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Plasma fibrinogen of black South Africans: the BRISK study

  • HH Vorster (a1), JC Jerling (a1), K Steyn (a2), CJ Badenhorst (a2), W Slazus (a3), CS Venter (a1), PL Jooste (a4) and LT Bourne (a2)...

Abstract

Objective:

To describe the distribution of plasma fibrinogen and relationships with other risk factors for coronary heart disease (CHD) and stroke in the black population of the Cape Peninsula.

Design:

A cross-sectional survey of a stratified proportional sample of randomly selected black men and women.

Setting:

Households in Gugulethu, Langa, Nyanga, New Crossroads, KTC, Old Crossroads and Khayelitsha in the Cape Peninsula, South Africa.

Subjects:

One subject per household (352 men and 447 women), aged 15–64 years, voluntarily participated. Visitors, pregnant, lactating, ill, mentally retarded and intoxicated subjects were excluded.

Results:

Mean fibrinogen (thrombin time coagulation method) of men and women were higher than published data for Europeans but slightly lower than values of black Americans. Women aged 45–54 years had the highest level (3.13 ± 0.89g1−1) and men aged 15–24 years had the lowest (2.13 ± 0.88g1−1). Fifteen per cent of the men and 12% of the women had a level greater than 1 standard deviation of the mean for their age group. Univariate and multivariate analyses revealed significant (P< 0.05) positive correlations of fibrinogen with smoking habit, age, body mass index (BMI), total and low-density lipoprotein (LDL) cholesterol, triglycerides, blood pressure and white blood cell count, and significant negative correlations with high-density lipoprotein (HDL) cholesterol, gamma glutamyl transferase (GGT), serum iron and ferritin. The correlations with BMI, serum lipoproteins, iron, ferritin, and GGT suggest that nutritional status and therefore diet influences plasma fibrinogen.

Conclusions:

Relatively high fibrinogen levels, tending to cluster with other, including diet-related, risk factors for CHD and stroke, were observed in black South Africans. It is suggested that fibrinogen may contribute to the high stroke incidence of this population group.

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Copyright

Corresponding author

*Corresponding author: E-mail vgehhv@puknet.puk.ac.za

References

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1Steyn, K. A policy proposal to manage chronic diseases of lifestyle in South Africa. S. Afr. Med. J. 1992; 82: 220–1.
2Popkin, BM. The nutrition transition in low-income countries: an emerging crisis. Nutr. Rev. 1994; 52: 285–98.
3Wilhelmsen, L, Svärdsudd, K, Korsan-Bengsten, K, Larsson, B. Fibrinogen as a risk factor for stroke and myocardial infarction. N. Engl. J. Med. 1984; 311: 5001–505.
4Meade, TW, Brozovic, M, Charkrabarti, RR, et al. Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet 1986; 2: 533–7.
5Kannel, WB, Wolf, PA, Castelli, WP. D'Agostino, RB. Fibrinogen and risk of cardiovascular disease. J. Am. Med. Assoc. 1987; 258: 1183–6.
6Yarnell, IWG, Fehilly, AM, Milbank, J, Kubicki, AJ. Eastham, R, Haynes, TM. Determinants of plasma lipoproteins and coagulation factors in men from Caerphilly, South Wales. J. Epidemiol. Comm. Health. 1983; 37: 137–40.
7Assman, G, Schulte, H. Results and conclusions of the prospective cardiovascular Münster (PROCAM) Study. In: Asmann, G, ed. Lipid Metabolism Disorders and Coronary Heart Disease. Munich: MMV Medizin Verlag, 1993: 1967.
8Folsom, AR, Wu, KK, Conlan, MG. Fibrinogen and cardiovascular risk in the atherosclerosis risk in communities (ARIC) study. In: Ernst, E, Koenig, W, Lowe, GDO, Mcade, TW. eds. Fibrinogen: a ‘New’ Cardiovascular Risk Factor. Vienna: Blackwell-MZV, 1992: 124–9.
9Erikson, H, Wilhelmsen, L, Welin, L, Larsson, B, Svärdsudd, , Tibblin, G. 21-year follow-up of CVD and total mortality among men born in 1913. In: Ernst, E, Koenig, W, Lowe, GDO, Meade, TW, eds. Fibrinogen: a ‘New’ Cardiorvascular Risk Factor. Vienna: Blackwell-MZV, 1992: 115–19.
10Tarallo, P, Henny, J, Gueguen, R, Siest, G. Reference limits of plasma fibrinogen. Eur. J. Clin. Chem. Clin. Biochem. 1992; 30: 745–51.
11Folsom, AR, Wu, KK, Davis, CE, Conlan, MG, Sorlie, PD, Szklo, M. Population correlates of plasma fibrinogen and factor VII. purative cardiovascular risk factors. Atherosclerosis 1991; 91: 191205.
12Lee, AJ, Smith, WCS, Lowe, GDO. Tunstall-Pedoe, H. Plasma fibrinogen and coronary risk factors: the Scottish Heart Health Study. J. Clin. Epidemiol. 1990; 43: 913–19.
13Cook, NS, Ubben, D. Fibrinogen as a major risk factor in cardiovascular disease. Trends Pharm. Sci. 1990; 11: 444–51.
14Humphries, SE, Cook, M, Dubowitz, M, Stirling, Y, Meade, TW. Role of genetic variation at the fibrinogen locus in determination of plasma fibrinogen. Lancet 1987; 1: 1452–55.
15Ernst, E. The role of fibrinogen as a cardiovascular risk factor. Atherosclerosis 1993; 100: 112.
16Iso, H, Folsom, AR. Sato, S, et al. Plasma fibrinogen and its correlates in Japanese and US population samples. Arterioscl. Thromb. 1993; 13: 783–90.
17Venter, CS, Vorster, HH. Silvis, A. Mia, F. Seftel, HC. Determinants of plasma fibrinogen levels in South African communites. In: Ernst, E, Koenig, W. Low, CDO, Meade, TW. eds. Fibrinogen: a ‘New‚ Cardiovacular Risk Factor. Vienna: Blackwell-MZV. 1992: 166–71.
18Steyn, K. Fourie, J, eds. BRISK Study Methodology. Coronary Heart Disease Risk Factor Study in the African Population of the Cape Peninsula. Technical report no. I. Medical Research Council, Parow, 1991: 144.
19Steyn, K, Jooste, PL, Bourne, L, et al. Risk factors for coronary heart disease in the black population of the Cape Peninsula. S. Afr. Med. J. 1991; 79: 480–5.
20Osterud, B. How to measure factor VII and factor VII activation. Haemostasis 1983; 13: 161–8.
21Stat Soft Incorporated. Complete Statistical System (CCS). Stat Soft Inc. 1991, Tulsa, OK 74104.
22Møller, L. Kristensen, TS. Plasma fibrinogen and ischemic heart disease risk factors. Arterioscler. Thromb. 1991; 11: 344–50.
23Balleisen, L, Bailey, J, Epping, PH, Schulte, H, Van de Loo, J. Epidemiological study on factor VII, factor VIlI and fibrinogen in an industrial population I. Thromb. Hemost. 1985; 54: 475.
24Farinaro, E. Prevention of coronary heart disease: scientific background and new clinical guidelines. In: Asmann, G. ed. Lipid Metabolism isorders and Coronary Heart Disease. Munich: MMV Medizin Verlag, 1993: 69139.
25Vorster, HH, Venter, CS. Fibrinogen as risk factor for coronary heart disease. Cardiovasc. J. S. Afr. 1994; 5: 117–24.
26Kannel, WB. CHD risk factors: a Framingham Study update. Hosp. Pract. 1990; 25: 119–27.
27Luria, MH, Erel, J, Sapoznikov, D, Gotsman, MS. Cardiovascular risk factor clustering and ratio of total cholesterol to high-density lipoprotein cholesterol in angiographically documented coronary artery disease. Am. J. Cardiol. 1991; 67: 131–6.
28Ernst, E. Oral contraceptives, fibrinogen and cardiovascular risk. Atherosclerosis 1992; 93: 15.
29Walker, ARP, Adam, A, Kustner, HGV. Changes in total death rate and in ischaemic heart disease death rate in interethnic South African populations. S. Afr. Med. J. 1993; 83: 602–5.
30Sherman, AJ. Coronary heart disease in black Americans; suggestions for research on psychosocial factors. Am. Heart. J. 1984; 3: 833–8.
31Vermaak, WJH. Ubbink, JB, Delport, R, Becker, PJ, Bissbort, SH, Ungerer, JPJ. Ethnic immunity to coronary heart disease? Atherosclerosis 1991; 89: 155–62.
32Franz, RC, Meiring, JL. Coetzee, WJC. Ethnic differences in the haemostatic, fibrinolytic and lipographic patterns. S. Afr. J. Surg. 1980; 18: 58–9.
33Jerling, JC, Vorster, HH, Oosthuzen, W, Silvis, N, Venter, CS. Differences in plasminogen activator inhibitor I activity between blacks and whites may be diet related. Haemostusis 1993; 24: 364–8.
34Wyndham, CH. Mortality from cardiovascular diseases in the various population groups in the Republic of South Africa. S. Afr Med. J. 1979; 56: 1023–30.
35Joubert, J. The MEDUNSA Stroke Data Bank. An analysis of 304 patients seen between 1986 and 1987. S. Afr. Med. J. 1991; 80: 567–70.
36Broderick, JP, Brott, T, Tomsick, T, Huster, G, Miller, R. The risk of subarachnoid and intracerebral hemorrhages in blacks as compared with whites. N. Engl. J. Med. 1992; 326: 733–6.
37Kittner, SJ, White, LR, Losonczy, KG, Wolf, PA, Hebel, JR. Black-white differences in stroke incidence in a national sample. J. Am. Med. Assoc. 1990; 264: 1267–70.
38Gaines, KJ, Chesney, C, Van der Zwaag, R, Cape, C. Racial differences in coagulation studies in stroke. Neurol. Res. 1992; 14: 103–8.
39Carter, LR, Walton, SE, Knowles, MK, Wing, S, Tyroler, HA. Social inequality of stroke mortality among US black populations, 1968 to 1987. Ethn. Dis. 1992; 2: 343–51.
40Casper, M, Wing, S, Strogatz, D. Variation in the magnitude of black - white differences in stroke mortality by community occupational structure. J. Epidemiol. Comm. Health 1991; 45: 302–6.
41Markowe, HLJ. Marmot, MG, Shipley, MJ, et al. Fibrinogen: a possible link between social class and coronary heart disease. Br. Med. J. 1985; 291: 1312–14.
42Netterstrøm, B, Søndergård, k, Damsgaard, MT, Olsen, O, Sjøl, A. Job strain and cardiovascular risk factors; a cross sectional study of employed Danish men and women. Br. J. Ind. Med. 1991; 48: 584689.
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Public Health Nutrition
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