Skip to main content
×
Home
    • Aa
    • Aa

Association between betel-nut chewing and chronic kidney disease in men

  • Che-Yi Chou (a1), Shi-Yann Cheng (a2), Jiung-Hsiun Liu (a1), Wen-Chun Cheng (a3), I-Min Kang (a4), Yu-Hsiang Tseng (a3), Chuen-Ming Shih (a3) and Walter Chen (a3)...
Abstract
AbstractBackground

Betel-nut use is associated with metabolic syndrome and obesity. However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. The present study was conducted to determine the association between betel-nut chewing and CKD in men.

Methods

We retrospectively reviewed health-check records of 3264 men in a hospital-based cross-sectional screening programme from 2003 to 2006. CKD was defined as estimated glomerular filtration rate less than 60 ml/min/1·73 m2 calculated by the Modification of Diet in Renal Disease formula. Risk factors for CKD including diabetes, hypertension, BMI, smoking, alcohol consumption and age were also considered.

Results

A total of 677 (20·7 %) men were found to have CKD and 427 (13·1 %) participants reported a history of betel-nut use. The prevalence (24·8 %) of CKD in betel-nut users was significantly higher than that (11·3 %) of participants without betel-nut use (P = 0·026). In multivariate logistic regression analysis with adjustments for age, hypertension, diabetes and hyperlipidaemia, betel-nut use was independently associated with CKD (P < 0·001). The adjusted odds ratio for betel-nut use was 2·572 (95 % CI 1·917, 3·451).

Conclusions

Betel-nut use is associated with CKD in men. The association between betel-nut use and CKD is independent of age, BMI, smoking, alcohol consumption, hypertension, diabetes and hyperlipidaemia.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Association between betel-nut chewing and chronic kidney disease in men
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Association between betel-nut chewing and chronic kidney disease in men
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Association between betel-nut chewing and chronic kidney disease in men
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Email d0931662451@yahoo.com.tw
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1. HW Kuo , SS Tsai , MM Tiao & CY Yang (2007) Epidemiological features of CKD in Taiwan. Am J Kidney Dis 49, 4655.

2. WC Yang , SJ Hwang , SS Chiang , HF Chen & ST Tsai (2001) The impact of diabetes on economic costs in dialysis patients: experiences in Taiwan. Diabetes Res Clin Pract 54, Suppl. 1, S47S54.

5. PC Gupta & S Warnakulasuriya (2002) Global epidemiology of areca nut usage. Addict Biol 7, 7783.

7. PS Ho , YC Ko , YH Yang , TY Shieh & CC Tsai (2002) The incidence of oropharyngeal cancer in Taiwan: an endemic betel quid chewing area. J Oral Pathol Med 31, 213219.

9. C-H Tseng (2006) Betel nut chewing is independently associated with urinary albumin excretion rate in type 2 diabetic patients. Diabetes Care 29, 462463.

11. DJ Hyman & VN Pavlik (2001) Characteristics of patients with uncontrolled hypertension in the United States. N Engl J Med 345, 479486.

12. SJ Hwang , CM Ballantyne , AR Sharrett , LC Smith , CE Davis , AM Gotto Jr & E Boerwinkle (1997) Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. Circulation 96, 42194225.

13. V Schachinger , MB Britten & AM Zeiher (2000) Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 101, 18991906.

15. KK Wary & RN Sharan (1988) Aqueous extract of betel-nut of north-east India induces DNA-strand breaks and enhances rate of cell proliferation in vitro. Effects of betel-nut extract in vitro. J Cancer Res Clin Oncol 114, 579582.

16. S-H Lin , Y-F Lin , S Cheema-Dhadli , MR Davids & ML Halperin (2002) Hypercalcaemia and metabolic alkalosis with betel nut chewing: emphasis on its integrative pathophysiology. Nephrol Dial Transplant 17, 708714.

17. B Stengel , ME Tarver-Carr , NR Powe , MS Eberhardt & FL Brancati (2003) Lifestyle factors, obesity and the risk of chronic kidney disease. Epidemiology 14, 479487.

18. A Shankar , R Klein & BE Klein (2006) The association among smoking, heavy drinking, and chronic kidney disease. Am J Epidemiol 164, 263271.

19. FM Chung , DM Chang , MP Chen , JC Tsai , YH Yang , TY Shieh , SJ Shin , TH Chen , TY Tai & YJ Lee (2006) Areca nut chewing is associated with metabolic syndrome: role of tumor necrosis factor-α, leptin, and white blood cell count in betel nut chewing-related metabolic derangements. Diabetes Care 29, 1714.

21. WC Chang , CF Hsiao , HY Chang , TY Lan , CA Hsiung , YT Shih & TY Tai (2006) Betel nut chewing and other risk factors associated with obesity among Taiwanese male adults. Int J Obes (Lond) 30, 359363.

22. CC Hsu , SJ Hwang , CP Wen , HY Chang , T Chen , RS Shiu , SS Horng , YK Chang & WC Yang (2006) High prevalence and low awareness of CKD in Taiwan: a study on the relationship between serum creatinine and awareness from a nationally representative survey. Am J Kidney Dis 48, 727738.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 2
Total number of PDF views: 44 *
Loading metrics...

Abstract views

Total abstract views: 97 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th May 2017. This data will be updated every 24 hours.