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A review of the MAFF Optimal Nutrition Status research programme: folate, iron and copper

Published online by Cambridge University Press:  02 January 2007

J Buttriss  and
J Hughes
J Buttriss*
Affiliation:
British Nutrition Foundation, 52–54 High Holborn, London WC1V 6RQ, UK
J Hughes
Affiliation:
7 Holmesdale Park, Coopers Hill Road, Nutfield, Surrey, RH1 4NW, UK
*
*Corresponding author: Email j.buttriss@nutrition.org.uk
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Abstract

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Objective:

The objective was to conduct a critical appraisal of research conducted within one of the UK government's research programmes, Optimal Nutrition Status, and to place the findings of this work in the context of the international research effort, to assist policy makers and advisers. Nine nutrients are addressed within the programme; the findings for three of these are reported here: folate/folic acid, iron and copper.

Design:

To conduct the review, the researchers had access to all unpublished progress reports, submitted to officials, arising from the projects. The overall assessment criterion was whether the information generated by the research programme could be regarded as reliable experimental data of direct relevance to setting optimal dietary requirements for the particular micronutrients. However, findings were also assessed against specific scientific criteria concerning understanding of the bioavailability, interactions, development of functional markers and inter-individual variations in metabolism, for each of the nutrients scrutinised.

Results:

The results of the review indicated that many important questions are indeed being addressed by the UK government's research programme, and that the work is contributing to the overall research effort being conducted world-wide on this important subject.

Conclusions:

Many major questions still need to be addressed before it will be possible to identify optimal intakes for various sub-populations. These priorities are summarised in the paper.

Keywords

FolateIronCopperResearch prioritiesOptimal nutrition status
Type
Research Article
Information
Public Health Nutrition , Volume 5 , Issue 4 , August 2002 , pp. 595 - 612
Copyright
Copyright © CABI Publishing 2002

References

1Department of Health. Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects No. 41. London: HMSO, 1991; 161–6.Google Scholar
2Buttriss, J, Hughes, J. A review of the MAFF optimal nutrition status programme. BNF Nutr. Bull. 2000; 25(1): 79–80.CrossRefGoogle Scholar
3Buttriss, J, Bundy, R, Hughes, J. An update of vitamin K: contribution of MAFF-funded research. BNF Nutr. Bull. 2000; 25(2): 125–34.CrossRefGoogle Scholar
4Hughes, J, Buttriss, J. An update on folate and folic acid: contribution of MAFF-funded research. BNF Nutr. Bull. 2000; 25(1): 113–34.CrossRefGoogle Scholar
5Hughes, J, Buttriss, J. An update on copper: contribution of MAFF-funded research. BNF Nutr. Bull. 2000; 25(4): 271–80.CrossRefGoogle Scholar
6Bellamy, MF, McDowell, IFW. Putative mechanisms for vascular damage by homocysteine. J. Inherited Metab. Disord. 1996; 20: 307–15.CrossRefGoogle Scholar
7McDowell, IFW, Ashfield-Watt, P. Approaches to defining optimal folate intake for cardiovascular health. Nutr. Food Sci. 1997; 6: 215–7.CrossRefGoogle Scholar
8Bellamy, MF, McDowell, IF, Ramsey, MW, Brownlee, M, Bones, C, Newcombe, RG, Lewis, MJ. Hyperhomocysteinaemia after an oral methionine load acutely impairs endothelial function in healthy subjects. Circulation 1998; 98: 1848–52.CrossRefGoogle Scholar
9Still, RA, McDowell, IFW. Clinical implications of plasma homocysteine measurement in cardiovascular disease. J. Clin. Pathol. 1998; 51: 183–8.CrossRefGoogle ScholarPubMed
10Bellamy, MF, McDowell, IFW, Ramsey, MW, Brownlee, M, Newcombe, RG, Lewis, MJ. Oral folate enhances endothelial function in hyperhomocysteinaemic subjects. Eur. J. Clin. Invest. 1999; 29: 659–62.CrossRefGoogle ScholarPubMed
11McDowell, IFW. Homocysteine and cardiovascular disease. J. Int. Fed. Clin. Chem. 1998; 10: 73–6.Google Scholar
12Doshi, SN, Goodfellow, J, Lewis, MJ, McDowell, IF. Homocysteine and endothelial function. Cardiovasc Res. 1999; 42: 578–82.CrossRefGoogle ScholarPubMed
13McNulty, H. Folate requirements for health in different population groups. Br. J. Biomed. Sci. 1995; 52: 110–9.Google ScholarPubMed
14McNulty, H. Folate requirements for health in women. Proc. Nutr. Soc. 1997; 56: 291–303.CrossRefGoogle ScholarPubMed
15Moat, SJ, Bonham, JR, Powers, HJ. Circulating antioxidant enzyme activity is influenced by homocysteine. Netherlands J. Med. 1998; 52: S58.Google Scholar
16Ashfield-Watt, PAL, Knowles, RM, Cale, SB, Clark, ZE, McDowell, IFW. A practical dietary intervention lowers plasma homocysteine in hyperlipidaemic patients. Heart 1999; 81(Suppl. 1): 30.Google Scholar
17Finglas, PM, Wigertz, K, Vahteristo, L, Witthoft, CM, Southon, S, de Froidmont-Gortz, I. Standardisation of HPLC procedures for the determination of naturally-occurring folates in food. Food Chem. 1999; 64: 245–55.CrossRefGoogle Scholar
18Cuskelly, GJ, McNulty, H, Scott, JM. Low levels of folic acid fortification make a significant difference in folate status in young women: implications for the prevention of neural tube defects. Am. J. Clin. Nutr. 1999; 70: 234–9.CrossRefGoogle Scholar
19McNulty, H, Cuskelly, GJ, Ward, M. Response of red cell folates to intervention: implications for folate recommendations for the prevention of neural tube defects. Am. J. Clin. Nutr. 2000; 71(5): 1308S–11S.CrossRefGoogle ScholarPubMed
20Department of Health. Folic Acid and the Prevention of Disease. Report on Health and Social Subjects No. 50. London: HMSO, 2000.Google Scholar
21Gregory, J, Foster, K, Tyler, H, Wiseman, M. The Dietary and Nutritional Survey of British Adults. London: HMSO, 1990.Google Scholar
22Ministry of Agriculture, Fisheries and Food (MAFF). National Food Survey. London: HMSO, 1998.Google Scholar
23Scott, JM. Folate and vitamin B12. Proc. Nutr. Soc. 1999; 58: 441–8.CrossRefGoogle ScholarPubMed
24Scott, JM, Weir, DG. Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry. J. Cardiovasc. Risk 1998; 5(4): 223–7.CrossRefGoogle ScholarPubMed
25Graham, IM, Daly, LE, Refsum, HM, Robinson, K, Brattstrom, LE, Ueland, PM, Palma-Reis, RJ, et al. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project. J. Am. Med. Assoc. 1997; 277: 1775–81.CrossRefGoogle ScholarPubMed
26Selhub, J, Jacques, PF, Wilson, PW, Rush, D, Rosenberg, IH. Vitamin status and intake as primary determinants of homocysteine in an elderly population. J. Am. Med. Assoc. 1993; 270: 2693–8.CrossRefGoogle Scholar
27Clarke, R. Homocysteine and cardiovascular disease. Overview. J. Cardiovasc. Risk 1998; 5(4): 213–5.CrossRefGoogle ScholarPubMed
28Clarke, R, Collins, R. Can dietary supplements with folic acid or vitamin B6 reduce cardiovascular risk? Design of clinical trials to test homocysteine hypothesis of vascular disease. J. Cardiovasc. Risk 1998; 5(4): 249–55.CrossRefGoogle ScholarPubMed
29Weisberg, T, Tran, P, Christensen, B, Sibani, S, Rozen, R. A second genetic polymorphism in methylenetetrahydofolate reductase (MTHFR) associated with decreased enzyme activity. Mol. Genet. Metab. 1998; 64(3): 169–72.CrossRefGoogle Scholar
30Freudenheim, JL, Marshall, JR, Vena, JE, Laughlin, R, Brasure, JR, Swanson, MK, Nemoto, T, Graham, S. Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients. J. Natl. Cancer Inst. 1996; 88(6): 340–8.CrossRefGoogle ScholarPubMed
31Clarke, R, Smith, AD, Jobst, KA, Refsum, H, Sutton, L, Ueland, PM. Folate, vitamin B12 and serum total homocysteine levels in confirmed Alzheimer disease. Arch. Neurol. 1998; 55: 1449–55.CrossRefGoogle ScholarPubMed
32Kelly, P, McPartlin, J, Goggins, M, Weir, DG, Scott, JM. Unmetabolized folic acid in serum: acute studies in subjects consuming fortified food and supplements. Am. J. Clin. Nutr. 1997; 65(6): 1790–5.CrossRefGoogle ScholarPubMed
33Sweeney, MR, McPartlin, J, Weir, DG, Scott, JM. Folic acid fortification of bread: effect of chronic consumption on unmetabolised folic acid in serum. Proc. Nutr. Soc. 2000; 59(OCA): 82A.Google Scholar
34Bates, CJ, Mansoor, MA, van der Pols, J, Prentice, A, Cole, TJ, Finch, S. Plasma total homocysteine in a representative sample of 972 British men and women aged 65 and over. Eur. J. Clin. Nutr. 1997; 51(10): 691–7.CrossRefGoogle Scholar
35Harvey, L, Majsak-Newman, G, Fairweather-Tait, SJ, Baker, A, Cachman, K, Flynn, A, Lewis, D, Crewes, H. Effect of dietary copper intake on biochemical indices associated with copper metabolism. In: Roussel, AM, Anderson, RA, Favier, AE, eds. Proceedings of the Tenth International Symposium on Trace Elements in Man and AnimalEvian, France2–7 May 1999. New York: Kluwer Academic/Plenum Publishers, 2000; 959–60.Google Scholar
36Turley, E, McKeown, A, Harvey, LJ, Fairweather-Tait, SJ, Crewes, HM, Strain, JJ. Assessing copper status – a review. Nutr. Food Sci. 1997; 6: 229–32.CrossRefGoogle Scholar
37Fairweather-Tait, SJ. Bioavailability of copper. Eur. J. Clin. Nutr. 1997; 51(Suppl. 1): 24S–6S.Google ScholarPubMed
38Crews, HM, Baxter, MJ, Lewis, DJ, Havermeister, W, Fairweather-Tait, SJ, Harvey, LJ, Majsak-Newman, G. Multi-element and isotope ratio determinations in foods and clinical samples using inductively coupled plasma–mass spectrometry. In: Trace Elements in Man and Animals – 9. Ottawa, Canada: NRC Research Press, 1997.Google Scholar
39Lewis, AJ. The role of copper in inflammatory disorders. Agents Actions 1984; 15: 513–9.CrossRefGoogle ScholarPubMed
40Rock, A, Mazur, A, Rayssiguier, Y, Kehoe, C, O'Connor, JM, Bonham, MP, Strain, JJ. Effect of copper supplementation in middle aged people on plasma anti-oxidants and red blood cell oxidizability: FOODCUE Study. In: Roussel, AM, Anderson, RA, Favier, AE, eds. Proceedings of the Tenth International Symposium on Trace Elements in Man and AnimalEvian, France2–7 May 1999. New York: Kluwer Academic/Plenum Publishers, 2000; 475–6.Google Scholar
41Olivares, M, Uauy, R. Copper as an essential nutrient. Am. J. Clin. Nutr. 1996; 63: 791S–6S.CrossRefGoogle ScholarPubMed
42Ministry of Agriculture, Fisheries and Food (MAFF). 1994 Total Diet Study: Metals and Other Elements. Food Surveillance Information Sheet No. 131. London: MAFF, 1997.Google Scholar
43Gregory, J, Lowe, S, Bates, CJ, Prentice, A, Jackson, LV, Smithers, G, Wenlock, R, Farron, M. National Diet and Nutrition Survey: Young People aged 4 to 18 years. London: The Stationery Office, 2000.Google Scholar
44Gibson, RS. Content and bioavailability of trace elements in vegetarian diets. Am. J. Clin. Nutr. 1984; 59: 1223S–32S.CrossRefGoogle Scholar
45Ministry of Agriculture, Fisheries and Food (MAFF). Duplicate Diet Study of Vegetarians – Dietary Exposure to 12 Metals and Other Elements. Food Surveillance Information Sheet No. 193. London: MAFF, 2001.Google Scholar
46Lonnerdal, B, Keen, CL. New functions of trace elements. Scand. J. Nutr. 1999; 43(Suppl. 2): 25S–6S.Google Scholar
47Strain, JJ. Defining optimal copper status in humans. Concepts and problems. In: Roussel, AM, Anderson, RA, Favier, AE, eds. Proceedings of the Tenth International Symposium on Trace Elements in Man and AnimalEvian, France2–7 May 1999. New York: Kluwer Academic/Plenum Publishers, 2000; 923–8.Google Scholar
48National Research Council. Recommended Dietary Allowances. Washington, DC: National Academy Press, 1989.Google Scholar
49Lund, EK, Wharf, SG, Fairweather-Tait, SJ, Johnson, IT. Oral ferrous sulfate supplements increase the free radical-generating capacity of feces from healthy volunteers. Am. J. Clin. Nutr. 1999; 69(2): 250–5.CrossRefGoogle ScholarPubMed
50Rehman, A, Collis, CS, Yang, M, Kelly, M, Diplock, AT, Halliwell, B, Rice-Evans, C. The effects of iron and vitamin C co-supplementation on oxidative damage to DNA in healthy volunteers. Biochem. Biophys. Res. Commun. 1998; 246(1): 293–8.CrossRefGoogle ScholarPubMed
51Fairweather-Tait, SJ, Johnson, IT, Wharf, SG, Lund, EK. Iron – getting the balance right. Nutr. Food Sci. 1997; 6: 212–4CrossRefGoogle Scholar
52Lund, EK, Wharf, SJ, Fairweather-Tait, SJ, Johnson, IT. The effects of dietary iron and phytate on cell proliferation and apotosis in rat large intestine. Gut 1996; 38(Suppl. 1): A19.Google Scholar
53Wharf, SG, Lund, EK, Parker, M, Johnson, IT, Fairweather-Tait, SJ. The feasibility of using exfoliated human colon cells to monitor the potential pro-oxidant effects of iron. In: Trace Elements in Man and Animals – 9. Ottawa, Canada: NRC Research Press, 1997.Google Scholar
54Collis, CS, Yang, M, Peach, SJ, Diplock, AT, Rice-Evans, C. The effects of ascorbic acid and iron cosupplementation on the proliferation of 3T3 fibroblasts. Free Radical Res. 1996; 25: 87–93.CrossRefGoogle ScholarPubMed
55Southon, S, Wright, AJA, Finglas, PM, Bailey, AL, Loughridge, JM, Walker, AD. Dietary intake and micronutrient status of adolescents: effect of vitamin and trace element supplementation on indices of status and performance in tests of verbal and non-verbal intelligence. Br. J. Nutr. 1994; 71: 897–918.CrossRefGoogle ScholarPubMed
56Fairweather-Tait, SJ, Minihane, AM, Eagles, J, Owen, L, Crews, HM. Rare earth elements as nonabsorbable fecal markers in studies of iron absorption. Am. J. Clin. Nutr. 1997; 65(4): 970–6.CrossRefGoogle ScholarPubMed
57British Nutrition Foundation. Iron: Nutritional and Physiological Significance. London: Chapman & Hall, 1995.Google Scholar
58De Andraca, I, Castillo, M, Walter, T. Psychomotor development and behavior in iron-deficient anemic infants. Nutr. Rev. 1997; 55: 125–32.CrossRefGoogle ScholarPubMed
59Oski, FA, Honig, AS, Helu, B, Howanitz, P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Paediatrics 1983; 71: 877–80.CrossRefGoogle Scholar
60Beard, J. One person's view of iron deficiency, development, and cognitive function. Am. J. Clin. Nutr. 1995; 62: 709–10.CrossRefGoogle ScholarPubMed
61Pollitt, E. Iron deficiency and educational deficiency. Nutr. Rev. 1997; 55: 133–41.CrossRefGoogle ScholarPubMed
62Allen, LH. Pregnancy and iron deficiency: unresolved issues. Nutr. Rev. 1997; 55: 91–101.CrossRefGoogle ScholarPubMed
63Levin, HM. A benefit–cost analysis of nutritional programs for anaemia reduction. Res Obs. 1986; 1: 219–45.CrossRefGoogle Scholar
64Cook, JD. Defining optimal body iron. Proc. Nutr. Soc. 1999; 58: 489–95.CrossRefGoogle ScholarPubMed
65Babbs, CF. Free radicals and the etiology of colon cancer. Free Radical Biol. Med. 1989; 8: 191–200.CrossRefGoogle Scholar
66Weinberg, ED. Roles of iron in neoplasia: promotion, prevention and therapy. Biol. Trace Element Res. 1992; 34: 123–40.CrossRefGoogle ScholarPubMed
67Tseng, M, Sandler, RS, Greenberg, ER, Mandel, JS, Haile, RW, Baron, JA. Dietary iron and recurrence of colorectal adenomas. Cancer Epidemiol. Biomark. Prev. 1997; 6(12): 1029–32.Google ScholarPubMed
68Klausner, RD, Rouault, TA, Harford, JB. Regulating the fate of mRNA: the controls of cellular iron metabolism. Cell 1993; 72: 19–28.CrossRefGoogle ScholarPubMed
69MacPhail, AP, Charlton, R, Bothwell, TH, Bezwoda, WR. Experimental fortificants. In: Clydesdale, FM, Weimer, KL, eds. Iron Fortification of Foods. New York: Academic Press, 1985; 55–75.CrossRefGoogle Scholar
70Hurrell, RF. Bioavailability of iron. Eur. J. Clin. Nutr. 1997; 51(Suppl. 1): S4–S8.Google ScholarPubMed
71Gregory, J, Collins, DL, Davies, SW, Hughes, JM, Clarke, PC. National Diet and Nutrition Survey: Children aged 1½ to 4½ years. Vol. 1. Report of the Diet and Nutrition Survey. London: HMSO, 1995.Google Scholar
72Cook, JD, Watson, SS, Simpson, KM, Lipschitz, DA, Skikne, BS. The effect of high ascorbic acid supplementation on body iron stores. Blood 1984; 64: 721–6.CrossRefGoogle ScholarPubMed
73Hallberg, L, Brune, M, Rossander, L. Effects of ascorbic acid on iron absorption from different types of meals. Studies with ascorbate rich foods and synthetic ascorbic acid given in different amounts with different meals. Hum. Nutr. Appl. Nutr. 1986; 40A: 97–113.Google Scholar
74Baird, IM, Walters, RL, Sutton, DR. Absorption of slow-release iron and effects of ascorbic acid in normal subjects and after partial gastrectomy. Br Med J. 1974; 4: 505–8.CrossRefGoogle ScholarPubMed
75Levine, M. New concepts in the biology and chemistry of ascorbic acid. N. Engl. J. Med. 1986; 314: 892–902.Google ScholarPubMed
76Hunt, JR, Gallagher, SK, Johnson, LK. Effect of ascorbic acid on apparent iron absorption by women with low iron stores. Am. J. Clin. Nutr. 1994; 59: 1381–5.CrossRefGoogle ScholarPubMed
77Hallberg, L, Rossander-Hulten, L, Brune, M, Gleerup, A. Calcium and iron absorption: mechanism of action and nutritional importance. Eur. J. Clin. Nutr. 1992; 46: 317–27.Google ScholarPubMed
78Minihane, AM, Fairweather-Tait, SJ. Effect of calcium supplementation on daily nonheme-iron absorption and long-term iron status. Am. J. Clin. Nutr. 1998; 68(1): 96–102.CrossRefGoogle ScholarPubMed
79Worwood, M, Thorpe, SJ, Heath, A, Flowers, CH, Cook, JD. Stable lyophilised reagents for the serum ferritin assay. Clin. Lab. Haematol. 1991; 13: 297–305.CrossRefGoogle ScholarPubMed
80Wurzlemann, JI, Silver, A, Schreinemachers, DM, Sandler, RS, Everson, RB. Iron intake and the risk of colorectal cancer. Cancer Epidemiol. Biomark. Prev. 1996; 5(7): 503–7.Google Scholar