Single and repeat applications of herbicides or herbicide combinations were made over-the-top of young cotton (Gossypium hirsutum L.). DMSA (disodium methanearsonate) and MSMA (monodosium methanearsonate) applied 4 or 8 weeks after emergence had less effect on cotton yield, boll components, and fiber properties than did applications made 12 weeks after emergence. Most single, over-the-top applications of DSMA, fluometuron [1,1-dimethyl-3-(α,α,α-trifluoro-m-tolyl)urea], or DSMA with fluometuron 4 weeks after emergence did not affect cotton yield, boll components, or fiber properties. One or two applications of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] or prometryn [2,4-bis(isopropylamino)-6-(methylthio)-s-triazine] alone, or with DSMA, reduced cotton yields. Applications of 1.1 and 2.2 kg/ha of fluometuron over-the-top of cotton 2 to 8 weeks after emergence did not affect cotton yields, boll components, or fiber properties.