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Role of serotonin in obsessive-compulsive disorder

Published online by Cambridge University Press:  06 August 2018

H. G. Baumgarten  and
Z. Grozdanovic
H. G. Baumgarten*
Affiliation:
Institute of Anatomy, University Clinic Benjamin Franklin, Free University of Berlin, Germany References: Baumgarten & Grozdanovic, 1995, 1997; Jacobs & Fornai, 1993; Unnoila et al, 1993; Soubrie, 1986; Spoont, 1992; Sugihara et al, 1995; Törk 1990; van de Kar & Brownfield, 1993
Z. Grozdanovic
Affiliation:
Institute of Anatomy, University Clinic Benjamin Franklin, Free University of Berlin, Germany
*
Correspondence: Professor H. G. Baumgarten, Institute of Anatomy, University Clinic Benjamin Franklin, Free University of Berlin, Königin-Luise-Strasse 15, D-14195 Berlin, Germany. Fax: +49 30 838 8445 1902
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Abstract

Background Serotonin may play a role in the pathophysiology of obsessive-compulsive disorder (OCD) because of the anti-obsessional effect of selective serotonin reuptake inhibitors (SSRJs).

Method The literature is reviewed on knowledge of the role of serotonergic neurons in brain function, studies on monoamine metabolites in cerebrospinal fluid (CSF), various stress neuropeptides, neuroendocrine and behavioural challenge after administration of direct and indirect serotomimetic compounds, and neuroanatomical data on brain circuits organising behaviour.

Results In most of the OCD cases analysed, CSF 5-hydroxyindoleacetic acid and homovanillic acid concentrations do not significantly differ from age-corrected controls. However, a relationship appears to exist between pre-treatment levels of these metabolites and clinical response to drugs acting on the serotonin transporter. Abnormalities in CSF arginine vasopressin, corticotropin-releasing hormone, oxytocin and somatostatin levels have been reported in OCD. Long-term treatment with high-doses of clomipramine, fluvoxamine, and fluoxetine tend to correct these neuropeptide abnormalities.

Conclusions We hypothesise that continuous treatment with SSRJs alters serotonin turnover and neuropeptide expression patterns in OCD-entertaining functional forebrain/midbrain circuits.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 173 , Issue S35: New perspectives in research and treatment of obsessive-compulsive disorder , August 1998 , pp. 13 - 20
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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