The pre-emergence use of 3–(3,4–dichlorophenyl)–1,1–dimethylurea (diuron) offers a means of controlling weeds in cotton during the extremely critical period of stand establishment (1, 2, 6, 8, 9, 10, 11). The amount of diuron required to give effective weed control without injury to cotton has been observed to vary between locations. Factors such as temperature, moisture, light conditions, and physical and chemical properties of the soil may be involved in causing variation in the activity of this herbicide.