas, LA, Shary, JR et al. (2008) 25-Hydroxylation of vitamin D3: relation to circulating vitamin D3 under various input conditions. Am J Clin Nutr 87, 17381742.
15. Malmberg, P, Karlsson, T, Svensson, H et al. (2014) A new approach to measuring vitamin D in human adipose tissue using time-of-flight secondary ion mass spectrometry: a pilot study. J Photochem Photobiol B 138, 295301.
16. Borel, P, Caillaud, D & Cano, NJ (2015) Vitamin d bioavailability: state of the art. Crit Rev Food Sci Nutr 55, 11931205.
17. Reboul, E, Goncalves, A, Comera, C et al. (2011) Vitamin D intestinal absorption is not a simple passive diffusion: evidences for involvement of cholesterol transporters. Mol Nutr Food Res 55, 691702.
18. Reboul, E (2015) Intestinal absorption of vitamin D: from the meal to the enterocyte. Food Funct 6, 356362.
19. Daiger, SP, Schanfield, MS & Cavalli-Sforza, LL (1975) Group-specific component (Gc) proteins bind vitamin D and 25-hydroxyvitamin D. Proc Natl Acad Sci USA 72, 20762080.
20. Haddad, JG, Jennings, AS & Aw, TC (1988) Vitamin D uptake and metabolism by perfused rat liver: influences of carrier proteins. Endocrinology 123, 498504.
21. Speeckaert, M, Huang, G, Delanghe, JR et al. (2006) Biological and clinical aspects of the vitamin D binding protein (Gc-globulin) and its polymorphism. Clin Chim Acta 372, 3342.
22. Mendel, CM (1989) The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev 10, 232274.
23. Safadi, FF, Thornton, P, Magiera, H et al. (1999) Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest 103, 239251.
24. Zella, LA, Shevde, NK, Hollis, BW et al. (2008) Vitamin D-binding protein influences total circulating levels of 1,25-dihydroxyvitamin D3 but does not directly modulate the bioactive levels of the hormone in vivo . Endocrinology 149, 36563667.
25. Abboud, M, Gordon-Thomson, C, Hoy, AJ et al. (2013) Uptake of 25-hydroxyvitamin D by muscle and fat cells. J Steroid Biochem Mol Biol 144, 232236.
26. Moussa, M, Gouranton, E, Gleize, B et al. (2011) CD36 is involved in lycopene and lutein uptake by adipocytes and adipose tissue cultures. Mol Nutr Food Res 55, 578584.
27. Jones, KS, Schoenmakers, I, Bluck, LJ et al. (2012) Plasma appearance and disappearance of an oral dose of 25-hydroxyvitamin D2 in healthy adults. Br J Nutr 107, 11281137.
28. Cheng, JB, Motola, DL, Mangelsdorf, DJ et al. (2003) De-orphanization of cytochrome P450 2R1: a microsomal vitamin D 25-hydroxilase. J Biol Chem 278, 3808438093.
29. Schuster, I (2011) Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta 1814, 186199.
30. Zhu, J & DeLuca, HF (2012) Vitamin D 25-hydroxylase - four decades of searching, are we there yet? Arch Biochem Biophys 523, 3036.
31. Gupta, RP, Hollis, BW, Patel, SB et al. (2004) CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res 19, 680688.
32. Aiba, I, Yamasaki, T, Shinki, T et al. (2006) Characterization of rat and human CYP2J enzymes as vitamin D 25-hydroxylases. Steroids 71, 849856.
33. Guo, YD, Strugnell, S, Back, DW et al. (1993) Transfected human liver cytochrome P-450 hydroxylates vitamin D analogs at different side-chain positions. Proc Natl Acad Sci U S A 90, 86688672.
34. Yamasaki, T, Izumi, S, Ide, H et al. (2004) Identification of a novel rat microsomal vitamin D3 25-hydroxylase. J Biol Chem 279, 2284822856.
35. Postlind, H, Axen, E, Bergman, T et al. (1997) Cloning, structure, and expression of a cDNA encoding vitamin D3 25-hydroxylase. Biochem Biophys Res Commun 241, 491497.
36. Rahmaniyan, M, Patrick, K & Bell, NH (2005) Characterization of recombinant CYP2C11: a vitamin D 25-hydroxylase and 24-hydroxylase. Am J Physiol Endocrinol Metab 288, E753E760.
37. Zoico, E, Franceschetti, G, Chirumbolo, S et al. (2014) Phenotypic shift of adipocytes by cholecalciferol and 1alpha,25 dihydroxycholecalciferol in relation to inflammatory status and calcium content. Endocrinology 155, 41784188.
38. Wamberg, L, Christiansen, T, Paulsen, SK et al. (2012) Expression of vitamin D-metabolizing enzymes in human adipose tissue-the effect of obesity and diet-induced weight loss. Int J Obes (Lond) 37, 651657.
39. Nykjaer, A, Dragun, D, Walther, D et al. (1999) An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 96, 507515.
40. Dusso, AS, Brown, AJ, Slatopolsky, E (2005) Vitamin D. Am J Physiol Renal Physiol 289, F8F28.
41. Gacad, MA, Chen, H, Arbelle, JE et al. (1997) Functional characterization and purification of an intracellular vitamin D-binding protein in vitamin D-resistant new world primate cells. Amino acid sequence homology with proteins in the hsp-70 family. J Biol Chem 272, 84338440.
42. Teegarden, D, Nickel, KP & Shi, L (2000) Characterization of 25-hydroxyvitamin D binding protein from intestinal cells. Biochem Biophys Res Commun 275, 845849.
43. Li, J, Byrne, ME, Chang, E et al. (2008) 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Biochem Mol Biol 112, 122126.
44. Ching, S, Kashinkunti, S, Niehaus, MD et al. (2011) Mammary adipocytes bioactivate 25-hydroxyvitamin D(3) and signal via vitamin D(3) receptor, modulating mammary epithelial cell growth. J Cell Biochem 112, 33933405.
45. Nimitphong, H, Holick, MF, Fried, SK et al. (2012) 25-hydroxyvitamin d(3) and 1,25-dihydroxyvitamin d(3) promote the differentiation of human subcutaneous preadipocytes. PLoS ONE 7, e52171.
46. Lips, P (2006) Vitamin D physiology. Prog Biophys Mol Biol 92, 48.
47. Carlberg, C & Seuter, S (2009) A genomic perspective on vitamin D signaling. Anticancer Res 29, 34853493.
48. Bikle, DD, Gee, E & Pillai, S (1993) Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol 101, 713718.
49. Bouillon, R, Carmeliet, G, Verlinden, L et al. (2008) Vitamin D and human health: lessons from vitamin D receptor null mice. Endocr Rev 29, 726776.
50. Issa, LL, Leong, GM & Eisman, JA (1998) Molecular mechanism of vitamin D receptor action. Inflamm Res 47, 451475.
51. Plum, LA & DeLuca, HF (2010) Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov 9, 941955.
52. Kamei, Y, Kawada, T, Kazuki, R et al. (1993) Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 193, 948955.
53. Clemente-Postigo, M, Munoz-Garach, A, Serrano, M et al. (2015) Serum 25-hydroxyvitamin d and adipose tissue vitamin d receptor gene expression: relationship with obesity and type 2 diabetes. J Clin Endocrinol Metab 100, E591E595.
54. Turano, C, Gaucci, E, Grillo, C et al. (2011) ERp57/GRP58: a protein with multiple functions. Cell Mol Biol Lett 16, 539563.
55. Nemere, I, Safford, SE, Rohe, B et al. (2004) Identification and characterization of 1,25D3-membrane-associated rapid response, steroid (1,25D3-MARRS) binding protein. J Steroid Biochem Mol Biol 89–90, 281285.
56. Nemere, I & Hintze, K (2008) Novel hormone ‘receptors’. J Cell Biochem 103, 401407.
57. Lisse, TS, Adams, JS & Hewison, M (2013) Vitamin D and microRNAs in bone. Crit Rev Eukaryot Gene Expr 23, 195214.
58. Ishida, Y, Taniguchi, H & Baba, S (1988) Possible involvement of 1 alpha,25-dihydroxyvitamin D3 in proliferation and differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 151, 11221127.
59. Kong, J & Li, YC (2006) Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab 290, E916E924.
60. Blumberg, JM, Tzameli, I, Astapova, I et al. (2006) Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J Biol Chem 281, 1120511213.
61. Mutt, SJ, Hypponen, E, Saarnio, J et al. (2014) Vitamin D and adipose tissue – more than storage. Front Physiol 5, 228.
62. Vu, D, Ong, JM, Clemens, TL et al. (1996) 1,25-Dihydroxyvitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation. Endocrinology 137, 15401544.
63. Farmer, SR (2006) Transcriptional control of adipocyte formation. Cell Metab 4, 263273.
64. Ricciardi, CJ, Bae, J, Esposito, D et al. (2014) 1,25-Dihydroxyvitamin D/vitamin D receptor suppresses brown adipocyte differentiation and mitochondrial respiration. Eur J Nutr 54, 10011012.
65. Narvaez, CJ, Simmons, KM, Brunton, J et al. (2013) Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. J Cell Physiol 228, 20242036.
66. Kong, J, Chen, Y, Zhu, G et al. (2013) 1,25-Dihydroxyvitamin D3 upregulates leptin expression in mouse adipose tissue. J Endocrinol 216, 265271.
67. Marcotorchino, J, Gouranton, E, Romier, B et al. (2012) Vitamin D reduces the inflammatory response and restores glucose uptake in adipocytes. Mol Nutr Food Res 56, 17711782.
68. Manna, P & Jain, SK (2012) Vitamin D upregulates glucose transporter 4 (GLUT4) translocation and glucose utilization mediated by cystathionine-gamma-lyase (CSE) activation and H2S formation in 3T3L1 adipocytes. J Biol Chem 287, 4232442332.
69. Marcotorchino, J, Tourniaire, F, Astier, J et al. (2014) Vitamin D protects against diet-induced obesity by enhancing fatty acid oxidation. J Nutr Biochem 25, 10771083.
70. Sergeev, IN & Song, Q (2014) High vitamin D and calcium intakes reduce diet-induced obesity in mice by increasing adipose tissue apoptosis. Mol Nutr Food Res 58, 13421348.
71. Domingues-Faria, C, Chanet, A, Salles, J et al. (2014) Vitamin D deficiency down-regulates Notch pathway contributing to skeletal muscle atrophy in old Wistar rats. Nutr Metab (Lond) 11, 47.
72. Amara, NB, Marcotorchino, J, Tourniaire, F et al. (2014) Multivitamin restriction increases adiposity and disrupts glucose homeostasis in mice. Genes Nutr 9, 410.
73. Sun, X & Zemel, MB (2007) Calcium and 1,25-dihydroxyvitamin D3 regulation of adipokine expression. Obesity (Silver Spring) 15, 340348.
74. Sun, X & Zemel, MB (2008) Calcitriol and calcium regulate cytokine production and adipocyte-macrophage cross-talk. J Nutr Biochem 19, 392399.
75. Lorente-Cebrian, S, Eriksson, A, Dunlop, T et al. (2012) Differential effects of 1alpha,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur J Nutr 51, 335342.
76. Gao, D, Trayhurn, P & Bing, C (2012) 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes. Int J Obes (Lond) 37, 357365.
77. Mutt, SJ, Karhu, T, Lehtonen, S et al. (2012) Inhibition of cytokine secretion from adipocytes by 1,25-dihydroxyvitamin D(3) via the NF-kappaB pathway. FASEB J 26, 44004407.
78. Guillot, X, Semerano, L, Saidenberg-Kermanac'h, N et al. (2010) Vitamin D and inflammation. Joint Bone Spine 77, 552557.
79. Wamberg, L, Cullberg, KB, Rejnmark, L et al. (2013) Investigations of the anti-inflammatory effects of vitamin D in adipose tissue: results from an in vitro study and a randomized controlled trial. Horm Metab Res 45, 456462.
80. Karkeni, E, Marcotorchino, J, Tourniaire, F et al. (2015) Vitamin D limits chemokine expression in adipocytes and macrophage migration in vitro and in male mice. Endocrinology 156, 17821793.
81. Tourniaire, F, Romier-Crouzet, B, Lee, JH et al. (2013) Chemokine expression in inflamed adipose tissue is mainly mediated by NF-kappaB. PLoS ONE 8, e66515.
82. Ding, C, Wilding, JP & Bing, C (2013) 1,25-dihydroxyvitamin D3 protects against macrophage-induced activation of NFkappaB and MAPK signalling and chemokine release in human adipocytes. PLoS ONE 8, e61707.
83. Suganami, T, Nishida, J & Ogawa, Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25, 20622068.
84. Lira, FS, Rosa, JC, Cunha, CA et al. (2011) Supplementing alpha-tocopherol (vitamin E) and vitamin D3 in high fat diet decrease IL-6 production in murine epididymal adipose tissue and 3T3-L1 adipocytes following LPS stimulation. Lipids Health Dis 10, 37.
85. Roth, CL, Elfers, CT, Figlewicz, DP et al. (2012) Vitamin D deficiency in obese rats exacerbates nonalcoholic fatty liver disease and increases hepatic resistin and Toll-like receptor activation. Hepatology 55, 11031111.
86. Narvaez, CJ, Matthews, D, Broun, E et al. (2009) Lean phenotype and resistance to diet-induced obesity in vitamin D receptor knockout mice correlates with induction of uncoupling protein-1 in white adipose tissue. Endocrinology 150, 651661.
87. Wong, KE, Szeto, FL, Zhang, W et al. (2009) Involvement of the vitamin D receptor in energy metabolism: regulation of uncoupling proteins. Am J Physiol Endocrinol Metab 296, E820E828.
88. Wong, KE, Kong, J, Zhang, W et al. (2011) Targeted expression of human vitamin D receptor in adipocytes decreases energy expenditure and induces obesity in mice. J Biol Chem 286, 3380433810.
89. Soares, MJ, Murhadi, LL, Kurpad, AV et al. (2012) Mechanistic roles for calcium and vitamin D in the regulation of body weight. Obes Rev 13, 592605.
90. Rowling, MJ, Gliniak, C, Welsh, J et al. (2007) High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice. J Nutr 137, 26082615.
91. Malloy, PJ & Feldman, BJ (2013) Cell-autonomous regulation of brown fat identity gene UCP1 by unliganded vitamin D receptor. Mol Endocrinol 27, 16321642.
92. Sun, X & Zemel, MB (2008) 1Alpha, 25-dihydroxyvitamin D and corticosteroid regulate adipocyte nuclear vitamin D receptor. Int J Obes (Lond) 32, 13051311.
93. Bouillon, R, Carmeliet, G, Lieben, L et al. (2014) Vitamin D and energy homeostasis-of mice and men. Nat Rev Endocrinol 10, 7987.
94. Gallagher, JC, Yalamanchili, V & Smith, LM (2013) The effect of vitamin D supplementation on serum 25OHD in thin and obese women. J Steroid Biochem Mol Biol 136, 195200.
95. Pereira-Santos, M, Costa, PR, Assis, AM et al. (2015) Obesity and vitamin D deficiency: a systematic review and meta-analysis. Obes Rev 16, 341349.
96. Garcia, OP, Long, KZ & Rosado, JL (2009) Impact of micronutrient deficiencies on obesity. Nutr Rev 67, 559572.
97. Cheng, S, Massaro, JM, Fox, CS et al. (2010) Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes 59, 242248.
98. Caron-Jobin, M, Morisset, AS, Tremblay, A et al. (2011) Elevated serum 25(OH)D concentrations, vitamin D, and calcium intakes are associated with reduced adipocyte size in women. Obesity (Silver Spring) 19, 13351341.
99. Wortsman, J, Matsuoka, LY, Chen, TC et al. (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72, 690693.
100. Drincic, AT, Armas, LA, Van Diest, EE et al. (2012) Volumetric dilution, rather than sequestration best explains the low vitamin d status of obesity. Obesity (Silver Spring) 20, 14441448.
101. Parikh, SJ, Edelman, M, Uwaifo, GI et al. (2004) The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 89, 11961199.
102. Konradsen, S, Ag, H, Lindberg, F et al. (2008) Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47, 8791.
103. Bell, NH (1985) Vitamin D-endocrine system. J Clin Invest 76, 16.
104. Mai, XM, Chen, Y, Camargo, CA Jr. et al. (2012) Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study. Am J Epidemiol 175, 10291036.
105. Gonzalez-Molero, I, Rojo-Martinez, G, Morcillo, S et al. (2013) Hypovitaminosis D and incidence of obesity: a prospective study. Eur J Clin Nutr 67, 680682.
106. Gilbert-Diamond, D, Baylin, A, Mora-Plazas, M et al. (2010) Vitamin D deficiency and anthropometric indicators of adiposity in school-age children: a prospective study. Am J Clin Nutr 92, 14461451.
107. LeBlanc, ES, Rizzo, JH, Pedula, KL et al. (2012) Associations between 25-hydroxyvitamin D and weight gain in elderly women. J Womens Health (Larchmt) 21, 10661073.
108. Gagnon, C, Lu, ZX, Magliano, DJ et al. (2012) Low serum 25-hydroxyvitamin D is associated with increased risk of the development of the metabolic syndrome at five years: results from a national, population-based prospective study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab). J Clin Endocrinol Metab 97, 19531961.
109. Kamycheva, E, Joakimsen, RM & Jorde, R (2003) Intakes of calcium and vitamin d predict body mass index in the population of Northern Norway. J Nutr 133, 102106.
110. Teegarden, D, White, KM, Lyle, RM et al. (2008) Calcium and dairy product modulation of lipid utilization and energy expenditure. Obesity (Silver Spring) 16, 15661572.
111. Boon, N, Hul, GB, Sicard, A et al. (2006) The effects of increasing serum calcitriol on energy and fat metabolism and gene expression. Obesity (Silver Spring) 14, 17391746.
112. Salehpour, A, Hosseinpanah, F, Shidfar, F et al. (2012) A 12-week double-blind randomized clinical trial of vitamin D(3) supplementation on body fat mass in healthy overweight and obese women. Nutr J 11, 78.
113. Zittermann, A, Frisch, S, Berthold, HK et al. (2009) Vitamin D supplementation enhances the beneficial effects of weight loss on cardiovascular disease risk markers. Am J Clin Nutr 89, 13211327.
114. Sneve, M, Figenschau, Y & Jorde, R (2008) Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects. Eur J Endocrinol 159, 675684.
115. Wamberg, L, Kampmann, U, Stodkilde-Jorgensen, H et al. (2013) Effects of vitamin D supplementation on body fat accumulation, inflammation, and metabolic risk factors in obese adults with low vitamin D levels – results from a randomized trial. Eur J Intern Med 24, 644649.
116. Pathak, K, Soares, MJ, Calton, EK et al. (2014) Vitamin D supplementation and body weight status: a systematic review and meta-analysis of randomized controlled trials. Obes Rev 15, 528537.
117. Mason, C, Xiao, L, Imayama, I et al. (2014) Vitamin D3 supplementation during weight loss: a double-blind randomized controlled trial. Am J Clin Nutr 99, 10151025.
118. Vimaleswaran, KS, Berry, DJ, Lu, C et al. (2013) Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Med 10, e1001383.
119. Wang, TJ, Zhang, F, Richards, JB et al. (2010) Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 376, 180188.
120. Dorjgochoo, T, Shi, J, Gao, YT et al. (2012) Genetic variants in vitamin D metabolism-related genes and body mass index: analysis of genome-wide scan data of approximately 7000 Chinese women. Int J Obes (Lond) 36, 12521255.
121. Ochs-Balcom, HM, Chennamaneni, R, Millen, AE et al. (2011) Vitamin D receptor gene polymorphisms are associated with adiposity phenotypes. Am J Clin Nutr 93, 510.
122. Sulistyoningrum, DC, Green, TJ, Lear, SA et al. (2012) Ethnic-specific differences in vitamin D status is associated with adiposity. PLoS ONE 7, e43159.
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