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Green tea and coffee consumption is inversely associated with depressive symptoms in a Japanese working population

  • Ngoc Minh Pham (a1), Akiko Nanri (a1), Kayo Kurotani (a1), Keisuke Kuwahara (a1), Ayami Kume (a1), Masao Sato (a2), Hitomi Hayabuchi (a3) and Tetsuya Mizoue (a1)...
Abstract Objective

To examine the association between the consumption of green tea, coffee and caffeine and depressive symptoms.


Cross-sectional study. Consumption of green tea and coffee was ascertained with a validated dietary questionnaire and the amount of caffeine intake was estimated from these beverages. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression Scale. Multiple logistic regression analysis was performed to compute odds ratios and 95 % confidence intervals for depressive symptoms with adjustments for potential confounders.


Two workplaces in north-eastern Kyushu, Japan, in 2009.


A total of 537 men and women aged 20–68 years.


Higher green tea consumption was associated with a lower prevalence of depressive symptoms. Compared with participants consuming ≤1 cup/d, those consuming ≥4 cups green tea/d had a 51 % significantly lower prevalence odds of having depressive symptoms after adjustment for potential confounders, with significant trend association (P for trend = 0·01). Further adjustment for serum folate slightly attenuated the association. Coffee consumption was also inversely associated with depressive symptoms (≥2 cups/d v. <1 cup/d: OR = 0·61; 95 % CI 0·38, 0·98). Multiple-adjusted odds for depressive symptoms comparing the highest with the lowest quartile of caffeine consumption was OR = 0·57 (95 % CI 0·30, 1·05; P for trend = 0·02).


Results suggest that higher consumption of green tea, coffee and caffeine may confer protection against depression.

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1. Bromet, E, Andrade, LH, Hwang, I et al. (2011) Cross-national epidemiology of DSM-IV major depressive episode. BMC Med 9, 90.
2. Mathers, CD & Loncar, D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3, e442.
3. Ministry of Health, Labour and Welfare (2008) Vital Statistics of Japan. Tokyo: Health and Welfare Statistics Association.
4. Murakami, K & Sasaki, S (2010) Dietary intake and depressive symptoms: a systematic review of observational studies. Mol Nutr Food Res 54, 471488.
5. McKay, DL & Blumberg, JB (2002) The role of tea in human health: an update. J Am Coll Nutr 21, 113.
6. Butt, MS & Sultan, MT (2011) Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr 51, 363373.
7. Iso, H, Date, C, Wakai, K et al. (2006) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults. Ann Intern Med 144, 554562.
8. Chen, WQ, Zhao, XL, Hou, Y et al. (2009) Protective effects of green tea polyphenols on cognitive impairments induced by psychological stress in rats. Behav Brain Res 202, 7176.
9. Belmaker, RH & Agam, G (2008) Major depressive disorder. N Engl J Med 358, 5568.
10. Kimura, K, Ozeki, M, Juneja, LR et al. (2007) l-Theanine reduces psychological and physiological stress responses. Biol Psychol 74, 3945.
11. Ferré, S (2008) An update on the mechanisms of the psychostimulant effects of caffeine. J Neurochem 105, 10671079.
12. Ferré, S, Ciruela, F, Borycz, J et al. (2008) Adenosine A1–A2A receptor heteromers: new targets for caffeine in the brain. Front Biosci 13, 23912399.
13. Niu, K, Hozawa, A, Kuriyama, S et al. (2009) Green tea consumption is associated with depressive symptoms in the elderly. Am J Clin Nutr 90, 16151622.
14. Chen, X, Lu, W, Zheng, Y et al. (2010) Exercise, tea consumption, and depression among breast cancer survivors. J Clin Oncol 28, 991998.
15. Shimbo, M, Nakamura, K, Shi, HJ et al. (2005) Green tea consumption in everyday life and mental health. Public Health Nutr 8, 13001306.
16. Ruusunen, A, Lehto, SM, Tolmunen, T et al. (2010) Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study. Public Health Nutr 13, 12151220.
17. Lucas, M, Mirzaei, F, Pan, A et al. (2011) Coffee, caffeine, and risk of depression among women. Arch Intern Med 171, 15711578.
18. Hintikka, J, Tolmunen, T, Honkalampi, K et al. (2005) Daily tea drinking is associated with a low level of depressive symptoms in the Finnish general population. Eur J Epidemiol 20, 359363.
19. Chen, TS, Lui, CK & Smith, CH (1983) Folacin content of tea. J Am Diet Assoc 82, 627632.
20. Nanri, A, Hayabuchi, H, Ohta, M et al. (2012) Serum folate and depressive symptoms among Japanese men and women: a cross-sectional and prospective study. Psychiatry Res 200, 349353.
21. Shima, S, Shikano, T, Kitamura, T et al. (1985) New self-rating scale for depression. Jpn J Clin Psychiatry 27, 717723.
22. Radloff, LS (1977) A self-report depression scale for research in the general population. Appl Psychol Meas 1, 250267.
23. McDowell, I (2006) Depression. In Measuring Health: A Guide to Rating Scales and Questionnaires, 3rd ed., pp. 329393. New York: Oxford University Press.
24. Kobayashi, S, Murakami, K, Sasaki, S et al. (2011) Comparison of relative validity of food group intakes estimated by comprehensive and brief-type self-administered diet history questionnaires against 16 d dietary records in Japanese adults. Public Health Nutr 14, 12001211.
25. Science and Technology Agency (2005) Standard Tables of Food Composition in Japan, 5th revised and enlarged ed. Tokyo: Printing Bureau of the Ministry of Finance.
26. Ainsworth, BE, Haskell, WL, Whitt, MC et al. (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32, 9 Suppl., S498S516.
27. Gilbody, S, Lightfoot, T & Sheldon, T (2007) Is low folate a risk factor for depression? A meta-analysis and exploration of heterogeneity. J Epidemiol Community Health 61, 631637.
28. Kawachi, I, Willett, WC, Colditz, GA et al. (1996) A prospective study of coffee drinking and suicide in women. Arch Intern Med 156, 521525.
29. Hawton, K & van Heeringen, K (2009) Suicide. Lancet 373, 13721381.
30. Kuriyama, S, Hozawa, A, Ohmori, K et al. (2006) Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya Project. Am J Clin Nutr 83, 355361.
31. Llaneza, P, García-Portilla, MP, Llaneza-Suárez, D et al . (2012) Depressive disorders and the menopause transition. Maturitas 71, 120130.
32. Schliep, KC, Schisterman, EF, Mumford, SL et al . (2012) Caffeinated beverage intake and reproductive hormones among premenopausal women in the BioCycle Study. Am J Clin Nutr 95, 488497.
33. Liao, S, Kao, YH & Hiipakka, RA (2001) Green tea: biochemical and biological basis for health benefits. Vitam Horm 62, 194.
34. Zhu, WL, Shi, HS, Wei, YM et al. (2012) Green tea polyphenols produce antidepressant-like effects in adult mice. Pharmacol Res 65, 7480.
35. Levites, Y, Weinreb, O, Maor, G et al. (2001) Green tea polyphenol (–)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J Neurochem 78, 10731082.
36. Yokogoshi, H, Kobayashi, M, Mochizuki, M et al. (1998) Effect of theanine, R-glutamylethylamide, on brain monoamines and striatal dopamine release in conscious rats. Neurochem Res 23, 667673.
37. Nathan, PJ, Lu, K, Gray, M et al. (2006) The neuropharmacology of l-theanine (N-ethyl-l-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother 6, 2130.
38. Crespy, V & Williamson, G (2004) A review of the health effects of green tea catechins in in vivo animal models. J Nutr 134, 12 Suppl., 3431S3440S.
39. Stefanescu, C & Ciobica, A (2012) The relevance of oxidative stress status in first episode and recurrent depression. J Affect Disord 143, 3438.
40. Sarandol, A, Sarandol, E, Eker, SS et al. (2007) Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative–antioxidative systems. Hum Psychopharmacol 22, 6773.
41. Higdon, JV & Frei, B (2006) Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 46, 101123.
42. Scalbert, A & Williamson, G (2000) Dietary intake and bioavailability of polyphenols. J Nutr 130, 8S Suppl., 2073S2085S.
43. Natella, F, Nardini, M, Giannetti, I et al. (2002) Coffee drinking influences plasma antioxidant capacity in humans. J Agric Food Chem 50, 62116216.
44. Yamada, M, Sasaki, S, Murakami, K et al. (2010) Estimation of caffeine intake in Japanese adults using 16 d weighed diet records based on a food composition database newly developed for Japanese populations. Public Health Nutr 13, 663672.
45. Kempf, K, Herder, C, Erlund, I et al . (2010) Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: a clinical trial. Am J Clin Nutr 91, 950957.
46. Farah, A, Monteiro, M, Donangelo, CM et al . (2008) Chlorogenic acids from green coffee extract are highly bioavailable in humans. J Nutr 138, 23092315.
47. Lee, MJ, Wang, ZY, Li, H et al . (1995) Analysis of plasma and urinary tea polyphenols in human subjects. Cancer Epidemiol Biomarkers Prev 4, 393399.
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