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Ethical Aspects of Genetic Screening in Israel

Published online by Cambridge University Press:  26 September 2008

Michal Sagi
Michal Sagi
Affiliation:
Department of Human Genetics Hadassah University Hospital, Jerusalem
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Abstract

Advances in genetic research make it possible to identify carriers of a growing number of genetic diseases. The World Health Organization (WHO) published several preconditions for community carrier screening. This paper aims to present some of the dilemmas about screening in Israel and the difficulties in following the WHO's helpful criteria.

Information

Type
Genetic Services Eugenic Practices?
Information
Science in Context , Volume 11 , Issue 3-4 , Autumn-Winter 1998 , pp. 419 - 429
Copyright
Copyright © Cambridge University Press 1998

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References

Abeliovich, D., Quint, A., Weinberg, N., Verchezon, G., Lerer, I., Ekstein, J., and Rubinstein, E.. 1996. “Cystic Fibrosis Heterozygote Screening in the Orthodox Community of Ashkenazi Jews: The Dor Yesharim Approach and Heterozygote Frequency.” European Journal of Human Genetics 4:338–41.CrossRefGoogle ScholarPubMed
Barton, N. W., Furbish, F. S, Murray, G. I., Garfield, M., and Brady, R. O.. 1990. “Therapeutic Response to Intravenous Infusions of Glucocerebrosidase in a Patient with Gaucher Disease.” Proceedings of National Academy of Science USA 87:1913–16.CrossRefGoogle Scholar
Beutler, E. and Gelbart, T.. 1996. “Glucocerebrosidase (Gaucher disease).” Human Mutation 8:207–13.3.0.CO;2-6>CrossRefGoogle ScholarPubMed
Broide, E., Zeigler, M., Ecksetin, J., and Bach, G.. 1993. “Screening for Carriers of Tay-Sachs Disease in the Ultraorthodox Ashkenazi Jewish Community in Israel.” American Journal of Medical Genetics 47:213–15.CrossRefGoogle ScholarPubMed
Claus, E. B., Tisch, N., and Thompson, W. D.. 1991. “Genetic Analysis of Breast Cancer in the Cancer and Steroid Hormone Study.” American Journal of Human Genetics 48:232–42.Google ScholarPubMed
Cohen, T. 1998. Personal communication.Google Scholar
Croyle, R. T., Achilles, J. S., and Lerman, C.. 1997. “Psychologic Aspects of Cancer Genetic Testing.” Cancer 80:569–75.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Easton, D. 1997. “Breast Cancer Genes — What Are the Real Risks?” Nature Genetics 16:210–11.CrossRefGoogle ScholarPubMed
Gayther, S. A., and Ponder, B. A. J.. 1997. “Mutations of the BRC1 and BRC2 Genes and the Possibilities for Predictive Testing.” Molecular Medicine Today 3:168–74.CrossRefGoogle Scholar
Goodman, R. M. 1979. Genetic Dimensions Among the Jewish People. Baltimore: The Johns Hopkins University Press.Google Scholar
Grabowsky, G. A. 1997. “Gaucher Disease: Gene Frequencies and Genotype/Phenotype Correlations.” Genetic Testing 1:5–12.CrossRefGoogle Scholar
Kaback, M. 1981. “Heterozygote Screening and Prenatal Diagnosis in Tay-Sachs Disease: A Worldwide Update.” In Lysosomes and Lysosomal Storage Diseases, edited by Callahan, J. and Lowden, J. A., 331–40. New York: Raven Press.Google Scholar
Kaufman, M., Cohen, J. Grinshpun, Karpati, M., Peleg, L., Goldman, B., Akstein, E., Adam, A., and Navon, R.. 1997. “Tay-Sachs Disease and HAXA Mutations among Moroccan Jews.” Human Mutation 10:295–300.3.0.CO;2-G>CrossRefGoogle Scholar
Kerem, E., Kalman, Y. M., Yahav, Y., Shoshani, T., Abeliovich, D., Szeinberg, A., Rivlin, J., Blau, H., Tal, A., Ben-Tur, L., Springer, C., Augarten, A., Godfrey, S., Lerer, I., Branski, D., Friedman, M., and Kerem, B.. 1995. “Highly Variable Incidence of Cystic Fibrosis and Different Mutation Distribution among Different Jewish Ethnic Groups in Israel.” Human Genetics 96:193–97.CrossRefGoogle ScholarPubMed
Lerman, C., Daly, M., Sands, C., Balshem, A., Lustbader, E., Heggan, T., Goldstein, L., James, J., and Engstrom, P.. 1993. “Mammography Adherence and Psychological Distress among Women at Risk for Breast Cancer.” Journal of National Cancer Institute 85:1074–80.CrossRefGoogle ScholarPubMed
Miki, Y., Swensen, J., Slattuck-Gidens, D., Futreal, P. A., Harshman, K., Tavtigian, K., and Lui, A.. 1994. “A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRC1.” Science 266:66–71.CrossRefGoogle Scholar
Modell, B., and Kuliev, A. M.. 1991. “Services for Thalassaemia as a Model for Cost Benefit Analysis of Genetic Services.” Journal of Inherited Metabolic Diseases 14:640–51.CrossRefGoogle Scholar
National Academy of Science, National Research Council: Genetic Screening. 1975. Programs, Principles and Research. Washington, D.C.: NAS/NRC.Google Scholar
Newman, B., Austim, M. A., Lee, M., and King, M.-C.. 1988. “Inheritance of Human Breast Cancer: Evidence for Autosomal Dominant Transmission in High-Risk Families.” Proceedings of the National Academy of Science USA 85:3044–48.CrossRefGoogle ScholarPubMed
Renhart, G. 1997. Early Detection Program, Israeli Ministry of Health. Personal communication.Google Scholar
Roa, B. B., Boyd, A. A., Volcik, K., and Richards, C. S.. 1996. “Ashkenazi Jewish Population Frequencies for Common Mutations in BRC1 and BRC2.” Nature Genetics 14:185–87.CrossRefGoogle Scholar
Sagi, M. 1993. “Factors Influencing the Decision Whether to Have Prenatal Diagnosis in Families with Increased Risk for Genetic Disorders.” Ph.D. diss., The Hebrew University, Jerusalem.Google Scholar
Sagi, M., Shiloh, S., and Cohen, T.. 1992. “Application of the Health Belief Model in a Study on Parents' Intentions to Utilize Prenatal Diagnosis of Cleft Lip and/or Palate.” American Journal of Medical Genetics 44:326–33.CrossRefGoogle ScholarPubMed
Shiloh, S. 1996. “Genetic Counseling: A Developing Area of Interest for Psychologists.” Professional Psychology: Research and Practice 27:475–86.CrossRefGoogle Scholar
Struewing, J. P., Hartge, P., Wacholder, S., Baker, S. M., Berlin, M., McAdams, M., Timmerman, M. M., Brody, L. C., and Tucker, M. A.. 1997. “The Risk of Cancer Associated with Specific Mutations of BRCI and BRC2 among Ashkenazi Jews.” New England Journal of Medical Genetics 336:1401–08.CrossRefGoogle Scholar
Wooster, R., Bignell, G., Lancaster, J., Swift, S., Seal, S., Mangion, J., Collins, N., Gregory, S., Gumbs, C., and Micklem, G.. 1995. “Identification of the Breast Susceptibility gene BRC2.” Nature 378:789–92.CrossRefGoogle Scholar
Zimran, A., Kay, A., Gelbart, T., Garver, P., Thurston, D., Saven, A., and Beutler, E.. 1992. “Gaucher Disease: Clinical, Laboratory, Radiologic and Genetic Features in 53 Patients.” Medicine 71:337–53.CrossRefGoogle ScholarPubMed
Zlotogora, J. 1997. Personal communication.Google Scholar