Based on an original dataset of all articles on the Middle East in major political science journals during the past two decades, we assess trends in publishing on the region to explore whether it remains underrepresented in political science and how the field has evolved. We focus on the evolution of the total share of Middle East and North Africa (MENA)-focused articles, research topics, methods employed, and patterns of authorship by gender. The proportion of MENA-focused articles has increased, particularly after the 2011 Arab Spring uprisings, but remains strikingly low. With respect to topics and methods, research on the Middle East is increasingly integrated in mainstream political science, with articles addressing core disciplinary debates and relying increasingly more on statistical and experimental methods. Yet, these shifts may come at the expense of predominantly qualitative research, and primary topics may reflect the priorities of Western researchers while underplaying the major concerns of Middle Eastern publics.